Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis by William J Murphy, Robert J Canter, Nikhil Joshi, Sean J Judge, Morgan A Darrow, Steve W Thorpe, Alicia A Gingrich, Lauren M Perry, Sylvia M Cruz, Kara T Kleber, Louis B Jones, Ugur N Basmaci, Matthew L Settles, Blythe P Durbin-Johnson, Arta Monir Monjazeb, Janai Carr-Ascher, Jonathan A Eisen

“…In the tumor microenvironment, we observed a strong positive correlation between viral relative abundance and natural killer (NK) infiltration, and higher NK infiltration was associated with superior metastasis-free and overall survival by immunohistochemical, flow cytometry, and multiplex immunofluorescence analyses.Conclusions We prospectively demonstrate the presence of a distinct and measurable intratumoral microbiome in patients with STS at multiple time points. …”
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Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis by Fabiola Gonzalez-Ponce, Jorge Ivan Gamez-Nava, Eli Efrain Gomez-Ramirez, Melissa Ramirez-Villafaña, Heriberto Jacobo-Cuevas, Norma Alejandra Rodriguez-Jimenez, Eva Maria Olivas-Flores, Yussef Esparza-Guerrero, Alejandro Martelli-García, Aline Priscilla Santiago-Garcia, Cesar Arturo Nava-Valdivia, Alejandra Martinez-Hernandez, Sergio Antonio Gonzalez-Vazquez, Alfredo Celis, Carlos Enrique Cabrera-Pivaral, Sylvia Totsuka-Sutto, Ernesto German Cardona-Muñoz, Laura Gonzalez-Lopez

“…Dual-energy X-ray absorptiometry was used to quantify the skeletal muscle mass index (SMMI) (considering LSMM≤5.5 kg/m2) and the presence of rheumatoid cachexia (a fat-free mass index≤10 percentile and fat mass index≥25 percentile of the reference population). …”
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Preventive Effects of Intrauterine Injection of Bone Marrow-Derived Mesenchymal Stromal Cell-Conditioned Media on Uterine Fibrosis Immediately after Endometrial Curettage in Rabbit by Sanaz Bazoobandi, Nader Tanideh, Farhad Rahmanifar, Shahrokh Zare, Omid Koohi-Hosseinabadi, Iman Razeghian-Jahromi, Mehdi Dianatpour, Masoumeh Ahmadi, Arezoo Khoradmehr, Iraj Nabipour, Zahra Khodabandeh, Amin Tamadon

“…The MSC-CM were collected from cultivated BM-MSCs 48 hours after having been washed three times and replaced in serum-free media. Through a surgical approach, the caudal parts of the uteri were submitted to traumatic endometrial curettage, except for the intact negative uteri. …”
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A self-assembled nanoparticle vaccine elicits effective neutralizing antibody response against EBV infection by Ping Li, Ping Li, Ziyi Jiang, Jingjing Shi, Haochuan Sha, Zihang Yu, Yan Zhao, Sanyang Han, Lan Ma, Lan Ma, Lan Ma

“…These epitope peptides detected a binding capability with host cells were then fused by flexibility linkers and expressed in Escherichia coli to reduce the unnecessary glycan modifications to simulate their free-glycan status. The fused recombinant protein (L350) was displayed on the surface of ferritin-based nanoparticle. …”
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Income level is associated with differences in primary and secondary stroke prevention in China by Huiming Ren, Junrong Ma, Xu Guo, Ruijie Zhang, Liyuan Pu, Tian Zhao, Fangfang Zeng, Chang Shu, Liyuan Han, Yunzhi Wang, Qiang Li, Xiaojie Wang

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Pembrolizumab hybrid dosing is non-inferior to flat dosing in advanced non-small cell lung cancer: a real-world, retrospective bicenter cohort study by Egbert F Smit, Willemijn S M E Theelen, Michiel M Smeenk, Vincent van der Noort, Jeroen M A Hendrikx, Hanieh Abedian Kalkhoran

“…Overall survival (OS) and progression-free survival (PFS) were assessed by Kaplan-Meier estimation, compared by log-rank test and HRs were calculated with the Cox proportional hazards model in both unweighted and inverse probability of treatment weighted (IPTW) cohorts. …”
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A retrospective multicenter study on the efficacy and safety of disitamab vedotin monotherapy versus combination with anti-PD-1 immunotherapy in advanced gastric cancer by Shuailei Dong, Chen Wei, Xueting Wang, Xinyi Yang, Wei Shen, Shuyi Li, Jiye Xu, Yijie Ma, Liangyu Bie, Wenyue Yu, Ning Li

