Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study by Dabin Yun, Jung-Ho Yang, Jin-ah Sim, Minjung Kim, Ji Won Park, Seung Yong Jeong, Aesun Shin, Sun-Seog Kweon, Nan Song

“…The two-stage GWAS revealed statistically significant associations among MKLN1 (rs75170436, 7q32.3, beta (log odds ratio) = − 0.90, P meta  = 5.90 × 10–13), MMP14 (rs3751489, 14q11.2, beta (log odds ratio) = − 1.91, P meta  = 2.31 × 10–12). Post-GWAS functional analysis revealed strong associations on two genes highlighting deleterious effects and increased gene expression. …”
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What is the Role of Medical Informatics in Digital Healthcare? by Mihai TĂRÂŢĂ

“… • 1981 – Research on fuzzy sets for automated diagnostic approximation (National Symposium on Functional Analysis and Applications, Craiova). • 1985-1987 – Creation of a non-invasive system for recording late electrocardiographic and His potentials, making our lab the 7th in the world to achieve this noninvasively, in real-time…”
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Funding for sustainable development of rural communities: European experience by Liudmyla Romanchuk, Iryna Abramova, Yuliia Moroz, Pavlo Poplavskyi, Ihor Svitlyshyn

“…The research was carried out using the following methods: bibliometric, trend, cluster – to assess the scientific productivity of research, identify key trends in scientific approaches to the issues under study; comparative, systemic, institutional and functional analysis – to determine the functional links between different elements of the European Union (EU) funding system, as well as correlation and regression analysis – to establish the degree of interconnection between different sources of funding for rural communities in the EU member states. …”
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Transcriptional Sequencing and Gene Expression Analysis of Various Genes in Fruit Development of Three Different Black Pepper (Piper nigrum L.) Varieties by Choy Yuen Khew, Jennifer Ann Harikrishna, Wei Yee Wee, Ee Tiing Lau, Siaw San Hwang

“…These results indicate several candidate genes related to the development of flower and fruit in black pepper and provide a resource for future functional analysis and potentially for future crop improvement.…”
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Longitudinal DNA methylation profiles in saliva of offspring from mothers with gestational diabetes: associations with early childhood growth patterns by Teresa M. Linares-Pineda, Alfonso Lendínez-Jurado, Alberto Piserra-López, María Suárez-Arana, María Pozo, María Molina-Vega, María José Picón-César, Sonsoles Morcillo

“…Results We identified 6,968 DMPs at the postpartum stage and 5,132 after one year, with 50 sites remaining differentially methylated over time, 16 of which maintained consistent methylation directionality. Functional analysis linked several of these DMPs to genes involved in inflammation and metabolic processes, including CYTH3 and FARP2, both implicated in growth and metabolic pathways. …”
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Network Pharmacology and Experimental Validation of the Effects of Shenling Baizhu San, Quzhi Ruangan Fang and Gexia Zhuyu Tang on the Intestinal Flora of Rats with NAFLD by Guo J, Shi A, Sun Y, Zhang S, Feng X, Chen Y, Yao Z

“…Nine common hub genes were screened from the PPI network. GO functional analysis reported that these targets were mainly closely related to the response to bacterial molecules. …”
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Analysis of 1,25-dihydroxyvitamin D genomic action in human enteroids and colonoids reveals multiple regulatory effects of vitamin D in human intestinal physiology by Zachary K. Criss, Kali Deans-Fielder, James C. Fleet, Sylvia Christakos, Noah Shroyer

“…While 63 genes were vitamin D regulated across all four cultures (55 up, 8 down), we found that vitamin D regulated subgroups of genes within Dd, Co, Un, or Diff groups as well as set of genes that were unique to each culture. Functional analysis revealed several vitamin D-enriched gene ontologies or pathways including those for xenobiotic/drug metabolism in all four cultures. …”
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Identification and verification of international neuroblastoma staging system (INSS) stage-related genes as potential biomarkers for neuroblastoma prognostic models by Can Qi, Ziwei Zhao, Yanwei Qi, Yun Zhou, Fang Yue, Huizhong Niu, Guochen Duan, Zhiyong Zhong, Le Wang

“…CNR1, PRKACB, CDKN3, and PCLAF were found to significantly affect the overall survival and event-free survival of neuroblastoma patients and were positively correlated with the INSS advanced stages. The functional analysis of these four genes revealed their cancer-promoting effects and correlations with immune-inflammatory, cell cycle, and p53 signaling pathways. …”
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Association between taurine transporter SLC6A6 and breast cancer development and prognosis: a Mendelian randomization analysis by Xinping Huang, Hailong Shu, Man Xu, Weixiao Ke, Wanting Chen, Wenbin Huang, Hai Wang, Yifan Zhu, Yongxia Yang

“…Molecular docking, functional analysis, and immune infiltration analysis were employed to explore the mechanism of SLC6A6. …”
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INFORMATION PROVISION OF TOURISM AND ECONOMY IN AZERBAIJAN AND ITS BIBLIOMETRIC ANALYSIS by Sevda KHALAFOVA, Nadir ISMAYILOV

