Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation by Edith Pituskin, Stephen Foulkes, Rachel J. Skow, Thomas McMurtry, Calvin Kruger, Janet E. Bates, Daena Lamoureux, Joseph Brandwein, Elena Lieuw, Cynthia Wu, Nancy Zhu, Peng Wang, Daniel Sawler, Minakshi Taparia, Marlene Hamilton, Tiffany Comfort-Riddle, Tara Meyer, Gabor T. Gyenes, Ian Paterson, Carla M. Prado, Mark J. Haykowsky, Justin G. Greiner, Margaret L. McNeely, Puneeta Tandon, Richard B. Thompson

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A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in He... by Lee HW, Kang WY, Park JS, Lee JH, Park JJ, Gwon MR, Yoon YR, Seong SJ

“…Hae Won Lee,1 Woo Youl Kang,2 Ji Seo Park,1 Jae Hwa Lee,1 Jin Ju Park,1 Mi-Ri Gwon,1 Young-Ran Yoon,1 Sook Jin Seong1 1School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea; 2Clinical Trial Dossier Evaluation Team, Innovative Products Support Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of KoreaCorrespondence: Young-Ran Yoon, Professor, School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, 130 Dongdeok-Ro, Jung-gu, Daegu, 41944, Republic of Korea, Tel +82-53-420-4950, +82-53-420-5218, Email yry@knu.ac.kr Sook Jin Seong, Clinical Associate Professor, School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, 130 Dongduk-Ro, Jung-gu, Daegu, 41944, Republic of Korea, Tel +82-53-200-6351, +82-53-420-5218, Email wintersj@knu.ac.krBackground: YYD601 is a new dual delayed-release formulation of esomeprazole, developed to enhance plasma exposure and prolong the duration of acid suppression.Purpose: This study aimed to evaluate the safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of YYD601 20 mg following single and multiple oral administrations in healthy, fasting adult Koreans, and to compare these outcomes to those of the conventional esomeprazole 20 mg capsule.Methods: A randomized, open-label, two-period crossover study was conducted in 28 participants, who were divided into two treatment groups: one group received YYD601 20 mg, and the other received conventional esomeprazole 20 mg, once daily for five consecutive days. …”
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Surgical Outcomes and Sociodemographic Disparities Across All Races: An ACS-NSQIP and NHIS Multi-Institutional Analysis of Over 7.5 Million Patients by Dany Y. Matar, BA, Samuel Knoedler, Anthony Y. Matar, BS, Sarah Friedrich, PhD, Harriet Kiwanuka, MD, Ryoko Hamaguchi, MD, Carla M. Hamwi, BS, Gabriel Hundeshagen, MD, MMS, Valentin Haug, MD, Ulrich Kneser, MD, PhD, Keisha Ray, PhD, Dennis P. Orgill, MD, PhD, Adriana C. Panayi, MD, PhD

“…Racial groups (excluding Hispanic patients) with superior surgical outcomes from the NSQIP analysis were found in the NHIS analysis to report higher wealth, better healthcare access, improved food security, greater functional and societal independence, and lower frailty. …”
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Molecular identification of chitinase and its function in growth of Odontobutis potamophila by Siyu Lu, Lin Du, Ting Zhang, Dan Wang, Jinjuan Wan, Guoxing Liu, Yuning Hu, Yu Xu, Zhiqiang Xu, Xuguang Li

“…Chitinases are pivotal enzymes for the degradation of chitin, which play a role in food digestion. However, the functional roles of chitinases in teleosts remain under-explored. …”
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Human versus Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings (HumAn-1): protocol for a randomised controlled trial by Éimhín Ansbro, Jing Luo, Chung-Chou H Chang, Kaushik Ramaiya, Bruce L Rollman, Sylvia Kehlenbrink, Sae-Rom Chae, Abigail Foulds, Claire Josey, Christina Lalama, Margaret L Prust, Bedowra Zabeen, Graham Ogle

