Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional Series by Erika Crosetti, Andrea Borello, Andy Bertolin, Izabela Costa Santos, Marco Fantini, Giulia Arrigoni, Ilaria Bertotto, Andrea Elio Sprio, Fernando Luiz Dias, Giuseppe Rizzotto, Giovanni Succo

“…This analysis includes 66 patients who underwent OPHL between 1995 and 2017, reporting favorable oncological outcomes with overall survival (OS) of 87.4%, disease-specific survival (DSS) of 93.4%, and disease-free survival (DFS) of 85.5%. A recurrence rate of 10.6% was observed post-salvage OPHL, with vascular invasion and advanced pathological staging identified as significant predictors of recurrence. …”
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Discovering broad-spectrum inhibitors for SARS-CoV-2 variants: a cheminformatics and biophysical approach targeting the main protease by Safar M. Alqahtani

“…The binding entropy energies of these systems showed lower free energies, indicating their stable nature. Furthermore, the binding energies were revalidated using the water swap method that considers the role of the water molecules in bridging the ligands to the enzyme active site residues. …”
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The combination of a tyrosine kinase inhibitor and blinatumomab in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia or Philadelphia chromosome‐like acute... by Xiaoxia Wu, Shenqi Lu, Xinhui Zhang, Zhen Yang, Aining Sun, Depei Wu, Huifen Zhou, Miao Miao

“…The combination of blinatumomab and a TKI in the frontline setting has shown the safety and efficacy of the chemotherapy‐free treatment approach in patients with Ph + ALL. …”
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Evaluation of various RNA-seq approaches for identification of gene outrons in the flatworm Opisthorchis felineus by N. I. Ershov, D. E. Maslov, N. P. Bondar

“…Of the two rRNA depletion methods, a method based on the enzymatic normalization of cDNA (Zymo-Seq RiboFree) showed high efficiency. Compared to mRNA-seq, it provides an approximately twofold increase in the fraction of reads originating from outrons and introns. …”
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Biomonitoring PhIP, a Potential Prostatic Carcinogen, in the Hair of Healthy Men of African and European Ancestry by Robert J. Turesky, Clarence Jones, Jingshu Guo, Kari Cammerrer, Laura A. Maertens, Emmanuel S. Antonarakis, Zhanni Lu, Logan G. Spector

“…Healthy AA men were found to have a significantly higher mean hair PhIP level (2.12-fold) than White men on free-choice diets. However, this difference was not statistically significant after adjusting for melanin content. …”
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Ischaemia-reperfusion time differences in ST-elevation myocardial infarction in very young patients: a cohort study by Pablo Juan-Salvadores, Luis Mariano De La Torre Fonseca, Beatriz Calderon-Cruz, Cesar Veiga, Samuel Pintos-Rodríguez, Saleta Fernandez Barbeira, Victor Alfonso Jimenez Diaz, Andres Iñiguez Romo

“…Delays in healthcare represent one of the main factors related to the occurrence of MACE and non-event-free survival.…”
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In Vitro Investigation of Novel Peptide Hydrogels for Enamel Remineralization by Codruta Sarosi, Alexandrina Muntean, Stanca Cuc, Ioan Petean, Sonia Balint, Marioara Moldovan, Aurel George Mohan

“…The study involved 60 extracted teeth, free from cavities or other lesions, divided into four groups: a positive group (+), a negative group (−) and groups S1 and S2. …”
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Hopping backward to move forward: Single-leg backward hopping can better detect decreased quadriceps strength induced by a fatigue protocol compared to forward and vertical hopping by Yu Song, Lauren Salsgiver, Kaden Van Valkenburg, Natalie Christofferson, Yessica Lo, Zhichen Feng, Brenna McGuinness, Boyi Dai

“…Methods: Thirty-four injury-free participants performed single-leg forward, vertical, and backward hopping on both legs pre- and post-fatigue, with 1 leg experiencing a fatigue protocol. …”
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Extracellular Vesicles in Periodontitis: Pathogenic Mechanisms and Therapeutic Potential by Zhang L, Li X, Zhang B, Li R

“…Conversely, extracellular vesicles derived from dental stem cells (DSCs) have demonstrated the ability to regulate the local periodontal immune environment and foster the regeneration and repair of periodontal tissues, positioning them as a promising candidate for cell-free therapeutic approaches to periodontitis. This review aims to summarize the latest research on the involvement of EVs from different sources in the pathogenesis and treatment of periodontitis, especially to systematically elucidate the mechanism of EVs secreted by periodontal pathogens in periodontitis-related systemic diseases for the first time. …”
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Research on multi-objective control of PPCI diesel engine combustion process based on data driven modelling by Ziqiang Chen, Peng Ju, Zhe Wang, Du Huang, Lei Shi, Kangyao Deng

