Reservoir water level decline accelerates ground subsidence: InSAR monitoring and machine learning prediction of surface deformation in the Three Gorges Reservoir area by Jiaer Yang, Jiaer Yang, Pinglang Kou, Pinglang Kou, Xu Dong, Xu Dong, Ying Xia, Qinchuan Gu, Yuxiang Tao, Jiangfan Feng, Qin Ji, Weizao Wang, Ram Avtar

“…While LSTM models showed high accuracy, their limitations in complex geological settings highlight the need for hybrid approaches combining machine learning with physical models. Future research should emphasize developing integrated frameworks for long-term risk assessment and mitigation strategies in reservoir environments.ConclusionsThis study provides new insights into the complex surface dynamics in the Three Gorges Reservoir area, emphasizing the interplay of hydrological, geological, and anthropogenic factors. …”
Get full text

Spatiotemporal and genomic analysis of carbapenem resistance elements in Enterobacterales from hospital inpatients and natural water ecosystems of an Irish city by Mark Maguire, Carlos Serna, Natalia Montero Serra, Aneta Kovarova, Louise O’Connor, Niamh Cahill, Brigid Hooban, Niall DeLappe, Wendy Brennan, Genevieve Devane, Martin Cormican, Dearbháile Morris, Simone C. Coughlan, Georgios Miliotis, Bruno Gonzalez-Zorn, Liam P. Burke

“…This may facilitate their future detection in the clinical laboratory.…”
Get full text

Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts by Lewis Steell, Stefanie J. Krauth, Sayem Ahmed, Grace O. Dibben, Emma McIntosh, Peter Hanlon, Jim Lewsey, Barbara I. Nicholl, David A. McAllister, Susan M. Smith, Rachael Evans, Zahira Ahmed, Sarah Dean, Colin Greaves, Shaun Barber, Patrick Doherty, Nikki Gardiner, Tracy Ibbotson, Kate Jolly, Paula Ormandy, Sharon A. Simpson, Rod S. Taylor, Sally J. Singh, Frances S. Mair, Bhautesh D. Jani, the PERFORM research team

“…Health service delivery planning and future intervention design and risk assessment of people with MLTCs should consider both LTC counts and MLTC clusters to better meet the needs of specific populations.…”
Get full text

Brain development during the lifespan of cynomolgus monkeys by Zhiqiang Tan, Binbin Nie, Huanhua Wu, Bang Li, Jingjie Shang, Tianhao Zhang, Zeyu Xiao, Chenchen Dong, Chunyuan Zeng, Biao Wu, Lu Hou, Bin Guo, Yong Cheng, Jian Gong, Weijian Ye, Lin Xu, Yuefeng Li, Xiaojiang Li, Steven H. Liang, Baoci Shan, Hao Xu, Lu Wang

“…The age-specific brain template toolset and associated data offer a robust foundation for future investigations, facilitating a nuanced understanding of brain development in this primate species and, consequently, informing and advancing neuroscience research employing cynomolgus monkeys.…”
Get full text

Identifying subgroup of severe community-acquired pneumonia based on clinical metagenomics, a multicenter retrospective cohort study by Mingqiang Wang, Mingqiang Wang, Yue Jin, Yue Jin, Wenxiao Zhang, Wenxiao Zhang, Ling Ye, Ling Ye, Huanzhang Shao, Huanzhang Shao

“…The rapid identification of these phenotypes could facilitate the screening of sCAP patients responsive to corticosteroid in future prospective clinical trials.…”
Get full text

Comprehensive Evaluation of GPM-IMERG, CMORPH, and TMPA Precipitation Products with Gauged Rainfall over Mainland China by Guanghua Wei, Haishen Lü, Wade T. Crow, Yonghua Zhu, Jianqun Wang, Jianbin Su

“…The comprehensive assessment of the Integrated Multi-satellitE Retrievals for the Global Precipitation Measurement (IMERG) V05B is important for benchmarking the product’s continued improvement and future development. The performance of IMERG V05B precipitation products was systematically evaluated using 542 precipitation gauges at multiple spatiotemporal scales from March 2014 to February 2017 over China. …”
Get full text

Middle-age cerebral small vessel disease and cognitive function in later life: a population-based prospective cohort studyResearch in context by Ali Tanweer Siddiquee, Yoon Ho Hwang, Soriul Kim, Sung Jin Shin, Ji Soo Lee, June Christoph Kang, Min-Hee Lee, Hyeon Jin Kim, Seung Ku Lee, Chol Shin

“…Interpretation: Silent cSVD was independently associated with decline in executive functioning over 8-year follow-up period in this Korean middle-aged through elderly general population. Future studies considering wider spectrum of cSVD and longer follow-up durations may help predict further cognitive outcomes. …”
Get full text

Evaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh by Farhana Khanam, Natasha Y. Rickett, Faisal Ahmmed, Md Taufiqul Islam, Cecilia Kathure Mbae, Justin Im, Asma Binte Aziz, Beatrice Ongadi, Fahima Chowdhury, Ashraful Islam Khan, Afroza Akter, Md Golam Firoj, Sadia Isfat Ara Rahman, Kassa Haile, Se Eun Park, Martin Bundi Mwebia, Moses Mwangi, Benjamin Ngugi, Meseret Gebre Behute, Kelvin Kering, Suneth Agampodi, Suman Kanungo, Xinxue Liu, Andrew J. Pollard, K. Zaman, Deok Ryun Kim, Samuel Kariuki, Firdausi Qadri, John D. Clemens

“…The increasing seroprevalence with age suggests that these antibodies could serve as markers of cumulative past typhoid infections. Future research should explore these possibilities. …”
Get full text

IFN-<inline-formula><math display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> Maintains Immune Tolerance by Promoting M2 Macrophage Polarization... by Xinyu Feng, Cheng Yang, Ting Wang, Jinxin Zhang, Han Zhou, Bin Ma, Ming Xu, Ganzhen Deng

“…Causing, the wide range of cross-species activities of IFN-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula>, therefore we established a pregnant mouse model for the future confirmation of the above mechanism. The results verified that IFN-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> significantly improved this mechanism and maintained normal pregnancy status in mice, but miR-30b-5p significantly reduced the M2 polarization by inhibiting SOCS1, which activated the NF-κB signaling pathway, and then leading to the failure of embryo implantation. …”
Get full text

School-based mindfulness training in early adolescence: what works, for whom and how in the MYRIAD trial? by Susan Ball, Obioha C Ukoumunne, Tamsin Ford, Sarah Byford, Tim Dalgleish, Willem Kuyken, Jesus Montero-Marin, Kate Tudor, Alice Tickell, Catherine Crane, Ariane Petit, Elise Sellars, Laura Taylor, Maris Vainre, Benjamin Jones, Kirsty Griffiths, Elizabeth Nuthall, J Mark G Williams, Sarah-Jayne Blakemore, Katie Fletcher, Emma Medlicott, Anam Raja, Matthew Allwood, Louise Aukland, Tríona Casey, Nicola Dalrymple, Katherine De Wilde, Eleanor-Rose Farley, Jennifer Harper, Nils Kappelmann, Maria Kempnich, Liz Lord, Lucy Palmer, Alice Philips, Isobel Pryor-Nitsch, Lucy Radley, Anna Sonley, Jem Shackleford, Mark T Greenberg, Verena Hinze, Saz Ahmed, Marc Bennett, Lucy Foulkes, Cait Griffin, Konstantina Komninidou, Rachel Knight, Suzannah Laws, Jovita Leung, Jenna Parker, Blanca Piera Pi-Sunyer, Ashok Sakhardande, Lucy Warriner, Brian Wainman

“…Moreover, it may be contraindicated for students with existing/emerging mental health symptoms.Clinical implications Universal SBMT is not recommended in this format in early adolescence. Future research should explore social−emotional learning programmes adapted to the unique needs of young people.…”
Get full text

Association between major depressive disorder or depressive symptoms and the risk of vascular complications among patients with type 2 diabetes, and the mediating role of metabolic... by Guochen Li, Yongfu Yu, Chunqing Lin, Shichen Zheng, Hong Tu, Wanghong Xu

“…Interpretation: Our findings highlight the role of MDD and depressive symptoms in the development of vascular complications among people with T2DM, and suggest that the effect of improving mental health on vascular outcomes in patients with T2DM should be investigated in future work. Funding: Three-Year Public Health Action Plan of Shanghai.…”
Get full text

Ocean equity: from assessment to action to improve social equity in ocean governance by Nathan J. Bennett, Nathan J. Bennett, Nathan J. Bennett, Nathan J. Bennett, Veronica Relano, Katina Roumbedakis, Katina Roumbedakis, Katina Roumbedakis, Jessica Blythe, Mark Andrachuk, Joachim Claudet, Neil Dawson, David Gill, Natali Lazzari, Natali Lazzari, Natali Lazzari, Shauna L. Mahajan, Ella-Kari Muhl, Maraja Riechers, Mia Strand, Sebastian Villasante

“…Thus, we assert that proponents of sustainability must center social equity in future ocean governance, to address past social and environmental injustices, to align with international law and conservation policy, and to realize objectives of sustainability. …”
Get full text

Sex and race disparities in emergency department patients with chest pain and a detectable or mildly elevated troponin by Lucas M. Boyer, Anna C. Snavely, Jason P. Stopyra, Subha V. Raman, Jeffrey M. Caterino, Carol L. Clark, Alan E. Jones, Michael E. Hall, Carolyn J. Park, Brian C. Hiestand, Sujethra Vasu, Michael A. Kutcher, W. Gregory Hundley, Simon A. Mahler, Chadwick D. Miller

