Systematic surveillance of SARS-CoV-2 reveals dynamics of variant mutagenesis and transmission in a large urban population by Marie-Ming Aynaud, Lauren Caldwell, Khalid N. Al-Zahrani, Seda Barutcu, Kin Chan, Andreea Obersterescu, Abiodun A. Ogunjimi, Min Jin, Kathleen-Rose Zakoor, Shyam Patel, Ron Padilla, Mark C. C. Jen, Princess Mae Veniegas, Nursrin Dewsi, Filiam Yonathan, Lucy Zhang, Amelia Ayson-Fortunato, Analiza Aquino, Paul Krzyzanowski, Jared Simpson, John Bartlett, Ilinca Lungu, Bradly G. Wouters, James M. Rini, Michael Gekas, Susan Poutanen, Laurence Pelletier, Tony Mazzulli, Jeffrey L. Wrana

“…Furthermore, we found that VOC mutant derivatives and putative quasispecies that targeted functionally important residues and were found in future VOCs arose frequently, but were always extinguished. …”
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Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets by Yikuan Du, Yuying Huo, Yujia Yang, Peiqi Lin, Wuzheng Liu, Ziqin Wang, Wenqi Zeng, Jiahui Li, Zhonghan Liang, Chenyue Yuan, Jinfeng Zhu, Ziyi Luo, Yi Liu, Chunling Ma, Chun Yang

“…This will contribute to a better understanding of the interactions between sirtuins and obesity and bone, which will facilitate the development of new therapeutic strategies for obesity and OP in the future.…”
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Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy st... by Fu Zhao, Fu Zhao, Xiaojing Jiang, Yumeng Li, Tianjiao Huang, Zhikai Xiahou, Wenyang Nie, Qian Li

“…The C2 IGF2+ tumor subtype, linked to poor prognosis, offers a promising target for future therapies. Emphasizing immune infiltration and drug sensitivity, the research highlights personalized strategies to improve survival and quality of life for HGSOC patients.…”
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Shining light on knee osteoarthritis: an overview of vitamin D supplementation studies by Di Zhang, Miaoyu Ye, Yao Xu, Luyu Jiang, Yanmei Hu, Qi Zhang, Xiao Han, Qian Dai, Junhui Qian, Jian Luo, Qiang Yuan

“…Nevertheless, due to the generally low quality of current studies, future research should prioritize improving the quality of primary studies to establish the efficacy of vitamin D supplementation for KOA with more robust scientific evidence.Systematic review registrationThe protocol of this overview was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (https://www.crd.york.ac.uk/PROSPERO/) with the registration number CRD42024535841.…”
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Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER) by Landon Myer, Amy L Slogrove, Ushma Mehta, Mary-Ann Davies, Max Kroon, Greg Petro, Alexa Heekes, Andrew Boulle, Karen Fieggen, Chantal Stewart, Ayesha Osman, Natasha Rhoda, Emma Kalk, Florence Phelanyane, Jonathan Euvrard, Stefan Gebhardt, Kim Anderson

“…Analysis of key obstetric and neonatal health indicators derived from the PER are consistent with the aggregate data in the District Health Information System.Future plans This represents significant infrastructure, able to address clinical and epidemiological concerns in a low/middle-income setting.…”
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Call to Action: Lead Pharmacy into the Next Decade by Gregory Zumach, Kerry K Fierke, Gardner Lepp, Bridget McGugan, Marta Brooks, Anthony Olson, Andrew Bartlett, Nilushi Karunaratne, Betty Exintaris

“…Call to Action Through our work as scholars, we can provide evidence-based, pertinent, timely solutions to address these issues, in ways that make it easily transferable to broad audiences. The future of pharmacy leadership is in our hands and awaits our unique insights. …”
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Evaluating the Cellophane Production Supply Chain Using Multi-Criteria Decision-Making Approaches by َAhmad Jafarnejad, Amir Mohammad Khani

“…While this is more about learning the present state of the market, it is also important to realize future trends, customer needs, and competition. It includes information on marketing research, customer surveys, and competitive studies. …”
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Bringing MDMA-assisted therapy for PTSD to traditional healthcare systems: tending to set and setting by Dimitri Perivoliotis, Dimitri Perivoliotis, Kayla Knopp, Kayla Knopp, Shannon Remick, Allie Kaigle, Allie Kaigle, Christopher S. Stauffer, Christopher S. Stauffer, Chandra Khalifian, Chandra Khalifian, Tamara R. Wachsman, Bettye E. Chargin, Andrew W. Bismark, Andrew W. Bismark, Al Alam, Al Alam, Leslie Morland, Leslie Morland, Leslie Morland

“…These recommendations are intended to inform future MDMA-AT for PTSD research and, potentially, eventual clinical implementation efforts in traditional healthcare systems.…”
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Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure by Marcelo Rodrigues Dos Santos, Guilherme Wesley Peixoto daFonseca, Letícia Pironato Sherveninas, Francis Ribeiro deSouza, Antônio Carlos Battaglia Filho, Caio Eduardo Novaes, Rosa Maria Rodrigues Pereira, Carlos Eduardo Negrão, Antônio Carlos Pereira Barretto, Maria‐Janieire de Nazaré Nunes Alves

“…Conclusions Body fat distribution, particularly android and gynoid fat composition, together with other cofactors, might have an important adverse role on functional capacity in male patients with HFrEF. Future studies are needed to address possible mechanisms involved in this relationship.…”
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Exploring the benefits and prescribing informations of combining East Asian herbal medicine with conventional medicine in the treatment of rheumatoid arthritis: A systematic review... by Hee-Geun Jo, Jihye Seo, Eunhye Baek, Donghun Lee

