Experimental Studies on Physicochemical Parameters of Water Samples before and after Treatment with a Cold Atmospheric Plasma Jet and its Optical Characterization by Hom Bahadur Baniya, Rajesh Prakash Guragain, Gobinda Prasad Panta, Santosh Dhungana, Ganesh Kuwar Chhetri, Ujjwal Man Joshi, Bishnu Prasad Pandey, Deepak Prasad Subedi

“…Cold atmospheric plasma jet is an emerging technology for surface drinking water treatment to improve quality and surface modification that is chemical-free and eco-friendly. Cold plasma treatment of water samples results in changes in turbidity, pH, and conductivity and in the formation of reactive oxygen and nitrogen species (RONS). …”
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Complete metabolic response as early predictor of long-term efficacy after adoptive T cell therapy using tumor-infiltrating lymphocytes by Rikke Andersen, Troels Holz Borch, Eva Ellebaek, Inge Marie Svane, Helle Westergren Hendel, Kasper Madsen

“…Neither mOS (range 32.2–149.8+) nor median progression-free survival (mPFS; range 20.7–123.4+) were reached for patients with partial response (PR)/CMR (10 patients), whereas patients with PR/non-CMR (12 patients) had a mOS of 28.7 months (p=0.0016) and a mPFS of 7.8 months (p<0.0001).Overall, not achieving a CMR was associated with a short mPFS of 3.2 months, and 97.9% (47/48) of all patients in this group progressed within 12 months.Conclusion: In conclusion, early CMR is a strong predictor of long-term survival after TIL therapy in metastatic melanoma patients. …”
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Divergent values and perspectives drive three distinct viewpoints on grizzly bear reintroduction in Washington, the United States by Tara S. Easter, Anna R. Santo, Abigail H. Sage, Neil H. Carter, Kai M. A. Chan, Jason I. Ransom

“…We discuss the management implications of these findings for the North Cascades grizzly bear reintroduction, and for other large carnivore reintroductions. Read the free Plain Language Summary for this article on the Journal blog.…”
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Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Apical Membrane Antigen 1 (AMA1) by Umashankar Vetrivel, Shalini Muralikumar, B Mahalakshmi, K Lily Therese, HN Madhavan, Mohamed Alameen, Indhuja Thirumudi

“…Moreover, the backbone flexibility of hotspot residues in the hydrophobic cleft, which has been previously reported to be essential for accommodative binding of RON2 to AMA1, was also highly perturbed by these compounds. Furthermore, binding free energy calculations of these two compounds also revealed a significant affinity to AMA1. …”
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A Large Ship Detection Method Based on Component Model in SAR Images by Tiancheng Dong, Taoyang Wang, Xuefei Li, Jianzhi Hong, Maoqiang Jing, Tong Wei

“…Existing multiscale ship detection algorithms for SAR data employ multiscale feature pyramids or anchor-free extractors to capture features from large ship targets. …”
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The Carcinoma–Stromal Ratio of Colon Carcinoma Is an Independent Factor for Survival Compared to Lymph Node Status and Tumor Stage by Wilma E. Mesker, Jan M. C. Junggeburt, Karoly Szuhai, Pieter de Heer, Hans Morreau, Hans J. Tanke, Rob A. E. M. Tollenaar

“…The analysis of mean survival revealed: overall-survival (OS) 2.13 years, disease-free- survival (DFS) 1.51 years for CP-low and OS 7.36 years, DFS 6.89 years for CP-high. …”
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Comparative efficacy and safety of first-line neoadjuvant therapy for early-stage non-small cell lung cancer based on immune checkpoint inhibitor therapy: a systematic review and n... by Linfeng Wang, Guangda Zheng, Yue Hu, Ayidana Maolan, Yue Luo, Yue Li, Rui Liu

“…For patients without programmed death-ligand 1(PD-L1) selection, Toripalimab plus chemotherapy provided the best Pathological complete response (PCR) benefit (OR = 32.89,95% CI:7.88-137.32), best Major Pathological response (MPR) benefit (OR = 10.25, 95% CI: 5.81–18.10) and best Event-free survival (EFS) benefit (HR = 0.40,95% CI: 0.28–0.57). …”
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Posttranslational Nitration of Tyrosine Residues Modulates Glutamate Transmission and Contributes to N-Methyl-D-aspartate-Mediated Thermal Hyperalgesia by Carolina Muscoli, Concetta Dagostino, Sara Ilari, Filomena Lauro, Micaela Gliozzi, Erlisa Bardhi, Ernesto Palma, Vincenzo Mollace, Daniela Salvemini

“…The broader implication of our findings reinforces the notion that free radicals may contribute to various forms of pain events and the importance of the development of new pharmacological tool that can modulate the glutamate transmission without blocking its actions directly.…”
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Elevated SAMD3 expression in T cells predicts improved survival in pancreatic ductal adenocarcinoma patients by Lingyi Fu, Enliang Zhou, Shuo Li, Ziteng Li, Liyan Wu, Xinxin Zhou, Lang Tian, Bokang Cui

“…In PDAC patients, high SAMD3 levels in T cells were associated with improved overall survival (OS), disease-free survival (DFS), and T cell infiltration. A patient exhibiting partial response to combination immunotherapy also showed high SAMD3 levels in T cells. …”
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Assessing equity in preventing central line-associated bloodstream infections and surgical site infections in pediatric patients by Xiaoyan Song, Deena Levey, Jenhao Jacob Cheng, Monica Monteon, Annette Lee, Nada Harik, Denice Cora-Bramble, Rahul K. Shah

