Prebiotic fiber enteral supplementation after allogeneic transplantation: feasibility and impact on the microbiome by Sarah Andersen, Glen Kennedy, Merrilyn Banks, Bernadine Flanagan, Andrea Henden

“…The relative abundance of Faecalicatena gnavus increased in the standard group and declined in the prebiotic group (P = .0027). Functional analysis of the microbial genome showed decreased expression of antibiotic resistance genes in the prebiotic group only after EN provision (P = .00035). …”
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An iASPP‐derived short peptide restores p53‐mediated cell death in cancers with wild‐type p53 by Shi Qiu, Wei Qi, Wen Wu, Qian Qiu, Jiali Ma, Yingjun Li, Wenhui Fan, Junli Li, Yang Xu, Hai Chen, Jie Liu

“…Results Our data demonstrate that A8 can increase apoptosis rates in WT p53 cell lines. Functional analysis suggested that A8 restored the transcriptional function and DNA binding activities of p53 toward the Bax and PUMA gene promoters. …”
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Thyroid transcriptomic profiling reveals the differential regulation of lncRNA and mRNA related to prolificacy in Small Tail Han sheep with FecB++ genotype by Cheng Chang, Xiaoyun He, Ran Di, Xiangyu Wang, Miaoceng Han, Chen Liang, Mingxing Chu

“…A total of 17,217 lncRNAs and 39,112 mRNAs were identified including 96 differentially expressed lncRNAs (DELs) and 1054 differentially expressed mRNAs (DEGs). Functional analysis of genes with significant differences in expression level showed that these genes could be enriched in Ras signalling pathway, hedgehog (HH) signalling pathway, ATP-binding cassette (ABC) transporters and other signalling pathways related to animal reproduction. …”
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Integrated Transcriptomic and Metabolomic Analyses Reveal the Importance of the Terpenoid, Fatty Acid, and Flavonoid Pathways in Rice Cell Death and Defense by Pengfei Bai, Yanfang Liu, Laisa Gomes-Dias, Rachel Combs-Giroir, Shaoxing Dai, Naeyeoung Choi, Yun Lin, Matthew Bernier, Emmanuel Hatzakis, Guo-Liang Wang, Joshua J. Blakeslee

“…This study provides an overall landscape of the transcriptomic and metabolomic alterations in a lesion mimic mutant, identifying candidate defense-related genes and metabolites for functional analysis in rice.…”
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Xyloglucan endotransglucosylase/hydrolase 25 positively regulates the lead tolerance in Raphanus sativus by Tong Han, Yongmei Cui, Yang Jing, Meiying Liu, Xuanchao Chen, Yinghui Song, Xinping Gu, Jiahao Wang, Long Wang, Long Wang

“…Despite this, a comprehensive identification, molecular characterization, and functional analysis of the XTH gene family in R. sativus has been lacking. …”
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Multi-omics integrated analysis to generate transcriptome and protome profiles of resveratrol improving Paraquat-induced acute lung injury by Ziying Xu, Lijuan Huang, Zihui Yu, Yagang Gao, Ruikun Wang, Bing Du, Xiaohu Cui, Jing Yuan

“…Furthermore, cell functional analysis revealed that Resveratrol regulates mitochondrial function, the cell cycle, and inflammatory signaling pathways, improving the pathological state of both mice and A549 cells. …”
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Gut microbiome and metabolome interactions in Crohn’s disease: mechanistic insights into exclusive enteral nutrition-induced remission by Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Quan Zhou, Quan Zhou, Mengli Xue, Mengli Xue, Mengli Xue, Mengli Xue, Xing Yu, Xing Yu, Xing Yu, Xing Yu, Xue’e Chen, Xue’e Chen, Xue’e Chen, Xue’e Chen, Jintong Chen, Jintong Chen, Jintong Chen, Jintong Chen, Chengdang Wang, Chengdang Wang, Chengdang Wang, Chengdang Wang

“…The composition of the gut microbiome was analyzed through 16S rRNA gene sequencing, while metabolomic profiling was conducted using liquid chromatography–mass spectrometry (LC–MS). Functional analysis of microbial pathways was performed utilizing the KEGG Orthology (KO) and MetaCyc databases.ResultsEEN therapy induced significant structural shifts in the gut microbiome, including a reduction in the abundance of pro-inflammatory bacteria such as Fusobacterium and Veillonella. …”
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Transcriptomic Analysis of the Hepatopancreas in the Sex-Related Size Differences of <i>Macrobrachium nipponense</i> by Yabing Wang, Guangde Qiao, Yanfeng Yue, Shiming Peng, Hongtuo Fu

“…Clusters of orthologous groups and gene ontology functional analysis demonstrated that the DEGs for sex-related size in <i>M.nipponense</i> were associated with various biological functions. …”
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The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates by Qingbo Fang, Tianlai Qiu, Fenglan Chen, Xuqi Tian, Zijun Feng, Yanan Cao, Jinbing Bai, Jing Huang, Yanqun Liu

“…KEGG pathway level 3 was employed for functional analysis. Generalized linear models were used to explore the effect of drought on the gut microbiome. …”
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E3 ligase TRIM22 promotes melanoma proliferation by regulating cell cycle progression through K63-linked ubiquitination of p21 by Chen-xing Jin, Ting-ze Feng, Xiang Ji, Yan-song Liu, He-nan Qin, Yi-bin Teng, Chibuzo Sampson, Tian Xia, Hai-long Piao, Ji-wei Liu

