Profiling endogenous airway proteases and antiproteases and modeling proteolytic activation of Influenza HA using in vitro and ex vivo human airway surface liquid samples. by Stephanie A Brocke, Boris Reidel, Camille Ehre, Meghan E Rebuli, Carole Robinette, Kevin D Schichlein, Christian A Brooks, Ilona Jaspers

“…The objective of this study was to first profile extracellular proteases and antiproteases using human airway epithelial cell cultures and ex vivo nasal epithelial lining fluid (NELF) samples. Secondly, we present an optimized method for probing the proteolytic environment of airway surface liquid samples (in vitro and ex vivo) using fluorogenic peptides modeling the cleavage sites of respiratory viruses. …”
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STRUCTURAL AND FUNCTIONAL CONDITION OF THE KNEE JOINT IN PATIENTS WITH MONOGONARTHROSIS IN THE STAGE OF EXACERBATION by Taras Khanyk

“…Research methods: questionnaire, orthopedic examination, X-ray diagnostics, arthroscopy, laboratory diagnostics of blood (determination of C-reactive protein (CRP) as a serological marker of inflammation), synovial fluid (analyses of physical properties, biochemical, cytological, bacteriological), statistical. …”
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In-Line and Cross-Flow Coupling Vibration Response Characteristics of a Marine Viscoelastic Riser Subjected to Two-Phase Internal Flow by Xueping Chang, Jinming Fan, Wenwu Yang, Yinghui Li

“…The finite element method is adopted to directly solve the highly coupled nonlinear fluid-structure interaction equations. Model validations are firstly performed through comparisons with the published experimental data and numerical simulation results, and the characteristic curves of the in-line and cross-flow vibration pattern, the in-line and cross-flow displacement trajectories, the in-line and cross-flow space-time response of displacement, and the in-line and cross-flow space-time response of stress versus different parameters are obtained, respectively. …”
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Efficiency of the Use of Humidified Gas Fuel and Oxidizing Mixture by B. S. Soroka, N. V. Vorobyov

“…It is shown that the efficiency of the fuel-using system can be significantly increased when the potential (excess total enthalpy) of the working fluid (combustion products) is activated. There are additiоnal benefits due to the fact that the existing heat of products of combustion with humid air in a full range of temperatures – from the theoretical combustion temperature to ambient temperature under conditions of equilibrium, including account of the heat of condensation – increases with increasing moisture content of the initial components of combustion, viz. air-oxidizer and/or fuel gas.…”
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Patient stratification by genetic risk in Alzheimer's disease is only effective in the presence of phenotypic heterogeneity. by Jack Euesden, Muhammad Ali, Chloe Robins, Praveen Surendran, Padhraig Gormley, Alzheimer’s Disease Neuroimaging Initiative (ADNI), David Pulford, Carlos Cruchaga

“…Genome-wide association studies identified no loci associated with progression at genome-wide significance (α = 5×10-8); MR analyses provided no significant evidence of an association between cognitive decline in AD patients and protein levels in brain, cerebrospinal fluid (CSF), and plasma. Polygenic risk scores for AD risk did not reliably stratify fast from slow progressors; however, a deeper investigation found that APOE ε4 status predicts amyloid-β and tau positive versus negative patients (odds ratio for an additional APOE ε4 allele = 5.78 [95% confidence interval: 3.76-8.89], P<0.001) when restricting to a subset of patients with available CSF biomarker data. …”
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Analysis of Multifactor Influence Model on Energy Dissipation Rate of Rough-Strips Energy Dissipator in the Spillway Bend by Honghong Zhang, Zhenwei Mu, Fan Fan, Fanqi Li

“…The multifactor influence model of the energy dissipation rate considered nine factors, including bend radius of curvature Rc, bend width B, flow velocity of the bend inlet v, R-SED’s average height hL, R-SED’s arrangement angle θ, R-SED’s arrangement spacing ∆L, fluid density ρ, dynamic viscosity coefficient μ, and gravitational acceleration g. …”
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Fibrous Dysplasia of the Ethmoid Bone Diagnosed in a 10-Year-Old Patient by Zofia Resler, Monika Morawska-Kochman, Katarzyna Resler, Tomasz Zatoński

