Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study by Haiqing Zhao, Wei Zhang, Yuting Lu, Yin Dong, Zhihao He, Hongchao Zhen, Qin Li

“…The primary endpoint was the objective response rate (ORR); the secondary endpoints were disease control rate, overall survival (OS), and progression‐free survival (PFS). The trial was registered at ClinicalTrials.gov (NCT05809336). …”
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From the Banks of the Orkhon to the Banks of the Neva: the History of Mining and Transit of Mongolian Gold to the Russian Empire at the beginning of the 20th century. by Aldar A. Shirapov, Anna M. Plekhanova

“…The strengthening of the ruble exchange rate and its free conversion provided the country with an influx of foreign investment, which contributed to the constant growth of its economy. …”
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Phytochemical study and evaluation of the antidiabetic and antihyperglycemic activities of the fruit extracts of Physalis peruviana L. (Solanaceae) by Damien S.T. Tshibangu, Fortune S. Kavugho, Carlos N. Kabengele, Adrien T. Masunda, Gédéon N. Bongo, Giresse N. Kasiama, Domaine T. Mwanangombo, Clément L. Inkoto, Clément M. Mbadiko, Benjamin Z. Gbolo, Désiré M. Musuyu, Dorothée D. Tshilanda, Jean Paul K.N. Ngbolua, Pius T. Mpiana

“…On the one hand, polyphenols (flavonoids, tannins and anthocyanins) were identified in the aqeous extract, while free quinones were not ; on the other hand, steroids and terpenoids were revealed in the organic extract, while bound quinones were absent. …”
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USP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer by Zhongdong Xie, Hanbin Lin, Yuecheng Wu, Yanan Yu, Xintong Liu, Yating Zheng, Xiaojie Wang, Jiashu Wu, Meifang Xu, Yuting Han, Qiongying Zhang, Yu Deng, Lin Lin, Yan Linzhu, Li Qingyun, Xinjian Lin, Ying Huang, Pan Chi

“…Furthermore, a multicenter cohort study demonstrated that upregulated CENPF expression was strongly associated with poorer disease-free survival in CRC. Functional experiments showed that CENPF knockdown inhibited CRC cell invasion and metastasis both in vitro and in vivo. …”
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Assessment of Tumor Burden Score as a Feasible and Reliable Tool for Prognosis Prediction for Hepatocellular Carcinoma Undergoing Hepatectomy: A Multicenter, Retrospective Study by Guan R, Zheng Z, Deng M, Mei J, Lin Y

“…Overall survival (OS) and recurrence-free survival deteriorated incrementally with increasing TBS (P< 0.0001). …”
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Evaluation of reproductive and oncological outcomes after fertility-sparing surgery in cervical cancer patients with tumor > 2 cm by Kiarash Bahrehmand, Dóra Vesztergom, Barna Budai, Dániel Lengyel, Edina Lukács, Zoltán Novák

“…The primary objective was to evaluate the reproductive outcomes including the method of conception, postoperative pregnancy rate, fertility preservation rate, live birth rate, and preterm delivery rate, while the secondary objective was to evaluate 5-year disease-free survival (DFS) and 5-year overall survival (OS). …”
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Poor outcome despite modern treatments: A retrospective study of 99 patients with primary and secondary plasma cell leukemia by Camille Tessier, Richard LeBlanc, Jean Roy, Sabrina Trudel, Julie Côté, Marc Lalancette, Jean‐Samuel Boudreault, Émilie Lemieux‐Blanchard, Rayan Kaedbey, Michel Pavic

“…The median progression‐free survival (PFS) to frontline treatment and overall survival (OS) were, respectively, 4.8 (95% CI, 0.4–9.2) and 18.3 months (95% CI, 0.0–39.0) for pPCL and 0.8 (95% CI, 0.5–1.1) and 1.2 months (95% CI, 0.9–1.5) for sPCL (both p < 0.001). …”
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A comparative study of the production of methyl esters from non-edible oils as potential feedstocks: Process optimization and two-step biodiesel characterization by Jassinnee Milano, Mei Yin Ong, Sieh Kiong Tiong, F. Ideris, A.S. Silitonga, A.H. Sebayang, Chung Hong Tan, I.M.R. Fattah, Zahra Fona, Nazia Hossain

“…This study focuses on the biodiesel potential of Jatropha curcas, Calophyllum inophyllum, and Ceiba pentandra oils, which are rich in free fatty acids.This study explores the biodiesel potential of Jatropha curcas, Calophyllum inophyllum, and Ceiba pentandra oils, focusing on developing a unified set of process conditions for effectives conversion. …”
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Aligning strategic and participatory approaches to agri‐environment scheme design and implementation to enhance nature recovery outcomes by D. J. Baker, C. Nye, R. Wheeler, C. Masquelier, A. Binner, K. J. Gaston, M. S. Heard, M. Lobley, D. Smith, I. M. D. Maclean

“…This requires uniting knowledge across disciplines and cultures and ensuring that information is shared to support progressive refinement of scheme design and guidance towards achieving overall nature recovery goals. Read the free Plain Language Summary for this article on the Journal blog.…”
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Looking at Infrared Background Radiation Anisotropies with Spitzer: Large-scale Anisotropies and Their Implications by A. Kashlinsky, Richard G. Arendt, M. L. N. Ashby, J. Kruk, N. Odegard

