Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study by Gian Luca Erre, Matteo Piga, Anna Laura Fedele, Silvia Mura, Alessandra Piras, Maria Luisa Cadoni, Ignazio Cangemi, Martina Dessi, Gabriele Di Sante, Barbara Tolusso, Elisa Gremese, Alberto Cauli, Arduino Aleksander Mangoni, Pier Sergio Saba, Ciriaco Carru, Gianfranco Ferraccioli, Alessandro Mathieu, Giuseppe Passiu

“…To define the prevalence and determinants of peripheral microvascular endothelial dysfunction (ED) in a large series of rheumatoid arthritis (RA) patients free of previous cardiovascular events. Materials and Methods. …”
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Microtubule inhibition as a proposed mechanism for the anthelmintic effect of phytochemicals isolated from Cicerbita alpina by Mark James Horgan, Ines Sigg, Ioanna Poulopoulou, Francisco J. Rodriguez-Mejias, Eva Albertini, Pietro Fusani, Florian Fischer, Eftychia Martinidou, Daniela Schuster, Stefan Martens, Pidder Jansen Dürr, Matthias Gauly, Hermann Stuppner, Alexander Weiss, Veronika Temml, Bianka Siewert

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Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment incl... by Hidekazu Hirano, Naoki Takahashi, Yusuke Amanuma, Nobumi Suzuki, Daisuke Takahari, Takeshi Kawakami, Chie Kudo-Saito, Kengo Nagashima, Narikazu Boku, Ken Kato, Hirokazu Shoji

“…The primary endpoint is 6-month progression-free survival (PFS) rate. The target number of patients was set at 45 based on threshold and expected 6-month PFS rates of 35% and 60%, respectively, with a one-sided alpha error of 0.05 and power of 0.95. …”
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The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors by Jiajun Zhou, Jiajun Zhou, Wenhao An, Lei Guan, Lei Guan, Jinyu Shi, Qiaozhen Qin, Shuai Zhong, Zheng Huang, Rui Liu, Chenxing Wu, Zhong Ma, Xueling Qi, Xiaoxia Jiang, Yan Wang, Shouwei Li

“…Notably, PD-1 expression was identified as an independent prognostic factor for progression-free survival (PFS) and recurrence-free survival (RFS).ConclusionOur study highlighted the distinct characteristics of T cell infiltration and the significant expression of immune checkpoints in CNS GCTs, revealing the highly heterogeneous and immunosuppressive nature of the tumor microenvironment. …”
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TARGET Protein: the effect of augmented administration of enteral protein to critically ill adults on clinical outcomes—statistical analysis plan for a cluster randomized, cross-se... by Sophie Zaloumis, Matthew J. Summers, Jeffrey J. Presneill, Rinaldo Bellomo, Lee-anne S. Chapple, Marianne J. Chapman, Adam M. Deane, Suzie Ferrie, Craig French, Sally Hurford, Nima Kakho, Matthew J. Maiden, Stephanie N. O’Connor, Sandra L. Peake, Emma J. Ridley, An Tran-Duy, Patricia J. Williams, Paul J. Young, Amalia Karahalios, on behalf of the TARGET Protein Investigators, the Australian, New Zealand Intensive Care Society Clinical Trials Group

“…The primary outcome is the number of days free of the index hospital and alive at day 90. Secondary outcomes include proportion of patients alive at day 90, survivor-only analysis of days free of the index hospital at day 90, duration of invasive ventilation, ICU and hospital length of stay, incidence of tracheostomy insertion, renal replacement therapy, and discharge destination. …”
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Efek Pemberian Vitamin C Terhadap Aktifitas Katalase Hati Tikus Galur Wistar yang Terpapar Ion Pb by Elmatris Sy, Husnil Kadri, Eti Yerizel

“…Vitamin C is a non-enzymatic antioxidants, natural compounds that are strong antioxidants and free radical binding. This study to determine the Effect of Vitamin C to catalase activity of rat-wistar strain-liver. …”
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Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections by J Alfred Witjes, Alina Vrieling, Mihai G Netea, Leo A B Joosten, Katja K H Aben, Sita H Vermeulen, Joost L Boormans, Antoine G van der Heijden, Boris Novakovic, Jelmer H van Puffelen, Liesbeth van Emst, Denise Kooper, Tahlita C M Zuiverloon, Ursula T H Oldenhof, Tessel E Galesloot, Lambertus A L M Kiemeney, Egbert Oosterwijk

“…Gene-based association analysis of genetic variants in candidate trained immunity genes and their association with recurrence-free survival and progression-free survival after BCG therapy was performed to investigate the hypothesized link between trained immunity and clinical response.Results We found that intravesical BCG does induce trained immunity based on an increased production of TNF and IL-1β after heterologous ex vivo stimulation of circulating monocytes 6–12 weeks after intravesical BCG treatment; and a 37% decreased risk (OR 0.63 (95% CI 0.40 to 1.01)) for respiratory infections in BCG-treated versus non-BCG-treated NMIBC patients. …”
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Multicentre adaptive randomised trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin versus calcineurin inhibitor-based or sirolimu... by Simon Gates, Matthew Collin, Victoria Potter, Rebecca Bishop, Ronjon Chakraverty, Kavita Raj, Adrian Bloor, Andrea Hodgkinson, Jeff Davies, Emma Kempshall, Fiona Dignan, Ram Malladi, Siobhan Smith, Charlotte Gaskell, Gabrielle Smith

