Innovative applications and future trends of multiparametric PET in the assessment of immunotherapy efficacy by Tingting Qiao, Tingting Qiao, Zhaoping Cheng, Yanhua Duan

“…Metabolic parameters such as SUVmax, MTV, and TLG were significantly correlated with treatment response rates, progression-free survival (PFS), and overall survival (OS). The integration of multi-omics data (including genomics and proteomics) with PET imaging enhanced the sensitivity and accuracy of efficacy prediction. …”
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A holistic physics-informed neural network solution for precise destruction of breast tumors using focused ultrasound on a realistic breast model by Salman Lari, Hossein Rajabzadeh, Mohammad Kohandel, Hyock Ju Kwon

“…Our PINN-based solution operated efficiently in a mesh-free domain, achieving remarkable accuracy with significantly reduced computational demands, compared to conventional FEM techniques. …”
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Microencapsulation of Baker’s Yeast in Gellan Gum Beads Used in Repeated Cycles of Glucose Fermentation by Camelia Elena Iurciuc (Tincu), Catalina Peptu, Alexandru Savin, Leonard-Ionuț Atanase, Kaies Souidi, Grahame Mackenzie, Patrick Martin, Gerard Riess, Marcel Popa

“…These results highlight the potential of these bioreactors to be used in repeated fermentation cycles (minimum 10) without reducing their biocatalytic activity and maintaining their productivity at similar parameters to those obtained in the free yeast fermentation. Encapsulation of Saccharomyces cerevisiae into the gellan gum beads plays a role in the effective application of immobilized yeast for the fermentation process.…”
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Retroperitoneal Teratoma in an Adult: A Potential Pitfall in the Differential Diagnosis of Adrenal Myelolipoma by Madoka Kataoka, Hiroshi Fukushima, Yasukazu Nakanishi, Minato Yokoyama, Nobuaki Funata, Toru Motoi, Ken-ichi Tobisu, Fumitaka Koga

“…Histopathological examination revealed that the cystic tumor is composed of keratinized epidermis, mature fat, nerve, cartilage, bone, and sebaceous glands compressing the normal adrenal gland, leading to the diagnosis of retroperitoneal mature cystic teratoma. The patient remains free of recurrence 29 months after surgery. Retroperitoneal teratoma is relatively rare but clinically important because of high possibility of malignancy. …”
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A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma by Xiuyun Chen, SenLin Li, Lixue Cao, Shaoxian Chen, Qiuxiong Lin, Shilong Zhong

“…Patients in the high-risk group exhibited significantly reduced overall survival (OS) and progression-free survival compared to those in the low-risk group. …”
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Detection of The TNFSF Members BAFF, APRIL, TWEAK and Their Receptors in Normal Kidney and Renal Cell Carcinomas by Vassiliki Pelekanou, George Notas, Katerina Theodoropoulou, Marilena Kampa, Dimitrios Takos, Vassilia-Ismini Alexaki, Jelena Radojicic, Frank Sofras, Andreas Tsapis, Efstathios N. Stathopoulos, Elias Castanas

“…BAFF was found in all RCC; APRIL expression is associated with an aggressive phenotype, correlating negatively with patients' disease-free survival, while TWEAK and its receptor Fn14 are heterogeneously expressed, correlating negatively with the grade and survival of RCC patients. …”
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Digital breakthrough: will public administration be smart enough in a digital state and how smart are the elite and citizens by L. A. Vasilenko

“…Fourthly, discussing the presence of subjects of government acting on behalf of citizens, the author emphasized that the state has provided for the availability of a barrier-free information environment that provides high-quality public, medical and social services, but the issue of citizens as subjects of governance in digitalization processes is not provided. …”
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Case report: identification of novel variant in SLC26A2 gene and preimplantation genetic testing for monogenic disorders in preventing diastrophic dysplasia by Ziravard N. Tonyan, Yulia A. Nasykhova, Maria M. Danilova, Elena S. Shabanova, Olesya N. Bespalova, Igor Y. Kogan, Andrey S. Glotov

“…The successful application of PGT-M enabled the selection of an embryo free from inherited pathogenic variants from both parents, highlighting the importance of PGT-M in improving reproductive outcomes for affected families.…”
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Machine learning-based prediction of the mechanical properties of β titanium shape memory alloys by Naoki Nohira, Taichi Ichisawa, Masaki Tahara, Itsuo Kumazawa, Hideki Hosoda

“…This study developed machine learning (ML) models to predict the mechanical properties of Ni-free β-type titanium shape memory alloys (SMAs). …”
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A Narrative Review of Prognostic Gene Signatures in Oral Squamous Cell Carcinoma Using LASSO Cox Regression by Nur Fatinazwa Mohd Faizal, Saptarsi Shai, Bansi P. Savaliya, Lee Peng Karen-Ng, Rupa Kumari, Rahul Kumar, Vui King Vincent-Chong