“…The fluctuations are demonstrated to be free of Galactic and solar system foreground contributions out to the largest scales measured. …”
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Comparative study of the effects of different lipid oxidation simulation systems on the physicochemical properties of proteins isolated from four cultivated walnut (Juglans sigilla... by Wenyun Xiong, Lixin Ding, Wendie Cui, Lei Zhao, Shengbao Cai

“…In three simulation systems, YBWPI showed the greatest changes in carbonyl value, free sulfhydryl value and intrinsic fluorescence intensity. …”
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Urban vegetation and well‐being: A cross‐sectional study in Montreal, Canada by Rita Sousa‐Silva, Yan Kestens, Zoé Poirier Stephens, Benoit Thierry, Daniel Schoenig, Daniel Fuller, Meghan Winters, Audrey Smargiassi

“…Likewise, using different measures of well‐being may provide a more nuanced and comprehensive understanding of how vegetation impacts people's well‐being. Read the free Plain Language Summary for this article on the Journal blog.…”
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High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT) by Yuxuan Ding, Yong Feng, Yangfan Ye, Jiayi Shen, Chang Guo, Xia He, Liangjun Zhu, Lijun Wang

“…Secondary endpoints included the objective response rate (ORR), progression-free survival (PFS) and overall survival (OS). The study results showed that at three dose levels—single doses of 6Gy (n=3), 8Gy (n=3), and 10Gy (n=3)—the most common treatment-related adverse events (TRAEs) were nausea, vomiting, fatigue, and abnormal liver function. …”
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Describing viewpoints on human‐nature relationships to unveil socio‐environmental conflicts and support community‐based projects by Beatriz Demasi, Nina Garcia de Almeida Prado, Flávia Pereira Lima, Charbel N. El‐Hani, Renata Pardini

“…As a way of collectively reflecting about local perspectives on human‐nature relationships, the tool facilitates collaboration and finding ways forward. Read the free Plain Language Summary for this article on the Journal blog.…”
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Sex-specific differences in fit between two different types of body armour: A pilot study by Buttner Claire, Tiller Sharne-Louise, Vollenweider Nash, Canetti Elisa, Schram Ben, Dawes Jay, Lockie Robert, Orr Robin

“…After completing a variety of tasks, officers provided feedback on a subjective mannequin sketch and provided free text comments. Results. The heavier MBA received more negative comments than LEBA. …”
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Exploring avocado consumption and health: a scoping review and evidence map by Stephen A. Fleming, Tristen L. Paul, Rachel A. F. Fleming, Alison K. Ventura, Megan A. McCrory, Corrie M. Whisner, Paul A. Spagnuolo, Louise Dye, Jana Kraft, Jana Kraft, Nikki A. Ford

“…Interventions assessed the impact of diets enriched in monounsaturated fatty acids, diets higher/lower in carbohydrates, or in free-feeding conditions. Larger amounts of avocados were used in interventions than commonly consumed in observational studies (60–300 vs. 0–10 g/d, respectively). …”
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Quality improvement of plant-based white chocolate enriched with encapsulated blueberry juice by Rossi Indiarto, Natallina Wiranto Putri, Fetriyuna Fetriyuna, Edy Subroto, Arif Nanda Irawan, Dimas Rahadian Aji Muhammad, Mohd Nizam Lani

“…Therefore, this research presents a promising chocolate formula that is both appealing and healthy, particularly for consumers seeking lactose-free and vegan products.…”
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Challenges of early renal cancer detection: symptom patterns and incidental diagnosis rate in a multicentre prospective UK cohort of patients presenting with suspected renal cancer by Michelle Wilson, Naveen S Vasudev, Grant D Stewart, Adebanji Adeyoju, Jon Cartledge, Michael Kimuli, Shibendra Datta, Damian Hanbury, David Hrouda, Grenville Oades, Poulam Patel, Naeem Soomro, Mark Sullivan, Jeff Webster, Peter J Selby, Rosamonde E Banks

“…Comprehensive clinico-pathological and outcome data were also collected.Outcomes Type and frequency of reported symptoms, incidental diagnosis rate, metastasis-free survival and cancer-specific survival.Results Of 706 patients recruited between 2011 and 2014, 608 patients with a confirmed RCC formed the primary study population. …”
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Conservation and ecological screening of small water bodies in temperate riverine wetlands using UAV Photogrammetry (Middle Danube) by Dušanka Cvijanović, Maja Novković, Djuradj Milošević, Milica Stojković Piperac, Laszlo Galambos, Dubravka Čerba, Olivera Stamenković, Bojan Damnjanović, Minučer Mesaroš, Dragoslav Pavić, Vladica Simić, Ivana Trbojević, Ana Anđelković, Nusret Drešković, Barbara Stammel, Bernd Cyffka, Snežana Radulović

“…Conversely, sites experiencing eutrophication and a poor oxygen regime with species-poor fish assemblages correlated positively with a higher cover of amphibian and free-floating vegetation, as well as filamentous algae. …”
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Community disaster exposure and first onset of depression: A panel analysis of nationally representative South African data, 2008-2017. by Andrew Tomita, Busisiwe P Ncama, Yoshan Moodley, Rashieda Davids, Jonathan K Burns, Tafadzwanashe Mabhaudhi, Albert T Modi, Rob Slotow

“…We used panel data from the South African National Income Dynamics Study (SA-NIDS) from 2008-2017, consisting of 17,255 adult study participants who were depression free at baseline. Risk of first depression onset between individuals exposed and unexposed to community disaster was measured, accounting for multiple disaster exposure over time by fitting generalized estimating equation (GEE) regression models. …”
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