Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs by Abubakar Danmaigoro, Gayathri Thevi Selvarajah, Mohd Hezmee Mohd Noor, Rozi Mahmud, Md Zuki Abu Bakar

“…This effect is due to its nonselective nature causing injury to the cells as a result of reactive free oxygen radical’s release. Cockleshell-derived calcium carbonate nanoparticle (CS-CaCO3NP) is a pH-responsive carrier with targeted delivery potentials. …”
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Impact of Moderate to Severe Renal Impairment on Mortality and Appropriate Shocks in Patients with Implantable Cardioverter Defibrillators by Venkata M. Alla, Kishlay Anand, Mandeep Hundal, Aimin Chen, Showri Karnam, Tom Hee, Claire Hunter, Aryan N. Mooss, Dennis Esterbrooks, Syed M. Mohiuddin

“…One hundred and seventy-seven patients received appropriate shock(s); appropriate shock-free survival was lower in patients with severe CKD (GFR < 30) compared to mild or no CKD group (2.8 versus 4.2 yrs). …”
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Isoforsythiaside confers neuroprotection against Alzheimer’s disease by attenuating ferroptosis and neuroinflammation in vivo and in vitro by Chunyue Wang, Hongbo Jiang, Honghan Liu, Shanshan Chen, Hangyu Guo, Shuoshuo Ma, Weiwei Han, Yu Li, Di Wang

“…In APP/PS1 mice, erastin-damaged HT22 cells, and LPS-exposed BV2 cells, the neuroprotective effects against ferroptosis and neuroinflammation were investigated using immunohistochemistry, label-free proteomics, western blot, ELISA, MTT, fluorescence, and TEM. …”
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Cecal Patches Generate Abundant IgG2b-Bearing B Cells That Are Reactive to Commensal Microbiota by Masato Tsuda, Hiraku Okada, Natsuki Kojima, Fumiya Ishihama, Yuhei Muraki, Toshiki Oguma, Nanako Hattori, Takumi Mizoguchi, Kiyoaki Mori, Satoshi Hachimura, Yoshimasa Takahashi, Kyoko Takahashi, Shuichi Kaminogawa, Akira Hosono

“…Gene expression analysis of postswitched transcripts supported the differential expression of dominant antibody isotypes in B cells in GALT. Germ-free (GF) mice showed diminished GC B cells and had few IgA+ or IgG2b+ switched B cells in both the small and large intestinal GALT. …”
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Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Altered genes and pathways were correlated with overall survival (OS) and evaluated regarding their association with real-world progression-free survival (rwPFS) in patients treated with different chemotherapy agents. …”
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Development and Validation of a Nomogram to Predict Type 2 Diabetes Mellitus in Overweight and Obese Adults: A Prospective Cohort Study from 82938 Adults in China by Qingqing Liu, Jie Yuan, Maerjiaen Bakeyi, Jie Li, Zilong Zhang, Xiaohong Yang, Fangming Gao

“…We used prospective cohort study data for 82938 individuals aged ≥20 years free of T2DM collected between 2010 and 2016 and divided them into a training (n = 58056) and a validation set (n = 24882). …”
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Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome by Takeshi Nishida, Koichi Tsuneyama, Yasuhiko Tago, Koji Nomura, Makoto Fujimoto, Takahiko Nakajima, Akira Noguchi, Takashi Minamisaka, Hideki Hatta, Johji Imura

“…Ayu-narezushi, a traditional Japanese fermented food, comprises abundant levels of lactic acid bacteria (LAB) and free amino acids. This study aimed to examine the potential beneficial effects of ayu-narezushi and investigated whether ayu-narezushi led to improvements in the Tsumura Suzuki obese diabetes (TSOD) mice model of spontaneous metabolic syndrome because useful LAB are known as probiotics that regulate intestinal function. …”
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Immune Checkpoint Inhibitors +/− Chemotherapy for Patients With NSCLC and Brain Metastases: A Systematic Review and Network Meta‐Analysis by Lauren Julia Brown, Nicholas Yeo, Harriet Gee, Benjamin Y. Kong, Eric Hau, Inês Pires daSilva, Adnan Nagrial

“…Overall survival (OS) and progression‐free survival (PFS) in patients with and without BM were assessed. …”
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Protein quality of four indigenous edible insect species in Nigeria by Florence Inje Oibiokpa, Helmina Olufunmilayo Akanya, Ali Audu Jigam, Abubakar Ndaman Abubakar, Evans Chidi Egwim

“…Five iso-nitrogenous and isocaloric diets were formulated on a 10% protein basis with the insects and casein. A Nitrogen free diet was also formulated as control. Thirty six (36) young weanling albino rats (21–28 days old) were divided into 6 groups and fed with the diets ad libitum for 28 days. …”
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PI3Kδ inhibitor linperlisib combined with gemcitabine and oxaliplatin for relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm phase Ib/II trial by Peng Sun, Hong Cen, Haiyan Yang, Rui Huang, Zhen Cai, Xuekui Gu, Hanying Bao, Zusheng Xu, Zuhong Xu, Zhi-Ming Li

“…The median duration of response was 5.7 months (95% CI: 4.3–9.1), and the median progression-free survival was 5.4 months (95% CI: 1.8–6.7). The 1-year OS rate was 65.5% (95% CI: 48.1–78.3). …”
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UV-Vis spectroscopy and chemometric: a simple method to differentiate honey, partially ripe honey and nectars by L. M. Maldonado, K. Marcinkevicius, A.R. Álvarez, V.M. Salomón, M. Gaggiotti, N. Messina, M.A. Palacio, S. Medina, M.M. Maldonado, E. Orellano, E. L. Bedascarrasbure

