Risk factors for methotrexate treatment failure in tubal ectopic pregnancy: a retrospective cohort study by Linru Fu, Xinyan Liu, Zhao Tian, Zhe Du, Xinyi Wang, Xiuqi Wang, Xiaodong Li, Tao Xu, Zhijing Sun

“…Methods This retrospective study included female patients who were diagnosed with TEP at Peking Union Medical College Hospital (PUMCH) between January 2016 and December 2022. …”
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Long-Term Results of Cabergoline Add-on Long-Acting Somatostatin Analogue Therapy in Acromegaly Patients by Mehmet Muhittin Yalçın, Gizem Bedir Keser, Meriç Coşkun, Afruz Babayeva, Emrah Çeltikçi, Mehmet Arda İnan, Emetullah Cindil, Aylar Poyraz, Ethem Turgay Cerit, Alev Eroğlu Altınova, Müjde Aktürk, Füsun Baloş Törüner, Mehmet Ayhan Karakoç, İlhan Yetkin

“…Results: Seventeen (48.6%) patients were female. The median age was 46.0 (41-53) years, and the median disease age was 10 (3-43) years. …”
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The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression by Callan L. Attwell, Inés Maldonado-Lasunción, Ruben Eggers, Bastiaan A. Bijleveld, Ward M. Ellenbroek, Natascha Siersema, Lotte Razenberg, Dédé Lamme, Nitish D. Fagoe, Ronald E. van Kesteren, August B. Smit, Joost Verhaagen, Matthew R. J. Mason

“…Next, adeno-associated viral vectors were used to express these TF combinations in vivo in L4/L5 dorsal root ganglia to test whether they would promote regeneration in a spinal cord injury model (dorsal column lesion) in female rats. To determine whether they could activate the RAG program we carried out gene expression profiling on laser-dissected dorsal root ganglion neurons specifically expressing these TF combinations, and of DRG neurons that had been axotomized. …”
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Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosisResearch in context by Stylianos Papadopoulos, David Hardy, Frédérique Vernel-Pauillac, Magali Tichit, Ivo G. Boneca, Catherine Werts

“…Methods: To investigate the causes of death in lethal leptospirosis, we compared intraperitoneal infection of male and female C57BL6/J mice with 108 Leptospira of two strains of pathogenic L. interrogans. …”
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Full-thickness cervix reconstruction via collagen scaffolds in rabbits by Yaqian Li, Weijie Tian, Jianbin Guo, Yang Ye, Qianqian Gao, Yiwei Zhang, Xiaoyue Zhao, Jianwu Dai, Lan Zhu

“…Congenital deficiency or extensive cervical injury leads to female genital tract obstruction and cervical laxity, resulting in infertility or miscarriage. …”
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Weight-based enoxaparin thromboprophylaxis in young trauma patients: analysis of the CLOTT-1 registry by Sarah Lombardo, Ram Nirula, Elliott R Haut, Scott Brakenridge, Brandon Bruns, Charles E Wade, M Margaret Knudson, Thomas Scalea, Todd W Costantini, Lisa Marie Knowlton, David Spain, Ernest E Moore, Michelle K McNutt, Matthew J Martin, Andrew J Kerwin, George C Velmahos, Bruce Crookes, Marta McCrum, Lucy Kornblith, Mark D Cipolle, Laszlo N Kiraly, David J Milia, Alicia Mohr, Frederick Rogers, Sherry Sixta, Jade Nunez

“…WB patients were younger, female, more severely injured, and underwent major operation or major venous repair at a higher rate than individuals in the SFD group. …”
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Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis by Samuel R. Moen, Jeffrey R. Misialek, Timothy M. Hughes, Craig W. Johnson, Mark J. Sarnak, Sarah N. Forrester, W.T. Longstreth, Jr., Mercedes R. Carnethon, James S. Pankow, Sanaz Sedaghat

