Deepening the Modulatory Activity of Bioactive Compounds Against AFB1- and OTA-Induced Neuronal Toxicity Through a Proteomic Approach by Alessandra Cimbalo, Massimo Frangiamone, Lara Manyes

“…A proteomic approach using HPLC-MS/MS-QTOF was then employed to characterize the metabolic pathways affected by the presence of these components, as well as their ability to modulate the toxic effects exacerbated by mycotoxins. Gene ontology functional analysis revealed proteins primarily associated with nucleosome structure, such as the H3-H4 tetramer, H2A-H2B dimer, and HIRA, which were overexpressed in the presence of mycotoxins and, interestingly, downregulated with the addition of the functional ingredients. …”
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HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation by Kevin B Myant, Patrizia Cammareri, Michael C Hodder, Jimi Wills, Alex Von Kriegsheim, Balázs Győrffy, Mamun Rashid, Simona Polo, Elena Maspero, Lynsey Vaughan, Basanta Gurung, Evan Barry, Angeliki Malliri, Fernando Camargo, David J Adams, Antonio Iavarone, Anna Lasorella, Owen J Sansom

“…However, due to the large size of this gene and a lack of functional analysis of identified mutations, their significance to carcinogenesis is unclear. …”
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The Warta river valley in the Dębina area of Poznań – changes in land cover and land use in the context of natural assets and landscape qualities by Bożena Łukasik, Agnieszka Wilkaniec, Agnieszka Targońska

“…Material and methods: In the course of the work, functional analysis and identification of contemporary threats for Dębina will be performed, based on the analysis of historical materials and contemporary cartographic materials using GIS tools. …”
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Case Report: CD40LG Arg203Ile variant underlies atypical phenotype of X-linked hyper IgM syndrome by Takuro Nishikawa, Dan Tomomasa, Atsushi Hijikata, Hiroshi Kasabata, Yasuhiro Okamoto, Hans D. Ochs, Hirokazu Kanegane

“…This report highlights the importance of combining genetic testing with functional analysis when evaluating atypical XHIGM presentations to predict clinical severity and provide a scientific basis for personalized treatment strategies. …”
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Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation by Jonathan Tang, Yurong Huang, David H. Nguyen, Sylvain V. Costes, Antoine M. Snijders, Jian-Hua Mao

“…The vast majority of lncRNAs identified to be differentially expressed after LDIR in either BALB/c or SPRET/EiJ had a significantly correlated expression pattern with at least one LDIR responsive mRNA. Functional analysis revealed that the response to LDIR in BALB/c mice is highly dynamic with enrichment for genes involved in tissue injury, inflammatory responses, and mammary gland development at 2, 4, and 8 weeks after LDIR, respectively. …”
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Multi-Omics Analysis Provides Insights into Green Soybean in Response to Cold Stress by Yanhui Lin, Guangping Cao, Jing Xu, Honglin Zhu, Liqiong Tang

“…The DEGs and DEMs were further subjected to KEGG functional analysis. Finally, 11 metabolites (such as sucrose, lactose, melibiose, and dehydroascorbate) and 17 genes (such as <i>GOLS</i>, <i>GLA</i>, <i>UGDH</i>, and <i>ALDH</i>) were selected as candidates associated with cold tolerance. …”
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Development of a machine learning-derived programmed cell death index for prognostic prediction and immune insights in colorectal cancer by Jinping Li, Yan Jiang, Shengbin Nong, Liudan Liang, Liangchao Chen, Qiming Gong

“…A nomogram integrating PCDI with clinical variables showed strong predictive accuracy for 1-, 3-, and 5 year survival rates. Functional analysis revealed significant metabolic differences between high- and low-PCDI groups. …”
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IDO1-mediated M2 macrophage polarization alleviates the progression of ankylosing spondylitis by Kangqi Ji, Lingfei Wang, Weijie Liu, Genfeng Li, Xiaoyu Lian, Jun Fan, Chen Song, Yanpeng Jian

“…CCK-8, EdU, flow cytometry, ALP staining, and Alizarin red staining (ARS) assays were conducted for functional analysis. JASPAR predicted the binding sites between PPARγ and the promoter, which were further validated by luciferase and ChIP assays. …”
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Identifying Hub Genes and miRNAs Associated with Alzheimer’s Disease: A Bioinformatics Pathway to Novel Therapeutic Strategies by Elisa Gascón, Ana Cristina Calvo, Nora Molina, Pilar Zaragoza, Rosario Osta

“…Therefore, in this study, by means of bioinformatics analysis, AD-affected brain tissue was analyzed using the GSE138260 dataset, identifying 612 differentially expressed genes (DEGs). Functional analysis revealed 388 upregulated DEGs associated with sensory perception and 224 downregulated DEGs linked to the regulation and modulation of synaptic processes. …”
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An MLLM-Assisted Web Crawler Approach for Web Application Fuzzing by Wantong Yang, Enze Wang, Zhiwen Gui, Yuan Zhou, Baosheng Wang, Wei Xie