“…Conclusion: Non-white patients had higher rates of ACS following discharge despite lower rates of obstructive CAD following standardization of index cardiac testing. Future disparity works should explore care following the index encounter.…”
Get full text

Global, regional, and national burdens of heart failure in adolescents and young adults aged 10–24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease St... by Chengzhi Yang, Yuhe Jia, Changlin Zhang, Zening Jin, Yue Ma, Xuanye Bi, Aiju Tian

“…We also employed the Bayesian age-period-cohort models (BAPC) to predict the future burden of HF up to 2030. Findings: Globally, the prevalence and YLDs rates of HF among adolescents and young adults in 2021 were 148.1 (95% uncertainty interval [UI]: 118.8–185.7) and 14.4 (9.2–21.2) per 100 000 population, increased from 125.5 (100.0–157.7) and 12.2 (7.8–17.8) in 1990 respectively. …”
Get full text

Diagnosis, screening, and follow-up of patients with familial interstitial lung disease: Results from an international survey by Emil Vilstrup Moen, Thomas Skovhus Prior, Michael Kreuter, Wim A. Wuyts, Maria Molina-Molina, Marlies Wijsenbeek, Antonió Morais, Argyrios Tzouvelekis, Christopher J. Ryerson, Fabian Caro, Ivette Buendia-Roldan, Jesper M. Magnusson, Joyce S. Lee, Julie Morisett, Justin M. Oldham, Lauren K. Troy, Manuela Funke-Chambour, Maria Laura Alberti, Raphael Borie, Simon L. F. Walsh, Sujeet Rajan, Yasuhiro Kondoh, Yet H Khor, Elisabeth Bendstrup

“…The survey consisted of 74 questions divided into eight topics: characteristics of respondents, diagnosis, screening of first-degree relatives, screening tools, genetic testing methods, lung transplantation, ethical concerns, and future needs. Results Overall, 237 pulmonologists from 50 countries participated. …”
Get full text

Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

“…The identification of a shared TCRβ chain suggests that immune T cells in KS patients may target a common antigen. Future studies should further explore the immune microenvironment and unique T cell clonotypes, which could pave the way for the development of novel therapeutic strategies for KS patients.…”
Get full text

Effects of different vaccination regimes on the immunodiagnosis of tuberculosis in goats and evaluation of defined antigens by Patricia Cuenca-Lara, Patricia Cuenca-Lara, Miriam Blay-Benach, Miriam Blay-Benach, Zoraida Cervera, Zoraida Cervera, Cristian Melgarejo, Cristian Melgarejo, Julia Moraleda, Julia Moraleda, Iker A. Sevilla, Joseba M. Garrido, Mahavir Singh, Gareth J. Jones, Bernat Pérez de Val, Bernat Pérez de Val

“…Based on these results, the use of defined antigens in the current immunodiagnostic tests appears to be suitable in a future goat TB vaccination scenario.…”
Get full text

An open-label study evaluating the safety and efficacy of AMO-01 for the treatment of seizures in Phelan-McDermid syndrome by Tess Levy, J. Lloyd Holder, Jr., Joseph P. Horrigan, Michael F. Snape, Alison McMorn, Christina Layton, Hailey Silver, Kate Friedman, Hannah Grosman, Slayton Underwood, Danielle Halpern, Jessica Zweifach, Paige M. Siper, Alexander Kolevzon

“…These results provide preliminary support for the safety of AMO-01 and its efficacy in reducing seizures in adults with PMS. Future placebo-controlled studies with larger sample sizes and repeated dosing are warranted.…”
Get full text

Optimization of Identification and Zoning Method for Landscape Characters of Urban Historic Districts by Hong YUN, Zixuan HU, Zehao HU

“…The practical application of this method in Pun Tong Historic District has tested the operability of the method. In the future, the method can be extended to the general urban historic districts by superimposing the distribution of natural elements and other faceted elements to achieve a more comprehensive landscape character assessment.…”
Get full text

A non-randomised open-label exploratory ‘window of opportunity’ study of TG02 treatment in patients with locally advanced primary and recurrent RAS mutant colorectal cancer by Sara Roth, Kasmira Claire Wilson, Robert George Ramsay, Catherine Mitchell, Shienny Sampurno, Toan Duc Pham, Joseph Cherng Huei Kong, Stephen Q. Wong, Alexander Graham Heriot, Sanjeev Deva, Matthew Burge, Cecilie Sverdrup, Anne-Sophie Moller, Lukasz Kuryk, Jon Amund Eriksen, Magnus Jaderberg, John Raymond Zalcberg, Michael Michael

“…High PD-1 expression on post-treatment TILs encourages the addition of an immune checkpoint inhibitor to TG02 and potentially other studies of peptide vaccines in future studies.…”
Get full text