Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. by John H Ludes-Meyers, Hyunsuk Kil, Jan Parker-Thornburg, Donna F Kusewitt, Mark T Bedford, C Marcelo Aldaz

“…This will greatly facilitate the functional analysis of Wwox in adult mice and will allow investigating neoplastic transformation in specific target tissues.…”
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ASSESSMENT OF THE IMAGE OF UKRAINE IN THE EUROPEAN MEDIA AT THE BEGINNING OF THE FULL-SCALE AGGRESSION OF THE RUSSIAN FEDERATION by Natalya Kharkevych, Zoriana Velychko

“…The study used the historical-descriptive method, structural-functional analysis, analysis and synthesis method, content analysis method, comparative analysis, and discourse analysis. …”
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Research on the Digital Twin System for Rotation Construction Monitoring of Cable-Stayed Bridge Based on MBSE by Yuhan Zhang, Yimeng Zhao, Zhiyi Li, Wei He, Yi Liu

“…A V-model architecture for the digital twin system, based on requirements analysis, functional analysis, logical design, and physical design analysis (RFLP), is proposed. …”
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Transcription factor FoxO1 regulates myoepithelial cell diversity and growth by Rino Tokumasu, Rika Yasuhara, Seya Kang, Takahiro Funatsu, Kenji Mishima

“…However, detailed functional analysis of myoepithelial cells has not been determined owing to the few of the specific marker to isolate them. …”
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Molecular evolution and functional characterization of Drosophila insulin-like peptides. by Sebastian Grönke, David-Francis Clarke, Susan Broughton, T Daniel Andrews, Linda Partridge

“…We investigated the evolution, diversification, redundancy, and functions of the DILPs, combining evolutionary analysis, based on the completed genome sequences of 12 Drosophila species, and functional analysis, based on newly-generated knock-out mutations for all 7 dilp genes in D. melanogaster. …”
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Taxis in utterances with verbs of motion in the Russian language: nonstandard simultaneity situations by Elena Yu. Ivanova-Zhdanova, Irina P. Matkhanova

“…The main research method is functional analysis based on the theory of categorical situations by A.V. …”
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Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development. by Ariane Willems, Sergio R Batlouni, Arantza Esnal, Johannes V Swinnen, Philippa T K Saunders, Richard M Sharpe, Luiz R França, Karel De Gendt, Guido Verhoeven

“…Particular attention was paid to differences in SC maturation, SC barrier formation and cytoskeletal organization and to the molecular mediators potentially involved. Functional analysis of SC barrier development by hypertonic perfusion and lanthanum permeation techniques and immunohistochemical analysis of junction formation showed that SCARKO mice still attempt to produce a barrier separating basal and adluminal compartment but that barrier formation is delayed and defective. …”
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Whole gene sequencing identifies deep-intronic variants with potential functional impact in patients with hypertrophic cardiomyopathy. by Rita Mendes de Almeida, Joana Tavares, Sandra Martins, Teresa Carvalho, Francisco J Enguita, Dulce Brito, Maria Carmo-Fonseca, Luís Rocha Lopes

“…<h4>Conclusion</h4>This study provides a framework for scrutinizing variation along the complete intronic sequence of HCM-associated genes and prioritizing candidates for mechanistic and functional analysis. Our data suggest that deep intronic variation contributes to HCM phenotype.…”
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EXPERIMENTAL STUDIES OF A MODEL FOR OPTIMIZING THE PORTFOLIO OF A PROJECT-ORIENTED ORGANIZATION BASED ON THE ENTROPY CONCEPT by Alla Bondar, Svitlana Onyshchenko

“…Research methods: system analysis, functional analysis, operations research. Results. A model has been developed for forming a portfolio structure from projects of two categories – operational and development; the optimization criterion is to minimize the discrepancy between the desired and actually provided value of the organization. …”
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A Novel Splice-Site Variation in COL5A1 Causes Keratoconus in an Indian Family by Qinghong Lin, Lin Zheng, Zhengwei Shen, Liming Jie

“…A novel COL5A1 acceptor-splice-site mutation IVS50-4C > G was found in the 10 affected individuals in the three-generation KC family, but this was not found in any of the unaffected family members or unrelated healthy individuals. Gene functional analysis using the SpliceMan and ExonScan software predicted that the splice-site mutation was potentially associated with KC pathogenesis. …”
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Development of tetraculture spheroids as a versatile 3D model for personalized breast cancer research by Oliwia Piwocka, Karolina Sterzyńska, Agnieszka Malińska, Wiktoria M. Suchorska, Katarzyna Kulcenty

“…Including key elements of the tumor microenvironment supports individualized drug testing and functional analysis, serving as a reproducible and ethically favorable alternative to animal models and patient-derived explants.…”
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Associations and mediators between vitiligo and cardiovascular diseases: a Mendelian randomization study by Xiaoyan Zhang, Lei Pu, Cheng Pu, Qian He

