Comparative Metagenomic Analysis of the Gut Microbiota of Captive Pangolins: A Case Study of Two Species by Zhengyu Dai, Bowen Xie, Chungang Xie, Jinsuo Xiang, Xinmei Wang, Jing Li, Rongquan Zheng, Yanni Wang

“…However, the Chinese pangolins exhibited higher microbial diversity (Shannon index, <i>p</i> = 0.042; Simpson index, <i>p</i> = 0.037) and lower relative abundance of Proteobacteria compared with the Malayan pangolins. A functional analysis revealed significant differences in the metabolic pathways, where the Chinese pangolins demonstrated a higher potential for fiber degradation, whereas the Malayan pangolins exhibited elevated levels of antibiotic resistance genes and pathogenic taxa, such as <i>Escherichia coli</i>. …”
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BUREAUCRATISM AS AN INDICATOR OF SYSTEMIC CONTRADICTIONS IN THE EDUCATION SYSTEM by A. P. Usol'tsev

“…The study is made up of the comparative, structural and functional analysis of educational systems with the methods of modeling and forecasting application.Results and scientific novelty. …”
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Exploring the Association Between Human Blood Metabolites and Autism Spectrum Disorder Risk: A Bidirectional Mendelian Randomization Study by Wenhua Li, Suya Ma, Yunong Tian

“…Additionally, our analysis identified 13 potential metabolic pathways, among which tryptophan metabolism was the most notable (p = 0.0388). Gene Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes analysis highlighted crucial pathways, such as cellular glucuronidation, glucuronosyltransferase activity, and bile secretion, and the significance of the apical part of the cell. …”
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HOW IMPORTANT EDUCATION IS? AN EXPLORATIVE ANALYSIS OF THE DROPOUT PHENOMENON IN EASTERN EUROPE by Piera CASCIOLI, Emiliano COLANTONIO, Daniel BADULESCU

“…Improving the quality of the education system is therefore crucial (this is also confirmed by the variance decomposition analysis), even if it may not be enough: from the impulse response functions analysis, indeed, a shock exerted on the government expenditure on R&D in higher education produces positive effects on the (declining) dropout rate, but only for a short period. …”
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Chromosome-scale genome assembly and annotation of two geographically distinct strains of malaria vector Anopheles albimanus by Dieunel Derilus, Gareth D. Weedall, Michael W. Vandewege, Dhwani Batra, Mili Sheth, Lori A. Rowe, Ananias A. Escalante, Audrey Lenhart, Lucy Mackenzie Impoinvil

“…These newly assembled genomes will serve as an important resource for future research in comparative genomics, proteomics, epigenetics, transcriptomics, and functional analysis of this important malaria vector.…”
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G6PC1 expression as a prognostic biomarker associated with metabolic reprogramming and tumor microenvironment in hepatocellular carcinoma by Xilong Tang, Xilong Tang, Jianjin Xue, Jianjin Xue, Xiao Li, Xiao Li, Jie Zhang, Jiajia Zhou, Jiajia Zhou

“…HNF4A may act as a regulatory factor for G6PC1 in HCC. Functional analysis identified co-expressed genes associated with metabolism-related pathways. …”
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Examining the association between genetic polymorphisms and osteoporosis among post-menopausal women: a systematic review by Zainab Alhalwachi, Mira Mousa, Salsabeel Juneidi, Gabriela Restrepo-Rodas, Spyridon Karras, Habiba Alsafar, Fatme Al Anouti

“…Conclusion: This review strengthens the importance of conducting a robust, multi-ethnic, large cohort study with functional analysis to corroborate the findings of the six key genes associated with PMOP. …”
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Unraveling the Heterogeneity of CD8+ T-Cell Subsets in Liver Cirrhosis: Implications for Disease Progression by Kepu Zheng, Leiyang Dai, Shengning Zhang, Yingpeng Zhao, Wang Li, Yang Gao, Yuanyi Mang, Lingfeng Jiao, Yu Tang, Jianghua Ran

