Differences in Gender and Overall Survival for Temperature-Sensitive TP53 Mutations in Gastroesophageal Cancer by Danial H. Shaikh, Margaret Park, Jiandong Chen, Jeffrey Huang, Mark S. Friedman, Aamir N. Dam, Anjuli K. Luthra, Saraswathi Cappelle, Luis R. Pena, Jennifer B. Permuth, Shaffer R. S. Mok

“…Patients were then stratified based on the TP53 temperature sensitivity according to a recently reported functional analysis of its activity. Patients were also stratified based on a history of Barrett’s esophagus (BE), cancer stage, sex, and race. …”
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Human gut microbiota adaptation to high-altitude exposure: longitudinal analysis over acute and prolonged periods by Xianzong Ma, Changwei Duan, Xiaoying Wang, Yurong Tao, Lang Yang, Yongsheng Teng, Yuanming Pan, Mingjie Zhang, Junfeng Xu, Jianqiu Sheng, Xin Wang, Peng Jin

“…., Faecalibacterium, Roseburia, and Bifidobacterium), suggesting possible adverse health effects. Functional analysis indicated changes in metabolism-related pathways post-exposure, supporting the idea that high-altitude adaptations involve metabolic adjustments for energy management. …”
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The Knob Domain of the Fiber-1 Protein Affects the Replication of Fowl Adenovirus Serotype 4 by Xiaofeng Li, Zhixun Xie, You Wei, Zhiqin Xie, Aiqiong Wu, Sisi Luo, Liji Xie, Meng Li, Yanfang Zhang

“…Fiber-1-Δ2 has a greater ability to inhibit FAdV-4 replication than fiber-1-Δ1, and 933 differentially expressed genes (DEGs) were detected between the fiber-1-Δ1 and fiber-1-Δ2 groups. Functional analysis revealed these DEGs in a variety of biological functions and pathways, such as the phosphoinositide 3-kinase–protein kinase b (PI3K–Akt) signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway, cytokine–cytokine receptor interactions, Toll-like receptors (TLRs), the Janus tyrosine kinase–signal transducer and activator of transcription (Jak–STAT) signaling pathway, the nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) signaling pathway, and other innate immune pathways. …”
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A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction through dual-targeting mitochondrial and nuclear G4 enriched genome by Keli Kuang, Chunyan Li, Fatlinda Maksut, Deepanjan Ghosh, Robin Vinck, Maolin Wang, Joël Poupon, Run Xiang, Wen Li, Fei Li, Zhu Wang, Junrong Du, Marie-Paule Teulade-Fichou, Gilles Gasser, Sophie Bombard, Tao Jia

“…Pt-ttpy induces mtDNA deletion, copy reduction and transcription inhibition, hindering mt protein translation. Functional analysis reveals potent mt dysfunction without reactive oxygen species (ROS) induction. …”
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A Potential Antitumor Effect of Dendritic Cells Fused with Cancer Stem Cells in Hepatocellular Carcinoma by Ye-Bin Pang, Jian He, Bi-Yu Cui, Sheng Xu, Xi-Lei Li, Man-Ya Wu, Rong Liang, Yan Feng, Xing Guo, Xue-Hui Zhang, Xiao-Ling Luo

“…The fusion cells expressed a higher level of costimulatory molecules CD80, CD83, CD86, and MHC-I and MHC-II molecules HLA-ABC and HLA-DR than did immature DCs (P<0.05). And the functional analysis of fusion cell-induced CTLs also illustrated that CD90+HepG2/DC fusion cells showed a greater capacity to activate proliferation of lymphocytes in vitro (P<0.05). …”
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The Klebsiella pneumoniae tellurium resistance gene terC contributes to both tellurite and zinc resistance by Ruixiang Yang, Shuang Han, Yanshuang Yu, Hongru Li, John D. Helmann, Katharina Schaufler, Michael D. L. Johnson, Qiu E. Yang, Christopher Rensing

“…Further physiological functional analysis revealed that terC is not only important for Te(IV) resistance but also for resistance to Zn(II), Mn(II), and phage infection. …”
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Joint image reconstruction and segmentation of real-time cardiovascular magnetic resonance imaging in free-breathing using a model based on disentangled representation learning by Tobias Wech, Oliver Schad, Simon Sauer, Jonas Kleineisel, Nils Petri, Peter Nordbeck, Thorsten A. Bley, Bettina Baeßler, Bernhard Petritsch, Julius F. Heidenreich

