Associated adverse outcomes with tumor treating fields when combined to temozolomide versus temozolomide alone for the treatment of glioblastoma: a meta-analysis of randomized tria... by Yuanyuan Chen, Yan Chen, Hong Zhen, Danhua Lou

“…Conclusion TTF in combination with temozolomide was not associated with significantly worse adverse outcomes for the treatment of patients with glioblastoma. Hence, future trials should focus on the cost-effectiveness of TTF for the treatment of glioblastoma.…”
Get full text

A Subgroup of Latently Mycobacterium tuberculosis Infected Individuals Is Characterized by Consistently Elevated IgA Responses to Several Mycobacterial Antigens by Ralf Baumann, Susanne Kaempfer, Novel N. Chegou, Wulf Oehlmann, Ralf Spallek, André G. Loxton, Paul D. van Helden, Gillian F. Black, Mahavir Singh, Gerhard Walzl

“…In conclusion, the consistently elevated IgA levels in a subgroup of controls suggest higher mycobacterial load, a risk factor for progression to active TB, and together with high IgG levels may have prognostic potential and should be investigated in future large scale studies. The novel antigen NarL may also be promising for the antibody-based diagnosis of active TB cases.…”
Get full text

Application of large language models in disease diagnosis and treatment by Xintian Yang, Tongxin Li, Qin Su, Yaling Liu, Chenxi Kang, Yong Lyu, Lina Zhao, Yongzhan Nie, Yanglin Pan, Yuanyuan Ji

“…This paper highlights the rapid advancements in research on the diagnostic and therapeutic applications of LLMs across different medical disciplines and emphasizes the importance of policymaking, ethical supervision, and multidisciplinary collaboration in promoting more effective and safer clinical applications of LLMs. Future directions include the integration of proprietary clinical knowledge, the investigation of open-source and customized models, and the evaluation of real-time effects in clinical diagnosis and treatment practices.…”
Get full text

Women Empowered to Connect With Addiction Resources and Engage in Evidence-Based Treatment (WE-CARE)—an mHealth Application for the Universal Screening of Alcohol, Substance Use, D... by Krystyna Isaacs, Autumn Shifflett, Kajal Patel, Lacey Karpisek, Yi Cui, Maayan Lawental, Golfo Tzilos Wernette, Brian Borsari, Katie Chang, Tony Ma

“…The next version of WE-CARE will include normative scores for participants to self-evaluate their screening status compared with their age- and gender-matched peers and enhanced linkages to care features. Future development will focus on enhancing engagement to improve change behaviors and assess readiness for change.…”
Get full text

Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation by Chrissa Petersen, Adhini Kuppuswamy Satheesh Babu, Ceres Mattos Della Lucia, Henry A. Paz, Lisard Iglesias-Carres, Ying Zhong, Thunder Jalili, J David Symons, Kartik Shankar, Andrew P. Neilson, Umesh D. Wankhade, Pon Velayutham Anandh Babu

“…Further, our study provides significant proof of concept to warrant future research on the use of strawberries as a nutritional strategy to prevent vascular complications.…”
Get full text

Radiopharmaceuticals and their applications in medicine by Siqi Zhang, Xingkai Wang, Xin Gao, Xueyao Chen, Linger Li, Guoqing Li, Can Liu, Yuan Miao, Rui Wang, Kuan Hu

“…It emphasizes the significance and future prospects of theranostic-based radiopharmaceuticals in advancing precision medicine.…”
Get full text

Multiparametric MRI and artificial intelligence in predicting and monitoring treatment response in bladder cancer by Yuki Arita, Thomas C. Kwee, Oguz Akin, Keisuke Shigeta, Ramesh Paudyal, Christian Roest, Ryo Ueda, Alfonso Lema-Dopico, Sunny Nalavenkata, Lisa Ruby, Noam Nissan, Hiromi Edo, Soichiro Yoshida, Amita Shukla-Dave, Lawrence H. Schwartz

“…This review provides an update on the potential of QIBs and mpMRI-based radiomics and discusses the future applications of AI in BCa management, particularly in assessing treatment response. …”
Get full text

Spatial-Temporal Variation and Driving Forces of Carbon Storage at the County Scale in China Based on a Gray Multi-Objective Optimization-Patch-Level Land Use Simulation-Integrated... by Gui Chen, Qingxia Peng, Qiaohong Fan, Wenxiong Lin, Kai Su

“…However, several limitations remain, as follows: the singularity of carbon density data, and the research scope being confined to small-scale mountainous forest ecosystems. Future studies could consider collecting continuous annual soil carbon density data and employing land-use simulation models (such as PLUS or CLUMondo) appropriate to the study area’s dimensions.…”
Get full text

Experiences and opinions of adults with type 1 diabetes on the android-based open-source closed-loop system in China: a qualitative study by Chaofan Wang, Daizhi Yang, Jinhua Yan, Ping Ling, Mengyun Lei, Ying Ni, Xiaodi Guo, Qingying Huang

“…Mann-Whitney U test suggested that the satisfaction derived from glucose management with AAPS surpassed the satisfaction attributed to the enhancement of their overall quality of life (p<0.05).Conclusions Adults with T1D had generally positive experiences with AAPS. The future focus of AAPS research and development should be on optimising glycaemic management, improving device experience and reducing costs.Trial registration number NCT05726461; Pre-results.…”
Get full text

Modeling resistive-inductive evolution of currents in Wendelstein 7-X by L. van Ham, S.A. Lazerson, J.C. Schmitt, B.F. Lee, M. Beurskens, K.J. Brunner, N. Chaudhary, G. Fuchert, J. Geiger, M. Hirsch, J. Knauer, A. Langenberg, J.W. Oosterbeek, N. Pablant, E. Pasch, K. Rahbarnia, G. Weir, the W7-X Team

