Potential Role of the Resident Mesenchymal Stem-Like Cells in Renal Fibrogenesis after Ureteral Obstruction by Yong-Hua Peng, Jie Xiao, Chen Yan, Lan Luo, Tao-Sheng Li

“…The mechanisms of renal fibrogenesis after ureteral obstruction remain unclear. …”
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The fibronectin-targeting PEG-FUD imaging probe shows enhanced uptake during fibrogenesis in experimental lung fibrosis by Thomas J. Harr, Nikesh Gupta, Babita Rahar, Kristen Stott, Yadira Medina-Guevara, Metti K. Gari, Angie T. Oler, Ivy Sohee McDermott, Hye Jin Lee, Morteza Rasoulianboroujeni, Ashley M. Weichmann, Amir Forati, Kelsey Holbert, Trevor S. Langel, Kade W. Coulter, Brian M. Burkel, Bianca R. Tomasini-Johansson, Suzanne M. Ponik, Jonathan W. Engle, Reinier Hernandez, Glen S. Kwon, Nathan Sandbo, Ksenija Bernau

“…These data suggest that PEG-FUD targets fibronectin associated with active fibrogenesis in this model, making it a promising candidate for a clinically translatable molecular imaging probe to non-invasively determine pulmonary fibrosis disease activity, enabling accelerated therapeutic decision-making.…”
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Ultrastructural Characteristics of Rat Hepatic Oval Cells and Their Intercellular Contacts in the Model of Biliary Fibrosis: New Insights into Experimental Liver Fibrogenesis by Joanna Maria Lotowska, Maria Elzbieta Sobaniec-Lotowska, Dariusz Marek Lebensztejn, Urszula Daniluk, Piotr Sobaniec, Krzysztof Sendrowski, Jaroslaw Daniluk, Joanna Reszec, Wojciech Debek

“…Recently, it has been emphasized that hepatic progenitor/oval cells (HPCs) are significantly involved in liver fibrogenesis. We evaluated the multipotential population of HPCs by transmission electron microscope (TEM), including relations with adherent hepatic nonparenchymal cells (NPCs) in rats with biliary fibrosis induced by bile duct ligation (BDL). …”
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Liver Fibrosis and Altered Matrix Synthesis by Katrin Neubauer, Bernhard Saile, Giuliano Ramadori

“…However, until now, the elimination of the hepatotoxins has been the sole therapeutic concept available for the treatment of liver fibrogenesis in humans.…”
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Regulation of fibronectin and collagens type I, III and VI by TNF-α, TGF-β, IL-13, and tofacitinib by Frederik S. Gillesberg, Martin Pehrsson, Anne-Christine Bay-Jensen, Peder Frederiksen, Morten Karsdal, Bent W. Deleuran, Tue W. Kragstrup, Satoshi Kubo, Yoshiya Tanaka, Joachim H. Mortensen

“…Tofacitinib substantially reduced the formation of ECM proteins in response to IL-13, while fibrogenesis in response to TNF-α or TGF-β1 was marginally inhibited. …”
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An Evaluation of Cellulose Hydrogels Derived from <i>tequilana</i> Weber Bagasse for the Regeneration of Gingival Connective Tissue in Lagomorphs by Silvia López-Domínguez, Juan Carlos Cuevas-González, León Francisco Espinosa-Cristóbal, Judith Virginia Ríos-Arana, Rosa Alicia Saucedo Acuña, María Verónica Cuevas-González, Erasto Armando Zaragoza-Contreras, Karla Lizette Tovar Carrillo

“…This suggests that hydrogels contribute to the regeneration and/or repair of oral connective tissue, showing angiogenesis and fibrogenesis in 50 to 100% of rabbits tested with hydrogel cellulose membrane. …”
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Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C by Robert P Myers, Djamila Messous, Thierry Poynard, Francoise Imbert-Bismut

“…Leptin, the peptide product of the obesity gene (ob), has been implicated in hepatic fibrogenesis; circulating levels of leptin correlate with body fat mass. …”
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Non-invasive of liver fibrosis diagnostics: the role of serum markers by A. F. Sheptulina, Ye. N. Shirokova, V. T. Ivashkin

“…Investigations in the field of fibrogenesis processes made possible quantitative estimation of liver fibrosis by non-invasive tests based both on assessment of peripheral blood levels of substances, directly involved in various stages of extracellular matrix synthesis and disintegration, and on the routine laboratory tests reflecting activity of inflammation, degree of disorder of synthetic liver function and fibrosis progression.Conclusion. …”
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Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature by Firdevs Ulutaş, Erdem Çomut, Veli Çobankara

“…Systemic sclerosis (SSc) is an uncommon rheumatic disease in which the underlying main histopathologic feature is a thickening of the skin due to excessive accumulation of collagen in the extracellular tissue. Fibrogenesis, chronic inflammation, and ulceration may eventually promote skin neoplasms. …”
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Effects of Topical Emu Oil on Burn Wounds in the Skin of Balb/c Mice by Mohammad Afshar, Reza Ghaderi, Mahmoud Zardast, Parvin Delshad

