Effectiveness and Tolerability of DOR/3TC/TDF in Experienced People with HIV Switching from RPV/FTC/TDF: A Retrospective, Single Center Cohort Study by Stefania Cicalini, Simone Lanini, Roberta Gagliardini, Rita Bellagamba, Alessandra Vergori, Ilaria Mastrorosa, Valentina Mazzotta, Rozenn Esvan, Maria Maddalena Plazzi, Sandrine Ottou, Elisabetta Grilli, Federico De Zottis, Marisa Fusto, Jessica Paulicelli, Andrea Antinori

“…Notably, the switch to DOR/3TC/TDF did not result in adverse metabolic effects or significant changes in renal function. Analysis of lipid profiles showed stabilization in the majority of PLWH. …”
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Multiparametric cardiovascular magnetic resonance is associated with outcomes in pediatric heart transplant recipients by Andrew A. Lawson, Kae Watanabe, Lindsay Griffin, Christina Laternser, Michael Markl, Cynthia K. Rigsby, Joshua D. Robinson, Nazia Husain

“…Standard CMR ventricular volume and function analysis, T1 mapping with ECV, T2 mapping, and LGE assessment were performed. …”
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Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatment by Jing-Song Guan, Jing Jia, Ze-Xiu Huang, Yu-Qing Zhou, Jing-Jie Zheng, Qi-Man Lin, Yi-Fei Wang, Jiang-Lin Fan, Yao Wang, Yao Wang

“…The mechanism is investigated by high-throughput transcriptome analysis and transcription factor function analysis of androgen receptor.ResultsCH inhibits cellular functions and trigger ferroptosis in prostate cancer cells. …”
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Structural Insights into Ni‐Stabilized Fe‐Rich High‐Voltage Spinels: LiNixFe0.5−xMn1.5O4 by Anna Windmüller, Tingting Yang, Kristian Schaps, Anna Domgans, Frederik Zantis, Baolin Wu, Leyela Hassen Adem, Bikila Nagasa Olana, Chih‐Long Tsai, Shicheng Yu, Luc Raijmakers, Hans Kungl, Hermann Tempel, Rafal E. Dunin‐Borkowski, Shawn D. Lin, Mirijam Zobel, Bing Joe Hwang, Rüdiger‐A. Eichel

“…Rietveld and pair distribution function analysis show remarkable similarity in average and local structural features, supported by 4D scanning transmission electron microscopy. …”
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Bisphenol S interrupted axonogenesis on a human embryonic stem cells derived neural differentiation model: Conserved axon guidance and WNT signaling pathway involved by Wanqing Guo, Wei Xiong, Liang Wang, Xiaoya Wang, Yongru Zhou, Yili Chen, Xiaomeng Li, Lishi Zhang, Mengmei Ni, Jinyao Chen

“…Transcriptomics analysis showed that the main interrupted pathway enriched in axonogenesis, myelination, and neurotransmitter secretion by the GO function analysis and immune-related pathway by the KEGG analysis, besides, conserved axon guidance (Slit-Robo, Netrin-DCC, Semaphorin-Plexin) and WNT signaling pathway was also enriched in KEGG pathway analysis, which previously proved to regulate axonogenesis by directly acting on growth cones and inhibit axon growth by neuroinflammatory responses. …”
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Integration of transcriptome and metabolome reveals tolerance mechanism to high salinity stress in Crassostrea hongkongensis by Yixin Zhang, Qiwen Liang, Feifei Yu, Jiexiong Zhu, Jianfang Gui, Jinji Lin, Yishan Lu, Haiyuan Tao

“…A total of 33 differential metabolites (DMs) and 61 DMs were identified in 6 h and 48 h salinity-stress groups. KEGG function analysis showed that DMs mainly involved in free amino acids metabolism, pentose and glucuronate interconversions, fatty acids biosynthesis, aminoacyl-tRNA biosynthesis, pantothenate and CoA biosynthesis and so on. …”
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Single or Combined Supplementation of <i>Rhodotorula</i> Yeast Culture and <i>Bacillus Subtilis</i> Enhances Intestinal Barrier Function in Yellow-Feathered Broilers by Xiangtan Su, Ke Wang, Yeqing Liu, Xinyu Lu, Meiru Chen, Jianlong Dang, Gaowei Zhang, Guang Yang, Aiqin Gao, Yuanqing Xu

