The question of strains in AA amyloidosis by Gunilla T. Westermark, Ebba Nyström, Sofie Nyström, K. Peter R. Nilsson, Per Hammarström, Per Westermark

“…Abstract The existence of transmissible amyloid fibril strains has long intrigued the scientific community. …”
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Impact of High Glucose on Bone Collagenous Matrix Composition, Structure, and Organization: An Integrative Analysis Using an Ex Vivo Model by Rita Araújo, Ricardo N. M. J. Páscoa, Raquel Bernardino, Pedro S. Gomes

“…Histomorphometric analysis revealed disrupted collagen fibril architecture, characterized by altered fibril diameter, alignment, and spatial organization. …”
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Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis by Joan Chang, Adam Pickard, Jeremy A Herrera, Sarah O'Keefe, Richa Garva, Matthew Hartshorn, Anna Hoyle, Lewis Dingle, John Knox, Thomas A Jowitt, Madeleine Coy, Jason Wong, Adam Reid, Yinhui Lu, Cédric Zeltz, Rajamiyer V Venkateswaran, Patrick T Caswell, Stephen High, Donald Gullberg, Karl E Kadler

“…Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-I to assemble new fibrils. …”
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Contribution of Glycosaminoglycans to the Microstructural Integrity of Fibrillar and Fiber Crimps in Tendons and Ligaments by Marco Franchi, Viviana De Pasquale, Désirée Martini, Marilisa Quaranta, Maria Macciocca, Alessio Dionisi, Vittoria Ottani

“…Each crimp is composed of many knots of each single fibril or fibrillar crimps. Fibrillar and fiber crimps play a mechanical role in absorbing the initial loading during elongation of both tendons and ligaments, and in recoiling fibrils and fibers when tissues have to return to their original length. …”
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The Role of Decorin in Autoimmune and Inflammatory Diseases by Yuanji Dong, Jixin Zhong, Lingli Dong

“…As a matrix protein, the first discovered role of decorin is participating in collagen fibril formation. Many other functions of decorin in various biological processes have been subsequently identified. …”
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Biophysical and spectroscopical insights into structural modulation of species in the aggregation pathway of superoxide dismutase 1 by Vijay Raj Tomar, Shilpa Sharma, Soumik Siddhanta, Shashank Deep

“…The kinetic data supported a fragmentation-dominant mechanism for the fibril formation. Quercetin acts as inhibitor by delaying the formation of non-native dimer and soluble oligomers by decreasing the elongation rate. …”
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A Tongue Lesion as a Sign of a Systemic Disease by Chrysoula I. Liakou, Joan Koh, Antonios Tsimpidakis, Katrina Rios, Charalabos Paskalis, Athanasios Pipilis, Dimitrios Kantianis, Thomas Georgiadis, Evangelia Razis

“…Amyloidosis is the extracellular fibril deposition of a variety of proteins, many of which circulate as plasma ingredients. …”
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Atomistic simulations of PAP248-286 peptide oligomerization by A.O. Nikitina, A.R. Yulmetov, A.M. Kusova, V.V. Klochkov, D.S. Blokhin

“…Amyloid fibrils, dubbed SEVI (semen-derived enhancer of virus infection), contribute to the spread of HIV infection. …”
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Characterization of Asbestos in Ambient Air During Refractory Material Production from Magnesite Ore by Mehmet Ali Küçüker

“…The majority of the fibrils observed were noted to be other inorganic minerals (lizardite) fibrils. …”
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Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus by Lucie Caillon, Anais R. F. Hoffmann, Alexandra Botz, Lucie Khemtemourian

“…Finally, the development of successful antiamyloidogenic agents that prevent hIAPP fibril formation will be examined.…”
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Role of Copper and Zinc Ions in the Hydrolytic Degradation of Neurodegeneration-Related Peptides by Valentina Pirota, Enrico Monzani, Simone Dell’Acqua, Chiara Bacchella

