Construction of a potentially functional long noncoding RNA-microRNA-mRNA network in diabetic cardiomyopathy by Qiwen Cao, Zhihui Dong, Yangbo Xi, Jiana Zhong, Jianzhong Huang, Qunfeng Yang

“…Gene Ontology, Kyoto Encyclopedia of Gene and Genome pathway analysis, and Gene set enrichment analysis (GSEA) were employed for functional analysis. Protein-protein interaction (PPI) network and hub genes were also identified. …”
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Molecular Networks Involved in the Immune Control of BK Polyomavirus by Eva Girmanova, Irena Brabcova, Jiri Klema, Petra Hribova, Mariana Wohlfartova, Jelena Skibova, Ondrej Viklicky

“…Analysis of biopsies from asymptomatic viruria patients resulted in the identification of 5 differentially expressed genes (CD3E, CD68, CCR2, ICAM-1, and SKI) (P<0.05), and functional analysis showed a significantly heightened presence of costimulatory signals (e.g., CD40/CD40L; P<0.05). …”
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The highly pathogenic strain of porcine deltacoronavirus disrupts the intestinal barrier and causes diarrhea in newborn piglets by Xin Yao, Wei-Hong Lu, Wen-Ting Qiao, Yu-Qian Zhang, Bao-Ying Zhang, Hui-Xin Li, Jin-Long Li

“…By constructing 3D models, it was found that the S1-NTD/CTD and S2-HR-C regions produced structural alterations. Protein functional analysis showed that the structural changes of the three regions changed the epitope of S protein, the O-GalNAc glycosylation site and the 3C-like protease cleavage site. …”
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A Novel Immune-Related Three-Gene Signature and Immune Infiltration Insights in Psoriasis and Chronic Kidney Disease by Yin T, Zhang T, Ma L

“…Through further functional analysis, these genes were found to be primarily involved in the activation of inflammation and innate immune responses. …”
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First identification of a Neanderthal bone spear point through an interdisciplinary analysis at Abric Romaní (NE Iberian Peninsula) by Paula Mateo-Lomba, Andreu Ollé, Juan Luis Fernández-Marchena, Palmira Saladié, Juan Marín, M. Gema Chacón, Josep Vallverdú, Isabel Cáceres

“…Through an interdisciplinary, multi-technique, and multi-scale approach combining technology, taphonomy, and functional analysis, compelling evidence for manufacture, use, and hafting was uncovered. …”
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Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation by Yong Zhao, Hao Wang, Ming Lu, Xin Qiao, Bei Sun, Weihui Zhang, Dongbo Xue

“…The putative target genes were subjected to KEGG functional analysis. The functions of the target genes were primarily enriched in MAPK pathways. …”
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Identification of cuproptosis and ferroptosis-related subtypes and development of a prognostic signature in colon cancer. by Yinghao He, Fuqiang Liu, Qingshu Li, Zheng Jiang

“…In this study, utilizing data from TCGA and GEO databases, we examined the expression differences of ferroptosis and cuproptosis-related genes in colon cancer and identified two subtypes. Through functional analysis and bioinformatics methods, we elucidated pathway differences and biological characteristics between these two subtypes. …”
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Exploration of predictive markers associated with primary angle-closure glaucoma risk in companion dogs using genomic information by Ji Hyun Jun, Gwang Hyeon Lee, Zultsetseg Byambasuren, Hong Sik Kong

“…To assess the impact of non-synonymous SNP (nsSNPs), functional analysis of candidate genes, Hazard Assessment, and protein structure prediction were conducted. …”
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Heme Oxygenase 1/Peroxisome Proliferator-Activated Receptor Gamma Pathway Protects Intimal Hyperplasia and Mitigates Arteriovenous Fistula Dysfunction by Regulating Oxidative Stres... by Tingfei Xie, Yunpeng Xu, Lecai Ji, Xiaolu Sui, Aisha Zhang, Yanzi Zhang, Jihong Chen

“…Differentially expressed mRNAs (DEmRNAs) were screened and subjected to functional analysis. Thereafter, the mice with HO-1 knockdown and coprotoporphyrin IX chloride (COPP) pretreatment were used to investigate the roles of the HO-1/PPAR-γ pathway in AVF. …”
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Gastric Microbiota Associated with Gastric Precancerous Lesions in <i>Helicobacter pylori</i>-Negative Patients by Han-Na Kim, Min-Jeong Kim, Jonathan P. Jacobs, Hyo-Joon Yang

“…<i>Prevotella jejuni</i> and the genus <i>Parvimonas</i> were enriched in the IM group. A predictive functional analysis revealed enrichment of the ornithine degradation pathway in the IM and dysplasia groups, suggesting its role in persistent gastric mucosal inflammation associated with gastric precancerous lesions. …”
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Extensive In Silico Analysis of ATL1 Gene : Discovered Five Mutations That May Cause Hereditary Spastic Paraplegia Type 3A by Mujahed I. Mustafa, Naseem S. Murshed, Abdelrahman H. Abdelmoneim, Miyssa I. Abdelmageed, Nafisa M. Elfadol, Abdelrafie M. Makhawi