“…Research methods: special library science, historical, structural-functional analysis, systematic approach, generalization, sociological, statistical analysis and comparative analysis methods were used in the research process. …”
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Identification of lipid metabolism related immune markers in atherosclerosis through machine learning and experimental analysis by Hang Chen, Biao Wu, Biao Wu, Kunyu Guan, Liang Chen, Kangjie Chai, Maoji Ying, Dazhi Li, Weicheng Zhao

“…Finally, the expression variations of the identified pivotal genes were confirmed through experimental validation.ResultWGCNA identified 302 lipid metabolism-related genes in atherosclerotic samples, and functional analysis revealed that these genes are associated with multiple immune pathways. …”
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EVALUATION OF THE DYNAMICS OF OCCLUSION RATIO DURING ORTHODONTIC TREATMENT OF PATIENTS WITH PERMANENT BITE. by K.M. Lykhota

“…Investigation of violations of occlusion of dentitions is an integral part of the complex functional analysis of the dental maxillary apparatus. The most common clinical technique for the analysis of occlusive ratio is the technique of occlusion through articulation paper. …”
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Identification of Isoflavonoid Biosynthesis-Related R2R3-MYB Transcription Factors in Callerya speciosa (Champ. ex Benth.) Schot Using Transcriptome-Based Gene Coexpression Analysi... by Linchan Yu, Ding Huang, Jinyuan Gu, Dongjin Pan, Yong Tan, Rongshao Huang, Shaochang Yao

“…The results will provide information for further functional analysis and quality improvement through genetic manipulation of these potential R2R3-CsMYB genes in C. speciosa.…”
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Direct RNA sequencing reveals chicken post-transcriptional modifications in response to Campylobacter jejuni inoculation by Yanan Zhao, Yuanmei Wang, Yanru Ren, Long Liu, Tianyi Wang, Liying Liu, Xianyao Li

“…The transcripts containing m6A/m5C modifications displayed higher expression levels and shorter poly(A) tails than those without modifications. Functional analysis of these modules including differentially expressed transcripts (DETs), transcripts with differentially significant poly(A) tail length, m5C modified DETs, and m6A modified DETs showed that the negative regulation of interferon-beta production was enriched (P < 0.05). …”
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Modulation of early life gut microbiota through inclusion of earthworms and vermicompost in broiler diets by Muhammad Zeeshan Akram, Oyekunle John Oladosu, Nadia Everaert, Cornelia C. Metges, Gürbüz Daş

“…In P2, the CON-EW group exhibited increased Lactobacillus abundance while Escherichia-Shigella was overrepresented in the CON- group. Functional analysis showed that the CON-EW and CON-VC diets enriched the pathways related to Nicotinamide Adenine Dinucleotide biosynthesis and fermentation to acetate and lactate, whereas the CON- increased the biosynthesis of enterobactin and aerobactin. …”
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Expanding structural insights into DNA packaging apparatus and endolysin LysSA05 function of Epsilon15 bacteriophage by Muhammad Saleem Iqbal Khan, Ju Wu, Shenlin Ji, Demeng Tan, Bingrui Sui, Shanshan Peng, Jinbiao Zhan, Jiajun Yin

“…In this study, we present a structural and functional analysis of temperate bacteriophage Epsilon15 (ϵ15), focusing on its DNA packaging and injection machinery, along with characterization of the dual-acting endolysin LysSA05. …”
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Model Evaluasi Usability Menggunakan Confirmatory Factor Analysis pada KRS Online by Endah Ratna Arumi, Pristi Sukmasetya, Agus Setiawan

“…Abstract Nowadays, the development of computer software systems is not just a functional analysis. At this time, the software interface has begun to become a focus in software development. …”
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NCBP2 predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis by Shichao Li, Yulan Wang, Xi Yang, Miao Li, Guoxiang Li, Qiangqiang Song, Junyu Liu

“…Furthermore, the expression of NCBP2 was confirmed by immunohistochemistry (IHC) and functional analysis at the single-cell level was conducted using the CancerSEA database. …”
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BLH3 Regulates the ABA Pathway and Lignin Synthesis Under Salt Stress in <i>Lilium pumilum</i> by Wenhao Wan, Lingshu Zhang, Xingyu Liu, Huitao Cui, Miaoxin Shi, Hao Sun, Wei Yang, Xinran Wang, Fengshan Yang, Shumei Jin

“…Additionally, the functional analysis of the BLH transcription factor family provides new insights into how crops adapt to the extreme growth environment of saline-alkali soils.…”
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Shotgun metagenomic sequencing reveals the influence of artisanal dairy environments on the microbiomes, quality, and safety of Idiazabal, a raw ewe milk PDO cheese by Gorka Santamarina-García, Min Yap, Fiona Crispie, Gustavo Amores, Cathy Lordan, Mailo Virto, Paul D. Cotter

“…SourceTracker analysis revealed commercial feed and teat skin as major contributors to the raw milk microbiota (45.6% and 33.5%, respectively), being a source of, for example, Lactococcus and Pantoea, along with rennet contributing to the composition of whey and cheese (17.4% and 41.0%, respectively), including taxa such as Streptococcus, Pseudomonas_E or Lactobacillus_H. Functional analysis linked microbial niches to cheese quality- and safety-related metabolic pathways, with brine and food contact surfaces being most relevant, related to genera like Brevibacterium, Methylobacterium, or Halomonas. …”
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