Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial by Jing Wang, Tao Xu, Miao Liu, Jian Chen, Guang Yang, Weiwei Feng, Yulin Sun, Xiuyu Shi, Liping Zou

“…Secondary outcomes include the response rate (the rate of spasms-free), electroencephalogram hypsarrhythmia assessment and the psychomotor development assessment (Denver Developmental Screening Test). …”
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Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise by Madison R. Barshick, Kristine M. Ely, Keely C. Mogge, Lara M. Chance, Sally E. Johnson

“…Exercise causes the formation of free radicals and stimulates inflammatory gene expression in leukocytes and skeletal muscle. …”
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Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease by María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez

“…Molecular docking and molecular dynamics simulations were performed to provide a comprehensive understanding of the interactions between LRRK2 and the inhibitors in the data set and best molecules of the screening. Free energy of binding calculation along with hydrogen bond occupancy analysis and RMSD of the ligand in the pocket show CRA_1801 as the best candidate to be repurposed as LRRK2 inhibitor.…”
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Electronic and photophysical properties of copper (II) Complexes: Insights into solvatochromic Effects, Photoreduction, and fluorescence behavior by Haja Tar, Lama M. Alhomaidan, Lotfi Beji, Abrar S. Alnafisah, Noura Kouki, Sabri Messaoudi, Fahad M. Alminderej, Azizah A. Algreiby, Lotfi M. Aroua

“…While HL1 exhibits a single peak, HL2 displays two peaks, findings supported by calculated transition energies and oscillator strengths.Moreover, the oxidation processes of copper complexes with iodide salt and triethylamine unveil favorable electron transfer mechanisms, as corroborated by cyclic voltammograms and free energy change values. Photolysis experiments underpin the complexes’ behavior under light irradiation, revealing reversible photoreduction processes and the formation of novel photoproducts. …”
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An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing by Ziyi Zhou, Dengjun Zhang, Xuchao Ning, Linbo Jin, Yijing Lin, Chen Liang, Xin Wen, Tianhao Huang, Junli Zhou, Yiming Zhang

“…Both TA and okra extract possess antioxidant and antibacterial properties, and when they two acts synergistically they can effectively scavenge free radicals, enhance antibacterial action, diminishing the risk of wound infection. …”
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Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms by Mohammad Yasin Zamanian, Hamidreza Zafari, Maria K. Osminina, Alla A. Skakodub, Raed Fanoukh Aboqader Al‐Aouadi, Maryam Golmohammadi, Nikta Nikbakht, Iman Fatemi

“…Results from various studies demonstrate that liposomal DEX significantly inhibits arthritis progression in animal models, reduces joint inflammation and damage, and alleviates cartilage destruction compared to free DEX. The liposomal formulation also shows better hemocompatibility, fewer adverse effects on body weight and immune organ index, and a longer circulation time with higher bioavailability. …”
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Therapeutic effects of Pueraria lobata (Willd.) Ohwi root and Hovenia dulcis Thunb. extracts on alcoholic liver disease: Network pharmacology and experimental validation by Zhendong Chen, Yu Yue, Hongyan An, Haisu Yan, Hyeok-Joo Park, Pei Lin

“…Results: Treatment with the extract contributed to a significant reduction in the release of nitric oxide and reactive oxygen species in the ethanol-treated HepG2 cells; promoted the elevated expression of superoxide dismutase, catalase, and glutathione, indicating enhanced antioxidant defenses; and showed strong free radical-scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radicals. …”
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GAZE DIRECTION MONITORING MODEL IN COMPUTER SYSTEM FOR ACADEMIC PERFORMANCE ASSESSMENT by Olesia Barkovska, Yaroslav Liapin, Tetiana Muzyka, Ihor Ryndyk, Pavlo Botnar

“…The dynamic authentication based on the sequence of eye movements proposed in the model allows error-free user's eye area detection for further analysis of the test subject's behavior. …”
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Compliance status of tobacco control laws in the university setting of Bangladesh: an analytical study followed a mixed-method approach by Nasrin Akter, Bilkis Banu, Sujana Haque Chowdhury, Tahsin Tasneem Tabassum, Sarder Mahmud Hossain

“…This empirical outcome and evaluation strategy can guide to plan of future large-scale studies, which may lead to implementing effective intervention programmes focusing on the development of a tobacco-free environment in the university setting.…”
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A DFT study of lithium intercalation and metallization on oxygen-vacancy containing TiO2(110) by J. Juan, M.G. Sandoval, P. Bechthold, E.A. González, P.V. Jasen