“…Further analysis of the herbal prescriptions presented in this study will provide valuable direction for future research.…”
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Identification of EXPA4 as a key gene in cotton salt stress adaptation through transcriptomic and coexpression network analysis of root tip protoplasts by Qiankun Liu, Pengtao Li, Muhammad Jawad Umer, Mubashir Abbas, Yongqing Zhao, Yu Chen, Yanfang Li, Aiming Zhang, Yuling Liu, Yangyang Wei, Quanwei Lu, Mengying Yang, Yiman Liu, Xiaoyan Cai, Zhongli Zhou, Shuxun Yu, Fang Liu, Renhai Peng

“…Conclusion These findings underscore the functional significance of GaEXPA4 in the salt stress response. Future research should focus on elucidating the precise mechanisms of putative salt tolerance genes like GaEXPA4 and evaluating the potential of signaling pathways, such as MAPK, for engineering enhanced salt resilience in cotton. …”
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Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, Brazil by Monique Cristina dos Santos, Monique Cristina dos Santos, Natalia Fintelman-Rodrigues, Natalia Fintelman-Rodrigues, Aline de Paula Dias da Silva, Aline de Paula Dias da Silva, Rodolfo Leandro Nascimento Silva, Victor Corrêa Seixas, Amanda A. Batista-da-Silva, Amanda A. Batista-da-Silva, Marcelo Alves Ferreira, Patrícia T. Bozza, Fernando A. Bozza, Fernando A. Bozza, Fernando A. Bozza, Thiago Moreno L. Souza, Thiago Moreno L. Souza

“…Thus, enhancing surveillance in slums could be important for future epidemic/pandemic preparedness by connecting virus genetic diversity in this region with its circulation at divergent locations.…”
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Gambaran Elektrolit dan Gula Darah Pasien Kejang Demam yang Dirawat di Bangsal Anak RSUP Dr. M. Djamil Periode Januari 2010 - Desember 2012 by Khairunnisa Imaduddin, Iskandar Syarif, Rahmatini Rahmatini

“…The patients with febrile seizure show decrease serum sodium and calcium, normal serum potassium, and increase non-fasting blood glucose level. Expected future studies have a lot of samples in determining the electrolytes and blood glucose in patients with febrile seizure.…”
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Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

“…Timely recognition of <i>C. difficile</i> co-infection and use of targeted anti-inflammatory and supportive therapies may improve patient management. Future studies should expand on these findings to optimize care and guide therapeutic strategies.…”
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Evolution paths of urban forms influenced by landforms: Asynchrony but convergence by Chao Yang, Qiyan Huang, Qiong Xian, Meng Yuan, Xiaoming Cong, Lisha Xun, Jianxiong Cheng, Hongyi Pan

“…It contributes to urban form research and provides a theoretical foundation for devising context-specific urban development policies for current and future scenarios.…”
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Lateralized differences in power spectra across different frequency bands during NREM sleep in patients with primary insomnia by Jiao Huang, Jiao Huang, Jing Ye, Mingjie Gao, Wentao Gao, Weijia Chen, Yifeng Zhu, Yongbo Wang, Daijin Huang, Yunhui Lv, Hong Shi

“…Primary insomnia was associated with significant fragmented sleep, and an increase in beta1 power was related to the number of awakenings.SignificanceThese findings revealed the hemispheric lateralization characteristics of power spectral disturbances during non-rapid eye movement sleep in primary insomnias and provided valuable insights for selecting electrode placements in future power spectral analyses of primary insomnias.…”
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Characterization of the colostrum proteome of primiparous Holstein cows and its association with colostrum immunoglobulin G concentrations by Ezequias Castillo-Lopez, Patrick Biber, Arife Sener-Aydemir, Karin Hummel, Ebrahim Razzazi-Fazeli, Nicole Reisinger, Qendrim Zebeli, Susanne Kreuzer-Redmer, Thomas Hartinger

“…Thus, results suggest that the colostrum proteomic profile is associated with the content of IgG. Future research should deeply explore the association of these findings with pre-calving nutrition status and blood composition of the cow, and with passive immunity transfer to the calf.…”
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Quantification of Forest Regeneration on Forest Inventory Sample Plots Using Point Clouds from Personal Laser Scanning by Sarah Witzmann, Christoph Gollob, Ralf Kraßnitzer, Tim Ritter, Andreas Tockner, Lukas Moik, Valentin Sarkleti, Tobias Ofner-Graff, Helmut Schume, Arne Nothdurft

“…The presence of sufficient natural regeneration in mature forests is regarded as a pivotal criterion for their future stability, ensuring seamless reforestation following final harvesting operations or forest calamities. …”
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Deciphering the role of epigenetics in plant pathogen resistance: Strategies for sustainable sugarcane management by Faisal Mehdi, Yuanli Wu, Shuzhen Zhang, Yimei Gan, Zhengying Cao, Shuting Jiang, Limei Zan, Benpeng Yang

“…By clarifying these molecular pathways, the review lays a foundation for future research that seeks to strengthen sugarcane against biotic stressors and ensure the sustainability of sugar and bioenergy production.…”
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Explore the evolution of winter wheat production and its response to climate change under varying precipitation years in the Loess Plateau of China by Donglin Wang, Yanbin Li, Binbin Zhang, Tengcong Jiang, Siyu Wu, Wenjie Wu, Yi Li, Jianqiang He, Deli Liu, Qinge Dong, Hao Feng

“…To clarify the transformation process of precipitation and the mechanism how it change the crop yield, particularly in the Loess Plateau where precipitation frequently alternates between dry and wet years, this study used the down-scaling global climate model (GCMs) data to simulate and predict the change trend of winter wheat yield from 1961 to 2100 under varying precipitation conditions in two future climate scenarios (SSP245 and SSP585), employing the APSIM model. …”
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