Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis by Vinzenz Fleischer, Tobias Brummer, Muthuraman Muthuraman, Muthuraman Muthuraman, Falk Steffen, Milena Heldt, Maria Protopapa, Muriel Schraad, Gabriel Gonzalez-Escamilla, Sergiu Groppa, Stefan Bittner, Frauke Zipp

“…Two key measures from each modality were determined and related to subsequent disability progression: lesion volume (LV), gray matter volume (GMV), retinal nerve fiber layer, ganglion cell-inner plexiform layer, serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein. …”
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Adsorption, in vitro digestion and human gut microbiota regulation characteristics of three Poria cocos polysaccharides by Fangming Zhang, Hui Zheng, Tao Zheng, Pan Xu, Yao Xu, Yuxin Cao, Fan Jia, Yiqiong Zeng, Yubing Fan, Kai He, Xinwen Dai, Fengfei Hou, Yong Yang

“…Considering the beneficial role of dietary fiber and the traditional use of PC, ASP may also contribute substantially to the therapy function of PC. …”
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Effectiveness and tolerability of the combined use of anti-VEGF agents in clinical practice by A.V. Kuroyedov, O.V. Gapon’ko, V.V. Gorodnichiy, S.V. Diordiychuk, I.V. Kondrakova, N.M. Sol’nov, N.E. Fomin

“…Best-corrected visual acuity (BCVA), intraocular pressure, and retinal nerve fiber layer (RNFL) thickness were measured. These parameters were compared at different time points during the treatment.…”
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不同产地山桐子品质分析及综合评价 Quality analysis and comprehensive evaluation of Idesia polycarpa by 邹康，常云鹤，宋明发，刘晓燕，何劲，马立志 ZOU Kang, CHANG Yunhe, SONG Mingfa, LIU Xiaoyan, HE Jin, MA Lizhi

“…The results showed that there were certain degree of differences in contents of oil, protein, ash, crude fiber, total sugar, total phenol and total flavone in fruit of Idesia polycarpa Maxim from different geographic regions. …”
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Lyophilized and Oven-Dried <i>Manilkara zapota</i> Extracts: Characterization and <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i> Analyses by María Fernanda Rivas-Gastélum, Patricia Ariadna Galindo-Castillo, Juan Esparza-Sánchez, Miriam Irene Jiménez-Pérez, Yocanxóchitl Perfecto-Avalos, Luis Eduardo Garcia-Amezquita, Diego E. Navarro-López, Edgar R. López-Mena, Eugenio Sánchez-Arreola, Juan Pablo Tamayo-Martínez, Humberto L. Mendoza-Figueroa, María Magdalena Crosby-Galván, Elsa Margarita Crosby-Galván, Jorge L. Mejía-Méndez, Angélica Lizeth Sánchez-López

“…It was demonstrated that lyophilization or oven-drying approaches influenced the insoluble, total dietary fiber and digestible carbohydrates among samples. …”
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MMS21通过维持MCM2-7复合物稳定性促进肝细胞癌增殖活性 by 李文佳, 朱元昕, 胡开顺

“…方法利用GEPIA2和CPATC数据库分析MMS21在肝细胞癌中的mRNA和蛋白表达变化及与患者预后的关系；设计两条siRNA分别敲低肝癌细胞内源性MMS21的表达，并采用流式细胞技术检测细胞周期分布比例；进行BrdU染色和DNA fiber实验检测细胞增殖能力与DNA合成速度；构建带有MYC标签的MMS21蛋白过表达载体，并在细胞系SK-hep1中建立其稳定表达的细胞株；利用Co-IP联合质谱分析的方法鉴定MMS21的互作蛋白组并进行信号通路富集分析；采用Western Blot，检测MMS21对细胞周期相关蛋白的影响。…”
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Diagnostic markers of severe diabetic macular edema in patients with type 2 diabetes by S.A. Suk, S.Yu. Mogilevskyy

