Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats by Elin Strand, Vegard Lysne, Mari Lausund Grinna, Pavol Bohov, Asbjørn Svardal, Ottar Nygård, Rolf K. Berge, Bodil Bjørndal

“…In heart, PPARα activation leads to overall lower levels of free FAs and specific changes in certain FAs, compared with control. …”
Get full text

Size distribution of extracellular vesicles in pretreatment ascites and plasma is correlated with primary treatment outcome in advanced high-grade serous carcinoma by Maruša Herzog, Ivan Verdenik, Borut Kobal, Katarina Černe

“…The correlations of the EV concentration and size distribution in ascites and plasma with treatment outcome, progression-free survival (PFS) and overall survival (OS) were analysed. …”
Get full text

Preparation and Properties of Antifreeze Rewarming Hydrogel Dressings by Meng Yan, Xiaorong Dong, Jingjing Sun, Yijun Liu, Shengchao Yang, Xing Tian, Shuang Zheng, Lisha Yin, Yanan Fu, Dongmei Li, Lin Cui, Gang Li, Zhongpeng Qiu, Zhiyong Liu

“…Herein, the PAM/CS/MXene30/Betaine5/AgNPs200(PCM30B5A200) hydrogel based on chitosan (CS) and acrylamide (AM) is designed and fabricated by thermally initiated free radical polymerization. The dressing has excellent rewarming properties, anti‐freezing properties, tensile properties, repeatable self‐adhesion and antibacterial properties. …”
Get full text

Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysis by Hongbin Lu, Lulu Luo, Jie Mi, Min Sun, Huaping Wang, Zheng Wang, Wenwen Ding

“…The value of sPD-L1 in predicting the overall survival (OS) and progression-free survival (PFS) of patients with DLBCL was analyzed by computing the combined hazard ratios (HRs) and 95% confidence intervals (CIs). …”
Get full text

Fabrication and In Vivo Evaluation of In Situ pH-Sensitive Hydrogel of Sonidegib–Invasomes via Intratumoral Delivery for Basal Cell Skin Cancer Management by Maha M. Ghalwash, Amr Gamal Fouad, Nada H. Mohammed, Marwa M. Nagib, Sherif Faysal Abdelfattah Khalil, Amany Belal, Samar F. Miski, Nisreen Khalid Aref Albezrah, Amani Elsayed, Ahmed H. E. Hassan, Eun Joo Roh, Shaimaa El-Housiny

“…The IPHS-INV formulation outperformed the permeation and bioavailability of free SDB by 7.14 and 6 times, respectively, and sustained its release by 57.41%. …”
Get full text

Novel Predictive Strategy Using CA19-9 and Fecal Elastase Levels to Make Treatment Decisions for Resectable Pancreatic Cancer: A Retrospective Study by Hyung Sun Kim, Woojin Kim, Won-Gun Yun, Hye-Sol Jung, Youngmin Han, Mirang Lee, Wooil Kwon, Jin-Young Jang, Joon Seong Park

“…The same trend was confirmed in the analysis with recurrence-free survival. <b>Conclusions:</b> This study presents a new predictive strategy using combined CA19-9 and FE-1 levels to determine the treatment for resectable pancreatic cancer.…”
Get full text

LncRNAs in serum-derived extracellular vesicles are potential biomarker and correlated with immune infiltration in gastric cancer by Juan Ding, Yunyan Teng, Rongshu Cui, Jin Liu, Ke Xiao, Zhaogang Dong, Yi Zhang, Xiaofei Xu

“…Furthermore, high EV linc-ROR and RMRP expression levels were associated with worse disease-free survival and overall survival (OS). Univariate and multivariate Cox regression analyses confirmed that linc-ROR was the only independent prognostic factor for GC. …”
Get full text

Phenolic Acid and Flavonoid Content Analysis with Antioxidant Activity Assessment in Chinese <i>C. pi. Shen</i> Honey by Ningxin Qi, Wen Zhao, Chenghua Xue, Lin Zhang, Han Hu, Yue Jin, Xiaofeng Xue, Rui Chen, Jinzhen Zhang

“…Shen</i> honey by colorimetric, UPLC-MS/MS, Ferric ion Reducing Antioxidant Power (FRAP), 2,2-bisazo-bis (3-ethyl-benzothiazole-6-sulfonic acid) (ABTS) free radical capacity, and 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH) scavenging ability methods. …”
Get full text

Probing aspects of extracellular vesicle associated AAV allows increased vector yield and insight into its transduction and immune-evasive properties by Ming Cheng, Demitri de la Cruz, Adam V. Crain, Paula Espinoza, Carrie Ng, Zachary C. Elmore, Aravind Asokan, Casey A. Maguire

“…We used density gradient ultracentrifugation to separate EV-AAV from free AAV to determine the yields and functional activity of EV-AAV. …”
Get full text

Combined Therapy of Catheter Ablation and Left Atrial Appendage Closure for Patients with Atrial Fibrillation: A Case-Control Study by Bin-Feng Mo, Jian Sun, Peng-Pai Zhang, Wei Li, Mu Chen, Jia-Li Yuan, Yi Yu, Qun-Shan Wang, Yi-Gang Li

