Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations by Ismail Hdoufane, Mehdi Oubahmane, Youssef Habibi, Christelle Delaite, Mohammed M. Alanazi, Driss Cherqaoui

“…Moreover, through a systematic analysis, MD simulations and MM-GBSA binding free energy calculations revealed that the best candidates Ergotamine, S55746, NPC478048, Lifirafenib, and NPC77101 are highly stable drug candidates in complex with TMPRSS4, displaying low RMSD and RMSF values with strong binding stability. …”
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Changes in Texture and Flavor of Dehydrated Shiitake Mushroom during Rehydration by LI Qianyu, CAO Xuehui, ZHUO Qiuchen, YOU Kaiyan, LIANG Zhitang, ZHU Danshi

“…In addition, the antioxidant activity of mushroom rehydrated at 40 ℃ was higher than that of mushroom rehydrated at 100 ℃, the loss of soluble protein was less, and the content of free amino acids was higher and reached its maximum after 30 min. …”
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The The Pluralistic Method Exploration on Mathematics Learning: A Case Study of Students with Diverse Academic Skill Levels by Mewa Zabeta, Nikmah Nurvicalesti, Ratnasari Ratnasari, Isania Marsel Viliyati

“…Member checking means getting confirmation from teachers or students about the research findings so the findings remain objective and free of bias during the data collection and analysis process. …”
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Successful Resection of Isolated Para-Aortic Lymph Node Recurrence from Advanced Sigmoid Colon Cancer following 156 Courses of FOLFIRI Regimen by Kaoru Takeshima, Kazuo Yamafuji, Atsunori Asami, Hideo Baba, Nobuhiko Okamoto, Hidena Takahashi, Chisato Takagi, Kiyoshi Kubochi

“…The patient maintained a good quality of life without any side effects throughout the whole course of his treatment and remains disease-free at 24 months without chemotherapy after resection of the isolated PLN. …”
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THE PROBLEM OF SEARCHING THE MEANING OF HUMAN EXISTENCE: CONTEMPORARY CONTEXT by V. M. Petrushov, V. M. Shapoval

“…The decisive force, which may encourage nudging to the positive changes, can be either the free will of people who have realized the criticality of the situation or external natural and social circumstances that will make people reorganize radically. …”
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Fat droplets in the cerebrospinal fluid (CSF) spaces of the brain by Mark Reed, Christopher Miller, Cortney Connor, Jason S. Chang, Forshing Lui

“…It is rare to find free floating fat droplets in the cerebral spinal fluid (CSF) spaces of the brain. …”
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A Simulation Study on the Swelling and Shrinking Behaviors of Nanosized Montmorillonite Based on Monte Carlo and Molecular Dynamics by Kaiwen Tong, Jianhua Guo, Shanxiong Chen, Fei Yu, Shichang Li, Zhangjun Dai

“…The results showed that the basal spacing, free swelling ratio, and void ratio were positively correlated with water content but were inversely proportional to the change of CEC. …”
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Synthesis and Characterization of Bioactive Acylpyrazolone Sulfanilamides and Their Transition Metal Complexes: Single Crystal Structure of 4-Benzoyl-3-methyl-1-phenyl-2-pyrazolin-... by Omoruyi G. Idemudia, Alexander P. Sadimenko, Anthony J. Afolayan, Eric C. Hosten

“…A moderate to low biological activities have been exhibited by synthesized compounds when compared with standard antimicrobial agents on screening the synthesized compounds against Staphylococcus aureus, Bacillus pumilus, Proteus vulgaris, and Aeromonas hydrophila for antibacterial activity and against free radical 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) for antioxidant activity.…”
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Multistaged In Silico Discovery of the Best SARS-CoV-2 Main Protease Inhibitors amongst 3009 Clinical and FDA-Approved Compounds by Ibrahim H. Eissa, Abdulrahman M. Saleh, Sara T. Al-Rashood, Abdul-Aziz M. M. El-Attar, Ahmed M. Metwaly

“…Finally, MM-PBSA studies were conducted and indicated the favorable bonding of the Mpro-levobupivacaine complex with a free energy value of −235 kJ/mol. The fulfilled outcomes hold out hope of beating COVID-19 through more in vitro and in vivo research for the named compounds.…”
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Use of Coontail as a Natural Phytoremediation Feed Additive for Common Carp by Kiziloğlu Ümmühan, Yıldırım Önder, Çantaş İsmail Berat

