Cost Effectiveness Analysis of Eribulin Mesylate as a Treatment for Metastatic Breast Cancer in Spain: Management in the Later Line of Therapy by Gabriel Tremblay, Unnati Majethia, Ilias Kontoudis, Jesús De Rosendo

“…Model inputs were overall survival, progression-free survival and costs relating to chemotherapies, grade 3/4 adverse events and healthcare utilization. …”
Get full text

Lipotoxicity and metabolic disorders at obesity by V. T. Ivashkin, M. V. Mayevskaya

“…It is possible to explain lipotoxicity phenomenon as follows: in conditions of insulin resistance glucose stops to be an energy source and is substituted by lipolysis, therefore a plenty of free fatty acids is formed, having potential of toxicity and realizing metabolic disorders in target organs: the liver, the pancreas, muscles. …”
Get full text

5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects by Liangliang Hu, Ting Meng, Davies Marabada, Zhichao Jin, Qing Huang, Shijie Wei, Zhizhong Wang

“…Pharmacokinetic analyses revealed that 5-FUSA-β-CD and 5-FUBA-β-CD were eliminated slowly and their half-lives were longer than that of free 5-FU. Distinct linkers were meticulously designed and synthesized to generate 5-Fluorouracil-β-Cyclodextrin conjugates that exhibit differential anti-colon cancer activity and half-lives. …”
Get full text

Effect of Motor Blockage on Transient Characteristics of Asymmetric Flow in a Double-suction Centrifugal Fan by S. Du, X. Wu, Z. Wang, W. Yang, Z. Yang, Z. Wang, W. Zhang

“…Numerical results reveal that compared with the baseline motor-free model, the motor blockage of the two models decreases the flow rate by 30.4% and 20.8%, respectively, at the obstructed inlet of the fan, and the inflow is non-uniform and presents a local reversed flow. …”
Get full text

Efficiency of a macroroughness block ramp in reducing the impact of low-head dams on riverine fish dispersion by Tomanova Sylvie, Courret Dominique, Richard Sylvain, Mercier Olivier, Guillemin Axel, Labedan Mathilde, Sagnes Pierre

“…Macroroughness ramps (e.g. with a rough bed and protruding blocks evenly distributed in staggered rows) are nature-like fishways offering a wide range of flow conditions and are expected to be very efficient tools to reduce the impact of weirs on the free movements of most life-stages of riverine fish species. …”
Get full text

Physical determinants of daily physical activity in older men and women. by Laura Karavirta, Timo Aittokoski, Katja Pynnönen, Timo Rantalainen, Kate Westgate, Tomas Gonzales, Lotta Palmberg, Joona Neuvonen, Jukka A Lipponen, Katri Turunen, Riku Nikander, Erja Portegijs, Taina Rantanen, Søren Brage

“…<h4>Methods</h4>In this cross-sectional study, a population-based cohort of 75, 80, and 85-year-old men and women (n = 409, 62% women) underwent laboratory-based assessment of walking speed, maximal knee extension strength, and body fat percentage. Free-living physical activity was assessed as total PAEE, and light (LPA) and moderate-to-vigorous physical activity (MVPA) using individually calibrated combined accelerometry and heart rate sensing. …”
Get full text

Plasma mcfDNA Sequencing May Improve Usual Care Diagnostics to Detect HHV-8 Among Outpatient People with Advanced HIV by Sarah Park, Brian Epling, Morgan Richey, Daniel Lupu, Mona Mughar, Irini Sereti

“…Methods: Pathogen-agnostic plasma microbial cell-free DNA sequencing was applied to banked samples from 116 outpatients included in 2 previous prospective studies of patients with antiretroviral treatment-naïve, advanced HIV (CD4 count ≤100 cells/µL). …”
Get full text

Treatment Interruption and Regimen Change in Firstgeneration versus Second-generation Tyrosine Kinase Inhibitors used as First-line Therapy for Chronic Myeloid Leukemia by Melea A. Ward, Gang Fang, Kristy L. Richards, Christine M. Walko, Stephanie R. Earnshaw, Laura E. Happe, Susan J. Blalock

“…**Background:** Research has shown that treatment interruptions are associated with worse failure-free survival in chronic myeloid leukemia (CML); however they are commonly used in clinical trials to manage adverse events. …”
Get full text

Beliefs about HIV cure: A qualitative study of people living with HIV in Soweto, South Africa by Fatima Laher, Naledi Mahlangu, Mbalenhle Sibiya

“…Thirdly, anticipated socio-behavioural effects: beliefs existed that cures might improve happiness, reduce emotional burdens of disclosure, facilitate HIV-free generations, increase risk behaviours, and reduce health checks, but not change societal attitudes to HIV. …”
Get full text

Phosphaturic mesenchymal tumor: Clinicopathological features with outcomes in 10 patients with review of literature by Vivek C. Parameshwar, Bharat Rekhi, Ashwini Duggad, Mukta Ramadwar

