Influence of ethnicity on cyclin-dependent kinase inhibitor efficacy and toxicity: A systematic review and meta-analysis by Roberto Buonaiuto, Aldo Caltavituro, Margherita Tafuro, Alessandra Longobardi, Giuliana Pavone, Pierluigi De Santis, Roberta Caputo, Carmine De Angelis, Lucia Del Mastro, Fabio Puglisi, Mario Giuliano, Grazia Arpino, Martina Pagliuca, Michelino De Laurentiis

“…We included studies comparing CDK4/6i (palbociclib, ribociclib, abemaciclib, dalpiciclib) + ET versus placebo + ET. Progression-free survival (PFS) and overall survival (OS), hazard ratios (HR), and 95 % confidence intervals (CI) were extracted for the two subgroups of interest. …”
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Germline Human Leukocyte Antigen Status is Associated With Immunotherapy-Induced Pneumonitis and Treatment Response in Patients With Non–Small Cell Lung Cancer With High Programmed... by Alvin H.K. Cheung, MBBS, PhD, Zeta Mui, MPhil, Walter W. Yeung, PhD, Chit Chow, PhD, Mandy F. Yu, BSc, Olivia H. Chen, MD, PhD, Kit-Yee Wong, MPhil, Fuda Xie, MPhil, Yat Ming Lau, MBBS, Alfred S-L. Cheng, PhD, Wei Kang, PhD, Ka-Fai To, MBChB, Tony S. Mok, MD, Molly S.C. Li, MBBS

“…Results: It was observed that the germline HLA-C homozygosity and HLA-DRB1∗13 expression were related to a worse progression-free survival and treatment response. Importantly, all patients (7/7 patients) who developed pneumonitis in our cohort expressed the HLA-DPB1∗02 allele, and the incidence of pneumonitis was 31.8% (7/22 patients) in patients expressing this allele compared with 0% (0/20 patients) in those without this allele (p = 0.009). …”
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Synthesis of silver Nanoparticles@Carbon Dot nanocomposites using Aegle marmelos and Euphorbia hirta: Anti vibriocidal and antioxidant properties by Gali Raman, Sirangu Joseph, D Ramachandran, Phanindra Babu Kasi, Abhinash Marukurti, Alavala Matta Reddy, P Vijaya Nirmala, V S Manikanta, R. Lohitha Kavya, K Sarojani, Anitha Kadimi, Silpa Rani Medapalli, S B Sonia Shankar, G Dinesh Ratna, K Gayathri, P Tirupathi Rao

“…The in vitro antioxidant studies revealed effective radical scavenging activity with the lowest IC50 value of 5.29 μg/mL on DPPH nitrogen free radical by AM AgNP@CD NCs. The present study found effective antivibriocidal and antioxidant properties of biomass derived AgNP@CD NCs.…”
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Characteristics and clinical significance of immune cells in omental milky spots of patients with gastric cancer by Yasunobu Mano, Yasunobu Mano, Yuka Igarashi, Yuka Igarashi, Keisuke Komori, Keisuke Komori, Itaru Hashimoto, Itaru Hashimoto, Hayato Watanabe, Kosuke Takahashi, Kazuki Kano, Hirohito Fujikawa, Takanobu Yamada, Hidetomo Himuro, Hidetomo Himuro, Taku Kouro, Taku Kouro, Feifei Wei, Feifei Wei, Kayoko Tsuji, Kayoko Tsuji, Shun Horaguchi, Shun Horaguchi, Shun Horaguchi, Mitsuru Komahashi, Mitsuru Komahashi, Mitsuru Komahashi, Takashi Oshima, Tetsuro Sasada, Tetsuro Sasada

“…When univariate Cox proportional hazards regression models were used to search for prognostically relevant genes specific to G3, 23 potential prognostic genes were identified as common genes associated with relapse-free survival and overall survival. In addition, the multivariate Cox proportional hazards model using these prognostic genes and clinicopathological information showed that combining the B cell marker CD19 and Ly had a high predictive accuracy for prognosis. …”
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Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study by Juanjuan Zhang, Sabina Rayamajhi, Amrish Thapa, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Shunming Zhang, Tingjing Zhang, Xuena Wang, Zhixia Cao, Jun Dong, Xiaoxi Zheng, Xu Zhang, Xinrong Dong, Xing Wang, Shaomei Sun, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu

