What are the cost-savings and health benefits of improving detection and management for six high cardiovascular risk conditions in England? An economic evaluation by Katy Cooper, Alan Brennan, David Bagguley, Helen Buckley Woods, Chloe Thomas, Penny Breeze, Michael Gillett, Edward Goka, Hazel Y Squires, Gilly Brenner, Joanna Leaviss, Mark Clowes, Laura Heathcote

“…Objectives To estimate the cost savings and health benefits of improving detection of individuals at high risk of cardiovascular disease (CVD) in England, to determine to which patient subgroups these benefits arise, and to compare different strategies for subsequent management.Design An economic analysis using the School for Public Health Research CVD Prevention Model.Setting England 2018.Participants Adults aged 16 and older with one or more high cardiovascular risk conditions, including hypertension, diabetes, non-diabetic hyperglycaemia, atrial fibrillation, chronic kidney disease and high cholesterol.Interventions Detection of 100% of individuals with CVD high risk conditions compared with current levels of detection in England. …”
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Phenotypic Trajectories From Acute to Stable Phase in Heart Failure With Preserved Ejection Fraction: Insights From the PURSUIT‐HFpEF Study by Yuki Matsuoka, Yohei Sotomi, Daisaku Nakatani, Katsuki Okada, Akihiro Sunaga, Hirota Kida, Taiki Sato, Daisuke Sakamoto, Tetsuhisa Kitamura, Sho Komukai, Masahiro Seo, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Shunsuke Tamaki, Yoshio Yasumura, Takahisa Yamada, Shungo Hikoso, Yasushi Sakata

“…[N=242 (22.0%)]; Phenotype 3, higher prevalence of atrial fibrillation, higher tricuspid pressure gradient, and lower tricuspid annular plane systolic excursion [N=214 (19.5%)]; Phenotype 4, higher C‐reactive protein level and higher tricuspid pressure gradient [N=245 (22.3%)]; and Phenotype 5, poor nutritional status, poor renal function, and higher NT‐proBNP level [N=74 (6.7%)]. …”
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Economic impact of heart failure with preserved ejection fraction: insights from the ALDO‐DHF trial by Djawid Hashemi, Ludwig Dettmann, Tobias D. Trippel, Volker Holzendorf, Johannes Petutschnigg, Rolf Wachter, Gerd Hasenfuß, Burkert Pieske, Antonia Zapf, Frank Edelmann

“…We identified higher HF functional class (NYHA), male patients with low haemoglobin level, with high oxygen uptake (VO2max) and coronary artery disease, hyperlipidaemia, and atrial fibrillation as independent predictors for higher costs. …”
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A novel interpretable deep learning model for diagnosis in emergency department dyspnoea patients based on complete data from an entire health care system. by Ellen T Heyman, Awais Ashfaq, Ulf Ekelund, Mattias Ohlsson, Jonas Björk, Ardavan M Khoshnood, Markus Lingman

“…The model assembled a list of 1,596 variables by importance for diagnosis, on top were prior diagnoses of heart failure or COPD, daily smoking, atrial fibrillation/flutter, life management difficulties and maternity care. …”
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A supervised model to identify wolf behavior from tri-axial acceleration by Charlotte Lorand, Léa Bouet, Olivier Devineau, Marianna Chimienti, Alina L. Evans, Peggy Callahan, Mark Beckel, Timothy G. Laske, Ane Eriksen

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Global longitudinal strain and its dynamics after replacement of aortal valve in patients with severe aortic stenosis by N.V. Ponych, O.O. Nemchyna, O.J. Zharinov, O.A. Yepanchintseva, B.M. Todurov

“…In the examined patients, significant correlations were found between baseline GLS with functional class of heart failure, concomitant tricuspid insufficiency, atrial fibrillation, duration of QRS complex, LV EF, end-diastolic, endsystolic volume index (EDV, ESV) and volume left atrium (LA), left ventricular myocardial mass index, aortic valve orifice area index, E/A ratio, and Thei index. …”
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A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases by Eva Lukas, Rada R. Veeneman, Dirk J. A. Smit, Tarunveer S. Ahluwalia, Jentien M. Vermeulen, Gita A. Pathak, Renato Polimanti, Karin J. H. Verweij, Jorien L. Treur