“…Mucin-2 (<i>MUC2</i>) expression was significantly increased by RYC or BS alone (<i>p</i> < 0.05). In immune function analysis, IgM levels were significantly increased by RYC alone but decreased when RYC and BS were combined (<i>p</i> < 0.05), further highlighting their antagonistic interaction. …”
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Particulate matter pollution alters the bacterial community structure on the human skin with enriching the Acinetobacter and Pseudomonas by Dong Yan, Min Li, Chengbao Ge, Kuan Wang, Yujie Sun, Guoyan Song, Jialin Li, Yajuan Li, Fei Miao, Moyu Yan, Yile Zhang, Hua Hu, Tao Zhang, Dandan Fu, Xiangfeng Song, Liyan Yu, Zhongwei Tian

“…In vitro experiments confirmed that PM promoted the growth of the Acinetobacter and Pseudomonas strains. Function analysis revealed increased metabolic function and enrichment of antibiotic resistance- and pathogenicity-related functions during haze days, including the beta-lactamase gene and attachment invasion locus protein. …”
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A Novel Hypoxia-Related Gene Signature with Strong Predicting Ability in Non-Small-Cell Lung Cancer Identified by Comprehensive Profiling by Huajun Yang, Zhongan Wang, Ling Gong, Guichuan Huang, Daigang Chen, Xiaoping Li, Fei Du, Jiang Lin, Xueyi Yang

“…The upregulated genes were significantly enriched in 284 GO terms and 42 KEGG pathways, while the downregulated genes were significantly enriched in 184 GO terms and 25 KEGG pathways. Moreover, the function analysis by GSEA showed enrichment in the enzyme-linked receptor protein signaling pathway, hypoxia-inducible factor- (HIF-) 1 signaling pathway, and G protein-coupled receptor (GPCR) downstream signaling. …”
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Cloning and function prediction of full-length cDNA for cathepsin E derived from medaka (Oryzias latipes) by WANG Jiaqing, DONG Huiming, LI Zhengang, LI Shaoming, WANG Ruonan, FU Yujie

“…The overall shape of CtpE protein from medaka and porcine pepsinogen showed ellipsoid, and formed a relatively independent space entity.In conclusion, OlCtpE may play a very important role in the immune processing and presentation of exogenous antigen. Cloning and function analysis of the OlCtpE provide essential evidence for further studies on immune gene function.…”
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12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII by Shinsuke Nirengi, Benjamin Buck, Devleena Das, Carmem Peres Valgas da Silva, Jazmin Calyeca, Lisa A. Baer, Hsiang-Ling Huang, Pablo Vidal, Revati S. Dewal, Kelsey M. Pinckard, Elisa Félix-Soriano, Diego Hernandez-Saavedra, Andrew Gerea, Kavya Dathathreya, Silvia Duarte-Sanmiguel, Ty A. Saldana, Harrison L. Hookfin, Matthew W. Gorr, Valerie Bussberg, Juan J. Aristizabal-Henao, Michael A. Kiebish, Roeland J. W. Middelbeek, Laurie J. Goodyear, Paul M. Coen, Krishna Chinthalapudi, Loren E. Wold, Ana L. Mora, Thomas J. Hund, Daniel Gallego-Perez, Kristin I. Stanford

“…This study investigates the potential of the brown adipose tissue (BAT) derived lipokine 12,13-diHOME to mitigate age-induced impairments in cardiovascular function. Analysis of human and rodent plasma signaling lipids reveals a decline in 12,13-diHOME levels with age. …”
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Saline–Alkali Tolerance Evaluation of Giant Reed (<i>Arundo donax</i>) Genotypes Under Saline–Alkali Stress at Seedling Stage by Yangxing Cai, Xiuming Cao, Bin Liu, Hui Lin, Hailing Luo, Fengshan Liu, Dewei Su, Shi Lv, Zhanxi Lin, Dongmei Lin

“…The saline–alkali tolerance of <i>A. donax</i> seedlings was comprehensively evaluated using principal component analysis and membership function analysis based on 15 parameters. The results indicate that P_n, T_r and G_s are effective physiological indicators for assessing saline–alkali tolerance of <i>A. donax</i> seedlings. …”
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Effects of two foliar fertilizers on fruit quality and volatile flavor compounds in Jinhuangjin peach by YANG Xingwang, WANG Zhiqiang, DUAN Chenlei, WANG Yingying, XUE Guihong, PANG Lingzhi, SHI Meng, JI Xiaohao, ZHANG Deyan, WANG Xiaodi, WANG Haibo

