Modelling Hollow Microneedle-Mediated Drug Delivery in Skin Considering Drug Binding by Tanmoy Bhuimali, Sarifuddin, Diganta Bhusan Das, Prashanta Kumar Mandal

“…In contrast, the concentration of free verapamil in the tissue increases with increasing injection velocities. …”
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Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern by Tuğba Günler, Pinar Karabağli, Hicret Tiyek, Özge Keskin, Muslu K. Körez

“…However, no statistically significant result was found regarding overall survival and progression-free survival of CCA cases with MSI. Conclusion: According to the findings, CRAs with comedo cribriform patterns are tumors with more aggressive features. …”
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Investigation of the Effects of Different Hydrophilic and Hydrophobic Comonomers on the Volume Phase Transition Temperatures and Thermal Properties of N-Isopropylacrylamide-Based H... by Ahmet Okudan, Abdullah Altay

“…Temperature-sensitive, random cross-linked terpolymers of NIPA were prepared from methyl methacrylate (MMA), N-tert-butylacrylamide (NTBA), and acrylic acid (AA) using a free radical polymerization method. In the synthesis of terpolymer hydrogels, N,N-methylene bisacrylamide (BIS) was used as cross-linkers and ammonium persulfate (APS) as initiator. …”
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Inferring the energy cost of resistance to parasitic infection and its link to a trade-off by Frédéric Douhard, Carole Moreno-Romieux, Andrea B. Doeschl-Wilson

“…Among individuals, predicted responses assuming this positive energy cost conformed to the observed trade-off between resistance and storage, whereas a cost-free scenario incorrectly predicted no trade-off. …”
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Quantifying the Impact of Dysmenorrhea Symptoms on Quality-of-Life and Access to Oral Contraceptives by Income by Rhea Choksey, Rohan K. Mangal, Thor S. Stead, Terrika Jones, Rosa Flores, Latha Ganti

“…Most questions were multiple-choice while others permitted several answer selections or were free response. The data was analyzed using JMP statistical software…”
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Loss of p53 Expression in Gastric Epithelial Cells of Helicobacter pylori-Infected Jordanian Patients by Mohammad A. Abu-Lubad, Ghada F. Helaly, Weliam J. Haddadin, Dua’a A. K. Jarajreh, Amin A. Aqel, Munir A. Al-Zeer

“…Paraffin-embedded gastric biopsy samples from the archives for 50 Jordanian patients diagnosed with chronic H. pylori infection and 25 samples free of H. pylori infection and any other gastric abnormalities were selected. …”
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Time-Optimal Trajectory Planning along Parametric Polynomial Lane-Change Curves with Bounded Velocity and Acceleration: Simulations for a Unicycle Based on Numerical Integration by Chien-Sheng Wu, Zih-Yun Chiu, Jing-Sin Liu

“…This paper presents the comparative study of time-optimal velocities to minimize the time needed for traversal of three planar symmetric parametric polynomial lane-change paths followed by an autonomous vehicle, assuming that the neighboring lane is free. A simulated model based on unicycle that accounts for the acceleration and velocity bounds and is particularly simple for generating the time-optimal path parameterization of each lane-change path is adopted. …”
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Adipose-Derived Mesenchymal Stem Cells Promote M2 Macrophage Phenotype through Exosomes by June Seok Heo, Youjeong Choi, Hyun Ok Kim

“…Thus, iMΦ may be used as a novel stem cell-based cell-free therapy for the treatment of immune-mediated inflammatory disorders.…”
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Effects of Regional Trade Agreement to Local and Global Trade Purity Relationships by Siyu Huang, Wensha Gou, Hongbo Cai, Xiaomeng Li, Qinghua Chen

“…This indicates that although global and most regional trade relations gradually deteriorated during the period 2007–2017, RTAs generate trade relations among members, especially contributing to the relative prosperity of European Union (EU) and North American Free Trade Agreement (NAFTA) countries. In addition, we apply the network to reflect the purity of the trade relations among countries. …”
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The impact of temperature on cotton yield and production in Xinjiang, China by Yongyan Zhao, Yumeng Zhu, Shouli Feng, Ting Zhao, Luyao Wang, Zhihong Zheng, Nijiang Ai, Xueying Guan

“…Results show that Xinjiang has a shorter frost-free period (140–210 days) compared to the U.S. (235–300 days). …”
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NMR Analysis Method of Gas Flow Pattern in the Process of Shale Gas Depletion Development by Rui Shen, Zhiming Hu, Xianggang Duan, Wei Sun, Wei Xiong, Hekun Guo

