A Convenient and Sensitive LC-MS/MS Method for Simultaneous Determination of Carbadox- and Olaquindox-Related Residues in Swine Muscle and Liver Tissues by Heying Zhang, Wei Qu, Yanfei Tao, Dongmei Chen, Shuyu Xie, Lingli Huang, Zhenli Liu, Yuanhu Pan, Zonghui Yuan

“…The developed method can determine the real residue level of QCA and MQCA, whether they are present in free form or as glycine conjugates in tissues, together with the carcinogenic desoxy metabolites DCBX and DOLQ with high recovery. …”
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Improved Analgesic Effect of Paravertebral Blocks before and after Video-Assisted Thoracic Surgery: A Prospective, Double-Blinded, Randomized Controlled Trial by Lihua Chu, Xiaolin Zhang, Yaping Lu, Guohao Xie, Shengwen Song, Xiangming Fang, Baoli Cheng

“…Kaplan–Meier analysis showed patients with combination of preoperative and postoperative PVB had a higher PCIA-free rate than patients with either technique alone (p=0.003). …”
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Prediction and verification of the influence of the rs367781716 SN P on the interaction of ТАТА -binding protein with the promoter of the human АВСА9 gene by O. V. Arkova, I. A. Drachkova, T. V. Arshinova, D. A. Rasskazov, V. V. Suslov, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, L. K. Savinkova

“…We also determined the half-life and Gibbs free energy of the complex of TBP with the АВСА9 promoter. …”
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Targeting ferroptosis for improved radiotherapy outcomes in HPV‐negative head and neck squamous cell carcinoma by Joo Kyung Noh, Min Kyeong Lee, Yeonseo Lee, Minji Bae, Soonki Min, Moonkyoo Kong, Jung Woo Lee, Su Il Kim, Young Chan Lee, Seong‐Gyu Ko, Seon Rang Woo, Young‐Gyu Eun

“…This ferroptosis‐related gene signature (FRGS) was a significant predictor of overall survival and recurrence‐free survival in HPV‐negative HNSCC patients who received RT. …”
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Designing a broad-spectrum multi-epitope subunit vaccine against leptospirosis using immunoinformatics and structural approaches by Guneswar Sethi, Guneswar Sethi, Young Kyu Kim, Su-Cheol Han, Jeong Ho Hwang, Jeong Ho Hwang

“…Molecular dynamics simulations and MM-GBSA analysis confirmed the stability of these interactions and accurately calculated the intermolecular binding free energies. Immune simulations indicated robust B and T cell responses, and in silico cloning demonstrated that the vaccine could be successfully expressed in E. coli.DiscussionThese findings suggest that MESV is a promising candidate for leptospirosis prevention, providing robust immune responses and broad population coverage. …”
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Conservation and ecological screening of small water bodies in temperate riverine wetlands using UAV Photogrammetry (Middle Danube) by Dušanka Cvijanović, Maja Novković, Djuradj Milošević, Milica Stojković Piperac, Laszlo Galambos, Dubravka Čerba, Olivera Stamenković, Bojan Damnjanović, Minučer Mesaroš, Dragoslav Pavić, Vladica Simić, Ivana Trbojević, Ana Anđelković, Nusret Drešković, Barbara Stammel, Bernd Cyffka, Snežana Radulović

“…Conversely, sites experiencing eutrophication and a poor oxygen regime with species-poor fish assemblages correlated positively with a higher cover of amphibian and free-floating vegetation, as well as filamentous algae. …”
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Evaluation of an Interdisciplinary Educational Program to Foster Learning Health Systems: Education Evaluation by Sathana Dushyanthen, Nadia Izzati Zamri, Wendy Chapman, Daniel Capurro, Kayley Lyons

“…Further, they undertook voluntary weekly surveys to provide feedback on which aspects to continue and recommendations for improvements, via free-text responses. ResultsFrom the evaluation, it was evident that participants found the teaching model engaging, useful, valuable, and applicable to their work. …”
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Community disaster exposure and first onset of depression: A panel analysis of nationally representative South African data, 2008-2017. by Andrew Tomita, Busisiwe P Ncama, Yoshan Moodley, Rashieda Davids, Jonathan K Burns, Tafadzwanashe Mabhaudhi, Albert T Modi, Rob Slotow