“…SCTD was defined as abnormal serum thyroid-stimulating hormone levels and normal free thyroxine. Cox proportional hazards regression models were used to examine the association of edible mushrooms consumption with incident SCTD. …”
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The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…Methods: The seeds of local Tarom and Khazar cultivars were prepared and disinfected to produce identical, pathogen-free seedlings. Subsequently, the seeds were germinated and transferred to plastic pots filled with sterile soil. …”
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How can cervical screening meet the needs of vulnerable women? A qualitative comparative study with stakeholder perspectives from seven European countries by Partha Basu, Martin McKee, Adriana Băban, Marc Bardou, Ana Fernandes, Margarida Teixeira, Rebecca Moore, Nuno Lunet, David Ritchie, Romeu Mendes, Eric Lucas, Paolo Giorgi Rossi, Rosa Legood, Berit Andersen, Diana Taut, Keitly Mensah, João Firmino-Machado, Mariana Amorim, Mette Tranberg, Laura Bonvicini, Anneli Uusküla, Pia Kirkegaard, Paola Mantellini, Ines Baia, Liu Sun, Lise Rochaix, Camilla Fiorina, Luca Ghirotto, Anna Tisler, Firmino Machado, Rikke Buus Bøje, Raquel Rico Berrocal, Noemi Auzzi, Kerli Reintamm, Yulia Panayotova, Tatyana Kotzeva, Anna Foss, Rachel Greenley, Letizia Bartolini, Giusy Iorio, Cláudia Gouvinhas, Florian Nicula, Alexandra Tolnai, Vanessa Moore, Isabel Mosquera Metcalfe, Violette Delisle, Irina Todorova, Helena Ros Comesana, Meritxel Mallafré-Larrosa, Ginevra Papi, Nicoleta-Monica Pașca, Christiane Dascher-Nadel, Olivra Djuric

“…In Bulgaria and Romania, participants advocated for the need to secure free access, from screening to follow-up, and emphasised the need for organised screening with target population screening registries.Conclusion The study offers insights into stakeholders' recommendations for enhancing cervical cancer screening services for vulnerable women across seven European countries. …”
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Citizen science platforms can effectively support early detection of invasive alien species according to species traits by Pablo González‐Moreno, Ana A. Anđelković, Tim Adriaens, Christophe Botella, Jakovos Demetriou, Rita Bastos, Sandro Bertolino, Celia López‐Cañizares, Franz Essl, Živa Fišer, Milka Glavendekić, Marc Herremans, Philip E. Hulme, Viola Jani, Dimitra Katsada, Periklis Kleitou, Nicola La Porta, Katharina Lapin, Marta López‐Darias, Vanessa Lozano, Angeliki F. Martinou, Damiano Oldoni, Esra Per, Stephanie Rorke, Helen E. Roy, Karl‐Manfred Schweinzer, Kristijn Swinnen, Elena Tricarico, Joana R. Vicente, Maarten de Groot, Michael J. O. Pocock

“…We recommend that IAS surveillance programmes should be better connected with citizen science platforms, including greater acknowledgement of the role of citizen scientists and better data flow from smaller citizen science initiatives into global databases, to support efficient early detection. Read the free Plain Language Summary for this article on the Journal blog.…”
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Monitoring of Circulating Tumor DNA and Indication of De-Escalation Adjuvant Targeted Therapy for EGFR-Mutated NSCLC After Complete Resection by Song Dong, PhD, Bingfa Yan, PhD, Si-Yang Liu, PhD, Xuan Gao, PhD, Hui-Zhao Hong, MD, Hong-Ji Li, MD, Wei Gao, PhD, Hong-Hong Yan, PhD, Si-Yang Maggie Liu, PhD, Hai-Yan Tu, PhD, Yi Pan, PhD, Qing Zhou, PhD, Xue-Ning Yang, PhD, Xue-Feng Xia, PhD, Xin Yi, PhD, Wen-Zhao Zhong, PhD, Yi-Long Wu, MD, Jia-Tao Zhang, PhD

