The prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in colorectal cancer and colorectal anastomotic leakage patients: a retrospe... by Nuo Xu, Jian-Xin Zhang, Jia-Jie Zhang, Zhuo Huang, Lian-Chun Mao, Zhi-Yong Zhang, Wei-Dong Jin

“…Kaplan–Meier survival curve results showed that 5-year overall survival (OS) and disease-free survival (DFS) in the low NLR and PLR group were significantly higher than those in the high NLR and PLR group. …”
Get full text

Effects of perioperative treatment of resectable adenocarcinoma of esophagogastric junction by immunotherapy (Adebrelimab) combined with chemotherapy (XELOX): protocol for a single... by Yingyi Li, Yuqin Cao, Xipeng Wang, Chengqiang Li, Liqin Zhao, Hecheng Li

“…Secondary outcomes of the study include the objective response rate (ORR), R0 resection rate, major pathological response (MPR) rate, and pCR rate in combined positive score(CPS) ≥ 5 and MSI-H populations, event-free survival (EFS), and overall survival (OS). The exploratory outcomes are the biomarkers related to therapeutic efficacy, such as PD-L1 expression, microsatellite instability (MSI), tumor mutational burden(TMB), Epstein-Barr virus(EBV) infection, and circulating tumor DNA(ctDNA). …”
Get full text

Factors Affecting Utilization of Insecticide Treated Nets in Households Among Children Under Five Years of Age in Kazo Town Council, Kazo District. by Tumwebaze, Rodgers

“…The study recommended that plans be made to increase the number of free ITN s distributed to households, increase in community education and public awareness on ITN use.…”
Get full text

Factors Affecting Male Involvement in Family Planning at Kazo Health Center IV in Kazo Town Council Kazo District. by Ndyaguma, Laban

“…On recommendation the government should establishment of men's clinics so that men can feel free to go and utilize the services. The services should be user friendly to men in order to be utilized to the maximum Male only clinics should inform men about all family planning methods and provide condoms and vasectomy and counsel men with respect and sensitivity, more so Education, men need a lot of information on family planning so that they are well informed.…”
Get full text

Review of the Effectiveness of the Existing Municipal Solid Waste Management Systems in Uganda. Case Study of Kabale Municipal Council, Kabale Municipality, Kabale District. by Ainebyona, Joseph

“…Therefore, there is need for KMC to include all the people in working for the clean and health threat-free environment. The study also suggest that KMC should try to effect the existing systems plus adopting the modern techniques for the collection, transportation and disposing of solid waste in Kabale Municipality.…”
Get full text

Access to Primary Education By Children With Physical Disabilities in Bwambara Sub-County Rukungiri District. by Akatukunda, Faith

“…The recommendations that came out of the study were that schools should give admission to CWPD at a free cost, and Schools should put up a special desk for CWD so that when they come for admission they don't wait for long hours. …”
Get full text

Impact of Weed Infestation on Growth and Yield of Carrot Plants. by Mutabazi, Cosma

“…The above results generally indicated that marketable carrot root tubers were high compared to unmarketable ones simply because the blocks that were weeded experienced a weed-free environment which made carrot crops grow well and give high yields. …”
Get full text

Investigating Escherichia Coli (E. Coli) Contamination of Street Foods in Manjari Kabale District. by Unasi, Daniel

“…These foods were collected and analyzed and results showed that the food samples were E. coli free though contaminated with other bacterial species whose identity was not established. …”
Get full text

Integrated microbiome, transcriptome and metabolome insight into the alleviating mechanisms of sheep milk in a DSS-induced colitis mouse model by Wenna Yao, Ruilin Du, Shuo Yan, Teligun Bao, Huimin Zhang, Fang Yang, Yue Xue, Yulong Zhao, Siqin Bao, Xihe Li, Yongli Song

“…In this study, 30 mice were randomly divided into 3 groups. Mice had free access to sheep milk for 14 days, and free access to 2.5 % DSS started on the 7th day of SM administration and sustained for 7 days. …”
Get full text

Silicon photonic modulators with a 2 × 1 Fabry–Perot cavity by Cao Hengzhen, Xie Jin, Sun Weichao, Zhu Mingyu, Xiang Yuluan, Zhang Gong, Guo Jingshu, Shi Yaocheng, Dai Daoxin

“…Silicon photonics modulators based on a 2 × 1 Fabry–Perot (FP) cavity, which is circulator-free, are proposed and demonstrated by introducing two asymmetric multimode-waveguide grating (AMWG) reflectors and a short straight modulation section with interleaved PN junctions. …”
Get full text

Removal of Di (2-ethylhexyl) phthalate from groundwater by sodium persulfate activated by hollow micron zero-valent iron: Reaction mechanism and degradation path by Chunyang Gao, Bing Wang, Jingjing Zhao, Jvfeng Li, Xianyuan Du, Jin Zheng, Quanwei Song, Jiacai Xie