“…CXCL13+ Tex cells displayed T-cell exhaustion markers like PDCD1, HAVCR2, TIGIT, and TNFRSF9. Functional analysis implicated potential roles of these cells in immunosuppression. …”
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Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4 by Shaoliang Zhu, Gang Wang, Yuxuan Zhang, Mengjie Zou, Zhi Li, Shenhong Qu, Xiaosu Zou, Wenqian Nong, Weiwei Miao, Qicong Chen, Juanmei Mo, Huibing Chen, Lequn Li, Xiaofeng Dong, Honglin Luo

“…Methods: Cell experiments including FISH, western blot, flow cytometry and functional analysis were used to elucidate the effects of lnc-EST885 on cell proliferation, apoptosis, migration and EMT processes. …”
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Genome-wide characterization and expression profiling of the TGA gene family in sweet orange (Citrus sinensis) reveal CsTGA7 responses to multiple phytohormones and abiotic stresse... by Min Wang, Min Wang, Yue Ma, Yu-Xin Qiu, Si-Si Long, Wen-Shan Dai, Wen-Shan Dai

“…Nevertheless, the systematic identification and functional analysis of the TGA family in citrus remains unreported. …”
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Association between gut microbiota and short-chain fatty acids in children with obesity by Shihan Li, Xinyu Ma, Hong Mei, Xuening Chang, Peiling He, Lingli Sun, Han Xiao, Shiqiong Wang, Ruizhen Li

“…Kyoto encyclopedia of genes and genomes (KEGG) functional analysis revealed 28 enriched KEGG pathways, of which/with the phosphotransferase system (PTS) and enhanced biofilm formation by Escherichia coli were particularly significant in the OG. …”
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Exploiting <i>Brassica rapa</i> L. subsp. <i>pekinensis</i> Genome Research by Faujiah Nurhasanah Ritonga, Zeyu Gong, Yihui Zhang, Fengde Wang, Jianwei Gao, Cheng Li, Jingjuan Li

“…However, challenges exist in integrating multi-omics for the functional analysis of genes and for developing potential traits for Chinese cabbage improvement. …”
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EIF2S1 in Urinary Extracellular Vesicles as a Novel Diagnostic Marker for Bladder Cancer by Eisuke Tomiyama, Kazutoshi Fujita, Kyosuke Matsuzaki, Ryohei Narumi, Makoto Matsushita, Yujiro Hayashi, Mamoru Hashimoto, Taigo Kato, Koji Hatano, Atsunari Kawashima, Takafumi Minami, Tetsuya Takao, Shingo Takada, Hirotsugu Uemura, Jun Adachi, Takeshi Tomonaga, Norio Nonomura

“…Additionally, EV‐EIF2S1 distinguished patients with BCa from those without BCa and hematuria in a suitable manner (ROCAUC: 0.92). Functional analysis of EIF2S1 in the BCa cell lines (T24 and 5637) showed that EIF2S1 knockdown markedly inhibited cell proliferation and induced cell cycle arrest and apoptosis, suggesting its essentiality for BCa cell growth and survival. …”
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Characterization of rhizosphere bacterial communities in oilseed rape cultivars with different susceptibility to Plasmodiophora brassicae infection by Yue Deng, Yue Deng, Wenxian Wu, Xiaoqing Huang, Xiaoqing Huang, Xiaoxiang Yang, Xiaoxiang Yang, Yaoyin Yu, Yaoyin Yu, Zhongmei Zhang, Zhongmei Zhang, Zijin Hu, Xiquan Zhou, Kang Zhou, Kang Zhou, Yong Liu, Yong Liu, Lei Zhang, Lei Zhang