“…The enhanced stability of neuronal peptides provided by metal coordination can increase local levels of amyloidogenic species capable of seeding fibril growth, resulting in aberrant protein depositions and deficits in neuronal activity.…”
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FIRM image analysis: A machine learning workflow for quantifying extracellular matrix components from electron microscopy images. by Nicholas T Gigliotti, Justin Lee, Emily H Mang, Giancarlo R Zambrano, Mitra L Taheri

“…FIRM had similar deviation from the ground truth in the number of identified fibrils, fibril size, and size distributions when compared to human analyses. …”
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Second-generation anti-amyloid monoclonal antibodies for Alzheimer’s disease: current landscape and future perspectives by Byeong-Hyeon Kim, Sujin Kim, Yunkwon Nam, Yong Ho Park, Seong Min Shin, Minho Moon

“…These MABs targeting Aβ are categorized based on their affinity to diverse conformational features of Aβ, including monomer, fibril, protofibril, and plaque forms of Aβ as well as pyroglutamate Aβ. …”
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An Ethnobotanical Survey of Indigenous Knowledge on Medicinal Plants Used by Communities to Treat Various Diseases around Ensaro District, North Shewa Zone of Amhara Regional State... by Mikias Teshome, Firew Kebede, Tamene Yohannes

“…The highest informant consensus was documented for the plant Ocimum lamiifolium used by 75% of informants for its medicinal value in treating fibril illness. Cucumis ficifolius and Eucalyptus globules are used by 41% and 39% of informants ranking second and third, respectively, for their medicinal value. …”
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BMP9 induces postnatal zonal stratification of immature articular cartilage through reconfiguration of the existing collagen framework by Miles Anderson-Watters, Ilyas M. Khan

“…These data suggest a possible mechanism whereby MMP3 induces proteoglycan turnover and depolymerises collagen fibrils enabling them to undergo spatial reorganisation. …”
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Photophysical Properties of Fluorescent Probe Thioflavin T in Crowded Milieu by Natalia P. Rodina, Maksim I. Sulatsky, Anna I. Sulatskaya, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov

“…Thioflavin T (ThT) is a widely used fluorescent probe of amyloid fibrils, which accompanies many serious neurodegenerative and other diseases. …”
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“Pillaring Effects” in Cross-Linked Cellulose Biopolymers: A Study of Structure and Properties by Inimfon A. Udoetok, Lee D. Wilson, John V. Headley

“…The attenuation of SA for CLE-0.5 may relate to surface grafting onto cellulose beyond the stoichiometric cellulose and EP ratio since ca. 30% of the hydroxyl groups of cellulose are accessible for cross-linking reaction due to its tertiary fibril nature. Scanning electron microscopy (SEM) results reveal the variable surface roughness and fibre domains of cellulose due to cross-linking. …”
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The alkaline treatment and its influence on the physicomechanical properties of plantain pseudostem fibers - A comparative study of treated and untreated fibers by Oswaldo Hurtado-Figueroa, Humberto Varum, María Isabel Prieto, Romel J. Gallardo Amaya, Alfonso Cobo Escamilla

“…Excessive hemicellulose removal was found to cause fibril separation and detachment. Considerable contraction of vascular bundles occurred. …”
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Inhibition of Aβ Aggregation by Cholesterol-End-Modified PEG Vesicles and Micelles by Shota Watanabe, Motoki Ueda, Shoichiro Asayama

“…At a 10-fold molar ratio, thioflavin T (ThT) assay revealed that Chol-PEG₂₀₀₀ delayed Aβ fibril elongation by 20 hours, while Chol-PEG₅₀₀ delayed it by 40 hours against Aβ peptide. …”
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The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration by Chiara Cencioni, Silvia Malatesta, Virginia Vigiano Benedetti, Valerio Licursi, Livia Perfetto, Federica Conte, Danilo Ranieri, Armando Bartolazzi, Martina Kunkl, Loretta Tuosto, Alberto Larghi, Geny Piro, Antonio Agostini, Giampaolo Tortora, Vincenzo Corbo, Carmine Carbone, Francesco Spallotta

“…Results The dysmetabolic-associated higher PDAC aggressiveness was paralleled by collagen fibril enrichment due to prolyl 4-hydroxylase subunit alpha 1 (P4HA1) increased function. …”
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