Real world data of cabozantinib in patients with hepatocellular carcinoma: Focusing on dose setting and modification by Hironao Okubo, Hitoshi Ando, Shunsuke Nakamura, Yusuke Takasaki, Koichi Ito, Yuka Fukuo, Kenichi Ikejima, Hiroyuki Isayama

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Identification of a novel chemotherapy benefit index for patients with advanced ovarian cancer based on Bayesian network analysis. by Shuxiao Ma, Lu Zhou, Yi Liu, Hui Jie, Min Yi, Chenglin Guo, Jiandong Mei, Chuan Li, Lei Zhu, Senyi Deng

“…The AUC of internal validation and two external validation cohorts were 0.87, 0.71 and 0.70, respectively. Molecular function analysis indicated that the CBI-low subgroup is characterized by the activation of cancer-related signaling pathways, immune-related biological processes, higher TP53 mutation rate, particularly with a better response to immune checkpoint blockade (ICB) treatment, while the CBI-high subgroup is characterized by inhibition of cell cycle, less response to ICB treatment, and potential therapeutic targets.…”
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The Effects of Mixed <i>Robinia pseudoacacia</i> and <i>Quercus variabilis</i> Plantation on Soil Bacterial Community Structure and Nitrogen-Cycling Gene Abundance in the Southern... by Yi Yang, Jing Chen, Yiwei Zheng, Rui Jiang, Yuqiang Sang, Jinsong Zhang

“…Employing FAPROTAX for predictive bacterial function analysis in various soil layers, this study found that nitrogen-cycling processes such as nitrification and denitrification were most prominent in pure <i>R</i>. …”
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Investigating the mechanism of action of hemofugal and blood-stasis-expelling soup in the treatment of coronary heart disease based on network pharmacology by ·yusuf Arslan, Ma Yun, Wang Qi

“…The PPI network map was analyzed by CyoNCA plug-in for network topology analysis, and Centiseape plug-in was used to screen the key targets, and MetaScape database was used for GO function analysis and KEGG pathway enrichment analysis. …”
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Ribosomal protein mutation suppresses gonadal leader cell migration defects in mig-17/ADAMTS mutants in Caenorhabditis elegans by Hon-Song Kim, Kaito Mitsuzumi, Shohei Kondo, Rie Yamaoka, Shinji Ihara, Hiroshi Otsuka, Chizu Yoshikata, Yukihiko Kubota, Takumi Tomohiro, Toshinobu Fujiwara, Kenji Kimura, Fumio Motegi, Yukimasa Shibata, Mikiko Takahashi, Kiyoji Nishiwaki

“…Intestine-specific overexpression of mutant RPL-20 protein resulted in a slow-growth phenotype and suppressed the mig-17 gonadal defects, but these effects were much weaker when wild-type RPL-20 was overexpressed, suggesting that the mutant RPL-20 protein acquired a novel function. Analysis of ribosome profiles revealed reduced biogenesis of the 60 S subunit, leading to a reduction of 80 S ribosomes in the rpl-20 mutant. …”
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Predicting and Controlling Multiple Transmissions of Rotavirus Using Computational Biomedical Model in Smart Health Infrastructures by Titus Ifeanyi Chinebu, Kennedy Chinedu Okafor, Omowunmi Mary Longe, Kelvin Anoh, Henrietta Onyinye Uzoeto, Victor Onukwube Apeh, Ijeoma Peace Okafor, Bamidele Adebisi, Chukwunenye Anthony Okoronkwo

“…Applying Lyapunov function analysis, we prove that the global stability of disease‐free and endemic equilibria exists under breastfeeding and vaccination conditions when the primary reproduction number is less than unity. …”
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miR-455 inhibits neuronal cell death by targeting TRAF3 in cerebral ischemic stroke by Yao ST, Tang B, Li G, Fan RM, Cao F

“…Furthermore, TRAF3 was proved&amp;nbsp;to be a direct target of miR-455, and miR-455 could negatively suppress TRAF3 expression. Biological function analysis showed that TRAF3 silencing displayed the neuroprotective effect in ischemic stroke and could enhance miR-455-induced positive impact on ischemic injury both in vitro and in vivo. …”
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A novel mouse model for X-linked Alport syndrome induced by splicing mutation in the Col4a5 gene by Zhitao Ye, Di Lu, Shumin Zhou, Guanyu Li, Lili Long, Jiayi Zhang, Ming Liu, Xia Gao

“…Col4α5-deficient mice exhibited growth retardation and reduced lifespan. Renal function analysis indicated progressive deterioration, with high levels of BUN and creatinine. …”
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Tracking Long-Term Ozone Pollution Dynamics in Chinese Cities with Meteorological and Emission Attribution by Hongrui Li, Xiaoyong Liu, Zijian Liu, Mengyang Li, Tong Wu, Peicheng Li, Peng Zhou

“…Empirical orthogonal function analysis further reveals distinct spatial patterns of emission influence: long-term O₃ trends in mega-cities such as Beijing, Tianjin, and Shanghai are driven mainly by local emissions (1.5–3% contribution), while key transport hubs including Xi’an, Tangshan, and Langfang are markedly affected by traffic-related emissions (>2%). …”
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Electronic Nose System Based on Metal Oxide Semiconductor Sensors for the Analysis of Volatile Organic Compounds in Exhaled Breath for the Discrimination of Liver Cirrhosis Patient... by Makhtar War, Benachir Bouchikhi, Omar Zaim, Naoual Lagdali, Fatima Zohra Ajana, Nezha El Bari