“…Intra-observer reliability was good (intraclass correlation coefficient = 0.77, 95% confidence interval [0.75, 0.79], p < 0.001). In functional analysis, a positive bias was observed for ejection fractions derived from the proposed model compared to the clinical reference standard (RT-BH mean: 58.5 ± 5.6%, bias: +3.47%, 95% confidence interval [−0.86, 7.79%], RT-FB mean: 57.9 ± 10.6%, bias: +1.45%, [−3.02, 5.91%], Cartesian mean: 54.9 ± 6.7%). …”
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Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease by Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero

“…Bioinformatics analyses were conducted. Functional analysis was performed using primary neuronal cultures, and the impact of the variant was assessed through immunocytochemistry and electrophysiology. …”
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Whole Genome Sequencing Reveals the Distribution of Resistance and Virulence Genes of an Enterohemorrhagic Escherichia coli O157∶H7 Strain from Swine by Yan ZHOU, Qiyang WAN, Shujiao ZHU, Hui ZHANG, Hongduo BAO, Ran WANG

“…The Prokka software was used to predict the genome sequence information, and the genome sequence information was predicted through UniProt, KEGG and KEGG Pathway, GO, Pfam, COG, TIGERfams, RefSeq and NR databases were used for gene prediction and annotation, and then the carbohydrate enzyme (CAZy), pathogen and host interaction (PHI), virulence factor (VFDB) and drug resistance gene (CARD) databases were used Perform gene functional analysis.【Result】The genome size of enterohemorrhagic E. coli O157 ∶ H7 strain EO157-1 is 5 404 747 bp, and the GC content is 50.49%. …”
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Temporal changes of neurobehavior in rats following varied blast magnitudes and screening of serum biomarkers in early stage of brain injury by Ning Ma, Hong Wang, Qing Lu, Jinren Liu, Xiaolin Fan, Liang Li, Qi Wang, Xiao Li, Boya Yu, Yuhao Zhang, Junhong Gao

“…Two co-expressed proteins were validated. Functional analysis revealed significant enrichment of 1121, 2096, and 1121 Gene Ontology (GO) items and 33, 47, and 26 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, indicating extensive molecular responses to overpressure in the early phase. …”
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The cnf1 gene is associated with an expanding Escherichia coli ST131 H30Rx/C2 subclade and confers a competitive advantage for gut colonization by Landry L. Tsoumtsa Meda, Luce Landraud, Serena Petracchini, Stéphane Descorps-Declere, Emeline Perthame, Marie-Anne Nahori, Laura Ramirez Finn, Molly A. Ingersoll, Rafael Patiño-Navarrete, Philippe Glaser, Richard Bonnet, Olivier Dussurget, Erick Denamur, Amel Mettouchi, Emmanuel Lemichez

“…Hence, gut colonization factor function of cnf1 was confirmed for another clinical strain ST131-H30Rx/C2. In addition, functional analysis of the cnf1-positive clinical strain EC131GY ST131-H30Rx/C2 and a cnf1-deleted isogenic strain showed no detectable impact of the CNF1 gene on bacterial fitness and inflammation during the acute phase of bladder monoinfection. …”
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Reemplazo total de cadera en pacientes menores de 50 años: ¿tiene la fijación no cementada mejores resultados? by L. Perez Alamino, G. Garabano, J. Rodriguez, F. Lopreite, C. Pesciallo

“…Loosening, demarcation, complications, and prosthesis survival were assessed. Functional analysis was performed with the modified Harris Hip Score and Visual analogue scale was collected. …”
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The method of formation of skills of simulation modeling the it professional by E. N. Guseva, I. Y. Efimova, T. N. Varfolomeeva

“…A specialist in simulation modeling should possess integrative interdisciplinary knowledge from related scientific fields, for example, probability theory and mathematical statistics, higher mathematics, be familiar with other methods of solving economic problems: linear, nonlinear, dynamic programming, optimization; show proficiency in structural and functional analysis; be able to explore complex processes and systems comprehensively.Materials and methods. …”
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I disturbi del neurosviluppo: verso un modello clinico integrato by Flavia Morfini

“…In gestalt therapy the focus is on contact needs and how those needs are blocked; in behavioral cognitive orientation the emphasis is on mental patterns as behavior triggers, while in the applied analysis of behavior the single aspects of a behavioral process are examined, defining the latter functional analysis. Therefore, an analytical and systematic vision of the function of behavior is present in Aba. …”
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Insights into the Driving Factors of Methane Emission from Double-Season Rice Field Under Different Fertilization Practices in South China by Jin Zheng, Yusheng Lu, Peizhi Xu, Kaizhi Xie, Changmin Zhou, Yaying Li, Haoyang Geng, Qianyuan Wang, Wenjie Gu

