Neural Stem Cells in Drosophila: Molecular Genetic Mechanisms Underlying Normal Neural Proliferation and Abnormal Brain Tumor Formation by Nidhi Saini, Heinrich Reichert

“…Identification of novel candidate genes that control neuroblast self-renewal and differentiation as well as functional analysis of these genes in normal and tumorigenic conditions in a tissue-specific manner is now possible through genome-wide transgenic RNAi screens. …”
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Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. by Claire E Kelly, Efstathia Thymiakou, James E Dixon, Shinya Tanaka, Jonathan Godwin, Vasso Episkopou

“…The defects range from severe reduction of motor axon extension as observed in the dorsal forelimb to shortening of presynaptic branches of the phrenic nerve, as observed in the diaphragm. Molecular functional analysis showed that in the context of the spinal cord Ark2C enhances transcriptional responses of the Smad1/5/8 effectors, which are activated (phosphorylated) downstream of Bone Morphogenetic Protein (BMP) signals. …”
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Study of risk factors associated with the development of malocclusion by Petrović Đorđe, Vukić-Ćulafić Branka, Ivić Stojan, Đurić Milanko, Milekić Bojana

“…Data for Questionnaire for Epidemiological Surveillance were obtained from medical records of patients, heteroanamnesis, objective findings, functional analysis of stomatognathic system, and additional diagnostic methods. …”
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Genome-wide analysis clarifies the population genetic structure of wild gilthead sea bream (Sparus aurata). by Francesco Maroso, Konstantinos Gkagkavouzis, Sabina De Innocentiis, Jasmien Hillen, Fernanda do Prado, Nikoleta Karaiskou, John Bernard Taggart, Adrian Carr, Einar Nielsen, Alexandros Triantafyllidis, Luca Bargelloni, Aquatrace Consortium

“…Seascape analysis suggested that this differentiation was mainly due to difference in salinity, this being also supported by preliminary genomic functional analysis. These results are of fundamental importance for the development of proper management of this species in the wild and are a first step toward the study of the potential genetic impact of the sea bream aquaculture industry.…”
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Revealing the Complexity of Polysaccharides: Advances in NMR Spectroscopy for Structural Elucidation and Functional Characterization by Yaqin Liu, Lina Gao, Zeling Yu

“…This paper looks into the significant progress made in the structural and functional analysis of polysaccharides by nuclear magnetic resonance (NMR) spectroscopy. …”
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Optimization of Platelet-Rich Plasma Fraction Selection for Surgical Treatment of Macular Holes by V. N. Kazaykin, N. S. Demchenko, A. Yu. Kleimenov

“…Objective: based on clinical and morpho — functional analysis of retinal restoration and assessment of the cellular composition of platelet-rich plasma, to determine its optimal fraction for surgical treatment of macular hole. …”
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Gut microbiota profile in newly diagnosed pulmonary tuberculosis patients: an exploratory pilot study in southern India by Tejaswini Baral, Shaik Mohammad Abdul Fayaz, Mohan K. Manu, Chandrashekar Udyavara Kudru, Jitendra Singh, Chiranjay Mukhopadhyay, Mahadev Rao, Kavitha Saravu, Sonal Sekhar Miraj

“…At the genus level, specific taxa were upregulated or downregulated in PTB patients compared to HC. Functional analysis showed a depletion in biosynthesis pathways in PTB patients. …”
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Biological Characterization and Glucosinolate Degradation Mechanisms of Bacillus subtilis BSY82 in Rapeseed Meal by Hong-yu Lu, An-Ning Shi, Jun Wang, Li-Juan Liu, Jiang-Yi Tang, Ya-Jun Wang, Xue-Zhi Zhu, De-Feng Zhang, Li-Yan Liu, Qing Wang

“…No virulence factors were predicted, based on a comparative analysis of the strain’s coding genes against known virulence factor databases. Functional analysis showed that BSY82 had the ability to produce myrosinase. …”
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Brain-wide mapping of acute hypoxia-induced neuronal activation in mice: A c-Fos immunofluorescence study by Xingyao Yu, Pai Pang, Tao Liu, Xiufang Jiang, Jiayi Zhang, Xiangpei Yue, Jianjun Guo, Xiang Cheng, Tong Zhao, Yongqi Zhao, Zhonghua Dai, Lingling Zhu

“…To systematically characterize hypoxia-induced brain activation patterns, we conducted whole-brain mapping of neuronal activity changes in mice exposed to acute hypobaric hypoxia versus normoxic controls using c-Fos immunofluorescence, a robust marker of neuronal activation. Our functional analysis focused on key brain regions governing: cardiorespiratory homeostasis, attention, memory, emotional processing, motivation and reward. …”
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PLASMA-Privacy-Preserved Lightweight and Secure Multi-level Authentication scheme for IoMT-based smart healthcare by Hegde Manjunath, M. Karthik, Hegde Varun, Rao Rohini R., Mantoor Vinayak M., Bhat Radhakrishna