“…In settings where glycaemic control is typically poor and food insecurity is common, long-acting insulin analogues may offer tangible clinical benefits for people with T1D. …”
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Metabolic Profiling by UPLC–Orbitrap–MS/MS of Liver from C57BL/6 Mice with DSS-Induced Inflammatory Bowel Disease by Zhongquan Xin, Zhenya Zhai, Hongrong Long, Fan Zhang, Xiaojun Ni, Jinping Deng, Lunzhao Yi, Baichuan Deng

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International diet quality index and revised diet quality index relationship with type 2 diabetes disease: a case-control study by Amr Ali Mohamed Abdelgawwad El-Sehrawy, Bilal AbdulMajeed Mukhlif, Enwa Felix Oghenemaro, M. M. Rekha, Rohit Kumawat, Shilpa Sharma, M. Ravi Kumar, Nagat Salah Shalaby, Munthar Kadhim Abosaoda, Abed J. Kadhim

“…Research indicates that better dietary quality—higher intake of fruits, vegetables, and whole grains, and lower intake of processed foods—reduces T2DM risk. This study examines the relationship between T2DM and dietary quality indices (DQI-I and DQI-R) to determine if adherence can lower diabetes risk. …”
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Evaluation of seasonal variation, effect of extraction solvent on phytochemicals and antioxidant activity on Rosmarinus officinalis grown in different agro-ecological zones of Kiam... by Zelipha N. Kabubii, James M. Mbaria, Mbaabu P. Mathiu, John M. Wanjohi, Evans N. Nyaboga

“…Abstract Background Rosemary (Rosmarinus officinalis) is a commonly used culinary herb with great potential applications in the pharmaceutical, food, and cosmetics industries because of its reported bioactive phytochemicals and antioxidant properties. …”
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Eco-friendly alginate/PCL-TiO2 hybrid biocomposites: Preparation, properties, and methylene blue photodegradation by Bunga Fisikanta Bukit, Agus Wedi Pratama, Erna Frida, Bakti Berlyanto Sedayu, Dina Fransiska, Deni Purnomo, Emma Rochima, Istiqomah Rahmawati, Sona Suhartana, Firda Aulya Syamani

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Prevention Of Breast and Endometrial cancer using Total Diet Replacement (PROBE-TDR) trial: protocol for a randomised controlled trial by Robert Clarke, Emma J Crosbie, Basil G Issa, John Belcher, Helen Clarke, Anthony Howell, Michelle Harvie, Hannah Harrison, Cheryl Lombardelli, Suzanne Krizak, Katharine Sellers, Yit Y Lim, Caroline Parkin, Shruthi Patel, Anthony J Maxwell, Julie Wisely, Sacha J Howell

“…The TDR programme includes an initial 12-week period of TDR (850 kcal/day) followed by a 40-week food-based diet, based on the nutritional principles of a Mediterranean diet, as either continued weight loss (~1500 kcal/day) or weight loss maintenance (~2000 kcal/day). …”
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The health promoting sports coach: theoretical background and practical guidance by Benjamin Tézier, Kévin Barros, Susanna Geidne, Farid Bardid, Spartaco Grieco, Stacey Johnson, Sami Kokko, Barry Lambe, Arthur Lefebvre, Aoife Lane, Linda Ooms, Jan Seghers, Vassilis Sevdalis, Stephen Whiting, Anne Vuillemin, Aurélie Van-Hoye

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Functional Analysis of Durum Wheat GASA1 Protein as a Biotechnological Alternative Against Plant Fungal Pathogens and a Positive Regulator of Biotic Stress Defense by Mohamed Taieb Bouteraa, Walid Ben Romdhane, Alina Wiszniewska, Narjes Baazaoui, Mohammad Y. Alfaifi, Anis Ben Hsouna, Miroslava Kačániová, Stefania Garzoli, Rania Ben Saad

