Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research by Benjamin Punz, Maja Brajnik, Joh Dokler, Jaleesia D. Amos, Litty Johnson, Katie Reilly, Anastasios G. Papadiamantis, Amaia Green Etxabe, Lee Walker, Diego S. T. Martinez, Steffi Friedrichs, Klaus M. Weltring, Nazende Günday-Türeli, Claus Svendsen, Christine Ogilvie Hendren, Mark R. Wiesner, Martin Himly, Iseult Lynch, Thomas E. Exner

“…Application of the InstanceMaps tool (described herein) to research workflows of increasing complexity is presented to demonstrate its utility, starting from (i) documentation of a nanomaterial’s synthesis, functionalisation, and characterisation, over (ii) assessment of a nanomaterial’s transformations in complex media, (iii) description of the culturing of ecotoxicity model organisms Daphnia magna and their use in standardised tests for nanomaterials ecotoxicity assessment, and (iv) visualisation of complex workflows in human immunotoxicity assessment using cell lines and primary cellular models, to (v) the use of the instance map approach for the coordination of materials and data flows in complex multipartner collaborative projects and for the demonstration of case studies. Finally, areas for future development of the instance map approach and the tool are highlighted.…”
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A pan-cancer analysis of homeobox family: expression characteristics and latent significance in prognosis and immune microenvironment by Yuanhui Wang, Jie Gao, Ziyi Ren, Ziyi Shen, Wei Gu, Qinyi Miao, Xiaomeng Hu, Xiaomeng Hu, Yan Wu, Yan Wu, Wei Liu, Jia Jia, Jia Jia, Yi Cai, Chunpeng (Craig) Wan, Lei Sun, Tingdong Yan, Tingdong Yan

“…HOXB7 and HOXC6 may serve as potential targets for cancer treatment and the development of targeted compounds in the future.…”
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Analysis of drought and extreme precipitation events in Thailand: trends, climate modeling, and implications for climate change adaptation by José Francisco de Oliveira-Júnior, David Mendes, Helder Dutra Porto, Kelvy Rosalvo Alencar Cardoso, José Augusto Ferreira Neto, Emannuel Bezerra Cavalcante da Silva, Marlúcia de Aquino Pereira, Monica Cristina Damião Mendes, Bernardo Bruno Dias Baracho, Punyawi Jamjareegulgarn

“…The objective is to assess extreme drought and rainfall events in Thailand based on climate modeling through an ensemble for future projections of extreme climate indices. The climate indices used were Consecutive Dry Days (CDD), Maximum Number of Consecutive Summer Days (CSU), Consecutive Wet Days (CWD), Warm Spell Duration Index (WSDI), and Maximum Number of Consecutive Wet Days (WW) derived from simulations of an ensemble composed of six models from the Intergovernmental Panel on Climate Change (IPCC) via the Coupled Model Intercomparison Project Phase 6 (CMIP6) using Artificial Neural Networks (ANN) with the backpropagation method. …”
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Health care utilization patterns of patients enrolled in an interdisciplinary program for back pain by Sara Davin, Psy.D., MPH, Brittany Lapin, PhD., MPH, Belinda Udeh, PhD, Sarah Rispinto, PhD, Nicolas R. Thompson, MS, Ryan Honomichl, PhD, Andre Machado, MD, Irene L. Katzan, MD

“…These findings suggest that participation in a IPP could influence future value-based healthcare decisions, in turn also influencing cost.…”
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Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory study by Jaesub Park, Jaesub Park, Woo Jung Kim, Woo Jung Kim, Han Wool Jung, Han Wool Jung, Jae-Jin Kim, Jae-Jin Kim, Jin Young Park, Jin Young Park, Jin Young Park

“…These findings highlight the potential of EEG in detecting amyloid deposition. Future large-scale studies are needed to validate these preliminary findings and explore their clinical applications.…”
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Two-stage surgical treatment of cataracts with weakness of the lenticular zonular apparatus and uncompensated glaucoma by E.A. Ivachev, S.A. Kochergin