“…Bioinformatics analysis involved Protein-Protein Interaction (PPI) network, Gene Ontology (GO) and GeneMANIA functional analysis analysis. MR analysis indicated that genetically predicted vitiligo was significantly associated with higher risk of coronary heart disease (CHD) (OR = 1.0199, 95% CI = 1.0024–1.0377, p = 0.026). …”
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Compositional characteristics of the gut microbiome in patients with uremia by Zirui Wu, Mingjie Bian, Hong Zhang, Mengli Wang, Peng Wang, Yunxia Shao, Liang Shen, Guoping Zhu

“…We also detected the rare taxa Erysipelotrichaceae, which was present only in the uremic patient group. Predictive functional analysis suggested that an increased abundance of Ruminococcaceae and Lachnospirales, which are associated with indoxyl sulfate and phenylacetyl glutamine, and an increased abundance of Oscillospirales, which is associated with pyruvate metabolism, in uremic patients may strongly influence the gut environment according to renal function, resulting in dysbiosis associated with uremic toxin production. …”
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Improved approaches to genotyping MAOA-uVNTR polymorphisms with novel allele discovery by Areerat Hnoonual, Potchanapond Graidist, Pornprot Limprasert

“…The study identified five common alleles (2.5R, 3.5R, 4.5R, 5.5R) and discovered a novel allele, 3.3R, through fluorescent PCR. Functional analysis using luciferase reporter vectors demonstrated 1.5–2.0 times higher transcriptional activity for the 3.3R and 4.5R alleles compared with 3.5R and 5.5R alleles in LA-N-5 and SK-N-SH cell lines. …”
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Conceptual Approaches to the Formation of a Stable World Monetary and Financial System by A. V. Kuznetsov

“…The following methods were used to achieve the paper’s goal: scientific abstraction (to generalize the crisis-generating factors of the modern world monetary and financial system); structural and functional analysis (to justify the need to form a “non-dollar” interregional (transcontinental) monetary and financial space and the possibility of the BRICS countries creating their own payment and settlement infrastructure and international liquidity); deduction and comparison (to identify problems that hinder China’s promotion to the role of the leader of the new world economic order and disclosure of contradictions in the monetary and financial regionalization of the single European market). …”
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Psycholinguistic Specifics of Understanding by Ukrainian Students the Principles of Nomination of Linguocultural Models “clothing” in English and Ukrainian by Наталія Михальчук, Павло Левчук, Ернест Івашкевич, Людмила Ясногурська, Олена Чернякова

“…The methods of the research are: theoretical ones – categorical and structurally-functional analysis of the texts, the methods of systematization, modeling, generalization; empirical methods – the analysis of lexical units, the experiment. …”
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Impact of Investment on Labour Productivity in Azerbaijan's Chemical and Petrochemical Industry by Vilayat Ismayilov, Nizami Gafarov, Sabina Valiyeva

“…The research employed a combination of analytical methods, including statistical analysis of data from the State Statistical Committee of Azerbaijan on labour productivity and investment in the chemical and petrochemical sectors. Functional analysis was used to examine the role of labour productivity, while systematic analysis explored the factors influencing productivity. …”
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Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence. by Shi-qi An, Delphine L Caly, Yvonne McCarthy, Sarah L Murdoch, Joseph Ward, Melanie Febrer, J Maxwell Dow, Robert P Ryan

“…Electromobility shift assays showed that XC_3703 positively affected the binding of XC_2801 to the promoters of target virulence genes, an effect that was reversed by cyclic di-GMP. Genetic and functional analysis of YajQ family members from the human pathogens Pseudomonas aeruginosa and Stenotrophomonas maltophilia showed that they also specifically bound cyclic di-GMP and contributed to virulence in model systems. …”
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Inimese ja looduse suhte mõtestamine esseistikas. Funktsionaalne vaade eesti esseistikale by Asko Lõhmus

“…An important reason is that essay-writing is practised across different cultural systems (including scientists), providing potential grounds for cultural exchange. I conduct a functional analysis of 108 essays, selected as a stratified sample from 36 Estonian authors representing three groups (literature; science; other) since the 20th century. …”
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Impact of β-defensin 103 (DEFB103) copy number variation on bull sperm parameters and post-insemination uterine gene expression. by Ozge Sidekli, Edward J Hollox, Sean Fair, Kieran G Meade

“…As genetic diversity of DEFB103 CN was only apparent in the LF group, three bulls per CNV class (low, intermediate and high CN) were chosen for more detailed comparative functional analysis. Sperm from low CN bulls exhibited higher binding to the oviductal epithelium, while high CN increased sperm membrane fluidity in vitro (p < 0.05). …”
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