Adeno-associated virus-based gene therapy for hemophilia–addressing the gaps by Wolfgang Miesbach, Paul Batty, Pratima Chowdary, Sylvia Fong, Radoslaw Kaczmarek, Frank W.G. Leebeek, Brian Long, Johnny Mahlangu, Mike Makris, Glenn F. Pierce, Steven W. Pipe, Alok Srivastava, Jan Voorberg, Flora Peyvandi

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Nanoliposomal L-Asparaginase and Its Antitumor Activities in Lewis Lung Carcinoma Tumor-Induced BALB/c Mice by Thi Thao Do, Thi Phuong Do, Thi Nga Nguyen, Thi Cuc Nguyen, Thi Thu Phuong Vu, Thi Giang An Nguyen

“…This is the first time the antitumor activities of PEGylated nanoliposomal L-ASP have been assessed in LLC carcinoma tumor-induced BALB/c mice and showed significantly improved pharmacological properties compared to those of free L-ASP (P<0.05). Thus, nanoliposomal L-ASP should be considered for its widening applications against carcinoma tumors.…”
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Short- and Long-term Outcomes of One-stage Radical Resection and Anastomosis without Preoperative Decompression and Diverting Stoma between Incomplete Obstructive and Non-obstructi... by Kentaro Sato, Yosuke Fukunaga, Manabu Takamatsu, Tatsuki Noguchi, Takashi Sakamoto, Shimpei Matsui, Toshiki Mukai, Tomohiro Yamaguchi, Takashi Akiyoshi

“…However, the rates of anastomotic leakage (2.1% vs. 2.3%, P=1), the 5-year overall survival (91.5% vs. 93.7%, P=0.436), and the 5-year relapse-free survival (80.2% vs. 85.6%, P=0.195) were comparable between the groups. …”
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Socially inclusive valorization of gold mill tailings from the small-scale gold mining sector by R.M. Balanay, R.P. Varela, A. Balbin, M.A. Lavapiez

“…Elevated levels of mercury, lead, and free cyanide were detected in the wastewater, with concentrations of 0.029 milligram per liter, 0.40 milligram per liter, and 1.9 milligram per liter, respectively, surpassing the allowable thresholds. …”
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RAS/BRAF Circulating Tumor DNA Mutations as a Predictor of Response to First-Line Chemotherapy in Metastatic Colorectal Cancer Patients by Jiannan Yao, Wanchun Zang, Yang Ge, Nathaniel Weygant, Pan Yu, Lei Li, Guanhua Rao, Zhi Jiang, Rui Yan, Linjia He, Yang Yu, Mulan Jin, Gang Cheng, Guangyu An

“…Patient clinicopathologic features and RAS/BRAF gene mutation status were evaluated by survival analysis for disease-free survival (DFS) and progression-free survival (PFS). …”
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A Circulating Subpopulation of Monocytic Myeloid-Derived Suppressor Cells as an Independent Prognostic/Predictive Factor in Untreated Non-Small Lung Cancer Patients by Eleni-Kyriaki Vetsika, Filippos Koinis, Marianthi Gioulbasani, Despoina Aggouraki, Anna Koutoulaki, Eirini Skalidaki, Dimitris Mavroudis, Vassilis Georgoulias, Athanasios Kotsakis

“…Increased percentages of monocytic-MDSCs were associated with worse response to treatment (P=0.02) and patients with normal levels of CD14+CD15+CD11b+CD33+HLA-DR−Lin− had longer overall survival and progression free-survival compared to those with high levels (P=0.008 and P=0.005, resp.). …”
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Metastatic Uterine Leiomyosarcoma in the Upper Buccal Gingiva Misdiagnosed as an Epulis by Andrea Cassoni, Valentina Terenzi, Davina Bartoli, Oriana Rajabtork Zadeh, Andrea Battisti, Mario Pagnoni, Davide Conte, Alessandro Lembo, Sandro Bosco, Francesco Alesini, Valentino Valentini