“…Furthermore, there was a significant positive correlation between the relative abundance of the CH₄-related key gene <i>mcrA</i> and these microorganisms. Functional analysis indicated that these potential methanogens primarily produce methane through the acetoclastic and hydrogenotrophic pathways. …”
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Comparative Outcomes of Minimally Invasive Versus Open Hallux Valgus Surgery: A Systematic Review and Meta-Analysis by Abdul-Hadi Kafagi, Abdul-Rhaman Kafagi, Marwan Tahoun, Omar Tariq Al Zareeni, Khaled El Aloul, Mohammad Usman Ahmad, Anand Pillai

“…The odds of hardware removal were significantly higher with MIS (OR = 2.37, CI: 1.41 to 4.00, <i>p</i> = 0.001). Functional analysis showed that MIS achieved significantly higher postoperative AOFAS scores (MD = 2.52, CI: 0.92 to 4.13, <i>p</i> = 0.002). …”
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Immunoglobulin A/PIGR axis as potential mediators of human abdominal aortic aneurysms revealed by topologically resolved proteomics by Isabel Cerro-Pardo, Estefanía Núñez, Belén Picatoste, Cristina Márquez-Gálvez, Lucía Ortega-Villanueva, Irene Raposo-Gutiérrez, Jes S. Lindholt, Luis Miguel Blanco-Colio, Almudena R. Ramiro, Jesús Vázquez, José Luis Martín-Ventura

“…Finally, the hematopoietic contribution of PIGR was assessed in experimental AAA (Ldlr −/− mice fed an atherogenic diet and 1 μg/Kg/min angiotensin II infusion for 28 days) by bone marrow transplantation experiments. Results Functional analysis of biological pathways altered in human AAA wall revealed a significant upregulation of components of the adaptive immune response, including IGHA1 and IGHA2, as well as the IGA receptor, PIGR. …”
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Metagenomic Analysis Reveals the Characteristics of Cecal Microbiota in Chickens with Different Levels of Resistance During Recovery from <i>Eimeria tenella</i> Infection by Jianqiang Tang, Liyue Dong, Meihui Tang, Areej Arif, Honghong Zhang, Genxi Zhang, Tao Zhang, Kaizhou Xie, Shijie Su, Zhenhua Zhao, Guojun Dai

“…Additionally, beneficial cecal microorganisms such as <i>Flavonifractor_sp__An10</i>, <i>Pseudoflavonifractor</i>, and <i>Faecalicoccus</i> were significantly decreased in both the R_JR and R_JS groups (<i>p</i> < 0.05) compared to the R_JC group. Predictive functional analysis using the KEGG and CAZy databases further indicated that the cecal microbiota in the R_JR group exhibited enhanced metabolism-related pathways, whereas these pathways were significantly diminished in the R_JS group, potentially influencing the recovery process from coccidial infection. …”
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Single-cell multi-omics analysis identifies SPP1+ macrophages as key drivers of ferroptosis-mediated fibrosis in ligamentum flavum hypertrophy by Chengshuo Fei, Yanlin Chen, Ruiqian Tan, Xinxing Yang, Guanda Wu, Chenglong Li, Jiawei Shi, Shiyong Le, Wenjie Yang, Jiajia Xu, Liang Wang, Zhongmin Zhang

“…An integrated multi-omics approach, encompassing scRNA-seq, bulk RNA sequencing (bulk RNA-seq), and Mendelian randomization (MR), was applied to conduct comprehensive functional analysis. Clinical tissue specimens and animal models were employed to further confirm the multi-omics findings. …”
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Oestrogen suppresses the adipogenesis of fibro/adipogenic progenitors through reactivating the METTL3–ESR1‐mediated loop in post‐menopausal females by Hao Zhou, Shujing Feng, Jinkui Cai, Xiexiang Shao, Siyuan Zhu, Han Zhou, Yongmin Cao, Ru Wang, Xingzuan Lin, Jianhua Wang

“…The effects of estrogen supplementation on muscular fatty infiltration and locomotor function in OVX mice were evaluated by immunofluorescent staining and functional analysis. Results Decreased expression of ESR1/METTL3 and increased adipogenesis ability in FAPs was found in post‐menopausal female. …”
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