Efficacy and safety of new protease inhibitor faldaprevir in treatment of hepatitis C by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…Faldaprevir has demonstrated equally good tolerability, high safety and antiviral activity in patients at different stages of fibrosis and liver cirrhosis in the range of interferon-free treatment modes.Conclusion. Clinical investigations demonstrated that combination of faldaprevir with interferon and ribavirin essentially increases treatment response rate both in previously untreated patients with 1-st genotype, and in patients with unsuccessful experience of antiviral therapy; it allows to reduce treatment duration in certain groups of patients. …”
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Spectrophotometric and computational characterization of charge transfer complex of selumetinib with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and its utilization in developing an... by Sarah Alrubia, Wafa A. AlShehri, Awwad A. Radwan, Nourah Z. Alzoman, Ibrahim A. Darwish

“…The ease of reaction occurrence, complex stability and its high absorptivity were proved by measuring its association constant (0.63 × 102 L/ mol), standard free energy change (-10.31 KJ/mol), molar absorptivity (ε) (3.78 × 103 L/mol/cm), and the SEL: DDQ stoichiometric ratio (1:1). …”
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Interventions promoting recovery from depression for patients transitioning from outpatient mental health services to primary care: A scoping review. by Anne Sofie Aggestrup, Frederik Martiny, Line Lund Henriksen, Annette Sofie Davidsen, Klaus Martiny

“…Four electronic databases were systematically searched using controlled index-or thesaurus terms and free text terms, as well as backward and forward citation tracking of included studies. …”
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The production process of chepa shutki: A traditional Bangladeshi fermented fish product by Jasmin Ara Farhana, Sijmen E. Schoustra, Ferdous Ahamed, Bas Zwaan, Oscar van Mastrigt

“…Chepa shutki is a sticky, solid, fermented, salt-free product from Bangladesh prepared from small-sized fish by local producers. …”
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Health-related quality of life outcomes reporting associated with FDA approvals in haematology and oncology by Bishal Gyawali, Pallawi Torka, Kristopher Attwood, Medhavi Gupta, Othman Salim Akhtar, Bhavyaa Bahl, Angel Mier-Hicks, Kayla Catalfamo

“…Proportion of included trials that reported HRQoL, latency between FDA approval and first report of HRQoL data, HRQoL outcomes, and their correlation with OS (overall survival) and PFS (progression-free survival) were analysed.Results Of the 233 trials associated with 207 FDA approvals, HRQoL was reported in 50% of trials, of which only 42% had the data reported by the time of FDA approval. …”
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Did selective kinase inhibitors change the management of patients with radioiodine-refractory thyroid cancer? by Tommaso Porcelli, Cristina Luongo, Anna Cerbone, Carmine Di Luccio, Mariantonia Nacchio, Maria Angela De Stefano, Martin Schlumberger, Domenico Salvatore

“…Grade ≥3 adverse events occurred in 13 (42%) patients treated with lenvatinib and only in 1 (9%) patient treated with DT. Progression-free survival (PFS) and overall survival rates at 1 year were 72% and 83% in lenvatinib-treated patients and 69% and 83% in DT-treated patients, respectively. …”
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Computational Study of the Phytochemical Constituents from Uncaria tomentosa Stem Bark against SARS-CoV-2 Omicron Spike Protein by Oscar Herrera-Calderon, Abdulrahman M. Saleh, Andres F. Yepes-Perez, Nada H. Aljarba, Saad Alkahtani, Gaber El-Saber Batiha, Renan Dilton Hañari-Quispe, Haydee Chavez, Josefa Bertha Pari-Olarte, Eddie Loyola-Gonzales, José Santiago Almeida-Galindo, José Francisco Kong-Chirinos, Taoufiq Benali

“…As results proanthocyanidin-C1 (-10.76 kcal/mol), quinovic acid-type 2 (-9.86 kcal/mol), and proanthocyanidin-B2 (-9.82 kcal/mol) were the constituents with the best binding free energy on the SARS-CoV-2 Omicron spike protein, and the best compound was stable during the dynamic simulation under physiological conditions. …”
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Spatiotemporal analysis of African swine fever spread in wild boar population in Russian Federation, 2007–2022 by O. I. Zakharova, A. A. Blokhin, O. A. Burova, I. V. Yashin, F. I. Korennoy

“…Prevention of the ASFV introduction from an infected region to a free one is the back bone in the infection prevention. …”
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Behind the lenses: Biases in the contribution of wildlife photography to biodiversity representation by Héctor Ruiz‐Villar, Ana Morales‐González, Jon Morant

“…Finally, we underscore the need to report compliance with ethical guidelines when photographing wildlife. Read the free Plain Language Summary for this article on the Journal blog.…”
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TEACHERS’ PROFESSIONAL COMMITMENT AS AN INDICATOR OF PSYCHOLOGICAL READINESS TO THE PROFESSIONAL STANDARDS IMPLEMENTATION by S. A. Minyurova, A. I. Kalashnikov