“…Objective: To assess equity in preventing CLABSIs and SSIs in pediatric patients at a free-standing pediatric hospital, where evidence-based infection prevention practices are consistently implemented. …”
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Brain Computer Interface on Track to Home by Felip Miralles, Eloisa Vargiu, Stefan Dauwalder, Marc Solà, Gernot Müller-Putz, Selina C. Wriessnegger, Andreas Pinegger, Andrea Kübler, Sebastian Halder, Ivo Käthner, Suzanne Martin, Jean Daly, Elaine Armstrong, Christoph Guger, Christoph Hintermüller, Hannah Lowish

“…The system is comprised of ergonomic and hassle-free BCI equipment; one-click software services for Smart Home control, cognitive stimulation, and web browsing; and remote telemonitoring and home support tools to enable independent home use for nonexpert caregivers and users. …”
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The effects of circuit hydraulic weight interval training on body composition and progression of resistance in recreationally exercising pre- and postmenopausal women: an 18-week q... by Małgorzata Socha, Paulina Ćwieląg, Waldemar Andrzejewski

“…Each participant from the CHWIT group took part in a total of 54 training sessions, developed for the Mrs.Sporty network, under the constant supervision of a qualified trainer.ResultsAfter 18 weeks of training in both intervention groups, ANCOVA demonstrated statistically significant (p < 0.05) decreased body fat (%), reduced thigh and arm circumference, and increased muscle component (kg) as the main part of fat-free body mass. Additionally, premenopausal women decreased their body mass, BMI, and waist and hip circumferences. …”
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A Fully Coupled Hydromechanical Model for CO2 Sequestration in Coal Seam: the Roles of Multiphase Flow and Gas Dynamic Diffusion on Fluid Transfer and Coal Behavior by Rui Yang, Weiqun Liu, Tianran Ma, Junhe Xie, Yang Hu, Rui Zhou, Yongjie Yang

“…Additionally, through the model application for long-term CO2 sequestration, we found that the stored CO2 molecules are mainly in an adsorbed state at the early injection stage, while with the continuous injection of gas, the stored CO2 molecules are mainly in a free state. Finally, the roles of multiphase flow and gas dynamic diffusion on fluid transfer and coal behavior were analyzed. …”
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Optimal trajectory of the neuroendoscope for third ventricle pavement access by Joana Sousa, Susana Maria Silva, Susana Maria Silva, Hélio Alves, Bruno Carvalho, Bruno Carvalho, José Maria Sousa, Manuel J. Ferreira-Pinto, Manuel J. Ferreira-Pinto, Manuel J. Ferreira-Pinto, Manuel J. Ferreira-Pinto, José Paulo Andrade, José Paulo Andrade

“…By defining a new trajectory and entry point interval, we aim to establish a standardized approach for FreeHand ETV, a vital technique when specialized tools are unavailable, or during emergencies.Methods187 MRIs were analyzed, with 30 having hydrocephalus. …”
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Lenvatinib versus sorafenib as second-line therapy following progression on atezolizumab–bevacizumab in patients with unresectable hepatocellular carcinoma: a multicenter retrospec... by Jaekyung Cheon, Shigeo Shimose, Hyung-Don Kim, Takashi Niizeki, Min-Hee Ryu, Tomotake Shirono, Baek-Yeol Ryoo, Hideki Iwamoto, Changhoon Yoo

“…Before PSM, LEN was associated with significantly improved progression-free survival (PFS) compared with SOR (median 4.9 vs. 3.3 months, p < 0.001); however, no significant difference in overall survival (OS) was observed (median 13.2 vs. 11.5 months, p = 0.651). …”
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Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis by Huann-Cheng Horng, Jin-Wei Xu, Yi-Shan Kuo, Yu-Sin Chen, Yu-Hsuan Chiu, Kuan-Hao Tsui, Yu-Tang Tung

“…This study underscores the potential of microbiome-modulating strategies in managing vaginal infections, paving the way for more targeted and side-effect-free VVC treatments.…”
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Dose-response risks of all-cause, cancer, and cardiovascular disease mortality according to sex-specific cigarette smoking pack-year quantiles by Jieun Hwang, Suyoung Jo, Heewon Kang, Eunsil Cheon, Sung-il Cho

“…Considering the persistent risks post-smoking cessation, it is vital to focus on preventing smoking initiation and providing proactive support for successful smoking cessation and maintenance of a smoke-free lifestyle.…”
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Effects and Potential Mechanisms of Pioglitazone on Lipid Metabolism in Obese Diabetic KKAy Mice by Jun Peng, Yi Huan, Qian Jiang, Su-juan Sun, Chun-ming Jia, Zhu-fang Shen

“…Pioglitazone treatment resulted in deteriorated microvesicular steatosis and elevated hepatic triglyceride levels, though plasma triglyceride and free fatty acid levels were reduced by the treatment, compared to nontreated KKAy mice. …”
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Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation by Jing Dong, Shahram Arsang-Jang, Tao Zhang, Zhongyuan Chen, Yung-Tsi Bolon, Stephen Spellman, Raul Urrutia, Paul Auer, Wael Saber

“…We evaluated the impact of donor mtDNA variants on recipients’ transplantation outcomes, including overall survival, relapse, relapse-free survival, and transplant-related mortality. …”
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Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients by Jae-Ghi Lee, Ilkyu Park, Hannah Lee, Seungyoon Nam, Jisup Kim, Won-Suk Lee, Myunghee Kang, Jung Ho Kim

“…It then assessed their 5-year event-free survival (EFS) and disease-specific survival (DSS) hazard ratios (HRs). …”
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