“…Even if resection was achieved in free margins, “local” relapse was observed 5 months after surgery.…”
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TROPION-Breast04: a randomized phase III study of neoadjuvant datopotamab deruxtecan (Dato-DXd) plus durvalumab followed by adjuvant durvalumab versus standard of care in patients... by Heather L. McArthur, Sara M. Tolaney, Rebecca Dent, Peter Schmid, Jamil Asselah, Qiang Liu, Jane Lowe Meisel, Naoki Niikura, Yeon Hee Park, Gustavo Werutsky, Giampaolo Bianchini, Jay C. Andersen, Robert Kozarski, Nana Rokutanda, Barbara Pistilli, Sibylle Loibl

“…Dual primary endpoints are pathological complete response by blinded central review and event-free survival by investigator assessment. Secondary endpoints include overall survival (key), distant disease-free survival, patient-reported outcomes, and safety. …”
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Synthesis and in-situ Mo microalloying of CuCr alloy by aluminothermic self-propagating reduction by Jin-ru Han, Zhi-he Dou, Ting-an Zhang, Wang An

“…It is found that the addition of Mo can effectively reduce the Gibbs mixing free energy Gm of CuCr melt and the Gibbs mixing free energy change ΔGm of melt before and after liquid phase decomposition. …”
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Tolerability and Effectiveness of Regorafenib Treatment in Patients with Unresectable Hepatocellular Carcinoma: Real-World Data from the United States by Finn RS, Iyer R, Kalman RS, Parikh ND, Cabrera R, Babajanyan S, Kaseb AO

“…Additional endpoints included overall survival and progression-free survival. Groups were compared descriptively.Results: Of 1005 patients, 65 were from the US and 940 were from other countries. 91% of patients in the US subset (n=59) and 92% in the non-US subset (n=862) experienced ≥ 1 TEAE. …”
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Children’s Eating Behavior Questionnaire Correlated with Body Compositions of Thai Children and Adolescents with Obesity: A Pilot Study by Ekkarit Panichsillaphakit, Yuda Chongpison, Puthita Saengpanit, Tanisa Kwanbunbumpen, Jaraspong Uaariyapanichkul, Sirinuch Chomtho, Chitsanu Pancharoen, Chonnikant Visuthranukul

“…However, Emotional Overeating was associated with fat-free mass index (correlation coefficient = 0.24, p=0.02) and girls with obesity had lower scores in “Slowness in Eating” compared to boys [mean 2.1 versus 1.8, 95% CI: (−0.06, −0.01), p=0.04]. …”
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Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches by Hui Qu, Bao-dong Xie, Jian Wu, Bo Lv, Jun-bo Chuai, Jian-zhong Li, Jun Cai, Hua Wu, Shu-lin Jiang, Xiao-ping Leng, Kai Kang

“…After 4 weeks, the rats repaired with this cell-seeded, cytokine-immobilized patch presented preserved cardiac function, beneficial morphology, enhanced cell infiltration, and functional vessel formation compared with the cytokine-free (MSC patch), cell-free (GF patch), or blank controls (EDC patch). …”
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Preparation and characterization of new silica-based heterofunctional biocatalysts utilizing low-cost lipase Eversa® Transform 2.0 and evaluation of their catalytic performance in... by Wagner C. A. Carvalho, Rayane A. S. Freitas, Milson S. Barbosa, Ariela V. Paula, Ernandes B. Pereira, Adriano A. Mendes, Elton Franceschi, Cleide M. F. Soares

“…Moreover, it obtained a productivity around 4.45 times that of free ET2.0 lipase, maintaining its original activity until the fourth cycle. …”
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Natural Concurrent Infections with Black Spot Disease and Multiple Bacteriosis in Farmed Nile Tilapia in Central Kenya by Daniel W. Wanja, Paul G. Mbuthia, Robert M. Waruiru, Lilly C. Bebora, Helena A. Ngowi