“…Ceratophyllum demersum is a submerged, rootless, free-floating macrophyte and natural aquatic phytoremediation. …”
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Speciation of heavy metals in coastal water of Qeshm Island in the Persian Gulf by A.R. Karbassi, S. Tajziehchi, H. Khoshgalb

“…According to the results, HSC diagrams showed that Cu and Cd were present as free ions. Lead, manganese, cobalt, zinc and nickel were respectively present as PbOH, MnOH, ZnOH, CoOH and NiOH in the Persian Gulf. …”
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Identification and characterization of antibacterial peptides produced by Lactobacillus plantarum 1407 by Silpa Sajan, Rupachandra Saravanan

“…L. plantarum culture exhibited maximum antibacterial activity at 40 °C, pH 8, and 0.7% salt concentration. The cell-free supernatant (CFS) was concentrated using a 3 kDa ultrafiltration membrane and the peptide fractions (<3 kDa) were further fractionated using Sephadex G-25 gel filtration chromatography. …”
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State tax policy in Ukraine: historical and legal aspect (based on the example of the XX century) by G. L. Gufman

“…Since January 1, 1946 a war tax was cancelled, and since September of the same year the free minimum for workers and employees was raised. …”
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Recent Advances in Three-Dimensional Stem Cell Culture Systems and Applications by Xiaowen Wu, Junxiang Su, Jizhen Wei, Nan Jiang, Xuejun Ge

“…In this review, we first present three-dimensional cell culture methods from two aspects: a scaffold-free culture system and a scaffold-based culture system. …”
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Small cell lung cancer with EML4-ALK fusion: report of a case responding to ALK TKI and literature review by Mingyue Wang, Hongzhi Liu, Ruixin Zhang, Runyu Li, Xiaoyu Qin, Fangling Ning, Lijun Tian

“…ALK inhibitor is currently being taken orally, and significant clinical response has been achieved. Progression-free survival (PFS) was more than 8 months. Result ALK rearrangement of SCLC is rare. …”
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Improvement of the knock-in effciency in the genome of human induced pluripotent stem cells using the CRISPR/Cas9 system by М. М. Gridina

“…Finally, I describe the most promising strategies, one-step reprogramming and genome editing, which allows gene-modifed integration-free hiPS cells to be efciently generated directly from somatic cells.…”
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Oxytocin attenuates demand for cocaine in female rats by Amy S. Kohtz, Hannah Davies, Belle Lin, Gary Aston-Jones

“…Using a within-session threshold behavioral economics (BE) procedure, we quantified demand elasticity (a, inverse motivation) and free consumption (Q0) in male and female rats to investigate the effect of OXT on cocaine demand. …”
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Influence of Deviatoric Stress on the Deformation and Damage Evolution of Surrounding Rock under Unloading Conditions by Gongyu Hou, Jinping Liang, Haoyong Jing, Jinxin Tan, Yongkang Zhang, Xi Yang, Xin Xie

“…When deviatoric stress increased to a relatively higher level, the radial strain rates were highly unstable, and the surrounding rock near or at the opening free surface was damaged locally and regionally. …”
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Discoloration Effects of High-Dose γ-Irradiation and Long-Term Thermal Aging of (U)HMW-PE by Anja Kömmling, Emmanouil Chatzigiannakis, Jörg Beckmann, Volker Wachtendorf, Kerstin von der Ehe, Ulrike Braun, Matthias Jaunich, Ulrich Schade, Dietmar Wolff

“…Therefore, the yellowing is assumed to originate from annealable color centers in the form of free radicals that are trapped in the crystalline regions of the polymer and recombine at elevated temperatures. …”
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Academic Motivation of Master Students Studying Pedagogical Science: Case of KFU by G. I. Ibragimov, A. A. Kalimullina, M. G. Ibragimov

“…Didactic conditions were experimentally promoted that enhance the motivational potential of research-oriented learning (taking into account the characteristics and levels of development of the corresponding types of students’ motivation; creating real opportunities for free choice of research topics for Master students; using work in pairs as a form of organizing educational and research activities; using a complex of stimulating methods for evaluating the study results). …”
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