“…Patients treated with RC48 MT or RC48 combined with anti-PD-1 IT from July 2021 to April 2023 were recruited for the study. The progression-free survival (PFS), overall survival (OS), objective-response rate (ORR), disease-control rate (DCR), and safety were studied. …”
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Estimation of tuberculosis incidence at subnational level using three methods to monitor progress towards ending TB in India, 2015–2020 by Swati Mahajan, Amar Shah, Sarit Sharma, Rituparna Das, Kathiresan Jeyashree, Mathavaswami Vijayageetha, Bhavesh Modi, Burugina Nagaraja Sharath, Vijay Singh, Shamim Mannan, Sairu Philip, Jasleen Kaur, Ranjani Ramachandran, Raghuram Rao, Sriram Selvaraju, Bency Joseph, Vaibhav Shah, Kiran Rade, Lalit Sankhe, Surinder Singh, Sandeep Chauhan, Anupam Banerjee, Devender Kumar, Ganapathy Kalaiselvan, Bhavin Vadera, Paras Mehta, Meenakumari Natarajan, Manoj Murhekar, Aswathy Sreedevi, Jeromie Thangaraj, Saravanakumar Velusamy, Sasidharan Akhil, Dhanapal Sudha Rani, Ramasamy Sabarinathan, Sakthivel Manikandanesan, Rajalakshmi Elumalai, Amarendra Mahapatra, Almas Shamim, Ashok Bhardwaj, Anil Purty, Anand Sridhar, Aniket Chowdhury, Asif Shafie, Avijit Choudhury, Deka Dhrubjyoti, Hardik Solanki, Krushna Sirmanwar, Kshitij Khaparde, Malik Parmar, Nisha Dahiya, Parija Debdutta, Quazi Ahmed, Ranjeet Prasad, Rohini Shinde, Rupali Baruah, Sandip Bharaswadkar, Shanta Achanta, Shibu Balakrishnan, Shivani Chandra, Sophia Khumukcham, Sudarsan Mandal, Sumitha Chalil, Venkatesh Roddawar, Kuldeep Sachdeva, Jayakrishna Kurada, Mayank Sharma, Debajyoti Mohapatra, Yogesh Patel, Sapna Thekkepat, Karthikeyan Kumaraswamy, Mallika Tharakan, Shramana Majumdar, Vrinda Manocha, Sukriti Chauhan, Shekhar Waikar, Puja Ambule, Krithika Murali, Devi Madhavi Bhimarasetty, Tulika Goswami, Darshan Mahyavanshi, Krutarth Bhrahmbhatt, Bhautik Modi, Anmol Gupta, Sunil Raina, Rajiv Kumar Gupta, Ratnesh Sinha, Manju Toppo, Gajen Medhi, Swati M Patki, Bishnu Ram Das, Lisa Sarangi, Afsal Hakim, Suresh Balan, Baer Philip Ravikumar, Subrata Baidya, Abhik Sinha, Boddepalli Nagendra Naidu, Bikash Chandra Nayak, Anoop Dev, Pallavi Boro, Debarshi Paul, Amrita Sarkar, Bhavesh Bariya, Jatin Chhaya, Dixit Chauhan, Mithun Sanghavi, Nilesh Thakor, Rohit Ram, Hinal Baria, Abhilash Sood, Anupam Parashar, Yangchen Dolma, Rakesh Bahl, Dilip Kumar, Mohammad Salim Khan, A K Jayasree, Zinia Nujum, Sheela P Haveri, Dinesh Bhatnagar, Subrata Kumar Palo, Priyesh Marskole, Prashant Verma, Dinesh Kumar Pal, Neelam Toppo, Sanjay R Quraishi, Sunil Panigrahi, Rambadan Chauhan, Jayashree Gothankar, Swapnali S Kadam, Dasi Rao, Sudhir Wanje, Pallavi Uplap, Ningombam Joenna Devi, Rikrak Ch Marak, Markordor Lyngdoh, Manoj B Patki, Satyajit Sundar Ray, Kavita Vasudevan, Mahesh Satija, Mahesh Choudhary, Mitin Parmar, Venkatesh Govindasamy, Karlapudi Nitesh Kumar, Goutham Thumari, Amar Tripura, Chanda Mog, Shampa Das, Ritesh Singh, Chandra Shekar Maity, Mamta Gehlawat