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Intricating connections: the role of ferroptosis in systemic lupus erythematosus by Guowang Zhao, Xinghai Li, Ying Zhang, Ying Zhang, Xingzi Wang, Li Deng, Juan Xu, Shumei Jin, Zan Zuo, Zan Zuo, Linting Xun, Linting Xun, Mei Luo, Mei Luo, Fan Yang, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi, Ping Fu

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The impact of nationality status and place of residency on health-related social needs and quality of life among Palestinian Refugees in Jordan by Hamza Alduraidi, Rahaf Issam Abu Zayid, Noor Mahmoud Jaber, Bassam Saleh Hijazi, Sa'ed Radwan Khamis, Hasan Fahed Awad, Marah Al-Khateeb, Saif alnour Mahmoud Aldhirat, Ahmad Amjed Toubasi

“…Results: All participants had needs in the mental health domain, and 179 (75.8 %) suffered from food insecurity. Living in Gaza and Husn camps correlated with increased odds of safety needs (OR = 4.27, 95%CI: 1.541 to 11.76 and OR = 2.936, 95%CI: 1.942 to 9.147) and financial needs (OR = 6.135, 95%CI: 2.062 to 18.181 and OR = 3.932, 95%CI: 1.765 to 8.210) compared to living outside camps. …”
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A lightweight wheat ear counting model in UAV images based on improved YOLOv8 by Ruofan Li, Xiaohua Sun, Kun Yang, Zhenxue He, Zhenxue He, Xinxin Wang, Xinxin Wang, Chao Wang, Chao Wang, Bin Wang, Fushun Wang, Fushun Wang, Hongquan Liu, Hongquan Liu

“…Wheat (Triticum aestivum L.) is one of the significant food crops in the world, and the number of wheat ears serves as a critical indicator of wheat yield. …”
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Dynamic development of gut microbiota and metabolism during and after weaning of kittens by Hong Zhang, Yang Ren, Siyu Wei, Hongli Jin, Yizhen Wang, Mingliang Jin

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Whole-genome resequencing landscape of adaptive evolution in Relict gull (Larus relictus) by Chao Yang, Qingxiong Wang, Kuo Sun, Lei Luo, Hao Yuan, Xuejuan Li, Yuan Huang, Hong Xiao

“…The findings identified several genes associated with the correlated changed life-history traits of L. relictus, including BMP4 involved in beak adaptation; HAND2, NEUROG1, COL11A2, and EDNRB involved in the evolution of the palate, soft palate, and tongue; PIGR and PLCB2 involved in an enhanced response to bitter taste by sensing chemical secretions released by staple food substrate insects to activate protective mechanisms. …”
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Interactions between NAD+ metabolism and immune cell infiltration in ulcerative colitis: subtype identification and development of novel diagnostic models by Linglin Tian, Huiyang Gao, Tian Yao, Tian Yao, Yuhao Chen, Linna Gao, Jingxiang Han, Lanqi Zhu, He Huang, He Huang, He Huang

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Magnetic hybrid chitin-horse manure humic acid for optimized Cd(II) and Pb(II) adsorption from aquatic environment by Rahmat Basuki, Yusuf Bramastya Apriliyanto, Elva Stiawan, Adya Rizky Pradipta, Bambang Rusdiarso, Budi Riza Putra

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Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy by Min Guo, Yicong Wu, Chad M. Hobson, Yijun Su, Shuhao Qian, Eric Krueger, Ryan Christensen, Grant Kroeschell, Johnny Bui, Matthew Chaw, Lixia Zhang, Jiamin Liu, Xuekai Hou, Xiaofei Han, Zhiye Lu, Xuefei Ma, Alexander Zhovmer, Christian Combs, Mark Moyle, Eviatar Yemini, Huafeng Liu, Zhiyi Liu, Alexandre Benedetto, Patrick La Riviere, Daniel Colón-Ramos, Hari Shroff

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