“…The primary outcome measure is GvHD-free, relapse-free survival at 1 year. Secondary outcomes include cumulative incidence of acute grade II-IV GvHD at 1 year, cumulative incidence of moderate and severe chronic GvHD at 1 year, overall survival at 1 year and cumulative incidence of non-relapse mortality at 1 year.Ethics and dissemination The protocol was approved by the West Midlands, Edgbaston Research Ethics Committee (20/WM/0195); initial approval was received on 11 September 2020, current protocol version (V.4.0) approval on 25 July 2023. …”
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An Optimal Fourth-Order Finite Difference Scheme for the Helmholtz Equation Based on the Technique of Matched Interface Boundary by Dongsheng Cheng, Jianjun Chen, Guangqing Long

“…To tackle this issue, the matched interface boundary (MIB) method is employed and developed, which is originally used to accommodate free edges in the discrete singular convolution analysis. …”
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Threshold Dynamics of a Huanglongbing Model with Logistic Growth in Periodic Environments by Jianping Wang, Shujing Gao, Yueli Luo, Dehui Xie

“…If R0 < 1, then the disease-free periodic solution is globally asymptotically stable and if R0 > 1, then the disease persists. …”
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Structural Features and Transcriptional Activity of Chicken PPARs (α, β, and γ) by Ichiro Takada, Mime Kobayashi

“…The chicken PPAR-gamma (cPPARγ) gene is shorter than that in humans and lacks a γ2 isoform. Moreover, in serum-free media, cPPARγ shows high transcriptional activity without exogenous ligands. …”
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Cosmic Rays Report from the Structure of Space by A. Annila

“…In this spectral feature, known as the “knee,” we relate to a distance of about 1.3 Mpc where the gravitational potential tallies the energy density of free space. At higher energies particles decelerate in a dissipative manner to attain thermodynamic balance with the vacuum. …”
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Protocol for generating liver metastasis microtissues to decipher cellular interactions between metastatic intestinal cancer and liver tissue by Maria Lamprou, Ana Krotenberg Garcia, Saskia Jacoba Elisabeth Suijkerbuijk

“…Here, we present a protocol for generating matrix-free microtissues recapitulating cellular interactions between intestinal cancer and hepatocyte-like cells using microscopy or transcriptomics/proteomics. …”
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Les nouveaux modes de gestion de la proximité euromaghrébine by Jean-Robert Henry

“…Whereas the European Union’s Mediterranean politics has been deadlocked and slow to react to the “Arab spring”, national strategies have more and more a free hand to compete with each other. While Germany moves economic leverage to broaden influence, François Hollande France moves diplomatic and military leverage to take back initiative in North and North-West Africa, putting aside the most questionable aspects of previous French president’s action. …”
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Human rights, television popular culture and the telenovela by John van Zyl

“…Such an attempt ap pears to involve two incompatible Ideas: highmindedness and Ideallsm on the one hand, and free choice and commerciallam on the other. However, there could be a way out. …”
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An optimized knight traversal technique to detect multiple faults and Module Sequence Graph based reconfiguration of microfluidic biochip by Basudev Saha, Mukta Majumder

“…The proposed approach also enumerates the traversal time for a fault‐free biochip. In addition to identifying the faulty electrodes, a Module Sequencing Graph based reconfiguration technique is proposed here to reinstate the device for normal bioassay operation.…”
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Impact of cloud cover on local remote sensing – Piaśnica River case study by Paszkuta Marcin

“…Here we are dealing with free-of-charge and generally available sources of satellite-based information. …”
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Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes by J. M. Liebler, S. L. Kunkel, R. M. Allen, M. D. Burdick, R. M. Strieter

“…In order to define the conditions under which human monocytes express MCP-1, monocytes were exposed to IFN-γ, IL- lβ, TNF-α, IL-4 or PHA under serum free conditions. There was no significant MCP-1 production by monocytes following exposure to IL-lβ, TNF-α or IL-4. …”
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``Prenatally diagnosed gastroschisis: A case report'' by Sakshi Dudhe, MBBS, Devyansh Nimodia, MBBS, Gaurav V. Mishra, MD, Pratapsingh Hanuman Parihar, MD, Anjali Kumari, MBBS, Rishitha Kotla, MBBS

“…The defect is characterized by the absence of a covering membrane, resulting in the free floating of extruded abdominal contents. Major complications associated with this condition include stillbirth, preterm delivery, and intrauterine growth restriction. …”
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Representation of the Expression of Ndebele Customary Law of Inheritance in Selected Educational Works in Zimbabwean Schools by Cordial Bhebe, Bekithemba Dube

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