“…Our findings revealed 13 studies that correlated a greater number of regulatory T cells (Tregs) cells in protective gene signatures with increased recurrence-free and overall survival rates. Conversely, two studies displayed an opposing trend in cases of OSCC. …”
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The immunity-promoting activity of porcine placenta in mice as an immunomodulator for functional foods by Zhiwei Zhou, Dan Wang, Wei Liu, Lang He, Pengkuan Liang, Junli Hao, Qun Sun

“…Results showed that porcine placenta contained placental peptides and 15 free amino acids, and the amounts of estrogen and progesterone in products developed from porcine placenta were within the limit of national standard. …”
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Morphological Features and In Vitro Cytopathic Effect of Acanthamoeba griffini Trophozoites Isolated from a Clinical Case by Arturo González-Robles, Lizbeth Salazar-Villatoro, Maritza Omaña-Molina, Maria Reyes-Batlle, Carmen M. Martín-Navarro, Jacob Lorenzo-Morales

“…Ultrastructurally, the cytoplasm showed the main organelles found in other free-living amoebae. Coincubation of trophozoites with MDCK cell monolayers resulted in a local damage to target cells after 24 h of interaction, suggesting that the cytopathic effect is contact-dependent. …”
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Modeling Ebola Virus Disease transmissions with reservoir in a complex virus life ecology by Tsanou Berge, Samuel Bowong, Jean Lubuma, Martin Luther Mann Manyombe

“…The reproduction number $\mathcal R_0$ for the full model with the environmental contamination is derived and the global asymptotic stability of the disease free equilibrium is established when $\mathcal R_0 < 1$. …”
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Endometrial Carcinoma Presenting with an Isolated Osseous Metastasis: A Case Report by Nesrine Tounsi, Ines Zemni, Fatma Saadalah, Maher Slimane, Nadia Boujelbene, Mohamed ali Ayadi, Chargui Rhiad, Rahal Khaled

“…The patient is clinically free of disease 10 months following diagnosis. Single-bone extrauterine metastatic site and local disease limited to the uterus had better survival outcomes than Stage IVb endometrial cancer with multiple metastatic sites. …”
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Nutrient inputs shape ecosystem functioning gradients along the pristine, upper Neretva River, Bosnia and Herzegovina by Rubén Del Campo, Barbara Jechsmayr, Veronika Settles, Melanie Ströder, Gabriel Singer

“…Here, we investigated how ecosystem functions and their diversity (estimated as multifunctionality) change along the continuum of the karstic, free-flowing Neretva River in Bosnia and Herzegovina. …”
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Partial unilateral ovarian torsion in a red-eared slider turtle (Trachemys scripta elegans) by Alessandro Vetere, Martina Gavezzoli, Lucia Victoria Bel, Rosanna Di Lecce, Martina Fumeo, Mattia Bonazzi, Francesco Di Ianni

“…Ultrasound revealed multiple, round, heterogeneous hyperechoic follicles and free anechoic fluid in the coelom. The color flow examination through the right pre-femoral fossa revealed the absence of blood flow in a group of follicles. …”
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Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruzi Activity by Darliane A. Martins, Ligiane R. Gouvea, Gabriel S. Vignoli Muniz, Sonia R. W. Louro, Denise da Gama Jaen Batista, Maria de Nazaré C. Soeiro, Letícia R. Teixeira

“…The tests performed using bloodstream trypomastigotes showed that the Cu(II)-N-donor precursors and the metal complexes were more active than the free fluoroquinolone.…”
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Cytoskeletal Vimentin Directs Cell‐Cell Transmission of Hepatitis C Virus by Yifan Xing, Zeyu Wen, Jie Mei, Xinyi Huang, Shuangshuang Zhao, Jin Zhong, Yaming Jiu

“…Genetic removal of vimentin markedly and specifically disrupts HCV cell–cell transmission without influencing cell‐free infection. Through mutual co‐immunoprecipitation screening, we identified that the N‐terminal 1–95 amino acids of vimentin exclusively interact with the HCV envelope protein E1. …”
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The Effect of Prior Gestational Diabetes on the Shape of the Glucose Response Curve during an Oral Glucose Tolerance Test 3 Years after Delivery by Timea Tänczer, Márk M. Svébis, Beatrix Domján, Viktor J. Horváth, Adam G. Tabák

“…We conducted a nested case-control study of GDM (n=47 early GDM, diagnosed between 16 and 20 weeks of gestation; n=40 late GDM, diagnosed between 24 and 28 weeks of gestation) and matched healthy controls (n=37, normal glucose tolerance during pregnancy) all free from diabetes at follow-up 3.4±0.6 years after delivery. …”
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Bird flock effect-based dynamic community detection: Unravelling network patterns over time by Siti Haryanti Hairol Anuar, Zuraida Abal Abas, Iskandar Waini, Mohd Fariduddin Mukhtar, Zejun Sun, Eko Arip Winanto, Norhazwani Mohd Yunos

“…The contributions are obtained for high quality community detected, free-parameter and well stability. To test its performance, extensive experiments were conducted on both synthetic and real-world networks. …”
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