“…We leveraged summary-level data of genome-wide association studies (PTSD: N = 1,222,882; atrial fibrillation (AF): N = 482,409; coronary artery disease (CAD): N = 1,165,690; hypertension (HT): N = 458,554; heart failure (HF): N = 977,323). …”
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Non‐invasive telemedical care in heart failure patients and stroke: post hoc analysis of TIM‐HF and TIM‐HF2 trials by Serdar Tütüncü, Marcus Honold, Kerstin Koehler, Oliver Deckwart, Friedrich Koehler, Karl Georg Haeusler

“…Rate of stroke/TIA within 12 months was in the intervention group similar compared with the control group (50.0% vs. 49.8%; P = 0.98) despite that the rate of newly detected atrial fibrillation (AF) was higher in the intervention group (14.1% vs. 1.6%; P < 0.001). …”
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Development and validation of a novel risk-predicted model for early sepsis-associated acute kidney injury in critically ill patients: a retrospective cohort study by Bo Li, Kun Zhang, Cong-Cong Zhao, Zi-Han Nan, Yan-Ling Yin, Li-Xia Liu, Zhen-Jie Hu

“…The external validation cohort was generated from a single-centre ICU database from China.Participants A total of 7179 critically ill patients with sepsis were included in the development cohort and 269 patients with sepsis were included in the external validation cohort.Results A total of 12 risk factors (age, weight, atrial fibrillation, chronic coronary syndrome, central venous pressure, urine output, temperature, lactate, pH, difference in alveolar-arterial oxygen pressure, prothrombin time and mechanical ventilation) were included in the final prediction model. …”
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Patients with chronic heart failure and predominant left atrial versus left ventricular myopathy by Xuanyi Jin, Wan Ting Tay, Dinna Soon, David Sim, Seet Yoong Loh, Sheldon Lee, Fazlur Jaufeerally, Lieng Hsi Ling, A. Mark Richards, Adriaan A. Voors, Carolyn S. P. Lam, Joost P. van Melle

“…Patients with predominant LA myopathy were older, had a higher prevalence of atrial fibrillation (AF), diabetes, higher plasma concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP), Growth differential factor 15(GDF15), high sensitivity Troponin T (hs-TNT) as well as more dilated left and right atria, and worse right atrial function compared to other groups (all p-values < 0.05). …”
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VCP regulates early tau seed amplification via specific cofactors by Sushobhna Batra, Jaime Vaquer-Alicea, Clarissa Valdez, Skyler P. Taylor, Victor A. Manon, Anthony R. Vega, Omar M. Kashmer, Sourav Kolay, Andrew Lemoff, Nigel J. Cairns, Charles L. White, Marc I. Diamond

“…We used immortalized cells and human neurons to study the effects of VCP on tau seeding. We exposed cells to fibrils or brain homogenates in cell culture media and measured effects on uptake and induction of intracellular tau aggregation following various genetic and pharmacological manipulations of VCP. …”
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Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons by Amir T. Marvian, Tabea Strauss, Qilin Tang, Benjamin J. Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S. Sutherland, William A. McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F. Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger

“…Method Monomers, oligomers, and fibrils of recombinant 2N4R Tau were produced and characterized by biochemical and biophysical methods. …”
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Impact of Late Ventricular Arrhythmias on Cardiac Mortality in Patients with Acute Myocardial Infarction by Takuma Takada, Koki Shishido, Takahiro Hayashi, Shohei Yokota, Hirokazu Miyashita, Hiroaki Yokoyama, Takashi Nishimoto, Tomoki Ochiai, Noriaki Moriyama, Kazuki Tobita, Shingo Mizuno, Futoshi Yamanaka, Masato Murakami, Yutaka Tanaka, Saeko Takahashi, Shigeru Saito