“…We used panel data from the South African National Income Dynamics Study (SA-NIDS) from 2008-2017, consisting of 17,255 adult study participants who were depression free at baseline. Risk of first depression onset between individuals exposed and unexposed to community disaster was measured, accounting for multiple disaster exposure over time by fitting generalized estimating equation (GEE) regression models. …”
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Case report: A case report and literature review on the efficacy of high-dose aumolertinib combined intrathecal pemetrexed by Ommaya reservoir for EGFR-mutated NSCLC with leptomeni... by Maoxi Zhong, Maoxi Zhong, Maoxi Zhong, Li Zhou, Li Zhou, Li Zhou, Jing Guo, Jing Guo, Jing Guo, Chuan Chen, Chuan Chen, Chuan Chen, Wei Wang, Wei Wang, Wei Wang, Xiaoping Huang, Xiaoping Huang, Xiaoping Huang, Yi Liu, Yi Liu, Yi Liu

“…As of the submission date, the patient achieved significant remission and a LM Progression-Free Survival (PFS) exceeding 20 months. This case highlights the positive impact of high-dose aumolertinib combined with intrathecal pemetrexed on NSCLC patients presenting with severe meningeal symptoms as the initial manifestation, offering a viable therapeutic approach for managing severe meningeal symptoms associated with LM, such as headache, nausea, neck stiffness, and vomiting.…”
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Assessing patient risk, benefit and outcomes in drug development: an observational study of regorafenib clinical trials by Matt Vassar, Vinay Prasad, Ryan McIntire, Alyson Haslam, Brody Dennis, Chance Bratten, Griffin K Hughes, Andriana M Peña, Chase Ladd, Brooke Gardner, William Nowlin, Reagan Livingston, Jordan Tuia

“…Next, we extracted median progression-free survival and overall survival in months, adverse event rates and objective response rate (ORR). …”
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Effects of Different Tea Varieties on the Quality of Enshi Yulu Tea by WANG Huanhuan, QIN Muxue, HU Xingming, YUAN Liping, QIN Xinxue, YU Zhi, ZHENG Shibing, ZHANG Qiang, NI Dejiang, CHEN Yuqiong

“…To investigate the effects of tea varieties on the quality of Enshi Yulu tea, 10 main tea cultivars (Fuyun 6, Echa 1, Chunbolü, Zhenong 117, Longjing 43, Wuniuzao, Zhongcha 108, Echa 10, Zhuyeqi, and Fuding Dabai) grown in Enshi were processed into Yulu tea, which was then evaluated for sensory quality, major physicochemical quality components (tea polyphenols, free amino acids, water extracts, and chlorophylls), dry tea color parameters (L*, a*, and b*), and volatile components. …”
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Clinical and molecular analyses of isolated central congenital hypothyroidism based on a survey conducted in Japan by Nao Shibata, Chikahiko Numakura, Takashi Hamajima, Kenichi Miyako, Ikuma Fujiwara, Jun Mori, Akihiko Saitoh, Keisuke Nagasaki

“…All six patients with low free thyroxine (FT4) levels detected in NBS carried IGSF1 pathogenic variants. …”
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Ethical education: Ways of moral consciousness development (understanding experience through Tyumen ethical and philosophical tradition) by E. N. Yarkova, A. G. Ivanov, Ya. V. Maltsev

“…Selivanov); the model of “shaping the ability of free choice and moral creativity” (V. I. Bakshtanovsky); the model of “immersion in the universe of morality” (V. …”
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Integrating machine learning and structure-based approaches for repurposing potent tyrosine protein kinase Src inhibitors to treat inflammatory disorders by Muhammad Waleed Iqbal, Muhammad Shahab, Zakir ullah, Guojun Zheng, Irfan Anjum, Gamal A. Shazly, Atrsaw Asrat Mengistie, Xinxiao Sun, Qipeng Yuan

