Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway by Huili Jiang, Xuhui Zhang, Yu Wang, Huimin Zhang, Jing Li, Xinjing Yang, Bingcong Zhao, Chuntao Zhang, Miao Yu, Mingmin Xu, Qiuyun Yu, Xingchen Liang, Xiang Li, Peng Shi, Tuya Bao

“…Interestingly, H89 inhibited the effects of acupuncture or fluoxetine on upregulating the expression of p-CREB, but not PKA-α. …”
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Treatment Options for Psychotic Depression in Adolescents: A Comprehensive Review by Perez-Rodriguez V, Aymerich C, Catalan A, Jauhar S, Salazar de Pablo G

“…For mild cases with predominance of depressive symptoms, antidepressant monotherapy with a serotonin selective reuptake inhibitor (eg fluoxetine, sertraline or citalopram) could be trialed first. …”
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Cardiovascular Side Effects of Atomoxetine and Its Interactions with Inhibitors of the Cytochrome P450 System by Pashtoon Murtaza Kasi, Rawad Mounzer, George H. Gleeson

“…Atomoxetine is a phenoxypropylamine derivative and is structurally related to the antidepressant fluoxetine. The common side effects reported with the use of atomoxetine include mainly GI disturbances. …”
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Synthesis and Antidepressant Activity of Some New 5-(1H-Indol-3-yl)-3-(substituted aryl)-4,5-dihydroisoxazoline Derivatives by Pravin O. Patil, Sanjay B. Bari

“…Compounds 3d and 3j were found to be potent molecules of this series, when compared with the reference drugs imipramine and fluoxetine. It clearly demonstrated that replacement of aromatic core by appropriate heterocycles such as pyridine and pyrrole on the 5-(1H-Indol-3-yl)-3-(Phenyl)-4,5-dihydroisoxazoline (3a) would generate more potent derivatives. …”
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Stress Induced Acral Lick Dermatitis in a Domestic Rabbit: A Case Report by Mukesh Srivastava, Anil Ahuja, S. Kachhawaha, N. K Singh, Ankita Sharma, J. P. Kachhawa

“…Rabbit was successfully managed with oral fluoxetine and topical application of ointment containing fluocinolone acetonide in 0.025% concentration along with intralesional injection of hydrocortisone of 0.15 mL diluted in normal saline at two sites of a lesion at interval of one week. …”
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Psychiatric and Behavioral Complications of GPi DBS in an Adolescent with Myoclonus Dystonia by Graciela Kriegel, Melanie I. Stuckey

“…His first admission to a psychiatric unit was for management of a manic episode following treatment for depression with fluoxetine, and he began to exhibit severe aggressive behavior. …”
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Differential Cytotoxicity Responses by Dog and Rat Hepatocytes to Phospholipogenic Treatments by James K. Morelli, Paul J. Ciaccio

“…The lysosomal modulator Bafilomycin A1 (Baf) rescued dog cells from cytotoxicity caused by 3 phospholipogenic 5HT1b antagonists and hydroxychloroquine, but not fluoxetine, and rescued rat cells from hydroxychloroquine and NMTMB, a 5HT1b antagonist. …”
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The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease by Edward C. Lauterbach, Leonardo F. Fontenelle, Antonio L. Teixeira

“…., drugs least likely to promote cellular neurodegenerative mechanisms balanced against their likelihood of promoting neuroprotective mechanisms) include pramipexole, valproate, lithium, desipramine, escitalopram, and dextromethorphan. Fluoxetine favorably affects transcription of multiple genes (e.g., MAPT, GBA, CCDC62, HIP1R), although it and desipramine reduced MPTP mouse survival. …”
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Action inflexibility and compulsive-like behavior accompany neurobiological alterations in the anterior orbitofrontal cortex and associated striatal nuclei by Laura M. Butkovich, Sophie T. Yount, Aylet T. Allen, Esther H. Seo, Andrew M. Swanson, Shannon L. Gourley

“…We found that these mice also demonstrate insensitivity to Pavlovian-to-instrumental transfer, as well as compulsive-like grooming behavior that is ameliorated by fluoxetine and inhibitory, but not excitatory, chemogenetic modulation of excitatory OFC neurons. …”
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Bifidobacterium breve BB05 alleviates depressive symptoms in mice via the AKT/mTOR pathway by Yanni Pan, Qingling Huang, Yuan Liang, Yuwuqi Xie, Fang Tan, Xingyao Long

“…IntroductionThis study investigates the potential of Bifidobacterium breve BB05 (BB05) in mitigating depressive symptoms in a mouse model of Chronic Unpredictable Mild Stress (CUMS), with fluoxetine as a positive control.Methods and ResultsHigh-dose BB05 (1.0 × 109 CFU/kg, BB05H) significantly reduced anxiety- and depression-like behaviors in CUMS mice, as measured by the open field test, tail suspension test, and forced swim test. …”
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Development and Validation of a LC/MS/MS Method for the Determination of Duloxetine in Human Plasma and Its Application to Pharmacokinetic Study by D. Chandrapal Reddy, A. T. Bapuji, V. Surayanarayana Rao, V. Himabindu, D. Rama Raju, Syed Syedba, H. L. V. Ravikiran