“…The tumor causes bone defects in the area of the nasal bone, leading to fluid retention in the peripheral parts of the right maxillary sinus. …”
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Multimodal Imaging of Nonenhancing Glioblastoma Regions by Flóra John MD, Natasha L. Robinette MD, Alit J. Amit-Yousif MD, Edit Bosnyák MD, Geoffrey R. Barger MD, Keval D. Shah MD, Sandeep Mittal MD, Csaba Juhász MD, PhD

“…The AMT uptake and rCBV (expressed as tumor to normal [T/N] ratios) were compared in nonenhancing tumor portions showing increased signal on T2/fluid-attenuated inversion recovery (T2/FLAIR) images. …”
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Advances in physiological and clinical relevance of hiPSC-derived brain models for precision medicine pipelines by Negin Imani Farahani, Negin Imani Farahani, Negin Imani Farahani, Lisa Lin, Lisa Lin, Lisa Lin, Shama Nazir, Shama Nazir, Shama Nazir, Alireza Naderi, Alireza Naderi, Alireza Naderi, Leanne Rokos, Leanne Rokos, Leanne Rokos, Anthony Randal McIntosh, Anthony Randal McIntosh, Lisa M. Julian, Lisa M. Julian, Lisa M. Julian, Lisa M. Julian

“…Continued advances in tissue engineering combined with innovations in genomics, high-throughput screening and imaging strengthen the physiological relevance of hiPSC models and thus their ability to uncover disease mechanisms, therapeutic vulnerabilities, and tissue and fluid-based biomarkers that will have real impact on neurological disease treatment. …”
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5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation by Jinque Luo, Jinque Luo, Xin Li, Xin Li, Li Zhang, Li Zhang, Meijing Deng, Jieyang Zhao, Jinghuan Zhang, Wenyu Tang, Qinghua Guo, Ling Wang

“…In this study, we investigated the therapeutic potential of 5-deoxy-rutaecarpine (5-DR), a rutaecarpine derivative, in attenuating LPS-induced ALI.MethodsIn this study, we evaluated the effects of 5-DR treatment in mice exposed to LPS, lung tissues, bronchoalveolar lavage fluid, and serum were collected for analysis. LPS-stimulated J774A.1 mouse macrophages were used to further investigate the anti-inflammatory effects of 5-DR in vitro. …”
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Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease by Maria Galluzzo, Elisa Ciraolo, Monica Lucattelli, Eriola Hoxha, Martina Ulrich, Carlo Cosimo Campa, Giuseppe Lungarella, Gerd Doring, Zhe Zhou-Suckow, Marcus Mall, Emilio Hirsch, Virginia De Rose

“…Tissue damage was assessed by histology and morphometry and inflammatory cell number was evaluated in bronchoalveolar lavage fluid (BALF). Furthermore, we assessed the effect of a specific PI3Kγ inhibitor (AS-605240) on inflammatory cell number in BALF. …”
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Clinical case of a pelvic fracture with massive retroperitoneal hematoma by D.A. Krishtafor, A.A. Krishtafor, A.V. Tsarev, D.V. Balyk, A.Y. Halushchak, V.A. Pelekh

“…Due to the clinic of active bleeding, the patient repeatedly underwent control ultrasound examinations of the abdominal cavity and pleural sinuses, but the presence of free fluid in the abdominal cavity could be confirmed only after 12 hours of treatment. …”
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Caffeic acid phenethyl ester restores mitochondrial homeostasis against peritoneal fibrosis induced by peritoneal dialysis through the AMPK/SIRT1 pathway by Ying Lu, Luyan Gao, Wenwen Zhang, Ying Zeng, Ji Hu, Kai Song