“…PLASMA’s performance was evaluated by comparing its computational and communication costs with related schemes, and functional analysis was demonstrated to show the security and efficiency of the scheme. …”
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Genome-Wide-Association-Analysis-Based Identification of Genetic Loci and Candidate Genes Associated with Cold Germination in Sweet Corn by Changjin Wang, Yulin Yu, Jie Liu, Ahmad Rizwan, Zain Abbas, Haibing Yu, Xinxin Cheng

“…Fourteen candidate genes associated with cold germination were identified through GO functional analysis and the functional expression of homologous genes. …”
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Selective loss of ATP carriers in favour of SLC25A43 orthologues in metamonad mitochondria adapted to anaerobiosis by Natalia Janowicz, Vít Dohnálek, Justyna Zítek, Priscila Peña-Diaz, Eva Pyrihová, Martin S. King, Michaela Husová, Vojtěch Žárský, Edmund Kunji, Alena Zikova, Vladimír Hampl, Pavel Dolezal

“…Heterologous expression of metamonad SLC25A43 carriers confirmed their mitochondrial localization, and functional analysis revealed that SLC25A43 orthologues represent a distinct group of ATP transporters, which we designate as ATP-importing carriers (AIC). …”
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A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning by Kailai Li, Junyi Liang, Nan Li, Jianbo Fang, Xinyi Zhou, Jian Zhang, Anqi Lin, Peng Luo, Hui Meng

“…The study found that NPC-RSS is closely associated with immune features, including chemokine factors and their receptor families and the major histocompatibility complex (MHC). Gene functional analysis revealed that NPC-RSS influences key signaling pathways such as Wnt/β-catenin, JAK-STAT, NF-κB, and T cell receptors. …”
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Delayed diagnosis of STAT1 gain-of-function variant in a patient with multiple endocrine autoimmunity and recurrent fungal infections by Sydney Sparanese, Rae Brager, David Fahmy, Jenny Garkaby

“…Genetic testing revealed a novel, missense mutation in STAT1. Functional analysis confirmed enhanced STAT1 protein phosphorylation, confirming a gain-of-function phenotype that explained her infectious and autoimmune manifestations. …”
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The role of gut microbiota and metabolomic pathways in modulating the efficacy of SSRIs for major depressive disorder by Ying Jiang, Yucai Qu, Lingyi Shi, Mengmeng Ou, Zhiqiang Du, Zhenhe Zhou, Hongliang Zhou, Haohao Zhu

“…Specific taxa, such as Ruminococcus, Bifidobacterium, and Faecalibacterium, were more abundant in the responder group. Functional analysis revealed upregulation of acetate degradation and neurotransmitter synthesis pathways in the responder group. …”
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Genome-wide association study to identify biological and metabolic pathways associated with carcass portion weights in turkeys by Emily M. Leishman, Ryley J. Vanderhout, Benjamin J. Wood, Christine F. Baes, Shai Barbut

“…The objective of this study was to conduct a genome wide association study (GWAS) and functional analysis on turkey carcass portion weights. Phenotypic data consisted of carcass portion weights (fillets, tenders, drums, thighs) obtained at processing (N = 646 – 1,478). …”
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Soil Microbial Adaptation and Biogeochemical Feedback in Degraded Alpine Meadows of the Qinghai–Tibetan Plateau by Bingzhang Li, Quzhen Gesang, Yan Sun, Yuting Wang, Jibin Nan, Jun Xu

“…Network analysis revealed a progressive loss of microbial connectivity, with Actinobacteria dominance increasing in heavily degraded soils, while cross-phylum interactions weakened. Functional analysis of biogeochemical cycling genes showed that carbon, nitrogen, and phosphorus cycling were all disrupted by degradation, but each exhibited unique response patterns. …”
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Genetic and biochemical characterizations of Zika virus NS2A protein by Xianwen Zhang, Xuping Xie, Jing Zou, Hongjie Xia, Chao Shan, Xinwen Chen, Pei-Yong Shi

“…Biochemical structural probing suggests that ZIKV NS2A has a single segment that traverses the ER membrane and six segments that peripherally associate with the ER membrane. Functional analysis has defined distinct NS2A residues essential for viral RNA synthesis or virion assembly. …”
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Exploring omics strategies for drug discovery from Actinomycetota isolated from the marine ecosystem by Manik Prabhu Narsing Rao, Syed Raziuddin Quadri, Manda Sathish, Ngoc Tung Quach, Wen-Jun Li, Wen-Jun Li, Arinthip Thamchaipenet, Arinthip Thamchaipenet

“…These comprehensive tools facilitate the discovery and functional analysis of new bioactive compounds by revealing the genetic blueprints underlying their biosynthesis. …”
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Global Transcriptome Analysis Reveals Distinct Aluminum-Tolerance Pathways in the Al-Accumulating Species Hydrangea macrophylla and Marker Identification. by Haixia Chen, Changping Lu, Hui Jiang, Jinhui Peng

“…Although the exact roles of these candidate genes remain to be examined, these results provide a platform for further functional analysis of the process of detoxification of Al in hydrangea.…”
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