“…After cutting out a deep scleral flap without penetration into the anterior chamber, a cohesive viscoelastic was injected using a cannula under the iris through corneal paracentesis already formed during phacoemulsification into the area of the posterior chamber in the projection of the future coloboma and fistula; then, the internal scleral flap was removed with the opening of the anterior chamber, the iris was inserted into the fistula, after that, the coloboma was formed; a part of viscoelastic was evacuated through the fistula without VB prolapse. …”
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Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study [version 2; peer review: 2 approved] by Eunice Lobo, Jyothi S. Menon, Deepa R., Supriya Bhavnani, Onno CP van Schayck, Shweta Dixit, Prashanth Nuggehalli Srinivas, Aditi Roy, Sumathi Swaminathan, Ruby Gupta, Poornima Prabhakaran, Prashanth Thankachan, Giridhara Rathnaiah Babu, Debarati Mukherjee, Siddhartha Mandal, Gauri Divan

“…The COINCIDE research infrastructure will comprise a valuable global health resource, including prospective cohort data, validated study tools, and stored biological and environmental samples for future studies.…”
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Anlotinib in combination with metronomic chemotherapy in HER2-negative metastatic breast cancer: an observational and retrospective study by Jiaxuan Liu, Jiayang Zhang, Huiping Li, Guohong Song, Lijun Di, Hanfang Jiang, Ying Yan, Huan Wang, Jing Wang, Xiaoran Liu, Bin Shao, Qiao Li

“…Within the context of real-world clinical practice, anlotinib in combination with metronomic chemotherapy provides a well-tolerated and effective treatment option for HER2-negative MBC, which warrants further investigation in the future.…”
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Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms by Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Massimo Breccia, Giuseppe A. Palumbo, Grazia Sanpaolo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G. Pelligra

“…MWPC thresholds were proposed for all other domains and summary scores.ConclusionThe study results demonstrate that the QOL-E is generally fit for purpose to assess treatment effects in populations with LR-MDS and the proposed MWPC thresholds can be used to assess within-patient treatment effect on PROs, as assessed by the QOL-E, in future studies.…”
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The transcriptional analysis of pepper shed light on a proviral role of light-harvesting chlorophyll a/b binding protein 13 during infection of pepper mild mottle virus by Weihong Lin, Shugen Zhang, Hao Zhang, Xiaomei Deng, Tong Jiang, Xifeng Chen, Laihua Dong, Qin Yan, Lianyi Zang, Yongping Xing, Zhenquan Wang, Qin Zhang, Kaitong Du, Huolin Shen, Junmin Zhang, Tao Zhou

“…This study provides valuable insights into the molecular mechanisms underlying resistance and susceptibility in pepper plants and may inform future strategies for disease management.…”
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Strategies and resources used by public health units to encourage COVID-19 vaccination among priority groups: a behavioural science-informed review of three urban centres in Canada by Tori Langmuir, Mackenzie Wilson, Nicola McCleary, Andrea M. Patey, Karim Mekki, Hanan Ghazal, Elizabeth Estey Noad, Judy Buchan, Vinita Dubey, Jana Galley, Emily Gibson, Guillaume Fontaine, Maureen Smith, Amjad Alghamyan, Kimberly Thompson, Jacob Crawshaw, Jeremy M. Grimshaw, Trevor Arnason, Jamie Brehaut, Susan Michie, Melissa Brouwers, Justin Presseau

“…., operationalizing the pros and cons BCT) and barriers/facilitators addressed in strategies/resources for ongoing and future COVID-19 vaccine uptake efforts among general and prioritised populations.…”
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Evaluating plasma biomarkers NfL, GFAP, GDF15, and FGF21 as indicators of disease severity in Charcot–Marie Tooth patients by Dace Pretkalnina, Dace Pretkalnina, Dace Pretkalnina, Elizabete Kenina, Elizabete Kenina, Linda Gailite, Dmitrijs Rots, Dmitrijs Rots, Kaj Blennow, Kaj Blennow, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Viktorija Kenina, Viktorija Kenina, Viktorija Kenina

“…These findings suggest that NfL and GFAP can be reliable disease indicators in future research.…”
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Rapid literature mapping on the recent use of machine learning for wildlife imagery by Nakagawa, Shinichi, Lagisz, Malgorzata, Francis, Roxane, Tam, Jessica, Li, Xun, Elphinstone, Andrew, Jordan, Neil R., O'Brien, Justine K., Pitcher, Benjamin J., Van Sluys, Monique, Sowmya, Arcot, Kingsford, Richard T.