“…According to OCT, area thickness was 355.68 ± 1.80 μm, min in fovea — 358.54 ± 2.40 μm, central sector — 401.06 ± 2.09 μm, volume — 10.42 ± 0.10 mm3, nerve fiber layer (NFL) + ganglion cell layer (GCL) + inner plexiform layer (IPL) average — 138.3 ± 0.7 μm, NFL + GCL + IPL min — 122.78 ± 0.60 μm, GCL — 97.2 ± 1.0 μm, NFL — 42.12 ± 0.20 μm. …”
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Obstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality by Kang Wu, Qiming Gan, Yuhong Pi, Yanjuan Wu, Wenjin Zou, Xiaofen Su, Sun Zhang, Xinni Wang, Xinchun Li, Nuofu Zhang

“…Conversely, mean thickness of G-front-inf-Triangul in right hemisphere (OR: 1.14; 95% CI: 1.05–1.23), mean orientation dispersion index in right tapetum (OR: 1.13; 95% CI: 1.04–1.23), and rfMRI connectivity ICA100 edge 258 (OR: 1.13; 95% CI: 1.04–1.22) showed opposite results. Conclusions Nerve fiber damage and imbalances in neuronal activity across multiple brain regions caused by hypoxia, particularly the frontal lobe, underlie the structural and the functional connectivity impairments in OSA.…”
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A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial by Xiaorong Wu, Alvin Surya Tjahyo, Vera Sergeyevna Brok Volchanskaya, Long Hui Wong, Xianning Lai, Yi Ning Yong, Farhana Osman, Shia Lyn Tay, Priya Govindharajulu, Shalini Ponnalagu, Rachel Tso, Hwee Sze Teo, Kaijie Khoo, Huan Fan, Chew Chan Goh, Clara Poh Lian Yap, Melvin Khee-Shing Leow, Christiani Jeyakumar Henry, Sumanto Haldar, Kevin Junliang Lim

“…The IG had significantly greater reductions in LDL cholesterol (q (Treatment×Time) = 0.01, β  = -0.16), total cholesterol (q (Treatment×Time) = 0.02, β  = -0.3) and HbA1c (q (Treatment×Time) = 0.04, β  = -0.004) compared with CG, alongside increases in fiber degrading species in IG, mediated through metabolites such as bile acids and amino acids. …”
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Identifying Hierarchically Triple Star Systems with Gaia DR3 and LAMOST by Tongyu He, Jiao Li, Jiangdan Li, Jianping Xiong, Xiaobin Zhang, Mikhail Kovalev, Qiyuan Cheng, Sufen Guo, Mingkuan Yang, Xuefei Chen, Zhanwen Han

“…In this study, we identified 23 triple systems by cross matching the Gaia DR3 non-single-star catalog with Large Sky Area Multi-Object Fiber Spectroscopic Telescope DR10 spectroscopic data, 18 of them are new discoveries. …”
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Exploring the effect of feeding broiler chickens a diet incorporating unfermented or fermented palm kernel cake: growth performance, digestibility, biochemical indices, digestive e... by Sindaye Daniel, Shehata Zeid, Liao Jinghong, Suqin Hang

“…Fermented PKC, particularly LPKC, improved the broiler chicken’s digestibility of crude protein, gross energy, crude fiber, lactase, and trypsin enzyme activities compared to the control group (p < 0.05). …”
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The effect of using red algae powder on growth indices, some serum and mucus indices, and mucus protein patterns in common carp (Cyprinus carpio) fry by Fatemeh Abdollahnejad, Seyed Hossein Hoseinifar, Hamed Paknejad, Abdolmajid Hajimoradlou, Mohamdreza Imanpuor

“…Seaweeds have high quantity of vitamins, minerals, protein, carotenoids, fiber, and essential fatty acids. In addition to being used as food, algae can have industrial, cosmetic, and medical uses. …”
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Association of tea consumption with all-cause/cardiovascular disease mortality in the chronic kidney disease population: an assessment of participation in the national cohort by Jin Li, Xing-Ling Chen, Xiao-Lu Ou-Yang, Xiao-Jiao Zhang, Yue Li, Shu-Ning Sun, Ling-Jun Wang, Zhong-Qi Yang, Shi-Hao Ni, Lu Lu