“…The comprehensive evaluation using principal component analysis combined with membership function analysis showed that the rankings for comprehensive evaluation in 2023 and 2024 were: amino acid selenium foliar fertilizer (AA-Se), water-soluble silicon fertilizer (WSF-Si), and control. …”
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Evolution of the Three Spectral Components in the Prompt Emission of GRB 240825A by Chen-Wei Wang, Wen-Jun Tan, Shao-Lin Xiong, Rahim Moradi, Yan-Qiu Zhang, Chao Zheng, Bing Li, Xiao-Bo Li, Cheng-Kui Li, Jia-Cong Liu, Yue Wang, Bo-Bing Wu, Sheng-Lun Xie, Wang-Chen Xue, Shu-Xu Yi, Zheng-Hang Yu, Peng Zhang, Shuang-Nan Zhang, Wen-Long Zhang, Zhen Zhang

“…Furthermore, the observed transition from positive to negative on the spectral lag can be interpreted as misalignment in the cross-correlation function analysis of pulses, which is caused by evolution of the soft and hard components.…”
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动态脑血流自动调节功能检查对急性缺血性卒中血管内血栓切除术后完全再通患者不良预后的预测价值 The Predictive Value of Dynamic Cerebral Autoregulation for Poor Prognosis in Acute Ischemic Stroke Patients with Complete Recanaliz... by 刘然1，2，王平平3，陈虹秀1，2，李娜1，2，周福波1，2，赵文博3，马青峰3，邢英琦1，2 (LIU Ran1,2, WANG Pingping3, CHEN Hongxiu1,2, LI Na1,2, ZHOU Fubo1,2, ZHAO Wenbo3, MA Qingfeng3, XING Yingqi1,2 )

“…Through transfer function analysis, parameters such as the phase difference, gain, and consistency of very low frequency (VLF) and low frequency at 12 hours and 5 days after EVT, as well as the difference in VLF phase difference between the two examinations, were obtained. …”
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Magnetic Fields in Massive Star-forming Regions (MagMaR). V. The Magnetic Field at the Onset of High-mass Star Formation by Patricio Sanhueza, Junhao Liu, Kaho Morii, Josep Miquel Girart, Qizhou Zhang, Ian W. Stephens, James M. Jackson, Paulo C. Cortés, Patrick M. Koch, Claudia J. Cyganowski, Piyali Saha, Henrik Beuther, Suinan Zhang, Maria T. Beltrán, Yu Cheng, Fernando A. Olguin, Xing Lu, Spandan Choudhury, Kate Pattle, Manuel Fernández-López, Jihye Hwang, Ji-hyun Kang, Janik Karoly, Adam Ginsburg, A.-Ran Lyo, Kotomi Taniguchi, Wenyu Jiao, Chakali Eswaraiah, Qiu-yi Luo, Jia-Wei Wang, Benoît Commerçon, Shanghuo Li, Fengwei Xu, Huei-Ru Vivien Chen, Luis A. Zapata, Eun Jung Chung, Fumitaka Nakamura, Sandhyarani Panigrahy, Takeshi Sakai

“…Using the Davis–Chandrasekhar–Fermi method with an angle dispersion function analysis, we estimate in this core a magnetic field strength of 6.2 mG and a mass-to-magnetic-flux ratio of 18. …”
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Clarification of the clinical significance of an intron variant in a case of Peutz–Jeghers syndrome with abnormal RNA splicing of STK11 by Aki Ishikawa, Masahiro Gotoh, Mineko Ushiama, Hiromi Sakamoto, Noriko Tanabe, Tomoko Watanabe, Hourin Cho, Masayoshi Yamada, Kokichi Sugano, Kouya Shiraishi, Makoto Hirata, Teruhiko Yoshida, Akihiro Sakurai

“…To validate the predicted impact of this variant on splicing, we performed functional analysis using a minigene assay. Functional analysis experiments demonstrated that this variant suppresses normal splicing, and the clinical significance of the STK11 variant, which was initially considered a variant of “uncertain significance,” was reclassified as “likely pathogenic” based on functional analysis. …”
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Some Functional Sections in Topological Sequence Spaces by Ahmet Ocak Akdemir, Merve Temizer Ersoy, Hasan Furkan, Maria Alessandra Ragusa

“…Summability is a particularly fertile field for functional analysis application. Summability through functional analysis has become one of the most fascinating disciplines since it contains both interesting and challenging issues. …”
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Evaluation of the thermal and light stability of β-carotene extracted from Mauritia flexuosa using ionic liquid by Anne Caroline Gouvêa Ferreira, Bruna Ribeiro de Lima, Octavio Ferreira de Matos, Rogério Eiji Hanada, Jaime Paiva Lopes Aguiar, Francisca das Chagas do Amaral Souza

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A Fold Bifurcation Theorem of Degenerate Solutions in a Perturbed Nonlinear Equation by Ping Liu, Yuwen Wang

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