L-Theanine Extends the Lifespan of <i>Caenorhabditis elegans</i> by Reducing the End Products of Advanced Glycosylation by Zhihang Huang, Haiming Jing, Yan Pan, Hongxia Cai, Wenjing Zhang, Jingyuan Zhu, Nan Zhang, Dan Wu, Wentao Xu, Hexiang Qiu, Huihui Bao, Guojun Li, Junyu Ning, Bo Xian, Shan Gao

“…These findings provide new insights for developing anti-aging strategies and lay the groundwork for further research on the potential benefits of L-theanine in mammals. Future studies could explore the molecular mechanisms, test L-theanine in mammalian models, and assess the long-term side effects.…”
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Evaluation of the Efficacy of Stem Cell Therapy in Ovariectomized Osteoporotic Rats Based on Micro-CT and Dual-Energy X-Ray Absorptiometry: A Systematic Review and Meta-Analysis by Zhencheng Xiong, Ping Yi, Jialiang Lin, Shengfeng Qiu, Li Shu, Chi Zhang

“…Due to the limited number and quality of studies related to some outcomes, more high-quality RCTs are still needed in the future to complement the existing findings.…”
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Clinical outcome changes in sarcopenic obesity: a meta-analysis of exercise training methods by Lei Chen, Haojing Zhou, Yichen Gong, Yi Tang, Hai Su, Zhongyi Zhang, Peijian Tong, Guoqian Chen

“…This underscores the clinical significance of exercise intervention in treating muscle-reducing obesity, suggesting future studies explore exercise intervention’s role and mechanism, particularly related to IGF-1, IL-6, and other cytokines.…”
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Using Laboratory Test Results for Surveillance During a New Outbreak of Acute Hepatitis in 3-Week- to 5-Year-Old Children in the United Kingdom, the Netherlands, Ireland, and Curaç... by Maaike C Swets, Steven R Kerr, Brian MacKenna, Louis Fisher, Merel van Wijnen, Diederik Brandwagt, Paul W Schenk, Pieter Fraaij, Leonardus G Visser, Sebastian Bacon, Amir Mehrkar, Alistair Nichol, Patrick Twomey, Philippa C Matthews, Malcolm G Semple, Geert H Groeneveld, Ben Goldacre, Iain Jones, J Kenneth Baillie

“…The approach holds potential as a tool for pandemic surveillance in future outbreaks. Our findings do not indicate the presence of a broader outbreak of mild hepatitis cases among young children, although there was an increase in elevated AST or ALT values locally in the Netherlands.…”
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Application of metagenomic next-generation sequencing in the diagnosis of post-stroke infections: a case series study using multiple sample types by Xiaopu Chen, Yong Liang, Wei Yang, Wenzhen He, Zhiqiang Xing, Shunxian Li, Shaoyu Cai, Jiping Fu, Xiaotang Peng, Manli Chen, Jiaming Wu

“…While mNGS shows promise in enhancing diagnostic accuracy and guiding clinical treatment, it high cost and technical challenges need addressing before widespread clinical adoption. Future research should focus on optimizing mNGS protocols, integration it with convertional diagnostic tools, and evaluating its cost-effectiveness and clinical impact through larger, multicentric studies.…”
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A new approach for evaluating regional permafrost changes: A case study in the Hoh Xil on the interior Qinghai‒Tibet Plateau by Yu-Xin Zhang, Lin Zhao, Chang-Wei Xie, Guo-Jie Hu, Shu-Hua Yang, De-Fu Zou, Yong-Ping Qiao, Xiang-Fei Li, Jia-Jie Peng

“…Model validation demonstrates the reliability of this approach for predicting long-term permafrost changes. Future regional permafrost changes were further simulated based on the latest warming scenarios (BCC-CSM2-MR) from the Coupled Model Intercomparison Project Phase 6. …”
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Glycerol Monolaurate Complex Improved Antioxidant, Anti-Inflammation, and Gut Microbiota Composition of Offspring in a Sow–Piglet Model by Dan Li, Min Yang, Zhao Ma, Lianqiang Che, Bin Feng, Zhengfeng Fang, Shengyu Xu, Yong Zhuo, Jian Li, JiHhua Wang, Zhengfan Zhang, Zehui Wu, Tao Lin, De Wu, Yan Lin

“…In conclusion, GML enhanced reproductive and growth performance by improving antioxidant and anti-inflammatory status and maintaining intestinal flora balance, making it a promising alternative to ATLL in future applications.…”
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The role of artificial intelligence in aortic valve stenosis: a bibliometric analysis by Shanshan Chen, Shanshan Chen, Changde Wu, Zhaojie Zhang, Lingjuan Liu, Yike Zhu, Dingji Hu, Chenhui Jin, Haoya Fu, Jing Wu, Songqiao Liu, Songqiao Liu, Songqiao Liu

“…Despite the progress, challenges such as model transparency and data security remain. Future research should focus on overcoming these challenges while enhancing collaboration among international institutions to further advance AI applications in cardiovascular medicine.…”
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The trend of phylogenetic and epitope variations of SARS-CoV-2 Omicron sub-lineages in Iran by Mehdi Shabani, Ahmad Nejati, Jila Yavarian, Jila Yavarian, Kaveh Sadeghi, Sevrin Zadheidar, Akram Sadat Ahmadi, Monire Ghadirali, Arghavan Zebardast, Adel Abedi, Mohammad Hossein Najmi, Nazanin-Zahra Shafiei-Jandaghi, Talat Mokhtari-Azad