“…Therefore, this study proposed a diesel engine control method that combines neural networks and model-free adaptive control in the absence of model and controller structure, which can achieve real-time coordination control of crank angle at 50 % of total heat release (CA50) and indicated mean effective pressure (IMEP) in the PPCI combustion process. …”
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Impact of corticosteroids on the efficacy of first-line pembrolizumab plus chemotherapy in patients with advanced non-small-cell lung cancer by Amytis Roboubi, Eric Wasielewski, Soraya Bordier, Amélie Turlotte, Geoffrey Pavaut, Arnaud Scherpereel, Alexis Cortot, Clément Gauvain

“…Methods: The primary endpoint was progression-free survival (PFS) according to SC exposure status (⩾10 mg/day), adjusted in a multivariate Cox model for the following confounders: age, performance status, hospital admission prior to treatment, number of metastatic sites, brain metastases, bone metastases, PD-L1 status, and histological subtype. …”
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Enhanced precise therapy of ROS-sensitive dual-layer shell nanoparticles loading quercetin on DSS-induced ulcerative colitis mice by Yang Bai, Danling Jiang, Boda Wu, Jiao Peng, Ji Wang, Yuhui Chen, Xi Li

“…Quercetin was encapsulated within a shell layer by the self-assembly of gelatin, followed by the polymerization of dopamine on the gelatin surface. Relative to the free form of quercetin, the dual-layer encapsulation enhanced the solubility and bioavailability of quercetin, achieved intragastric protection, and extended the resident time of quercetin in the gastrointestinal tract. …”
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Deep Learning-Based Glucose Prediction Models: A Guide for Practitioners and a Curated Dataset for Improved Diabetes Management by Saul Langarica, Diego de la Vega, Nawel Cariman, Martin Miranda, David C. Andrade, Felipe Nunez, Maria Rodriguez-Fernandez

“…Additionally, as part of our outcomes, we introduce a meticulously curated dataset inclusive of data from both healthy individuals and those with diabetes, recorded in free-living conditions. This dataset aims to foster research in this domain and facilitate equitable comparisons among researchers.…”
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The homogenization of China's city flowers and city trees by Zhuo Cheng, Ziyi Wu, Weizhe Chen, Wenxuan Li, Chen Lin, Qing Zhang, Chunlin Long

“…The study provides recommendations to address these issues and offers insights for cities that have yet to determine their CFTs. Read the free Plain Language Summary for this article on the Journal blog.…”
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NOL-7 serves as a potential prognostic-related biomarker for hepatocellular carcinoma by Qiucheng Lei, Yingchun Huang, Feiwen Deng, Huazhen Zheng, Xitao Hong, Peng Wang, Jin Lv, Huanwei Chen, Zhenling Ji

“…Elevated NOL7 expression correlated with decreased overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) (all P < 0.05). Multivariate analysis revealed that NOL7 was an independent prognostic factor that was significantly related to OS and DSS. …”
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Every little helps: exploring meat and animal product consumption in the Tesco 1.0 dataset by Rakefet Cohen Ben-Arye, Christopher Bryant, Katharina Hofmann

“…We also combined the Tesco 1.0 dataset with datasets from the London Datastore (a free and open data-sharing portal that provides over a thousand datasets to understand the city and develop solutions to its problems), and identified several demographic factors as predictors for the meat consumption. …”
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Rotationplasty for Unplanned Fixation of Pathological Fracture Distal Femoral Osteosarcoma by Chindanai Hongsaprabhas, Wittavat Chenboonthai, Phoomchai Suvaraksakul, Chris Charoenlap

“…Adjuvant chemotherapy was given after a free margin with good tumor necrosis which was achieved as shown in the pathological study. …”
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Satisfaction with a daily supportive text messaging program aimed at promoting psychological well-being of educators: Outcomes from implementation of the Wellness4Teachers by Belinda Agyapong, Pamela Brett-MacLean, Raquel da Luz Dias, Yifeng Wei, Vincent Israel Opoku Agyapong

“…Data was collected from educators who self-subscribed to the free Wellness4Teachers program in Canada. Participants’ satisfaction levels were assessed using a Likert scale to evaluate the responses to different aspects of the program. …”
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Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis by Wan-fu Lin, Mao-feng Zhong, Yu-ren Zhang, Huan Wang, He-tong Zhao, Bin-bin Cheng, Chang-quan Ling

“…A total of 297 potential studies were initially identified, and 9 studies comprising 2449 patients were finally enrolled to evaluate the association between the pretreatment PLR and clinical outcomes of overall survival (OS), disease-free survival (DFS), and event occurrence in patients with HCC in different BCLC stages. …”
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Comparison of Morphological and Functional MRI Assessments of Periprostatic Fat for Predicting Prostate Cancer Aggressiveness by David Freire Maia Vieira, Cecília Vidal de Souza Torres, André de Freitas Secaf, Matheus de Moraes Palma, Gabriel de Lion Gouvea, Jorge Elias Júnior, Rodolfo Borges Reis, Valdair Muglia

“…Using the Cox model, dPSA (p<0.01), systemic disease at diagnosis (p<0.01), and mean ADC (p<0.02) were independent predictors of overall survival (OS). For progression-free survival (PFS), only dPSA (p<0.01) and systemic disease at diagnosis (p<0.01) were significant predictors. …”
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