“…Sensitivity analysis was performed to ensure the reliability of our findings.Results After adjusting for age, sex, race, education level, marital, annual household income, energy intake, total water intake, protein intake, carbohydrate intake, dietary fiber, sugar beverages, milk whole, total monounsaturated fatty acids, total polyunsaturated fatty acids, total saturated fatty acids, smoking, metabolic equivalent of task for physical activity level (MET-PA), BMI, diabetes, hypertension, urinary albumin, estimated glomerular filtration rate (eGFR), CVD, cancer, serum sodium, serum potassium, and serum phosphorus, setting the individuals without tea consumption record as reference. …”
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Diffuse Ionized Gas in the Anticenter of the Milky Way by Shiming Wen, Wei Zhang, Lin Ma, Yunning Zhao, Man I. Lam, Chaojian Wu, Juanjuan Ren, Jianjun Chen, Yuzhong Wu, Guozhen Hu, Yonghui Hou, Yongheng Zhao, Hong Wu

“…Using data from the Large Area Multi-Object fiber Spectroscopic Telescope Medium-Resolution Spectroscopic Survey of Nebulae, we create a sample of 17,821 diffuse ionized gas spectra in the anticenter region of the Milky Way by excluding fibers in the directions of H ii regions and supernova remnants. …”
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Optimizing fodder yield and quality through integrated organic nutrient amendments in multi-crop system by Santosh Onte, Santosh Onte, Vrushabh Vijay Fiskey, Manjunath S. Melavanki, Airadevi P. Angadi, Prasanna S. Pyati, Magan Singh, Dileep Kumar, Sanjivkumar Angadarao Kochewad, Sudhir Kumar, Hari Om, Vijendra Kumar Meena, Kamal Garg, Vetrivel Karunakaran, Manish Kanwat, Babu Lal Meena, Yogananda Shivalli Boregowda, Rahul Bellagi, K. Naveena, Sunil Chandersheker, Elisa Azura Azman, Sanjeev Kumar

“…Furthermore, T6 significantly enhanced forage quality, as evidenced by higher crude protein (6.4–14.8%), ether extract (19.2–40.1%), and total ash (6.5–22.1%) contents, coupled with reductions in fiber components. These findings highlight the effectiveness of integrated organic nutrient amendments in enhancing both yield and quality, offering a sustainable strategy to improve livestock feed and promote environmentally friendly agricultural practices.…”
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Effects of water flow treatment on muscle quality, nutrient composition and volatile compounds in common carp (Cyprinus carpio) by Lei Wang, Lingran Wang, Chang Liu, Di Feng, Jintai Huang, Zhan Jin, Fangran Ma, Jiaxin Xu, Yuyue Xu, Meng Zhang, Miao Yu, Hongxia Jiang, Zhigang Qiao

“…Results indicated that SG improved water-holding capacity, muscle fiber density, hardness, and chewiness, while IG enhanced gumminess, springiness, and resilience. …”
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Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway by DanDan Liu, Hui Wang, Jialong Li, Siqi Sheng, Shu Wang, Ye Tian

“…The kidney from mice was stained with masson’s trichrome staining for collagen fiber expression, while alpha-smooth muscle actin (α-SMA) expression was determined via immunohistochemical staining. …”
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Ophthalmic risk factors for primary open angle glaucoma by V.P. Erichev, A.V. Kuroyedov, S.Yu. Petrov, A.Yu. Brezhnev, A.A. Antonov, A.A. Vitkov, Yu.K. Murakhovskaya

“…<p> <i>Primary open angle glaucoma (POAG) is a chronic progressive optic neuropathy, characterized by morphological changes in the optic nerve head and retinal nerve fiber layer. This review analyzes the development of the risk factors for POAG over several decades. …”
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Diseño de losas de hormigón con geometría optimizada Design of concrete pavement with optimized slab geometry by Juan Pablo Covarrubias V.

“…Besides the executed tests demonstrated that fiber concrete slabs may endure until 20 times more traffic before cracking and they are able to provide a longer life span after cracking. …”
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Endo 180 participates in collagen remodeling of the periodontal ligament during orthodontic tooth movement by Liyuan Chen, Danqing He, Zixin Li, Shengjie Cui, Min Yu, Zimo Zhao, Yuetong Chen, Jiayi Song, Nan Jiang, Huajie Yu, Yan Liu

“…Results Force application increased OTM distance and disrupted collagen fiber organization, with a greater decrease in collagen elastic modulus on the mesial side than on the distal side of the PDL. …”
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