“…We found that Li migration is stopped at the bulk-like defect-free layers in the direction normal to the surface. …”
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Anlotinib as Maintenance Therapy After First-Line Chemotherapy Combined with Consolidation Radiation for Extensive-Stage Small Cell Lung Cancer by Jinbo Ma MD, Xiaoyan Ma MS, Wei Zhang MD, Shanliang Hu MS, Rukun Zang MS, Xiaolong Wu MS, Jie Song MD

“…The primary endpoints were progression-free survival (PFS) and overall survival (OS) after the first diagnosis, and the secondary endpoints were prognostic factors and safety. …”
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Chemical, Mineralogical, and Refractory Characterization of Kaolin in the Regions of Huayacocotla-Alumbres, Mexico by L. M. Romero-Guerrero, R. Moreno-Tovar, A. Arenas-Flores, Y. Marmolejo Santillán, F. Pérez-Moreno

“…The variables that affect the kaolin stability temperature were determined by principal components with the XLSTAT free program.…”
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Valley charge-transfer insulator in twisted double bilayer WSe2 by LingNan Wei, Qingxin Li, Majeed Ur Rehman, Yangchen He, Dongdong An, Shiwei Li, Kenji Watanabe, Takashi Taniguchi, Martin Claassen, Kostya S. Novoselov, Dante M. Kennes, Angel Rubio, Daniel A. Rhodes, Lede Xian, Geliang Yu, Lei Wang

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The potential of the amaranth collection maintained at VIR in the context of global plant breeding and utilization trends by D. V. Sokolova, A. E. Solovieva, A. M. Zaretsky, T. V. Shelenga

“…Its seeds and leaf biomass contain a high-quality gluten-free protein, fatty acids, squalene (a polyunsaturated hydrocarbon), flavonoids, vitamins, and minerals. …”
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Composite submental flaps in facial reconstructive surgery involving the zygoma and orbit by Usman Khan, Sebastian Haupt, Matthew Rigby, S. Mark Taylor, Martin Corsten, Jonathan Trites

“…Abstract Background The submental island flap (SIF) is a reliable option for reconstructing defects in the facial region and offers several advantages when compared to free-flap alternatives. While the reconstructive applications of the SIF have been demonstrated in the lower face, there are limited reports on its utility as a composite flap for reconstructing defects of the upper facial skeleton. …”
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Photothermal Laser Printing of Sub‐Micrometer Crystalline ZnO Structures by Matthias Steurer, Paul Somers, Kristian Kraft, Lukas Grünewald, Steven Kraus, Florian Feist, Bastian Weinert, Erich Müller, Stefanie Dehnen, Claus Feldmann, Yolita M. Eggeler, Christopher Barner‐Kowollik, Martin Wegener

“…Finally, the herein‐demonstrated ZnO printing requires no post‐processing and is a cleanroom‐free technique for the fabrication of crystalline semiconductors.…”
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Phenolic and amino acid profiles, and antioxidant properties of third generation snack foods adding Citrus mitis by-products and milk powder: impact of extrusion processing and mic... by Xóchitl Ariadna Ruiz-Armenta, Carlos Iván Delgado-Nieblas, José de Jesús Zazueta-Morales, Ernesto Aguilar-Palazuelos, Perla Rosa Fitch-Vargas, José Alberto Gallegos-Infante, José Ángel López-Valenzuela, María Fernanda Quintero-Soto

“…Sixteen phenolic acids, nine flavonoids, and a hydroxy acid were identified in free and bound extracts by UPLC coupled to ESI-MS. …”
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Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer by Dominika Wróbel-Dudzińska, Jorge Alio, Alejandra Rodriguez, Ewa Suchodoła-Ratajewicz, Ewa Kosior-Jarecka, Beata Rymgayłło-Jankowska, Agnieszka Ćwiklińska-Haszcz, Tomasz Żarnowski

“…The patients were given autologous platelet-rich plasma drops five times a day and additionally preservative-free artificial tears and a vitamin A ointment at night for maximum 3 months. …”
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Efficacy and safety of faricimab for neovascular age-related macular degeneration: a systematic review and network meta-analysis by Francisco Rodríguez, Daniel Samacá-Samacá, Claudia Hernández-Castillo, Laura Prieto-Pinto, Carolina Sardi, Hugo Ocampo, Joshua Kock, Fabián Hernández

“…Results also showed that more patients treated with faricimab were free from post-treatment retinal fluid compared with aflibercept every 8 weeks, and both ranibizumab and bevacizumab, in the fixed and pro re nata (PRN) assessed schedules. …”
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Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer by Yugang Wu, Min Jin, Huanbai Xu, Zhang Shimin, Songbing He, Liang Wang, Yanyun Zhang

“…Therefore, the disease-free survival of all patients after curative resection can be considered in association with all three markers expression.…”
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