“…Furthermore, 22 patients with stages IB to III disease who had previously suspended their TKI treatment based on undetectable MRD were included in the adaptive group, with an average duration of TKI 3.9 (range: 0–35.0) months. The 2-year disease-free survival rate of these 22 patients was 80.2%, and the median was not reached. …”
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J-TAIL-2: A Prospective, Observational Study of Atezolizumab Combined With Carboplatin and Etoposide in Patients With Extensive-Stage SCLC in Japan by Eisaku Miyauchi, MD, PhD, Makoto Nishio, MD, PhD, Kadoaki Ohashi, MD, PhD, Atsushi Osoegawa, MD, PhD, Eiki Kikuchi, MD, PhD, Hideharu Kimura, MD, PhD, Yasushi Goto, MD, PhD, Junichi Shimizu, MD, PhD, Hiroshige Yoshioka, MD, PhD, Ichiro Yoshino, MD, PhD, Toshihiro Misumi, PhD, Nobuyuki Katakami, MD, PhD, Masahide Oki, MD, PhD, Takashi Kijima, MD, PhD, Kenichi Chikamori, MD, PhD, Kazumi Nishino, MD, PhD, Yuki Kobayashi, MS, Asako Miwa, BA, Misa Tanaka, MS, Akihiko Gemma, PhD

“…Secondary end points included overall survival (OS), progression-free survival (PFS), and safety in select subgroups, including the IMpower133-unlike (i.e., Eastern Cooperative Oncology Group performance status 2 or more, interstitial lung disease, autoimmune disease) versus IMpower133-like groups. …”
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Several factors that predict the outcome of large B‐cell lymphoma patients who relapse/progress after chimeric antigen receptor (CAR) T‐cell therapy can be identified before cell a... by Alice Sýkorová, František Folber, Kamila Polgárová, Heidi Móciková, Juraj Ďuraš, Kateřina Steinerová, Aleš Obr, Adriana Heindorfer, Miriam Ladická, Ľubica Lukáčová, Erika Čellárová, Ivana Plameňová, David Belada, Andrea Janíková, Marek Trněný, Tereza Jančárková, Vít Procházka, Andrej Vranovský, Margaréta Králiková, Jan Vydra, Lukáš Smolej, Ľuboš Drgoňa, Martin Sedmina, Eva Čermáková, Robert Pytlík

“…The median progression‐free survival (PFS) and overall survival (OS) were 4.3 and 26.4 months, respectively. …”
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Anti-LAG-3 antibody LBL-007 plus anti-PD-1 antibody toripalimab in advanced nasopharyngeal carcinoma and other solid tumors: an open-label, multicenter, phase Ib/II trial by Gang Chen, Dong-Chen Sun, Yi Ba, Ya-Xiong Zhang, Ting Zhou, Yuan-Yuan Zhao, Hong-Yun Zhao, Wen-Feng Fang, Yan Huang, Zhen Wang, Chao Deng, De-Sheng Hu, Wei Wang, Jin-Guan Lin, Gui-Ling Li, Su-Xia Luo, Zhi-Chao Fu, Hai-Sheng Zhu, Hui-Li Wang, Sheng-Li Cai, Xiao-Qiang Kang, Li Zhang, Yun-Peng Yang

“…In immunotherapy-naive NPC patients (n = 12), ORR was 33.3%, disease control rate (DCR) was 75%, and median progression-free survival (PFS) was 10.8 months (95% CI, 1.3 to not estimated). …”
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The Clinical Features, Risk Factors, and Outcome of Aneurysmal Lesions in Behcet’s Disease by Jiaxin Zhou, Jing Shi, Jinjing Liu, Luxi Sun, Lu Li, Chaoran Li, Xiuhua Wu, Yining Wang, Xinping Tian, Xiaofeng Zeng, Yi Liu, Wenjie Zheng, Yan Zhao

“…The respective estimated cumulative 1- and 5-year relapse-free rates were 91.3% and 76.3%, and the respective estimated 1- and 5-year survival rates were 95.0% and 87.2%. …”
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Editorial by Christian Gütl