“…In the present study, we explored whether adding caffeic acid phenethyl ester (CAPE) to peritoneal dialysis fluid (PDF) improved peritoneal fibrosis caused by PD and explored the molecular mechanism. …”
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Age influences the circulating immune profile in pediatric sepsis by Grace Fisler, Grace Fisler, Grace Fisler, Mariana R. Brewer, Mariana R. Brewer, Mariana R. Brewer, Omar Yaipen, Clifford S. Deutschman, Clifford S. Deutschman, Clifford S. Deutschman, Matthew D. Taylor, Matthew D. Taylor, Matthew D. Taylor

“…Patients were included if they were &lt; 21 years, admitted to the PICU, and received fluid resuscitation and antibiotics. Peripheral blood mononuclear cells were isolated from samples collected on PICU day 1.ResultsEighty patients were enrolled. …”
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Network of Mediators for Vascular Inflammation and Leakage Is Dysbalanced during Cytoreductive Surgery for Late-Stage Ovarian Cancer by Sven Klaschik, Jennifer Gehlen, Claudia Neumann, Mignon-Denise Keyver-Paik, Martin Soehle, Stilla Frede, Markus Velten, Andreas Hoeft, Tobias Hilbert

“…Cytoreductive surgery (CS) in late-stage ovarian cancer patients is often challenging due to extensive volume shifts, and high fluid intake may provoke postoperative complications. …”
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Hydration in young water polo players: A bioelectrical impedance vector analysis (BIVA) approach by Sofia Serafini, Andrea Di Blasio, Iris Prestanti, Andrea Di Credico, Andrea Fusco, Jacopo Cilli, Gabriele Mascherini, Ruggero D'Anastasio, Pascal Izzicupo

“…The resistance reduction indicates that BIVA captured the compensation for dehydration resulting from fluid intake.…”
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Epidemiological Characteristics of Meningococcal Meningitis (2016 to 2018) Four Years after the Introduction of Serogroup A Meningococcal Conjugate Vaccine in Benin by Togbemabou Primous Martial Godjedo, Alidehou Jerrold Agbankpe, Moussiliou Noël Paraiso, Tamegnon Victorien Dougnon, Marie Hidjo, Lamine Baba-Moussa, Honore Bankole

“…This is a prospective, descriptive, analytical study, and it took place from 2016 to 2018. Cerebrospinal fluid (CSF) samples were taken after the identification of meningitis cases. …”
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Radon on Mars and the Moon derived from Martian and lunar meteorites by Frédéric Girault, Ludovic Ferrière, Carine Sadaka, Íñigo de Loyola Chacartegui Rojo, Rémi Losno, Frédéric Moynier, Frédéric Perrier, Pierre-Yves Meslin

“…Abstract The radioactive gas radon-222, a fluid and aerosol tracer in Earth’s lithosphere and atmosphere, can also reveal subtle rock physics processes in extraterrestrial environments, such as those involving water, but remains poorly constrained in planetary bodies due to the limited number of samples available. …”
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Exploring natural convection and heat transfer dynamics of Al2O3-H2O nanofluid in a modified tooth-shaped cavity configuration by Bijan Krishna Saha, Jahidul Islam Jihan, Goutam Barai, Nur Jahangir Moon, Goutam Saha, Suvash C. Saha

“…Additionally, exploring the impact of magnetic forces on natural convection (NC) is important in various industrial processes.Aims: The purpose of the study is to examine how different factors influence HT and fluid flow within the cavity. This includes examining the roles of the heated rectangular vertical wall (RVW), the adiabatic circular cylinder, and the magnetic force on the NC of Al2O3H2O nanofluid.Method and validations: This study solves the governing equations and corresponding boundary conditions using Galerkin's weighted residual-based finite element methods. …”
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Salivary Protein Profile and Food Intake: A Dietary Pattern Analysis by Teresa Louro, Carla Simões, Wilmara Lima, Laura Carreira, Paula Midori Castelo, Henrique Luis, Pedro Moreira, Elsa Lamy

“…Our results support the association of salivary proteomics and different dietary patterns and highlight the need of considering food consumption habits in studies using saliva, since this is a factor associated with variations in the composition of this fluid.…”
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