“…In this study, we found that expression of TRIM22 was abnormally upregulated in melanoma tissues, correlating with tumor stages. Functional analysis demonstrated that TRIM22 promoted melanoma cell proliferation in vitro. …”
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Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia. by Ignat Drozdov, Bernhard Svejda, Bjorn I Gustafsson, Shrikant Mane, Roswitha Pfragner, Mark Kidd, Irvin M Modlin

“…The network was confirmed to be non-random, scale-free, and highly modular. Functional analysis of gene co-expression modules revealed processes including 'Nervous system development', 'Immune response', and 'Cell-cycle'. …”
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Concept «EDUCATION» and its Subconcepts in the Consciousness of Ukrainian managers by Наталія Михальчук, Наталія Харченко, Георгій Калмиков, Ернест Івашкевич, Едуард Івашкевич, Наталія Хупавцева, Інна Мисан

“…Theoretical methods were categorical and structurally-functional analysis of lexical units, the methods of systematization, modeling, generalization; empirical ones – the analysis of lexical units, the experiment. …”
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In vitro protein expression profile of cultivated muscle cells from Labeo rohita by B. S. Yashwanth, Nevil Pinto, A. Sathiyanarayanan, Kiran D. Rasal, S. Sanjeeva, Michael Saad, Reza Ovissipour, David L. Kaplan, Mukunda Goswami

“…The metascape depicts the network of significantly enriched proteins with functional annotation of protein-encoding genes. Functional analysis of differentially expressed proteins was marked as glycolytic (eno1 and eno3), metabolic (pgm, smyd1, ak1, aldob and bpgm), cytoplasmic ribosomal (rpl27, rpl3 and eifa5) and carbon metabolic (pdh) pathways across the three passages. …”
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DIGITAL TRANSFORMATION OF BUSINESS MANAGEMENT: INNOVATIVE MODELS, FORECAST SCENARIOS AND CURRENT CHALLENGES OF ECONOMY MODERNIZATION by I.V. Burtnyak, T.V. Khaludilo

“…The stages of transition from traditional approaches to digital models have been examined through functional analysis in the context of societal reproduction—production, distribution, exchange, and consumption—while a historical review of the evolution of management thought has been combined with an analysis of contemporary practices. …”
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Multi-omics-based construction of a palmitoylation-driven prognostic model reveals tumor immune phenotypes in osteosarcoma by Jingyu Chen, Feihu Chen, Haiping Zhang, Yuanlong Hu, Xingyu Zhou, Xijia Weng, Guofeng Bao, Xiaomin Ding

“…Elevated PPS levels correlated with unfavorable clinical outcomes, diminished immune cell presence, and suppressed immune checkpoint molecule levels. Functional analysis revealed enrichment of oncogenic and immunosuppressive pathways in the high-PPS group. …”
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Mixture of common and uncommon pathways and genes regulating primary and secondary immunoglobulin M responses in chickens by Somayeh Kianpoor, Alireza Ehsani, Rasoul Vaez Torshizi, Ali Akbar Masoudi, Mohammad Reza Bakhtiarizadeh

“…Likewise, 10 SNPs were identified in the LTA QTL (Quantitative trait locus) region for IgM2. Functional analysis showed that hub genes of RET, ANGPT1, ATP6V0B, LAMTOR2, and HSP90AA1 were significantly enriched in the pathways related to negative regulation of B-cell activation and proliferation, B-cell receptor signaling pathway, and negative regulation of T-helper 17 type immune response. …”
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Methodology for Assessing the Transport Accessibility of Capital Objects in a Megacity Based on Geoinformation Data by S. V. Mkhitaryan, Zh. B. Musatova, T. V. Murtuzalieva, G. S. Timokhina, I. P. Shirochenskaya

“…Purpose: to present the author's methodology and the test results for calculating integral indicators of transport accessibility on the basis of weighted normalized private indicators for three housing estates in Moscow.Methods: the study is based on the application of methods for collecting factual material, its processing, systematic, comparative historical and structural-functional analysis, which were supplemented by multivariate analysis of secondary information using content analysis of existing methods for calculating indicators of transport accessibility of capital objects. …”
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Case Presentation: Functional Assessment of a CASR Variant Identified in a Patient with Hypercalcaemia Confirms Familial Hypocalciuric Hypercalcaemia in the Patient and a Sister Pr... by Bryan K. Ward, Kirsten A. Loffell, John P. Walsh, Warwick D. Howe, Suzanne J. Brown, Scott G. Wilson

“…This identified a heterozygous variant in the CASR, NM_000388.4:c.T101C: p.Leu34Pro (L34P). Functional analysis showed that the L34P variant was unable to produce mature, dimerized receptor and did not respond to Ca++ ions. …”
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Effect of PTGES3 on the Prognosis and Immune Regulation in Lung Adenocarcinoma by Wenyan Jiang, Qiong Wei, Haiqin Xie, Dandan Wu, Haiyan He, Xuedong Lv

“…Moreover, co-expression analysis and cross-analysis revealed that three genes, including CACYBP, HNRNPC, and TCP1, were correlated and interacted with PTGES3. Functional analysis of these genes revealed that PTGES3 was primarily enriched in oocyte meiosis, progesterone-mediated oocyte maturation, and arachidonic acid metabolism pathways. …”
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Cytogenetic abnormalities in thymus cells as a possible side effect of combined skeletal muscle laser therapy (experimental study) by N. V. Bulyakova, V. S. Azarova

“…Objective: the functional analysis of the thymus during a course of laser therapy of the calf muscles of adult rats. …”
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