“…Based on the systematized results of survey, the key structural components of teachers’ commitment can be listed as follows: “professional affectivity” (identification and emotional attachment to the chosen specialty, satisfaction with the calling, feeling of professional pride, acceptance of the goals and values), “professional stability” (feeling of resignation challenges, feeling of a professional duty), and “professional activity” (feeling of full-time commitment and complete dedication, spending free time and energy for the sake of professional self-realization). …”
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Estimation of antioxidant and hypolipidemic activities of extracts of Citrus x aurantium leaves in vitro by Loulia Al Hawat, Loai Alallan

“…The antioxidant activity of various concentrations of extracts was estimated by measurement of the ability of each extract to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical. Hypolipidemic activity of various concentrations of extracts was estimated by measurement of the bile acid binding capacity. …”
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The experimental and numerical studies on the effects of the operating conditions on the performance of breastshot waterwheel by Agato Agato, Deendarlianto Deendarlianto, Indarto Indarto, Alfeus Sunarso

“…In the numerical simulation, the hydraulic channel was considered to be laterally symmetric, therefore only half of the section was taken into account. The simulation of free surface movement was calculated using the volume of fluid (VOF) method, and the static and rotating region interface was treated using the sliding mesh interface (SMI). …”
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Clinicopathologic Characteristics and Long-Term Outcome of Gastric Cancer Patients with Family History: Seven-Year Follow-Up Study for Korean Health Check-Up Subjects by Jooyoung Lee, Su Jin Chung, Ji Min Choi, Yoo Min Han, Joo Sung Kim

“…Overall survival (OS) and recurrence-free survival (RFS) were assessed as primary outcomes. …”
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China’s chrysanthemum in the global market: evaluating the international competitiveness and influencing factors by Bo Pan, Bo Pan, Yingxin Du, Qingbing Chen, Qingbing Chen, Yaoyao Wang, Lijie Chen, Lijie Chen, Haiying Li, Conglin Huang, Kang Gao

“…While we do not find significant effect of the Belt and Road Initiatives, we find that Chinese exporters of cut chrysanthemums tend to choose to export to China’s partners of free trade agreement. This study then provides policy suggestions regarding enhancing the international competitiveness of China’s cut chrysanthemums including promoting innovation strengthening international cooperation.…”
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Cathepsin C Is Involved in Macrophage M1 Polarization via p38/MAPK Pathway in Sudden Cardiac Death by Jialin Dai, Jiangjin Liu, Qiong Zhang, Yang An, Bing Xia, Changwu Wan, Yuanyuan Zhang, Yanni Yu, Jie Wang

“…A total of 2784 proteins were obtained from label-free quantitative proteomic analysis. This included a total of 265 differential proteins which were involved in SCD-related processes, such as inflammation, muscle system process regulation, metal ion transport, and lysosomal pathway. …”
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Impacts of Elevated Atmospheric CO2 and O3 on Paper Birch (Betula papyrifera): Reproductive Fitness by Joseph N. T. Darbah, Mark E. Kubiske, Neil Nelson, Elina Oksanen, Elina Vaapavuori, David F. Karnosky

“…Here, we report on the long-term effects of CO3 and O3 for paper birch seedlings exposed for nearly their entire life history at the Aspen FACE (Free Air Carbon Dioxide Enrichment) site in Rhinelander, WI. …”
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Microbial-based natural products as potential inhibitors targeting DNA gyrase B of Mycobacterium tuberculosis: an in silico study by Tilal Elsaman, Magdi Awadalla Mohamed, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla

“…Consequently, targeting this enzyme is of particular interest in developing new drugs for the treatment of drug-resistant tuberculosis, including multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB).MethodsIn the present study, multiple computational tools were adopted to screen a microbial-based natural products database (NPAtlas) for potential inhibitors of the ATPase activity of MBT DNA gyrase.Results and discussionTwelve hits were initially identified as the top candidates based on their docking scores (ranging from −9.491 to −10.77 kcal/mol) and binding free energies (−60.37 to −73.21 kcal/mol). Following this, computational filters, including ADME-T profiling and pharmacophore modeling, were applied to further refine the selection. …”
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The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine by Andy Tseng, Syed Muzzammil Ahmad, Abdul Hamid, Kabirullah Lutfy

“…Mice were then conditioned with ethanol (2 g/kg) versus saline on days 2 to 4 and then tested under a drug-free state for postconditioning place preference on day 5. …”
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Morphological features of bovine placenta in case of viral, bacterial and protozoal infections by O. V. Sokolova, L. I. Drozdova, I. A. Shkuratova

“…After sampling, the material was fixed in a 10% neutral formalin solution, then xylene-free method  for histological preparation  was used. …”
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Procalcitonin and High APACHE (Acute Physiological and Chronic Health Evaluation) Level Are Associated with the Course of Acute Kidney Injury in Patients with SARS-CoV-2 by Jorge Andrade Sierra, Claudia Delgado Astorga, Miriam Gabriela Nava Vargas, Enrique Rojas Campos, Kevin Javier Arrelano Arteaga, Karla Hernández Morales, Carlos A. Andrade Castellanos, Antonio de Jesús Andrade-Ortega, Luis Gerardo González Correa

“…The survival analysis free of AKI according to procalcitonin levels and APACHE scores demonstrated a lower survival in patients with procalcitonin >0.5 ng/ml (p=0.001) and APACHE >15 points (p=0.004). …”
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