“…Moreover, Emu oil had a positive effect on fibrogenesis and synthesis of collagen. The findings indicate that although Emu oil delays the healing process, it has a positive effect on wound healing and it increases the number of hair follicles in the margins of the wound.…”
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c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes by Nicolas Pallet, Eric Thervet, Dany Anglicheau

“…Because c-jun-N-terminal kinase (JNK), which is activated during ER stress, is implicated in kidney fibrogenesis, we undertook the current study to identify the role of JNK signaling in EPCs induced by CsA. …”
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Pentoxifylline inhibits the fibrogenic activity of pleural effusions and transforming growth factor-β by P. Entzian, M. Schlaak, U. Seitzer, Y. Acil, M. Ernst, P. Zabel

“…We screened pleural effusions for mediators thought to interfere with fibrogenesis (transforming growth factor-β (TGF-β), tumour necrosis factor α (TNFα), soluble TNF-receptor p55 (sTNF-R)) and correlated the results with patient clinical outcome in terms of extent of pleural thickenings. …”
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Influence of Mast Cells in Drug-Induced Gingival Overgrowth by Tamilselvan Subramani, Vidhya Rathnavelu, Swee Keong Yeap, Noorjahan Banu Alitheen

“…At the cellular level, gingival fibrogenesis is initiated by several mediators which induce the recruitment of a large number of inflammatory cells, including MCs. …”
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OSAS-Related Inflammatory Mechanisms of Liver Injury in Nonalcoholic Fatty Liver Disease by Elena Paschetta, Paola Belci, Anna Alisi, Daniela Liccardo, Renato Cutrera, Giovanni Musso, Valerio Nobili

“…Several studies suggest that the chronic intermittent hypoxia (CIH) of OSAS patients may per se trigger liver injury, inflammation, and fibrogenesis, promoting NAFLD development and the progression from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. …”
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Myofibroblast-derived exosomes enhance macrophages to myofibroblasts transition and kidney fibrosis by Wenqiang Yu, Jinfang Song, Shuangquan Chen, Jiayi Nie, Chujun Zhou, Jiamin Huang, Hua Liang

“…Here, we examined the role of myofibroblast-derived exosomes in MMT and kidney fibrogenesis. In vitro, transforming growth factor-β1 stimulated the differentiation of kidney fibroblasts into myofibroblasts and promoted exosome release from myofibroblasts. …”
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Isoniazid and Rifampicin Produce Hepatic Fibrosis through an Oxidative Stress-Dependent Mechanism by Ayan Biswas, Suman Santra, Debasree Bishnu, Gopal Krishna Dhali, Abhijit Chowdhury, Amal Santra

“…A combined dose of INH (50 mg) and RMP (100 mg) per kg body weight per day was administered to mice by oral gavage, 6 days a week, for 4 to 24 weeks for the assessment of liver injury, oxidative stress, and development of hepatic fibrosis, including demonstration of changes in key fibrogenesis linked pathways and mediators. Results. …”
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The Role of PPARs in Lung Fibrosis by Heather F. Lakatos, Thomas H. Thatcher, R. Matthew Kottmann, Tatiana M. Garcia, Richard P. Phipps, Patricia J. Sime

“…Evidence is accumulating that the peroxisome proliferator-activated receptors (PPARs) play important roles in regulating processes related to fibrogenesis, including cellular differentiation, inflammation, and wound healing. …”
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Liver macrophage-derived exosomal miRNA-342-3p promotes liver fibrosis by inhibiting HPCAL1 in stellate cells by Wenshuai Li, Lirong Chen, Qi Zhou, Tiansheng Huang, Wanwei Zheng, Feifei Luo, Zhong Guang Luo, Jun Zhang, Jie Liu

“…HPCAL1, which is a fibrogenesis suppressor, could inhibit TGF-β signaling in HSCs by regulating the ubiquitination of Smad2 through direct interactions with its EF-hand 4 domain. …”
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TGFβ1 Controls PPARγ Expression, Transcriptional Potential, and Activity, in Part, through Smad3 Signaling in Murine Lung Fibroblasts by Allan Ramirez, Erin N. Ballard, Jesse Roman

“…We, however, hypothesized that antifibrotic pathways mediated by PPARγ are influenced by TGFβ1, causing an imbalance towards fibrogenesis. Consistent with this, primary murine primary lung fibroblasts responded to TGFβ1 with a sustained downregulation of PPARγ transcripts. …”
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15-Deoxy-Δ12,14-Prostaglandin J2 Inhibits Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury via Redox Pathway by Xin Liu, Shuangshuang Jia, Weiyang Li, Le Yang, Lin Yang, Lin Wang, Liying Li

“…It has been reported that bone marrow-derived mesenchymal stem cells (BMSCs) have capacity to migrate to the damaged liver and contribute to fibrogenesis in chronic liver diseases. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), an endogenous ligand for peroxisome proliferator-activated receptor gamma (PPARγ), is considered a new inhibitor of cell migration. …”
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