“…Two districts in India were declared TB free in 2020.…”
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Efficacy and safety of perioperative sintilimab plus platinum-based chemotherapy for potentially resectable stage IIIB non-small cell lung cancer (periSCOPE): an open-label, single... by Xiangyang Yu, Chujian Huang, Longde Du, Chunguang Wang, Yikun Yang, Xin Yu, Shengcheng Lin, Chenglin Yang, Hongbo Zhao, Songhua Cai, Zhe Wang, Lixu Wang, Xiaotong Guo, Baihua Zhang, Zhentao Yu, Jie He, Kai Ma

“…The key secondary endpoints included the objective response rate (ORR), radical resection (R0) rate, pathological complete response (pCR) rate, event-free survival (EFS), disease-free survival (DFS), OS, treatment-related adverse events (TRAEs), surgical complications, and surgery delay rate. …”
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Presenting a model of ecotourism and sustainable tourism development with an emphasis on foreign exchange and economic development of Qeshm Island by Naser Rajabi, Vahid Reza Mirabi, Khosro Moradi Shahdadi

“…The statistical population in the qualitative section includes 19 experts, including managers and experts in the field of tourism, hoteliers, travel agencies, tours and ecotours; by means of the snowball sampling method, and in the quantitative section, it includes 244 employees of the Cultural Heritage Organization, handicrafts and tourism of Qeshm Free Zone. Data collection in the qualitative part was done using semi-structured interviews of the members of the statistical community, and data collection in the quantitative part was done through a questionnaire. …”
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The analysis of risk factors for diabetic kidney disease progression: a single-centre and cross-sectional experiment in Shanghai by Shan Huang, Juan Du, Nan Zhao, Wen Liu, Fan Hu, Xiaoxu Ge, Xiaohong Jiang, Wenfang Peng, Lisha Shen, Lili Xia

“…Finally, the receiver operating characteristics curve is used to verify the result.Results The logistic regression model indicated age (OR=1.020, p=0.017, 95% CI 1.004 to 1.040), systolic blood pressure (OR=1.013, p=0.006, 95% CI 1.004 to 1.022), waist circumference (OR=1.021, p=0.015, 95% CI 1.004 to 1.038), white blood cells (WBC, OR=1.185, p=0.001, 95% CI 1.085 to 1.295) and triglycerides (TG, OR=1.110, p=0.047, 95% CI 1.001 to 1.230) were risk factors for DKD, while free triiodothyronine (fT3, OR=0.711, p=0.011, 95% CI 0.547 to 0.926) was a protective factor for DKD in patients with type 2 diabetes mellitus (T2DM). …”
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Theoretical Study of Sphingomyelinases from <i>Entamoeba histolytica</i> and <i>Trichomonas vaginalis</i> Sheds Light on the Evolution of Enzymes Needed for Survival and Colonizati... by Fátima Berenice Ramírez-Montiel, Sairy Yarely Andrade-Guillen, Ana Laura Medina-Nieto, Ángeles Rangel-Serrano, José A. Martínez-Álvarez, Javier de la Mora, Naurú Idalia Vargas-Maya, Claudia Leticia Mendoza-Macías, Felipe Padilla-Vaca, Bernardo Franco

“…In this work, bioinformatic analyses showed that the protist aSMases are diverse enzymes, are evolutionarily related to hemolysins derived from bacteria, and showed a similar overall structure as parasitic, free-living protists and mammalian enzymes. AlphaFold3 models predicted the occupancy of cobalt ions in the active site of the aSMase6 enzyme. …”
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Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery by Syrine Abdeljaoued, Alexandre Doussot, Marie Kroemer, Emilien Laloy, Jean René Pallandre, Antoine El Kaddissi, Laurie Spehner, Myriam Ben Khelil, Adeline Bouard, Virginie Mougey, Ugo Chartral, Angélique Vienot, Julien Viot, Zaher Lakkis, Franck Monnien, Romain Loyon, Christophe Borg