“…We have also changed our license to CC BY, and future special issues will also be free of charge because of the KOALA funding. Looking back on the past year, we have further increased our visibility and taken steps to fully comply with the Diamond Open Content Standard and align our journal with the KOALA requirements. …”
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Comparative end-of-life communication and support in hospitalised decedents before and during the COVID-19 pandemic: a retrospective regional cohort study in Ottawa, Canada by Shirley H Bush, Monisha Kabir, Peter Lawlor, James Downar, Brandi Vanderspank-Wright, Sarina Isenberg, Peter Tanuseputro, Akshai Iyengar, Claire Dyason, Julie Lapenskie, Colleen Webber, Henrique Parsons, Samantha Rose Adeli, Ella Besserer, Leila Cohen, Valérie Gratton, Rebekah Murphy, Grace Warmels, Adrianna Bruni, Chelsea Noel, Brandon Heidinger, Koby Anderson, Kyle Arsenault-Mehta, Krista Wooller, Daniel Bedard, Paula Enright, Isabelle Desjardins, Khadija Bhimji

“…Objective To compare end-of-life in-person family presence, patient–family communication and healthcare team–family communication encounters in hospitalised decedents before and during the COVID-19 pandemic.Design In a regional multicentre retrospective cohort study, electronic health record data were abstracted for a prepandemic group (pre-COVID) and two intrapandemic (March–August 2020, wave 1) groups, one COVID-19 free (COVID-ve) and one with COVID-19 infection (COVID+ve). …”
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Photoaging smartphone app promoting poster campaign to reduce smoking prevalence in secondary schools: the Smokerface Randomized Trial: design and baseline characteristics by Michael Kreuter, Fabian N Fries, Titus J Brinker, Ute Mons, David A Groneberg, Anil Batra, Werner Seeger, Felix Herth, Julia Holzapfel, Tanja G Baudson, Katharina Sies, Lena Jakob, Hannah Maria Baumert, Marlene Heckl, Ana Cirac, Janina L Suhre, Verena Mathes, Hannah Spielmann, Nancy Rigotti, Tobias Raupach, Henning Gall, Claudia Bauer, Pat Marek, Chase H Harrison, Lava Taha, Andreas Owczarek, Felix J Hofmann, Roger Thomas

“…We took advantage of the widespread availability of mobile phones and adolescents’ interest in appearance to develop a free photoaging app which is promoted via a poster campaign in secondary schools. …”
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Sepsis-Associated Acute Kidney Disease Incidence, Trajectory, and Outcomes by Hsiu-Yin Chiang, Chih-Chia Liang, Ya-Luan Hsiao, Uyen-Minh Le, Yi-Ching Chang, Pei-Shan Chen, David Ray Chang, I-Wen Ting, Hung-Chieh Yeh, Chin-Chi Kuo

“…Conclusions: SA-AKD without recovery is associated with increased and long-term risks of KRT initiation, mortality, and increased risk of de novo CKD-ND for patients initially free of CKD. Further studies are warranted for managing AKI to AKD to CKD in real-world settings. …”
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Comparative Analysis of the Outcomes of Laparoscopic Right Hemicolectomy with D2 and D3 Lymphadenectomy in the Treatment of Patients with Right Colon Cancer by A. A. Nevolskikh, V. A. Avdeenko, Yu. Yu. Mikhaleva, T. P. Pochuev, P. V. Sokolov, R. F. Zibirov, I. P. Reznik, N. D. Silin, L. O. Petrov, S. A. Ivanov, A. D. Kaprin

“…The three-year overall and disease-free survival rates were 94.8 ± 3.0 and 100 % (p = 0.149) and 80.5 ± 5.8 and 88.7 ± 5.8 % (p = 0.177), respectively.Conclusions. …”
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Experimental analysis of micro-cavity influence on the effective solar absorptance of white sand curtain on porous obstructions of particle heating receivers by Rageh Saeed, Shaker Alaqel, Eldwin Djajadiwinata, Nader S. Saleh, Abdulelah Alswaiyd, Hany Al-Ansary, Syed Noman Danish, Abdelrahman El-Leathy, Zeyad Al-Suhaibani, Sheldon Jeter, Redhwan Almuzaiqer, Zeyad Almutairi

“…ESA was compared to that of another two PHR configurations: Bare, and free-fall PHRs. ESA measurements revealed a substantial enhancement in particle curtain absorptivity compared to the particle-packed bed. …”
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Osiąganie kompromisu potrzeb człowieka i przyrody by Karol Lewandowski

“…The biggest transformation of our planet's environment was the replacement of the atmosphere from oxygen-free to oxygenated realized by blue-green algae (Cyanophyta). …”
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