“…Additionally; we submitted the common six deleterious outcomes from the previous functional analysis tools to I-mutant 3.0 and MUPro, respectively, to investigate their effect on the structural level. …”
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Complete genome sequence of Pseudarthrobacter sp. NIBRBAC000502770 from coal mine of Hongcheon on Republic of Korea by Min-Kyu Park, Yeong-Jun Park, Myung-Suk Kang, Min-Ha Kim, Soo-Young Kim, Jae-Ho Shin

“…Genome annotation identified 4,209 genes, including 3,926 protein-coding genes, 51 tRNA genes, and 15 rRNA genes, with a G + C content of 66.1%. Functional analysis revealed genes related to plant growth promotion and heavy metal resistance, such as arsenate (arsR, arsC) and copper (copC, copD) resistance genes. …”
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Bioinformatics Analysis of Genes and Mechanisms in Postherpetic Neuralgia by Yong Qiu, Meng-Lei Hao, Xu-Tao Cheng, Zhen Hua

“…A total of 116 genes were up-regulated in the DRG of PHN rats, and 135 genes were down-regulated. Functional analysis revealed that variations were predominantly enriched for genes involved in neuroactive ligand-receptor interactions, the Jak-STAT signaling pathway, and calcium channel activity. …”
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A Critical Review of Proteomic Studies in Gestational Diabetes Mellitus by Tao Zhou, Lu Huang, Min Wang, Daozhen Chen, Zhong Chen, Shi-Wen Jiang

“…Although most of the studies only stayed in the stage of initial discovery, several proteins were further verified to be efficient for disease diagnosis. Functional analysis of all the combined significant proteins also showed that a small number of proteins are known to be involved in the regulation of insulin or indirect signaling pathways. …”
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Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology by Chauveau, Carine, Roby, Dominique

“…First, from genetic analyses by QTL (Quantitative Trait Locus) mapping and GWAs (Genome Wide Association studies), the identification, cloning and functional analysis of this gene have been used as a starting point for the exploration of the multiple and coordinated pathways acting together to mount the QDR response dependent on RKS1. …”
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Naoxintong Is Involved in the Coagulation Regulation of Warfarin Through the MAPK Pathway by Luo X, Chen L, Xu J, Li J

“…GO and KEGG were used for functional analysis. The effect of NXT on warfarin anticoagulation was then tested in rats by analyzing coagulation factors in blood before and after drug administration. …”
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The assessment of white blood corpuscles by geometric-morphometric analysis after the application of calcium aluminate and calcium silicate dental cements in wistar rats by Muhamed KATICA, Zurifa AJANOVIĆ, Aida BEŠIĆ, Ognjenka JANKOVIĆ, Emina DERVIŠEVIĆ, Nedžad HADŽIOMEROVIĆ, Faruk TANDIR 5 Smiljana PARAŠ, Amina LUČKIN, Vukoman JOKANOVIĆ

“…The results of discriminant functional analysis determined that there was a statistically significant difference in the shape of the lymphocytes between the experimental animals, to which dental cements were applied, compared to the lymphocytes from the control group. …”
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P-glycoprotein and/or Histone Deacetylase 2 Regulates Steroid Responsiveness in Childhood Nephrotic Syndrome by Harshit Singh, Narayan Prasad, Durga Prasanna Misra, Akhilesh Kumar Jaiswal, Vikas Agarwal

“…Materials and Methods: Thirty-one patients were recruited at baseline (n = 31) (before initiating steroid therapy); after 6 weeks of steroid therapy, 24 patients achieved remission (steroid-sensitive NS [SSNS] n = 24 mean age, 7.96 ± 3.90), whereas seven patients were resistant to steroids (SRNS, n = 7, mean age 10.00 ± 3.55). mRNA expression of HDAC2 and P-gp and functional analysis of P-gp and enzymatic activity of HDAC2 were analyzed at baseline, and at 6 weeks of steroid treatment and at the time of relapse. …”
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6-hydroxygenistein attenuates hypoxia-induced injury via activating Nrf2/HO-1 signaling pathway in PC12 cells by Pengpeng Zhang, Jie Zhang, Chuan Ma, Huiping Ma, Linlin Jing

“…The intersected targets were used for constructing PPI network and performing GO and KEGG functional analysis. We induced injury in PC12 cells under hypoxia conditions and observed the effects and molecular mechanisms of 6-OHG on cellular damage. …”
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Genome-Wide Analysis of DNA Methylation in Human Amnion by Jinsil Kim, Mitchell M. Pitlick, Paul J. Christine, Amanda R. Schaefer, Cesar Saleme, Belén Comas, Viviana Cosentino, Enrique Gadow, Jeffrey C. Murray

“…Using the Illumina Infinium HumanMethylation27 BeadChip, we identified genes exhibiting differential methylation associated with normal labor and preterm birth. Functional analysis of the differentially methylated genes revealed biologically relevant enriched gene sets. …”
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