“…Additionally, the contribution rate of free radicals in the degradation process of DEHP was in the order SO4-· > ·OH > 1O2. …”
Get full text

Combined effects of alginate based active edible coatings and irradiation treatment on the quality characteristics of Beef Meat at 2°C by Samir Smeti, Souha Tibaoui, Hayet Ben Haj Koubaier, Atef Lakoud, Naziha Atti

“…MYRT and ROS samples had the highest free radical scavenging activity (P<0.001) with an inhibition capacity of around 64.8 and 62.7%, respectively. …”
Get full text

Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway by Weiwei Tang, Xiaomin Huang, Yun-Di Yi, Fan Cao, Manli Deng, Jiawei Fan, Zheng-Xuan Jiang, Li-Ming Tao, Xianwen Wang, Lei Shi

“…This investigation demonstrated that esterified hyaluronic acid-curcumin nanoparticles (HA-CUR NPs) with superior aqueous dispersion exhibited exceptional antioxidant enzyme mimetic activity, incorporating superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and free radical scavenging ability. Further in vitro and in vivo experimental results validated the protective function of HA-CUR NPs against oxidative stress-induced damage and inflammatory responses, attenuated pathological progression, relieved microvascular damage, and regulated fundus blood flow in retinal vascular networks. …”
Get full text

Metabolite profile and antioxidant activities of Trikatu, black pepper, Javanese long pepper, and red ginger essential oils by Dewa Ayu Ika Pramitha, Tati Herlina, Iman Permana Maksum, Ari Hardianto, Abd. Wahid Rizaldi Akili, Jalifah Latip

“…Antioxidant activities of TR, BP, JLP, and RG essential oils was determined using the DPPH free radical scavenging assay. Results: The GC–MS analysis of BP, JLP, RG, and TR essential oils revealed the presence of 11 common compound, including linalool, caryophyllene, and beta-bisabolene. …”
Get full text

Photobiomodulation preconditioning for oral mucositis prevention and quality of life improvement in chemotherapy patients: a randomized clinical trial by Marwa Khalil, Omar Hamadah, Maher Saifo

“…After two weeks of follow-up, 80% of patients in Group 2 and 86.7% in Group 3 remained free of oral mucositis. The remaining patients in both groups experienced only mild erythema. …”
Get full text

CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells by You-Yu Liu, Wei-Lun Huang, Sin-Tian Wang, Hui-Ping Hsu, Tzu-Ching Kao, Wei-Pang Chung, Kung-Chia Young

“…Abstract Background HER2-positive patients comprise approximately 20% of breast cancer cases, with HER2-targeted therapy significantly improving progression-free and overall survival. However, subsequent reprogramed tumor progression due to PI3K signaling pathway activation by PIK3CA mutations and/or PTEN-loss cause anti-HER2 resistance. …”
Get full text

Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model by Liu RJ, Li M, Zhu Q, Liu HY, Zhang XX, Han XY, Yu MJ, Zhou JW, Han CY

“…In vivo testing and histopathological analysis demonstrated that the CAM-BE hydrogel significantly inhibited swelling in the rat auricle, compared to both the free CAM hydrogel and adapalene hydrogel.Conclusion: With their strong anti-inflammatory properties and improved skin penetration, binary ethosomes could be a viable new CAM delivery method. …”
Get full text

Multiphoton imaging-based quantifiable collagen signatures for predicting outcomes in patients with pancreatic ductal adenocarcinoma by Xiwen Chen, Jikui Miao, Xingxin Huang, Xiahui Han, Liqin Zheng, Jianxin Chen, Linying Chen, Lianhuang Li

“…A combination of label-free multiphoton imaging technique and computer-aided image processing method may offer a novel and promising approach for finding new biomarkers to improve prognosis prediction and thereby tailor treatment strategies more effectively.…”
Get full text

Impact of noninsulin-dependent diabetes mellitus (level of control) on sex hormone profile and erectile function by Abdullah A. Khawaji, Hossam S. El-Tholoth, Muath A. Albarakati, Bander A. Binjabaan, Abdulaziz Alzahrani, Abdulmajeed Althobity, Abdulmalik Almardawi, Khaled Bedaiwi, Mussa AlNuami

“…Well-controlled diabetics had lower BMI (P = 0.001), higher free testosterone (FT) (P = 0.0002), lower sex hormone-binding globulin (SHBG) (P = 0.0001), and higher IIEF scores (P < 0.0001) compared to the poorly controlled group, indicating better erectile function and potential benefits of weight management and improved testosterone availability. …”
Get full text

Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension by Heather L. Clark, Daniel Lachant, Allison N. Light, Deborah Haight, Samia Lopia, Nigel Mackman, R. James White

“…We generated platelet-free plasma and measured D-dimer, angiopoietin-2, thrombin time, soluble P-selectin, von Willebrand factor, and vascular endothelial growth factor. …”
Get full text