“…Our study shows that only the presence of CD103+CD69+ TRM cells is associated with longer recurrence-free survival of colorectal cancer patients with liver metastases. …”
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Efficacy and safety of surufatinib plus toripalimab in treatment-naive, PD-L1-positive, advanced or metastatic non-small-cell lung cancer and previously treated small-cell lung can... by Ying Cheng, Panpan Zhang, Ming Lu, Zhendong Chen, Lijie Song, Si Shi, Feng Ye, Xing Zhang, Baorui Liu, Dongmei Ji, Yanqiao Zhang, Weiguo Su, Michael Shi, Songhua Fan, Panfeng Tan, Chen Zhong

“…Secondary endpoints included duration of response (DoR), disease control rate, progression-free survival (PFS), overall survival (OS), and safety. …”
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Advancements in noninvasive techniques for transplant rejection: from biomarker detection to molecular imaging by Yuan Song, Yihui Wang, Wenyuan Wang, Yuji Xie, Junmin Zhang, Jing Liu, Qiaofeng Jin, Wenqian Wu, He Li, Jing Wang, Li Zhang, Yali Yang, Tang Gao, Mingxing Xie

“…For example, donor-derived cell-free DNA (dd-cfDNA) is highly sensitive in detecting early graft injury, whereas gene expression profiling effectively excludes moderate-to-severe acute rejection (AR). …”
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Acceptability of Overground Wearable Powered Exoskeletons for People with Spinal Cord Injury: A Multicenter Qualitative Study by Noémie Fortin-Bédard, Alice Pellichero, Stéphanie Leplaideur, Marie-Caroline Delebecque, Caroline Charette, Willy Allègre, Alyson Champagne, Caroline Rahn, Andréanne K. Blanchette, Laurent Bouyer, Jacques Kerdraon, Marie-Eve Lamontagne, François Routhier

“…Adjustments in their use, such as conducting training sessions in obstacle-free environment and technological improvements to address the device’s restrictive characteristics, heaviness, and massiveness are however still needed.…”
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Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination by Zachary S Morris, Paul M Sondel, Amy K Erbe, Alexander L Rakhmilevich, Amber M Bates, Peter M Carlson, Alexander A Pieper, Ravi B Patel, Jen Birstler, Joseph Grudzinski, Reinier Hernandez, Bryan P Bednarz, Jamey P Weichert, Arika S Feils, Matthew Rodriquez, Claire Sun, Ian Marsh

“…When the primary tumor ISV regimen was delivered in mice receiving 12 Gy EBRT to the secondary tumor, we observed improved overall survival and more disease-free mice with immune memory compared with either ISV or 12 Gy EBRT alone. …”
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Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study by Renhua Lu, Yan Fang, Wangshu Wu, Xiaojun Zeng, Tingting Liu, Yue Qian, Yuanyuan Xie, Yijun Zhou, Leyi Gu

“…The primary efficacy endpoint was to compare uremic toxin levels of indoxyl sulfate (IS), λ-free light chains (λFLC), and β2-microglobulin (β2-MG) before and after HFR treatment. …”
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Serum α1-AT Levels and <i>SERPINA1</i> Molecular Analysis in Breast Cancer: An Experimental and Computational Study by Guadalupe Ávalos-Navarro, Luis A. Bautista-Herrera, Asbiel Felipe Garibaldi-Ríos, Ramiro Ramírez-Patiño, Marisol Gutiérrez-García, Perla Briseño-Álvarez, Luis Felipe Jave-Suárez, Emmanuel Reyes-Uribe, Martha Patricia Gallegos-Arreola

“…The computational analysis showed that <i>SERPINA1</i> is overexpressed in BC with differential expression among subtypes; its overexpression is associated with a better prognosis, longer disease-free survival, and overall survival. Conclusions: α1-AT levels are increased in women with BC women compared to HW. …”
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Kinomic profiling to predict sunitinib response of patients with metastasized clear cell Renal Cell Carcinoma by Jeannette C. Oosterwijk-Wakka, Liesbeth Houkes, Loes F.M. van der Zanden, Lambertus A.L.M. Kiemeney, Kerstin Junker, Anne Y Warren, Tim Eisen, Ulrich Jaehde, Marius T Radu, Rob Ruijtenbeek, Egbert Oosterwijk

“…Introduction: Treatment with Sunitinib, a potent multitargeted receptor tyrosine kinase inhibitor (TKI) has increased the progression-free survival (PFS) and overall-survival (OS) of patients with metastasized renal cell carcinoma (mRCC). …”
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