“…Sensor’s measurement data were analyzed using machine learning techniques, such as principal component analysis (PCA), discriminant function analysis (DFA), and support vector machines (SVMs) that were utilized to uncover meaningful patterns and facilitate accurate classification of sensor-derived information. …”
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Influence of hemoglobin level and dose of administered recombinant human beta erythropoietin on survival of hemodialysis patients by Knežević Violeta, Milošević Aleksandra, Vodopivec Slavenka, Božić Dušan, Budošan Ivana, Majić Milena

“…Descriptive statistics, Anova, Manova, discriminant function analysis, Cox regressional model and Kaplan Meier survival curves were used as statistical methods. …”
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Screening and Comprehensive Evaluation of Drought Resistance in Cotton Germplasm Resources at the Germination Stage by Yan Wang, Qian Huang, Li Liu, Hang Li, Xuwen Wang, Aijun Si, Yu Yu

“…To comprehensively evaluate the drought resistance of cotton during the germination period, the values of drought resistance comprehensive evaluation (D-value), weight drought resistance coefficient (WDC-value), and comprehensive drought resistance coefficient (CDC-value) were calculated based on membership function analysis and principal component analysis. Cluster analysis based on the D-value divided the germplasm into five drought-resistant grades, followed by the selection of one extreme material, each from the strongly drought-resistant and strongly drought-sensitive groups. …”
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Mitochondrial mass and low mitochondrial membrane potential percentage of CD8+ T cell subsets are implicated with therapeutic effect in depressive disorder by Yiran Huang, Zhenni Chen, Yang Xu, Biqiong Ren, Biqiong Ren

“…Flow cytometry was used to monitor the frequency of T-lymphocyte subpopulations in depressed patients, mitochondrial mass (MM) and low mitochondrial membrane potential (MMPLow, %) was calculated by using the lymphocyte mitochondrial function analysis software (patented technology) in conjunction with the median fluorescence intensity of each subpopulation. …”
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Variation in Nutritional Qualities and Antioxidant Capacity of Different Leaf Mustard Cultivars by Wenjuan Cheng, Anqi Luo, Hongxia Li, Zhifeng Chen, Zhongrong Guan, Victor Hugo Escalona, Duchen Liu, Yu’nong Zhou, Fen Zhang, Zhi Huang, Yi Tang, Huanxiu Li, Bo Sun, Kehao Liang, Xuena Yu

“…Based on a comprehensive evaluation using a membership function analysis, LS12 was identified as the cultivar with the best nutritional quality and antioxidant capacity. …”
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Sexual size and shape dimorphism are consistent with predictions that both natural and sexual selection are driving the evolution of sexual dimorphism in Mormon crickets, Anabrus s... by Kevin A. Judge, Stacy R. Demma, Laura J. Robson, Patrick D. Lorch, Christopher J. Vinyard, Darryl T. Gwynne

“…We also used discriminant function analysis to test whether a previously enigmatic population, found to be genetically like gregarious populations, but exhibiting many aspects of solitary population behaviour, was morphologically more like solitary or gregarious populations. …”
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THE FUNDAMENTAL PRINCIPLES OF EFFECTIVE STATE SOCIAL-ECONOMICAL POLICY (Part 3) by E. A. Zhukov

“…Russia, like no other state in the world, has the potential all these production resources for timely, complete and quality provision of reasonable material and spiritual needs of all its citizens.Purpose: the aim of the presented final part of the research is a critical assessment of the tax legislation in force in Russia, and the reasoned justification that a reasonable tax system is an essential tool for sustainable economic growth.Methods: the methodological basis of the research was the General scientific methods of cognition (dialectic; coexistence of historic and logistic approaches; structure and function analysis; expert evaluation of social-economic policy).Results: considering Russia's economic potential and its use, it was noted that the modern state socio-economic policy is contrary to the objective economic laws of the formation of the social state. …”
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Effect of pretreatment with omega-3 polyunsaturated fatty acids (PUFAs) on hematological parameters and platelets aggregation in patients during elective coronary artery bypass gra... by Veljović Milić, Mihajlović Ivana, Subota Vesna, Antunović Mirjana, Jevđić Jasna, Udovičić Ivo, Popadić Ana, Vulović Tatjana

“…Infusion was given a day before surgery and repeated four hours before starting extracorporeal circulation (CPB) via the peripheral vein at single doses of 100 mL (25 mL/h). Platelet function analysis was performed using multiple electrode aggregometry (MEA, multiplate-analyzer) before starting CPB and 2 h postoperatively for the patients of both groups. …”
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Unraveling environmental influences on the spatial and temporal dynamics of cyanobacterial blooms in Lake Erhai during its early stage of eutrophication by Shangbo Yang, Jianzhong Lu, Xiaoling Chen, Xuejiao Hou, Zushuai Wei, Jinru Wu

“…We investigated the cyanobacterial phycocyanin concentration variability based on satellite observations from 2003 to 2019, by using the empirical orthogonal function analysis. We observed a decrease in the coverage of the dominant mode of variability in phycocyanin magnitudes compared to the period 2003 to 2011, with variations primarily occurring in the northern bays. …”
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Comparative analysis of adductor canal block combined with iPACK block versus femoral combined with sciatic nerve blocks: a propensity score matched study by Chao-Hsien Sung, Jen-Hao Liu, Chi-Feng Hung, Chun-Hsien Fu

“…Numeric rating scale (NRS) scores at different time points were primary outcome. Motor function analysis, including the motor blockade, maximum flexion angle and time to ambulation were secondary outcomes. …”
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An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence. by Michelle L Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T Nickels

“…To define the relationship between Arv1 function and azole susceptibility, we undertook a structure/function analysis of ScArv1. We identified several conserved amino acids within the ScArv1 homology domain (ScAhd) required for maintaining normal azole susceptibility. …”
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