“…When the reservoir pressure is higher than the critical desorption pressure, the adsorbed gas is not desorbed intensively, and the produced gas is mainly free gas. When the reservoir pressure is lower than the critical desorption pressure, the adsorbed gas is gradually desorbed, and the proportion of desorbed gas in the produced gas gradually increases.…”
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Berlin Congress 1878 Through the Eyes of Phanariot Alexander Karateodori Pashi by R. Mihneva, V. Kolev

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Tackling somatic DNA contamination in sperm epigenetic studies by Anamika Kumari, Anamika Kumari, Rajender Singh, Rajender Singh

“…However, detecting and dealing with somatic DNA contamination in semen samples can be a challenging task.MethodsIn the present study, we worked out a detailed and robust plan to deal with somatic cell DNA contamination in sperm epigenetic studies in order to draw error-free scientific conclusions. Apart from incorporating simple quality checks, such as microscopic examination and somatic cell lysis buffer (SCLB) treatment, we compared the Infinium Human Methylation 450K BeadChip data for sperm and blood samples to identify the CpG sites that were highly methylated in blood samples in comparison to sperm, but were unrelated to infertility.Results and discussionThe comparison of Infinium Human Methylation 450K BeadChip data for sperm and blood samples identified 9564 CpG sites that can be used as markers for analyzing somatic DNA contamination. …”
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Malathion-Induced Hematoxicity and Its Recovery Pattern in Barbonymus gonionotus by Cynthia E. Mrong, Md. R. Islam, Kamrunnaher Kole, Nusrat N. Neepa, Md. J. Alam, Md. R. Haque, Umme O. Rahman, Golam M. Mostakim

“…An experiment was conducted to assess malathion-induced hematological responses of Barbonymus gonionotus (silver barb) and its recovery patterns in malathion-free water. Fish (45 days old) were exposed to two sublethal concentrations, namely, 25% and 50% (i.e., 3.78 and 7.56 ppm) of LC50 (15.13 ppm) of malathion for 28 days, followed by a postexposure recovery period for the same time. …”
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A Retroperitoneal Leiomyosarcoma Presenting as an Adrenal Incidentaloma in a Subject on Warfarin by Ishrat N. Khan, Mohamed A. Adlan, Michael J. Stechman, Lakdasa D. Premawardhana

“…Cortisol after 1 mg dexamethasone, urinary free cortisol and catecholamines, plasma aldosterone renin ratio, and 17-hydroxyprogesterone were within the reference range. …”
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Administrative and legal principles of formation of tariffs for freight transportation by railway transport by Voroniatnikov O.

“…Currently, there is a clear division of tariffs into state-regulated tariffs and free tariffs for which JSC “Ukrzaliznytsia” independently sets the cost of services. …”
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Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil by Mariam Charkviani, Natia Murvelashvili, Francisco Barrera, Alisha Sharma, Randa Sharag Eldin, Nur Un Nisa Nabil

“…The patient’s symptoms and ECG findings gradually resolved, and two days later on discharge, patient was chest pain free and ECG was normal. This case supports the vasospastic hypothesis of 5-FU cardiac toxicity, describes its clinical course, and emphasizes the importance of better awareness and early recognition of the rare side effect as it may allow physicians to reduce the risk of life-threatening complications.…”
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Data Temperature Informed Streaming for Optimising Large-Scale Multi-Tiered Storage by Dominic Davies-Tagg, Ashiq Anjum, Ali Zahir, Lu Liu, Muhammad Usman Yaseen, Nick Antonopoulos

“…Cold data can be migrated away from high-performance nodes to free up performance for higher priority data. Existing studies classify hot and cold data primarily on the basis of data age and usage frequency. …”
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In Vitro Ability of a Novel Nanohydroxyapatite Oral Rinse to Occlude Dentine Tubules by Robert G. Hill, Xiaohui Chen, David G. Gillam

“…The aim of the study was to investigate the ability of a novel nanohydroxyapatite (nHA) desensitizing oral rinse to occlude dentine tubules compared to selected commercially available desensitizing oral rinses. Methods. 25 caries-free extracted molars were sectioned into 1 mm thick dentine discs. …”
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Vascular Guidance: Microstructural Scaffold Patterning for Inductive Neovascularization by Daniel Muller, Harvey Chim, Augustinus Bader, Matthew Whiteman, Jan-Thorsten Schantz

“…All prefabricated constructs transferred as free flaps survived and were viable. We term this concept “vascular guidance,” whereby neovascularization is guided through customized channels in a scaffold. …”
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