“…Metagenomic analysis of microbial metabolism also indicated differences in the rhizosphere bacterial community between susceptible and resistant cultivars that were infected with P. brassicae. Functional analysis of the nitrogen cycle showed that genes related to nitrification (nxrB) were upregulated in susceptible cultivars, while genes related to assimilatory nitrate reduction (nasA, narB, and nirA) were upregulated in resistant cultivars that were infected with P. brassicae. …”
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Identifying potential co-expressed genes and molecular mechanisms linking post-COVID-19 and Guillain-Barre syndrome through neutrophil extracellular trap-related genes by Jie-Hua Su, Dan-Yu Lin, Xiao-Huan Liu, Jie-Li Zhang, Zhong-Gui Li, En-Xiang Tao, Kai-Xun Huang

“…Bioinformatics functional analysis indicated that co-expressed DEGs were predominantly gathered in immune-related and inflammatory response pathways. …”
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CLEC12A-directed immunocytokine with target cell–restricted IL-15 activity for treatment of acute myeloid leukemia by Boris Klimovich, Boris Klimovich, Leonard Anton, Jinwon Jung, Yangmi Lim, Bora Lee, Jonghwa Won, Latifa Zekri, Latifa Zekri, Anna Chashchina, Anna Chashchina, Martin Pflügler, Jonas S. Heitmann, Jonas S. Heitmann, Gundram Jung, Helmut R. Salih, Helmut R. Salih

“…This antibody was then used to construct an immunocytokine (MIC12) that subsequently was characterized functionally. Analysis of NK cell activation, cytokine release, proliferation and anti-leukemia reactivity demonstrated that MIC12 induced superior target cell killing and NK cell expansion compared to Fc-optimized CLEC12A antibody, with efficacy being dependent on target antigen binding. …”
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Genetic Diversification of Tomato and Agricultural Soil Management Shaped the Rhizospheric Microbiome of Tomato (<i>Solanum lycopersicum</i>) by Máximo González, Juan Pablo Araya-Angel, Ashlie Muñoz, Adalid Alfaro-Flores, Massimiliano Cardinale, Alexandra Stoll

“…Additionally, co-occurrence network analysis identified two main clusters: first, taxa did not show any preferential associations to particular genotypes or soil types, while the second cluster revealed specific microbial patterns associated to fungal taxa in natural soil and bacterial taxa in agricultural soil. Finally, the functional analysis suggested the loss of specific functions through tomato domestication independently of soil type. …”
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Epigenetic Signatures in Ovarian Cancer to Determine Potential Diagnostic/Prognostic Biomarkers by Tuba Gunel, Maurice Jansen, Samet Topuz, Jean Helmijr, Servet Tunoğlu, Tugce Senturk Kirmizitas

“…Integration with The Cancer Genome Atlas (TCGA) data identified differentially expressed genes (DEGs) for functional analysis.Results: The analysis revealed significant alterations in DNA methylation patterns, with 62 hypermethylated and 2 hypomethylated DMRs in OC compared with HBDs. …”
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Rosaceae phylogenomic studies provide insights into the evolution of new genes by Lan Jiang, Xiaoxu Li, Kun Lyu, Han Wang, Zhiyuan Li, Wang Qi, Lin Zhang, Yunpeng Cao

“…Here, Type-I genes are found to have more relaxed selection pressure and lower Ks values than Type-II, indicating that these newly evolved Type-I genes may play important roles in driving phenotypic evolution. Functional analysis exhibited that newly formed fusion genes can regulate the phenotype traits of plant growth and development, suggesting the functional significance of these genes. …”
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Aggressive serous ovarian cancer subtype defined by high centrality lncRNA profiles and master transcription factors by Seonhyang Jeong, Young Suk Jo, Sunmi Park, Hwayoung Lee, Eun Gyeong Park, Sang Geun Jung, Jandee Lee

“…In vitro analyses were performed to determine if these lncRNAs regulate both the MTFs and target genes. Functional analysis enabled the lncRNA-based classification of HGSC into five groups: "Immune," "EMT," "Estrogen response," "EMT-Androgen response," and “Differentiation” groups. …”
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