“…The high rate of T-cell epitopes conservation in non-spike proteins among different sub-lineages of the Omicron in this study highlighted the importance of cell-mediated immunity and suggested that non-spike proteins might be more attractive targets for future SARS-CoV-2 vaccines.…”
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Fitness Profiling in Women Soccer: Performance Characteristics of Elite Turkish Women Soccer Players by Aras Beka Yaşar, Serdar Bayrakdaroğlu, Beyza Yıldız, İbrahim Can

“…It is thought that the results obtained are important to fill this lack in the literature and will be the reference source for future research.…”
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The health promoting sports coach: theoretical background and practical guidance by Benjamin Tézier, Kévin Barros, Susanna Geidne, Farid Bardid, Spartaco Grieco, Stacey Johnson, Sami Kokko, Barry Lambe, Arthur Lefebvre, Aoife Lane, Linda Ooms, Jan Seghers, Vassilis Sevdalis, Stephen Whiting, Anne Vuillemin, Aurélie Van-Hoye

“…It broadens the scope of coaching by incorporating health principles, while emphasising the need to adapt to the environment and context of the club. This work calls for future research to test the effectiveness and feasibility of these approaches in various sporting environments.…”
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Development and Validation of a Nomogram for Predicting Long-Term Net Adverse Clinical Events in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention by Junyan Zhang, Zhongxiu Chen, Ran Liu, Yuxiao Li, Hongsen Zhao, Yanning Li, Minggang Zhou, Hua Wang, Chen Li, Li Rao, Yong He

“…Internal validation showed strong predictive capability and clinical utility. Future research should validate the nomogram in diverse populations and explore new predictors for improved accuracy. …”
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The Burden of Type 2 Diabetes in Adolescents and Young Adults in China: A Secondary Analysis from the Global Burden of Disease Study 2021 by Junting Yang, Siwei Deng, Houyu Zhao, Feng Sun, Xiantong Zou, Linong Ji, Siyan Zhan

“…High BMI and environmental pollution emerge as primary risk factors and should be prioritized in future interventions.…”
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Evaluasi Usability Website Berita Online Prokal.Co Menggunakan Evaluasi Heuristic dan Webuse by M. Gilvy Langgawan Putra, Nisya Rani Sabilla, Sri R. Natasia

“…It affects PROKAL's plan to redesign the user interface of the website in 2020, because PROKAL still doesn’t know the needs and problems experienced by users also what website will look like in the future. Based on the description above, a usability evaluation study was conducted using the Heuristic method in order to find problems from the PROKAL.co website with reference to heuristic principles. …”
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The Disk Wind Contribution to the Gamma-Ray Emission from the Nearby Seyfert Galaxy GRS 1734−292 by Nobuyuki Sakai, Tomoya Yamada, Yoshiyuki Inoue, Ellis R. Owen, Tomonari Michiyama, Ryota Tomaru, Yasushi Fukazawa

“…Both of these show that future observations with the Cherenkov Telescope Array and the Southern Wide-field Gamma-ray Observatory could detect TeV emission from a disk wind in GRS 1734−292. …”
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Reduced functional independence and multimorbidity increases the risk of severe infection among older patients with Omicron: a multicenter retrospective cohort study by Wan Yu, Runnian Huang, Shuning Sun, Li Bu, Xin Chen, Yunhua Di, Shuwu Lin, Qian Li, Yang Yang, Xingyue Ye, Wenxu Wang, Rui Ren, Linze Xi, Ru Zhang, Yi Li, Xin Li, Tianbo Hou, Zibo Ning, Yang Peng, Difei Wang

“…Conclusions Our results provide further scientific evidence on the association between FI, multimorbidity, and disease severity in older COVID-19 patients, contributing to future health decision-making for COVID-19 and other infectious diseases.…”
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Effects of Neuromuscular Training on Performance and Injury Prevention in Youth Team Sports: Development of an Evidence-Based Educational Program by Markus Tschopp, Nicklaus Hess, Pascal Andrey, Adrian Rothenbühler, Fabian Studer

“…By addressing the complexities of knowledge transfer and considering the needs of diverse stakeholders, this program aims to bridge the gap between research and practice in enhancing performance and preventing injuries among young athletes in team sports. Future research should evaluate the effectiveness of this educational program in improving coach knowledge and behavior, as well as its impact on athlete performance and injury rates in youth team sports. …”
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Traditional herbal medicine for Guillain-Barré syndrome: A systematic review and meta-analysis by Somin Jung, Han-Gyul Lee, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Jung-Mi Park, Chang-Nam Ko

“…Hence, the present study was conducted to investigate the clinical evidence of herbal medicine treatment for GBS and to provide a research strategy for the future. Method: PubMed, Embase, Cochrane, CNKI, CiNii, and Science ON were searched from inception to December 4, 2024. …”
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Longitudinal assessment of diffusion-weighted imaging during magnetic resonance-guided radiotherapy in head and neck cancer by Simon Boeke, Jonas Habrich, Sarah Kübler, Jessica Boldt, Fritz Schick, Konstantin Nikolaou, Jens Kübler, Cihan Gani, Maximilian Niyazi, Daniel Zips, Daniela Thorwarth

“…Changes in ADC and volumes can be assessed, but future work needs to explore the potential for biologically guided treatment individualization. …”
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A mixed-methods observational study of strategies for success in implementation science: overcoming emergency departments hurdles by Deonni P. Stolldorf, Alan B. Storrow, Dandan Liu, Cathy A. Jenkins, Rachel A. Hilton, Karen F. Miller, Joy Kim, Deepika Boopathy, Satheesh Gunaga, Bory Kea, Joseph Miller, Sean P. Collins

“…We describe implementation barriers and facilitators, and the selection and refinement of implementation strategies, to facilitate future GUIDED-HF implementation. Methods A mixed-methods cross-sectional observational study was conducted in four United States EDs in two diverse healthcare systems in the Pacific West and Midwest. …”
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