“…Our survey, augmented with bibliometric analyses, provides valuable signposts for future studies to resolve and address shortcomings, gaps, and biases. …”
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KiKli Fit: Investigating the Implementation of a Physical Activity Program in Pediatric Cancer by Lars Rehbein, Ann Christin Schneider, Christina Hillebrech, Christina Schindera, Amika Singh, Katharina Eva, Valentin Benzing

“…Interest from other hospital units suggests the program’s broader applicability. Future efforts will focus on completing data analysis and exploring adaptations for other clinical settings. …”
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Clinical and analytical monitoring of patients with multiple sclerosis on anti-CD20 therapeutics: a real-world safety profile study by André Aires Fernandes, André Aires Fernandes, Ana Lídia Neves, Ana Lídia Neves, Daniela Ferro, Daniela Ferro, Mafalda Seabra, Mafalda Seabra, Teresa Mendonça, Ricardo Soares dos Reis, Ricardo Soares dos Reis, Maria José Sá, Joana Guimarães, Joana Guimarães, Pedro Abreu, Pedro Abreu

“…To better understand the clinical significance of hypogammaglobulinemia secondary to anti-CD20 treatment and to develop strategies for mitigating the associated potential infection risk, future studies with larger populations are essential.…”
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Oral probiotic extracellular vesicle therapy mitigates Influenza A Virus infection via blunting IL-17 signaling by Hongxia Zhou, Wenbo Huang, Jieting Li, Peier Chen, Lihan Shen, Wenjing Huang, Kailin Mai, Heyan Zou, Xueqin Shi, Yunceng Weng, Yuhua Liu, Zifeng Yang, Caiwen Ou

“…Our findings paved the ground for future application of LrEVs in influenza treatment and offered new mechanistic insights regarding the anti-inflammatory role of miR-4239.…”
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Potential impacts of marine fuel regulations on an Arctic stratocumulus case and its radiative response by L. F. Escusa dos Santos, L. F. Escusa dos Santos, H. C. Frostenberg, A. Baró Pérez, A. M. L. Ekman, A. M. L. Ekman, L. Ickes, E. S. Thomson

“…With the retreating sea ice, shipping activity will likely increase in the future, driven by economic activity and the potential for realizing time and fuel savings from using shorter trade routes. …”
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Role of C5aR2 in prognosis of patients with acute respiratory distress syndrome through negative modulation of C5a: A prospective observational study by Muhammed Rashid, Sreedharan Nair, Pooja Gopal Poojari, Vijetha Shenoy Belle, Vijayanarayana Kunhikatta, Daniel A. Vaz, Vishal Shanbhag, Viji Pulikkel Chandran, Shravya Chitrapady, Girish Thunga

“…However, adequately powered studies are required to confirm these findings in future.…”
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The Influences of Rootstock on the Performance of Pinot Noir (Vitis vinifera L.): Berry and Wine Composition by Yipeng Chen, Zijian Liang, Mark Krstic, Peter Clingeleffer, Kate Howell, Deli Chen, Pangzhen Zhang

“…Furthermore, the results could guide future studies in understanding the roles of rootstocks in regulating the metabolic pathways of phenolic and volatile production in the berries of grafted Pinot noir at the molecular level.…”
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Country-Specific Roadmaps for Scaling Up Integrated Care in Belgium, Slovenia, and Cambodia – Lessons Learned from the SCUBY Project by Martin Heine, Monika Martens, Daniel Boateng, Grace Marie Ku, Roy Remmen, Edwin Wouters, Srean Chhim, Por Ir, Antonjia Poplas Susič, Wim van Damme, Josefien van Olmen, Kerstin Klipstein-Grobusch, on behalf of the SCUBY consortium

“…These learnings help shape future policy dialogues and best practices to tackle chronic disease in each participating country.…”
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