“…Physicochemical parameters of pond water were temperature (28.2°C), dissolved oxygen (4.2 mgl−1), pH (8.5), ammonia free nitrogen (15.8 mgl−1), alkalinity (112 mgl−1), hardness (68 mgl−1), nitrites (0.058 mgl−1), nitrates (58 mgl−1), and phosphates (0.046 mgl−1). …”
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Analysis of thyroid function and structure and serum metabolomics in pregnant rats exposed to airborne contaminants: Combined perchlorate, thiocyanate, and nitrate exposure by Chenchen Wang, Xiaohui Xu, Jiangling Yuan, Ran An, Aierken Taxitiemuer, Yan Zhang, Tao Luo, Jing Zhou, Chang Wang, Ling Zhang, Shunhua Wu

“…We used liquid chromatography-tandem mass spectrometry metabolomics methods to investigate corresponding changes in serum metabolites and metabolic biomarkers and identify metabolism-related pathways. Results: Free triiodothyronine levels in the medium-and high-concentration groups and free thyroxine levels in the low-, medium-, and high-concentration groups were significantly lower than those in the control group. …”
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Lithuanian exile press during five decades of soviet ban by Silvija Vėlavičienė

“…The Lithuanian exile press underwent a difficult journey to free itself from censorship and suppression. The restrictions and bans on the exile press were lifted only in July 1989, marking the end of a press ban that lasted nearly five decades. …”
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The significance of risk stratification through nomogram-based assessment in determining postmastectomy radiotherapy for patients diagnosed with pT1 − 2N1M0 breast cancer by Chao Wei, Jie Kong, Huina Han, Xue Wang, Zimeng Gao, Danyang Wang, Andu Zhang, Jun Zhang, Zhikun Liu

“…PMRT led to a significant improvement in disease-free survival (DFS) among patients in the intermediate and high-risk groups (P = 0.036, P = 0.001), whereas the low-risk group did not experience a significant benefit (P = 0.475). …”
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Near telomere-to-telomere genome assemblies of Silkie Gallus gallus and Mallard Anas platyrhynchos restored the structure of chromosomes and “missing” genes in birds by Qiangsen Zhao, Zhongtao Yin, Zhuocheng Hou

“…We successfully annotated 20,253 and 19,621 protein-coding genes for Silkie and Mallard, respectively, and assembled gap-free sex chromosomes in Mallard for the first time. …”
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Solo Sonographically Guided PCNL under Spinal Anesthesia: Defining Predictors of Success by Akbar Nouralizadeh, Hamid Pakmanesh, Abbas Basiri, Mohammad Aayanifard, Mohammad Hossein Soltani, Ali Tabibi, Farzaneh Sharifiaghdas, Seyed Amir Mohsen Ziaee, Naser Shakhssalim, Reza Valipour, Behzad Narouie, Mohammad Hadi Radfar

“…Solo ultrasonographically guided PCNL under spinal anesthesia is feasible with an acceptable stone-free rate and complication rate.…”
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Outcomes in stage IIA versus stage IIB/III in the PALLAS trial [ABCSG-42/AFT-05/PrE0109/BIG-14-13]) by A. DeMichele, A. C. Dueck, D. Hlauschek, M. Martin, H. Burstein, G. Pfeiler, N. Zdenkowski, A. Wolff, M. Bellet-Ezquerra, E. Winer, M. Balic, K. Miller, M. Colleoni, D. Lake, G. Rubovsky, D. Cameron, J. Balko, C. F. Singer, Z. Nowecki, H. Iwata, N. Wolmark, K. A. Parraga, H. Rugo, G. G. Steger, T. Traina, G. Werutsky, D. Czajkowska, O. Metzger, S. El-Abed, K. P. Theall, R. D. Lu, P. O’Brien, C. Fesl, E. Mayer, M. Gnant

“…Additionally, no benefit to palbociclib was seen in this cohort in invasive breast cancer-free survival (iBCFS), locoregional relapse-free survival (LRFS), distant relapse-free survival (DRFS), or overall survival (OS). …”
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