“…Molecular Mechanics/Generalized Born Surface Area (MMGBSA) analysis validated their binding affinities by providing comparably lower binding free energies for orlistat (− 33.4743 ± 3.8908), acarbose (− 19.5455 ± 5.4702), and afatinib (− 36.4944 ± 5.4929) than the control, dasatinib (− 13.7785 ± 5.8058). …”
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The relation of radiological tumor volume response to histological response and outcome in patients with localized Ewing Sarcoma by Lianne M. Haveman, Andreas Ranft, Henk vd Berg, Anne Smets, Jarmila Kruseova, Ruth Ladenstein, Benedicte Brichard, Michael Paulussen, Thomas Kuehne, Heribert Juergens, Stephanie Klco‐Brosius, Uta Dirksen, Johannes H.M. Merks

“…Correlations between TVR, HisRes, event free survival (EFS), and overall survival (OS) were analyzed using chi‐square tests, log‐rank tests, and the Cox‐regression model. …”
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STRATEGY OF SOCIALLY-ANTHROPOLOGICAL DEVELOPMENT IN IDEAS AND SYSTEM OF MODERN SOCIAL PHILOSOPHY OF EDUCATION: INTEGRATION OF MODEL OF THE INSTRUMENTALISM AND THE NEOPRAGMATISM WIT... by Viktor Zinchenko

“…Considering growing requirement of a practical embodiment of ideas of freedom, justice, aspiration to realization of the human rights proclaimed a society, supporters of the concept of «new humanism» see the main objective in blocking a way to conformism, to a manipulation behaviour of the person and to create conditions for its free self-expression, for realization by the person of a fundamental choice of acts in a concrete situation and by that to warn danger of formation of the unified form of behaviour. …”
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Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 He... by S. Nardi-Hiebl, J. W. Ndieyira, Y. Al Enzi, W. Al Akkad, T. Koch, G. Geldner, C. Reyher, L. H. J. Eberhart

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Externally validated nomogram for predicting short-term pregnancy outcome of singleton pregnancies with fetal growth restriction (FGR) by Yang Li, Xiaohong Zhang, Junshu Xie, Fufen Yin, Mingrui Jin, Yujing Li, Xiuju Yin

“…Furthermore, the calibrations of the nomograms predicting the 28th and 34th TOP-free gestation week strongly corresponded to the actual survival outcome.Conclusion This prediction model may help clinicians in decision-making for singleton pregnancies with FGR, especially for patients with a single abnormal umbilical arterial flow or fetal anomaly, without induced labour indications for these abnormalities.…”
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Development of a Novel Co-Amorphous Curcumin and L-Arginine (1:2): Structural Characterization, Biological Activity and Pharmacokinetics by Jose Antonio Mancillas-Quiroz, Miriam del Carmen Carrasco-Portugal, Karina Mondragón-Vásquez, Juan Carlos Huerta-Cruz, Juan Rodríguez-Silverio, Leyanis Rodríguez-Vera, Juan Gerardo Reyes-García, Francisco Javier Flores-Murrieta, Jorge Guillermo Domínguez-Chávez, Héctor Isaac Rocha-González

“…The bioavailability of free plasmatic curcumin increased about 22.4 times when it was given as CAC12 relative to a phytosome formulation at the equivalent dose. …”
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Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors via the TRAIN mechanism by Bartlomiej Taciak, Maciej Bialasek, Malgorzata Kubiak, Ilona Marszalek, Malgorzata Gorczak, Olha Osadchuk, Daria Kurpiel, Damian Strzemecki, Karolina Barwik, Marcin Skorzynski, Julia Nowakowska, Waldemar Lipiński, Łukasz Kiraga, Jan Brancewicz, Robert Klopfleisch, Łukasz Krzemiński, Emilia Gorka, Anna Smolarska, Irena Padzinska-Pruszynska, Małgorzata Siemińska, Jakub Guzek, Jan Kutner, Marlena Kisiala, Krzysztof Wozniak, Giacomo Parisi, Roberta Piacentini, Luca Cassetta, Lesley M. Forrester, Lubomir Bodnar, Tobias Weiss, Alberto Boffi, Paulina Kucharzewska, Tomasz P. Rygiel, Magdalena Krol

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