“…A selective, high sensitive and high throughput liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method has been developed and validated for the chromatographic separation and quantitation of duloxetine in human EDTA plasma using fluoxetine (IS) as an internal standard. Analyte and IS were extracted from human plasma by liquid-liquid extraction using MTBE-n Hexane (80:20).The eluted samples were chromatographed on X-terra RP8 (50 mmx4.6 mm, 5 μm particle size) column by using mixture of 30 mM ammonium formate (pH-5.0±0.05) and acetonitrile as an isocratic mobile phase at a flow rate of 0.40 mL/min and analyzed by mass spectrometer in the multiple reaction monitoring (MRM) using the respective m/z 298.08→154.0 for duloxetine and 310.02→148.07 for IS. …”
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Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study by O. Malkesman, T. Asaf, L. Shbiro, A. Goldstein, R. Maayan, A. Weizman, N. Kinor, E. Okun, B. Sredni, G. Yadid, A. Weller

“…In the second phase, we examined the responsiveness of prepubertal WKY rats to different types of chronic antidepressant treatments: Fluoxetine, Desipramine, and dehydroepiandrosterone sulfate (DHEAS). …”
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Psychotropic Drugs in Dermatology Part 1: Anti-depressants and Mood Stabilisers by Varsha L. Kenkare, Bhushan Madke, Ankita Choudhary, Shiti Bose

“…These include selective serotonin reuptake inhibitors like citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline, alongside selective serotonin norepinephrine reuptake inhibitors such as venlafaxine, desvenlafaxine, and duloxetine. …”
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Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway by Peng Sun, Sheng Wei, Xia Wei, Jieqiong Wang, Yuanyuan Zhang, Mingqi Qiao, Jibiao Wu

“…Anger emotional stress led to abnormal expression of VEGF/VEGFR2 mRNA and protein and disorderly expression of key factors in the PI3K/AKT/mTOR signal pathway. Fluoxetine administration ameliorated behavioral abnormalities and damage to hippocampal neurons caused by anger emotional stress, as well as abnormal expression of some proteins in VEGF/VEGFR2 and its induced PI3K/AKT/mTOR signal pathway. …”
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Exploring voyeurism: a review of research by Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Justyna Drogoń, Edyta Gwóźdź, Adrian Muzyka, Julia Rydzek, Ewa Gardocka

“…Treatment primarily involves cognitive behavioral therapy (CBT), with pharmacological support using SSRIs like fluoxetine and paroxetine, showing effectiveness. Summary: The authors highlight the importance of further exploration into this topic and emphasize the need for a more accurate understanding of voyeurism's prevalence in the general population, as current data may be inconclusive.   …”
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Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing 5-HT3AR and 5-HT3BR Expression in the Rat Brain by Fang Li, Jizhen Feng, Dongmei Gao, Jieqiong Wang, Chunhong Song, Sheng Wei, Mingqi Qiao

“…PMS depression model rats were divided into depression and Shuyu- and fluoxetine-treated groups, which were compared to control rats for frontal lobe and hippocampal 5-HT3AR and 5-HT3BR expression and behavior. …”
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Myxedema Psychosis: Neuropsychiatric Manifestations and Rhabdomyolysis Unmasking Hypothyroidism by Sundus Sardar, Mhd-Baraa Habib, Aseel Sukik, Bashar Tanous, Sara Mohamed, Raad Tahtouh, Abdelrahman Hamad, Mouhand F. H. Mohamed

“…She was started on oral thyroxine 100 mcg/day, fluoxetine 20 mg daily, and as-needed haloperidol. She was closely followed and later transferred to the Psychiatry Hospital for further management. …”
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HEDDI-Net: heterogeneous network embedding for drug-disease association prediction and drug repurposing, with application to Alzheimer’s disease by Yin-Yuan Su, Hsuan-Cheng Huang, Yu-Ting Lin, Yi-Fang Chuang, Sheh-Yi Sheu, Chen-Ching Lin

“…A case study on Alzheimer's disease highlighted the model's practical applicability and interpretability, identifying potential drug candidates like Baclofen, Fluoxetine, Pentoxifylline and Phenytoin. Notably, over 40% of the predicted candidates in the clusters of commonly prescribed clinical drugs Donepezil and Galantamine had been tested in clinical trials, validating the model's predictive accuracy and practical relevance. …”
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A real-world analysis of antidepressant medications in US veterans aged 60 years and older: a comparative analysis by Ryan D Pittman, S Scott Sutton, Joseph Magagnoli, Tammy H Cummings

“…Patients prescribed bupropion, citalopram, duloxetine, escitalopram, fluoxetine, mirtazapine, paroxetine, sertraline, or venlafaxine were included. …”

Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance? by Monika Makar, Daria Michałka, Zuzanna Gałuszka, Natalie Papachristoforou, Justyna Głowacka, Aleksandra Kocjan, Emilia Bąk, Natalia Tekiela, Radosław Chmiel, Tomasz Bartuś

“…The combination of olanzapine and fluoxetine is effective for treating TRD, however, it may be associated with metabolic side effects. …”
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