“…Procedure-related complications of the combined group included one pericardial effusion and two groin haematomas, which did not differ significantly with those of the CA-only group (3.9% vs. 2.6%, P=0.650) or the LAAC-only group (3.9% vs. 2.6%, P=0.650), respectively. The AF-free rate of the combined group was comparable with that of the CA-only group after a mean of 2 years follow-up (67.1% vs. 69.7%, P=0.727). …”
Get full text

Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors by Estela Regina Ramos Figueira, Julia Fray Ribeiro, Thiago Costa Ribeiro, Ricardo Jureidini, Guilherme Naccache Namur, Thiago Nogueira Costa, Telesforo Bacchella, Ivan Cecconello

“…The median TNM stage was IIa (range, I–IV). The disease-free and patient survival rates were 87.5% and 100% at 3 years and 43.75% and 75% at 10 years, respectively. …”
Get full text

Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging by Qiqi Liu, Zhanxia Gao, Xiangyun Zhang, Qiannan Duan, Yue Zhang, Adam C. Midgley, Li Jiao, Ruming Liu, Mingsheng Zhu, Deling Kong, Jie Zhuang, Xinglu Huang

“…Abstract Nanozymes play a pivotal role in mitigating excessive oxidative stress, however, determining their specific enzyme-mimicking activities for intracellular free radical scavenging is challenging due to endo-lysosomal entrapment. …”
Get full text

Efficacy and Safety of CART Cell Therapy in Aggressive B‐Cell Lymphomas Involving the Gastrointestinal Tract by Lixia Ma, Yimeng Dou, Rui Liu, Teng Xu, Fan Yang, Peihao Zheng, Shaomei Feng, Yuelu Guo, Hui Shi, Fei Xue, Biping Deng, Xiaoyan Ke, Kai Hu

“…Their median follow‐up time was 22.49 months, while the medians of overall survival (OS) and progression‐free survival (PFS) were 10.88 and 5.47 months, respectively. …”
Get full text

Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits by Luciane Angela Nottar Nesello, Maria Luisa Maes Lima Beleza, Marihá Mariot, Luísa Nathália Bolda Mariano, Priscila de Souza, Adriana Campos, Valdir Cechinel-Filho, Sérgio Faloni Andrade, Luísa Mota da Silva

“…The total phenolic compounds and flavonoids were measured, as well as the in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenger activity. The gastroprotective effects of the extracts against 60% ethanol/0.3 M HCl were evaluated in mice. …”
Get full text

Research priorities for autosomal dominant polycystic kidney disease: a UK priority setting partnership by Tess Harris, Albert Ong, Paul J D Winyard, Richard N Sandford, Maryrose Tarpey, Hannah R Bridges, Wendy D Brown, Natasha L O’Brien, Ann C Daly, Bharat K Jindal, Gillian S Mundy, Albert J Power, John Sayer, Roslyn J Simms, Patricia D Wilson

Get full text

EVOLUTION OF THE PHENOMENON OF CITIZENSHIP IN THE CONTEXT OF HISTORICAL DEVELOPMENT OF THE WESTERN EUROPE by L. Y. Maximova

“…The basis for inclusion / exclusion was the binary oppositions “civilized – barbarians”, “free – dependent “, “possessing land ownership – not possessing such”, “adults – minors”, as a result only a small part of the population had the rights of citizens. …”
Get full text

The influence of different radiopacifying agents on hermetical sealing ability of calcium silicate and calcium aluminate dental cements by Ćetković Dejan, Zhiyu Cai, Vuković Nemanja, Vuković Zorica, Lei Huaxiang, Biočanin Vladimir, Huang Xiaojing, Jokanović Vukoman, Antonijević Đorđe, Dožić Aleksandra

“…The wettability, surface free energy (SFE), microporosity, nanoporosity and micro-gap size between the material and tooth root canal were evaluated. …”
Get full text

Recent Advances of Surfactant-Polymer (SP) Flooding Enhanced Oil Recovery Field Tests in China by Chen Sun, Hu Guo, Yiqiang Li, Kaoping Song

“…Although alkali-surfactant-polymer (ASP) flooding can make an incremental oil recovery factor (IORF) of 18% original oil in place (OOIP) according to large-scale field tests in Daqing, the complex antiscaling and emulsion breaking technology as well as potential environment influence makes some people turn to alkali-free SP flooding. With the benefit of high IORF in laboratory and no scaling issue to worry, SP flooding is theoretically better than ASP flooding when high quality surfactant is available. …”
Get full text

Socio-economic inequalities in access to COVID-19 tests in France in 2020: evidence from the EPICOV socio-epidemiological cohort by Pierre-Yves Geoffard, Pierre-Yves Geoffard, Florence Jusot, Antoine Sireyjol, Josiane Warszawski, Nathalie Bajos

“…In France, tests were free of charge until mid-October 2021 and became widely available after June 2020. …”
Get full text

Model of property relations in the Soviet Lithuania village (Case of Stungiai village) by Žilvinas Kačiuška

“…Proprietors used to spend almost all of their time free from work in the collective or state farms for own land cultivation and surplus product production.   …”
Get full text