“…Se registraron espectros entre 190 nm y 420 nm y se aplicaron diferentes métodos de proyección, incluyendo el análisis de componentes principales, FreeViz y el análisis discriminante lineal. De los resultados se concluye que la espectroscopía UV-Vis acoplada al análisis quimiométrico permite diferenciar el néctar recientemente recolectado de la miel parcialmente madura y de la miel y que los compuestos fenólicos están presentes principalmente en la miel, lo que podría incidir favorablemente en su actividad biológica.…”
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Prognostic Nutritional Index Predicts Early Mortality in Diffuse Large B-cell Lymphoma by Erman OZTURK, Tayfun ELIBOL, Emrah KILICASLAN, Beyza KABAYUKA, Işıl ERDOGAN OZUNAL

“…Pre-treatment IPI, R-IPI, and PNI scores and progression-free survival (PFS) and overall survival (OS) times were calculated. …”
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The Effects of Hyperacute Serum on the Elements of the Human Subchondral Bone Marrow Niche by Melinda Simon, Bálint Major, Gabriella Vácz, Olga Kuten, István Hornyák, Adél Hinsenkamp, Dorottya Kardos, Marcell Bagó, Domonkos Cseh, Adrienn Sárközi, Denes Horvathy, Stefan Nehrer, Zsombor Lacza

“…Hyperacute serum (HAS), a new serum derivative, has been designed to approximate the natural coagulation cascade with a single-step, additive-free preparation method. We investigated the effects of HAS on monolayer MSC cultures and in their natural niche, in 3D subchondral bone and marrow explants. …”
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Morphological analysis of sigmoid sinus anatomy: clinical applications to neurotological surgery by Kylen Van Osch, Daniel Allen, Bradley Gare, Thomas J. Hudson, Hanif Ladak, Sumit K. Agrawal

“…The secondary objective was to create a statistical shape model (SSM) of a dominant and non-dominant sigmoid sinus (SS) to provide a template for automated segmentation algorithms. Methods A free image processing software, 3D Slicer, was utilized to create three-dimensional reconstructions of the SS, jugular bulb (JB), facial nerve (FN), and external auditory canal (EAC) from micro-CT scans. …”
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Advancing Objective Mobile Device Use Measurement in Children Ages 6–11 Through Built-In Device Sensors: A Proof-of-Concept Study by Olivia L. Finnegan, R. Glenn Weaver, Hongpeng Yang, James W. White, Srihari Nelakuditi, Zifei Zhong, Rahul Ghosal, Yan Tong, Aliye B. Cepni, Elizabeth L. Adams, Sarah Burkart, Michael W. Beets, Bridget Armstrong

“…Future research should explore the performance of this technology in larger samples of children and in free-living environments.…”
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Prognostic factors for head and neck cancer of unknown primary including the impact of human papilloma virus infection by Lars Axelsson, Jan Nyman, Hedda Haugen-Cange, Mogens Bove, Leif Johansson, Shahin De Lara, Anikó Kovács, Eva Hammerlid

“…The overall and disease-free 5-year survival rates for all patients in the study were 82 and 74%. …”
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Profiles of traditional farms: soil texture, total inorganic N and bacteria-producing estate by Yuni Puji Hastuti, Iman Rusmana, T. Widiyanto

“…Media pertumbuhan bakteri dikondisikan bebas oksigen (oxygen free nitrogen/OFN method) , sedangkan kelimpahan bakteri dianalisis dengan rumus most porbable number (MPN). …”
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Rancher viewpoint diversity in human–wildlife coexistence management: The case of jaguar–livestock interaction in the region of Calakmul, Mexico by Elías J. Gordillo‐Chávez, Claudia Villanueva‐García, Enrique Melo‐Guerrero, Mircea G. Hidalgo‐Mihart, Miguel Lizana‐Avia, Fernando Rodríguez‐López, Victor J. Colino‐Rabanal

“…Our findings demonstrate the value of DCEs in providing valuable information for developing more effective and socially acceptable jaguar conservation policies that consider diverse perspectives and the people's characteristics in our sample population. Read the free Plain Language Summary for this article on the Journal blog.…”
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A lower atherogenic index of plasma was associated with a higher incidence of sarcopenia by Zhiping Duan, Yunda Huang, Xiaoling Liu, Huiyu Tang, Guihua Jiang, Wei Huang, Runfen Du, Dan Zhou, Hong Yang

“…This cohort study included 7,992 participants who were free of sarcopenia in 2011 in the China Health and Retirement Longitudinal Study and were followed up in 2013 and 2015. …”
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Brief intervention to reduce fatigue impact in patients with inflammatory arthritis: design and outcomes of a single-arm feasibility study by Paul Ewings, Emma Dures, Sarah Hewlett, Joanna Thorn, Mwidimi Ndosi, Siobhan Creanor, Jo Adams, Lance M McCracken, Joe Lomax, Susan Bridgewater, Bryan Abbott, Alice Berry, Marie Urban

“…The Fatigue - Reducing its Effects through individualised support Episodes in Inflammatory Arthritis (FREE-IA) study tested the feasibility of RHP training, intervention delivery and outcome collection ahead of a potential trial of clinical and cost-effectiveness.Methods In this single-arm feasibility study, eligible patients were ≥18 years, had a clinician-confirmed diagnosis of an inflammatory arthritis and scored ≥6/10 on the Bristol Rheumatoid Arthritis Fatigue (BRAF) Numerical Rating Scale (NRS) Fatigue Effect. …”
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