“…This study investigated the relationship between the timing of ventricular tachycardia or ventricular fibrillation (VT or VF) and prognosis in patients undergoing primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). …”
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UGT2B15 single nucleotide polymorphism reduces dabigatran acylglucuronide formation in humans by Jin-Woo Park, Jin-Woo Park, Jin-Woo Park, Jong-Min Kim, Young Yoon Bang, Kyoung-Ah Kim, Sungwook Yu, Ji-Young Park

“…BackgroundDabigatran etexilate (DABE), a prodrug of dabigatran (DAB), is a direct thrombin inhibitor used to prevent ischemic stroke and thromboembolism during atrial fibrillation. The effect of genetic polymorphisms on its metabolism, particularly UGT2B15, has not been extensively explored in humans. …”
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Health profile of residents of retirement villages in Auckland, New Zealand: findings from a cross-sectional survey with health assessment by Kathy Peri, Michal Boyd, Martin J Connolly, Joanna B Broad, Dale Bramley, Zhenqiang Wu, Katherine Bloomfield, Joanna Hikaka, Annie Tatton, Cheryl Calvert, Ann-Marie Higgins

“…Volunteers and sampled residents differed significantly, mainly in socio-behavioural respects.Conclusions Common conditions including hypertension, arthritis and atrial fibrillation, are recorded in interRAI as text, and thus overlooked in interRAI reports. …”
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Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome by Shi Tai, Xuping Li, Zhaowei Zhu, Liang Tang, Hui Yang, Liyao Fu, Xinqun Hu, Zhenfei Fang, Shenghua Zhou

“…Prevalence of hypertension (80.5% vs. 72.6%, P=0.020), atrial fibrillation (16.2% vs. 9.5%, P=0.008), and severe heart failure (61.0% vs. 44.2%, P<0.001) were higher in patients with hyperuricemia than in patients with normal sUA. …”
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Electrocardiography interpretation competency among pediatric and child health residents at Addis Ababa University, Ethiopia by Helen Mintesnot, Henok Tadele, Hayat Ahmed, Tamirat Moges, Etsegenet Gedlu

“…SVT diagnosis was associated resident’s juniority, p = 0.018 and the number of monthly ECG orders, p = 0.018. Atrial fibrillation diagnosis was associated with the service years before residency enrollment, p = 0.046. …”
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Safety and efficacy of intravenous thrombolysis: a systematic review and meta-analysis of 93,057 minor stroke patients by Mostafa Hossam El Din Moawad, Talal Salem, Anas Alaaeldin, Youssef Elaraby, Peter D. Awad, Amr Ahmed Khalifa, Ahmed El Naggar, Khaled Ashraf Mohamed, Mohamed Elhalal, Mostafa Badr, Ramy Abdelnaby

“…Most of the included patients had comorbidities such as hypertension, diabetes, previous stroke, smoking, atrial fibrillation, and hyperlipidemia. Of these, 10,850 received IVT while 82,207 did not. …”
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Parastomal hernia repair: A 10-year retrospective study at District General Hospital—Recurrence and complications by Ali Javaid, Karim Muhammad, Nafees Qureshi

“…Other complications noted were small bowel ileus, small bowel obstruction, hospital acquired pneumonia, atrial fibrillation, acute kidney injury, stoma necrosis, and iatrogenic ureteral injury. …”
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Patients admitted in an Intensive Care Unit with severe clinical manifestations of Influenza, october-december 2009 by Yenisey Quintero Mendez, Jorge Luis Ulloa Capestani, Rudis Monzón Rodríguez, Francisco García Valdés, Ramón E Álvarez Cepero, Jaime Geroy Gómez, Pablo Rodríguez Díaz, Alfredo Dario Espinosa Brito, Yanli Vázquez Villazón, Diley Moreno Ruiz, Octavio Rivero Rodríguez

“…In electrocardiograms, alterations were verified of ST-T in 12 sick persons (11,0%), sinusal tachicardia in 12 (11,0%), supraventricular arrhythmias (that included acute auricular fibrillation and supraventricular paroxysmal tachicardia) in 7 (6,4%) and ventricular arrhythmias in 2 (1,8%). …”
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