“…It includes three core components: page state mining, functionality analysis, and automatic operation generation. …”
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Genome-Wide Identification and Characterization of Fox Genes in the Honeybee, Apis cerana, and Comparative Analysis with Other Bee Fox Genes by Hongyi Nie, Haiyang Geng, Yan Lin, Shupeng Xu, Zhiguo Li, Yazhou Zhao, Songkun Su

“…These results may facilitate a better understanding of the potential physiological functions of the Fox gene family in A. cerana and provide valuable information for a comprehensive functional analysis of the Fox gene family in Hymenopterans.…”
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Research Progress on Natural Active Proteins from Eggshell Membrane, as Well as the Preparation, Functional Mechanisms, and Applications of Their Enzymatic Peptides by Na ZHANG, Yanan GAO, Rong ZHANG, Xueqin ZHAO, Shuyan LIU, Dan JIANG

“…Future research priorities are also discussed, particularly the potential of digital and informational techniques in predicting the bioactivity and functional analysis of eggshell membrane components. This review is expected to provide new perspectives and references for the high-value utilization of egg processing byproducts.…”
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Biophysical, Spatial, Functional, and Constructive Analysis of the Pre-Hispanic Terraces of the Ancient City of Pisaq, Cusco, Peru, 2024 by Francis Huaman, Doris Esenarro, Jesus Prado Meza, Jesica Vilchez Cairo, Carlos Vargas Beltran, Crayla Alfaro Aucca, Cecilia Arriola, Valeria Peña Calle

“…The findings include a biophysical analysis related to ecological and economic zoning (EEZ), which determines variables for preservation and reforestation; a spatial analysis measuring the cultivation terraces, with areas ranging from 4.89 ha to 110.20 ha; a functional analysis examining geophysical aspects such as seismic resistance and microclimate effects due to the greenhouse effect; and a constructive analysis that characterizes terrace typologies from an architectural perspective. …”
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Neuroendocrine characterization into schizophrenia: norepinephrine and melatonin as promising biomarkers by Junwei Shen, Xin Li, Yinghua Zhong, Jiechun Zhang, Hongyun Qin, Fazhan Chen, Xudong Zhao

“…The GC-MS analysis revealed significant differences in 79 metabolites; while the LC-MS analysis identified 419 significantly differential metabolites. Functional analysis reveals that these differential metabolites predominantly contribute to metabolic and neuro-related processes. …”
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Zeugma as a Method of Pragmatic Focusing in a Literary Text (Based on the Material of the German Language) by Ju. G. Timralieva

“…The elements of the paratactic series are usually nouns (homogeneous subjects, additions, circumstances), but the analysis also reveals cases of illogical combinations represented by other parts of speech, as well as examples with heterogeneous morphological forms within the same zeugmatic construction. The functional analysis of the zeugma demonstrates the rich stylistic potential of this rhetorical figure, which acts as a means of humor and satire in literary texts, serving to convey emotional states, semantic saturation of the utterance, and the increment of new meanings.Conclusion. …”
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Primary utopian elements in the North Caucasian traditional epic «The Narts»: understanding in the context of contemporary social reality by A. M. Siyukhova, I. A. Abdokova

“…The main method is the method of structural and functional analysis to identify the role of a specific utopian idea in the structure of the Nart epic as a form of reflection of the socio-cultural forms of existence of the ethnos. …”
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Isomorphisms of some algebras of analytic functions of bounded type on Banach spaces by S.I. Halushchak

“…The theory of analytic functions is an important section of nonlinear functional analysis. In many modern investigations topological algebras of analytic functions and spectra of such algebras are studied. …”
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Mechanism of Protective Effect of Mongolia Medicine Nagab-9 on LPS-Induced Acute Lung Injury Based on an Integrated Network Pharmacology and Experimental Verification by Shi Liu, Jiuwang Yu, Zeyu Chen, Lidao Bao

“…ALI-related targets were collected from relevant disease databases, and an intersection of these targets was used to construct a protein-protein interaction (PPI) network to identify core targets. Functional analysis through Gene Ontology (GO) and KEGG pathway enrichment was performed. …”
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Clinical and Functional Characterization of Novel AGL Variants in Two Families with Glycogen Storage Disease Type III by Tingting Yu, Hao Fu, Aoyu Yang, Yan Liang

“…Based on the ACMG criteria, both variants were considered likely pathogenic, in accordance with the functional analysis results, which demonstrated that the mutated protein was still localized in the cytoplasm and that the glycogen content of cells transfected with the mutated AGL was increased compared to cells transfected with the wild-type one. …”
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Identifying Hub Genes and Immune Cell Infiltration for the Progression of Carotid Atherosclerotic Plaques in the Context of Predictive and Preventive Using Integrative Bioinformati... by Han Zhang, Yinde Huang, Xin Li, Wenbin Chen, Yu Lun, Jian Zhang

“…LASSO regression analysis was subsequently performed to obtain five hub genes as potential biomarkers for carotid atherosclerotic plaques. The functional analysis emphasized the vital roles played by the inflammation- and immune system-related pathways in this disease. …”
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