“…Simulations of ECCD and heating power steps show THRIFT is capable of capturing the dynamical evolution of the current in response to changes in current sources. Future uses of THRIFT include validating and benchmarking other non-inductive current models.…”
Get full text

N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1 by Toru Miwa, Toru Miwa, Akihito Tarui, Akihito Tarui, Teppei Kouga, Yasunori Asai, Yasunori Asai, Hideaki Ogita, Hideaki Ogita, Taro Fujikawa, Nobuhiro Hakuba, Nobuhiro Hakuba

“…The dual role of SIRT1 emphasizes the need for precise modulation of its expression for effective therapeutic interventions. Future research should explore mechanisms underlying SIRT1-induced cochlear damage and strategies to maintain balanced SIRT1 expression. …”
Get full text

La transformation de l’ancien centre de détention secrète de Derb Moulay Cherif en musée des « années de plomb » (Casablanca, Maroc) by Anissa Habane

“…The third is blocked by the inability to make use of the building itself has prevented it from being turned into a museum for the time being, to preserve memory and educate future generations. The development of the CDS-DMC remains an important memorial issue, given the lack of interest shown by the authorities and those in power. …”
Get full text

Advances and applications on non-Hermitian topological photonics by Yan Qiuchen, Zhao Boheng, Zhou Rong, Ma Rui, Lyu Qinghong, Chu Saisai, Hu Xiaoyong, Gong Qihuang

“…In this review article, we focus on the recent advances and applications on non-Hermitian topological photonics, including the non-Hermitian topological phase transition and skin effect, as well as the applications emerging prosperously in reconfigurable, nonlinear and quantum optical systems. The possible future research directions of non-Hermitian topological photonics are also discussed at the end. …”
Get full text

Assessment of the Diversity of Tomato (Solanum Lycopersicum L.) Accessions in the Nigeria National Gene Bank Using Simple Sequence Repeat (SSR) Markers by Olabisi Olajire, Olusola Oduoye, Zainab Jamaleddine, Olatunde Fajimi, David Coker, Abiodun Sunday, Opeyemi Oluwasanya, Best Anukwu, Abiodun Ogundele, Omowumi Ayekun, Yetunde Amos

“…The results showed that SSR markers were successfully used to discriminate among the tomato accessions based on the PIC and genetic diversity values, hence promoting their use for future crop improvement and contributing to food security.…”
Get full text

Longitudinal associations between air pollution and incident dementia as mediated by MRI-measured brain volumes in the UK Biobank by Rhiannon Thompson, Xinning Tong, Xueyi Shen, Jinjun Ran, Shengzhi Sun, Xiaoxin Iris Yao, Chen Shen

“…Our findings provide novel evidence that differences in brain volume may mediate these relationships. Future research is required to prove this mechanism and establish the other mechanisms through which exposure to air pollution might increase dementia risk.…”
Get full text

Targeted gut microbiome therapy: Applications and prospects of probiotics, fecal microbiota transplantation and natural products in the management of type 2 diabetes by Luqi Qin, Bei Fan, Yixia Zhou, Jiahuan Zheng, Rao Diao, Fengzhong Wang, Jiameng Liu

“…Based on these current studies, future research should be focused on large-scale, long-term clinical studies and further investigation on the potential role of the gut virome in T2DM. …”
Get full text

The Impact of COVID-19 Pandemic on the Diagnosis, Treatment, and Outcomes of Colorectal Cancer in Singapore by Hui Lionel Raphael Chen, Piea Peng Lee, Yun Zhao, Wei Hao Caleb Ng, Jiashen Zhao, Yu En Christopher Tan, Bo Jie Sean Loh, Kah-Hoe Pierce Chow, Hiang Khoon Tan, Kwong-Wei Emile Tan

“…Healthcare policies should facilitate early cancer screening, diagnosis, and treatment to reduce cancer-related morbidity for future pandemics.…”
Get full text

The Prevalence of Dermoscopy Use Among Dermatology Residents in Riyadh, Saudi Arabia: Cross-Sectional Study by Abdullah Almeziny, Rahaf Almutairi, Amal Altamimi, Khloud Alshehri, Latifah Almehaideb, Asem Shadid, Mohammed Al Mashali

“…Dermoscopy use is increasing worldwide, but to date, no study has documented the attitudes toward and use of dermoscopy among future dermatologists in Saudi Arabia. …”
Get full text

Advancing the application of the analytical renal pathology system in allograft IgA nephropathy patients by Xumeng Liu, Huiwen Fang, Dongmei Liang, Qunjuan Lei, Jiaping Wang, Feng Xu, Shaoshan Liang, Dandan Liang, Fan Yang, Heng Li, Jianghua Chen, Yuan Ni, Guotong Xie, Caihong Zeng

“…Besides, a higher allograft survival was noticed among patients in the high-level groups of the maximum and ratio of endothelial cells, as well as the maximum and density of podocytes.Conclusion We propose that the ARPS could be implemented in future clinical practice with outstanding capability.…”
Get full text

Climate change risks illustrated by the Intergovernmental Panel on Climate Change (IPCC) “burning embers” by P. Marbaix, P. Marbaix, P. Marbaix, A. K. Magnan, A. K. Magnan, A. K. Magnan, V. Muccione, V. Muccione, P. W. Thorne, Z. Zommers

“…The database lays the groundwork for future risk assessments and the development of burning embers by providing a standardized baseline of risk data. …”
Get full text