“…All those patients were free of disease until the last follow-up. Conclusion: This constitutes the first largest comprehensive study on these rare tumors from our country. …”
Get full text

Dramatic response of advanced pulmonary sarcomatoid carcinoma to tislelizumab combined with anlotinib: a case report by Ranran Li, Xiliang Di, Yuan Li, Hao Li, Chonghua Liu

“…At this point, the patient has achieved over a year of progression-free survival, with overall survival exceeding 39 months. …”
Get full text

An injectable, expandable polyacrylamide cryogel decreases blood loss and improves survival in a porcine model of junctional hemorrhage by Al-Murtadha Al-Gahmi, Syed Muntazir Andrabi, S. M. Shatil Shahriar, Carlos P. Jara, Jingwei Xie, Mark A. Carlson

“…They underwent transection of the right femoral artery/vein, followed by 30 s of free bleed, 3 min of manual compression, and observation for up to 3 h. …”
Get full text

The effect of the nisin-based pharmaceutical formulation used in the treatment plan for cows with subclinical mastitis on the milk microbiota by M. N. Isakova, Ya. Yu. Lysova

“…A microbiological testing of cow milk on day 14 from the beginning of the treatment showed that the number of microbiota-free samples increased to 88.6%, while in 1.4% of cases Staphylococcus aureus isolates were recovered (103 CFU/mL). …”
Get full text

Protective and immunomodulatory effects of the novel probiotic yeast Pichia kudriavzevii isolated from a home-made kefir during infection in human colon epithelial cells: An explor... by Angela Maione, Marianna Imparato, Annalisa Buonanno, Marilena Galdiero, Elisabetta de Alteriis, Marco Guida, Emilia Galdiero

“…In this study we aimed to explore the protective effects of a probiotic yeast Pichia kudriavzevii (Y1) and its cell-free supernatant (CFS-Y1) during infection simulated in vitro using Caco-2 cells. …”
Get full text

Investigating the Association between Healthy Eating Index and Early Childhood Caries in Iranian Preschool Children: A Case-Control Study by Maryam Mehrabkhani, Taraneh Movahhed, Mohsen Nematy, Melika Hoseinzadeh, Homeira Mohammadi

“…Methods: In the current case-control study, 732 preschool children (aged 3–6 years) were examined for dental caries and then categorized into two groups of children with ECC, or who were Caries-Free (CF). Then, the HEI was measured by analyzing a validated food frequency questionnaire, which their parents were requested to complete. …”
Get full text

A comparative dataset on the GC–MS analysis and antioxidant activity of Selaginella bryopteris from different geolocations of IndiaMendeley Data by Utkarsha Srivastava, Ashwani Mathur

“…The comparative antioxidant assessment of the extracts from all three geolocations was undertaken by three different methods of free radical scavenging activity by DPPH assay, FRAP assay and total antioxidant capacity determination by Phosphomolybdate assay. …”
Get full text

Polymerase chain reaction for detection of some highly dangerous viral fish disease agents by A. S. Tarasova, A. V. Perchun, V. P. Melnikov

“…Pathogen spread often occurs during the transportation of fish from infected farms to the disease-free ones. Therefore, the import of fish stocking material to Russia from countries with a different epidemic situation requires risk-based monitoring and forecasting. …”
Get full text

Sulfatase modifying factor 2 as a predictive biomarker for urothelial carcinoma by Wei-Ting Kuo, Yi-Chen Lee, Jia-Bin Liao, Ching-Jiunn Tseng, Yi-Fang Yang

“…High SUMF2 mRNA levels were associated with poor overall survival (OS) and disease-free survival (DFS) in bladder UC (BLCA) from The Cancer Genome Atlas (TCGA) dataset. …”
Get full text

Initiating agri‐environmental collaboration at landscape scale requires bridging structures, regional facilitators and addressing the expectations of actors by Stefan Schüler, Isabelle Arimond, Annika Hass, Menko Koch, Jule M. Huber, Volker Ruwisch, Manuel Bartens, Tobias Plieninger, Catrin Westphal

“…This is particularly relevant when local actors have little experience with joint measure implementation and institutional framework conditions for collaborative governance are limited or not provided. Read the free Plain Language Summary for this article on the Journal blog.…”
Get full text

THE USING OF DIGITAL TOOLS IN THE PROJECT ACTIVITIES OF STUDENTS OF PEDAGOGICAL SPECIALTIES OF HIGHER EDUCATION INSTITUTIONS by Liudmyla Nezhyva, Svitlana Palamar, Nataliia Semenii

“…The main criteria for selecting digital tools were: simple interface (so students can master its functionality faster); compliance to the State Standard for Primary Education; didactic value; accessibility (the age of pupils and the ability to comprehend tasks developed with the help of the proposed digital tools were taken into account); technical and methodological support (present on all proposed digital resources, which facilitates understanding of their interface); very important criterion is the wide functionality on a free basis; the ability to adapt in various modern conditions during offline and online learning.  …”
Get full text