“…The analytic sample consisted of 6,646 participants (mean [SD] age 62 [10] years; 53% female; 39% White, 27% African American, 12% Chinese American, and 22% Hispanic/Latino). …”
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Global esophageal cancer epidemiology in 2022 and predictions for 2050: A comprehensive analysis and projections based on GLOBOCAN data by Ling Qi, Mengfei Sun, Weixin Liu, Xuefeng Zhang, Yongjun Yu, Ziqiang Tian, Zhiyu Ni, Rongshou Zheng, Yong Li, Xiangxiang Pan

“…In all regions worldwide, the incidence and mortality rates were higher in males than in females (with a male-to-female ASR ratio ranging from 1.10 to 28.7). …”
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Efficacy and Safety of High-dose versus Standard-dose Prazosin in Paediatric Scorpion Envenomation: A Single-blinded Randomised Controlled Study by Apoorva Gayatri Abbadi, Hidaytullah R Bijapure, Chandrika R Doddihal, Bhavana B Lakhkar, Y Rohith, VJ Prakash, Kumar BM Prasanna, Mallanagouda Patil

“…Forty-eight (56%) of the children were over five years old (12, 21 and 15 were in Groups A, B and C, respectively). The male-to-female ratio of 1.8:1, 2.6:1 and 1.8:1 in Groups A, B and C, respectively. …”
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Correlation between follicle diameter and pre-ovulatory metabolic profile in Bos grunniens by Jiuru Yan, Jiuru Yan, Jiuru Yan, Yuxin Fu, Yuxin Fu, Yuxin Fu, Lan Lan, Huizhu Zhang, Huizhu Zhang, Huizhu Zhang, Ling Huang, Ling Huang, Yaying Wang, Yaying Wang, Xianrong Xiong, Xianrong Xiong, Xianrong Xiong, Shi Yin, Shi Yin, Shi Yin, Jian Li, Jian Li, Jian Li, Honghong He, Honghong He, Honghong He

“…IntroductionIn this study, we investigated the metabolic profiles of yak (Bos grunniens) follicles during the development period from the perspective of metabolomics, aiming to screen out the differential metabolites of yak follicles in different sizes and potential pathways during yak follicle development and to provide a basis for the study of follicle development and developmental mechanisms in the further stage of development.MethodsA total of 20 four-year-old female yaks were selected, and follicles of different sizes were collected after slaughter and divided into d < 3 mm, 3–6 mm and d > 6 mm. …”
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Investigating the Effect of Different Levels of Butyric Acid Glycerides and Clove Oil on Growth Performance, Blood Parameters and Tibia Bone Characteristics of Broiler Chickens by Seyyedeh azam khatami, Mir Daryoush Shakouri, Nemat Hedayat Evrigh

“…Material and Methods: A total of 300 male and female broilers (Ross 308) with a completely randomized design with a 2 × 3 factorial arrangement, two levels of butyric acid glycerides (0 and 0.2 %) and three levels of clove oil (0, 500 and 1000 mg/kg) were used. …”
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Urine kidney injury molecule-1 predicts subclinical kidney disease among persons living with HIV initiating tenofovir disoproxil fumarate-based ART in Zambia by Freeman W. Chabala, Edward D. Siew, Edward D. Siew, Edward D. Siew, C. William Wester, C. William Wester, Alana T. Brennan, Alana T. Brennan, Alana T. Brennan, Masauso M. Phiri, Michael J. Vinikoor, Michael J. Vinikoor, Sepiso K. Masenga, Muktar H. Aliyu, Muktar H. Aliyu, Muktar H. Aliyu

“…Baseline eGFR, creatinine, age, female sex, and BMI predicted the risk of overt TDF-associated nephrotoxicity. …”
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MicroRNAs Expression Profile in MN1-Altered Astroblastoma by Francesca Gianno, Evelina Miele, Claudia Sabato, Elisabetta Ferretti, Simone Minasi, Francesca Romana Buttarelli, Debora Salerno, Natalia Pediconi, Giuseppe Rubens Pascucci, Francesca Guerrieri, Andrea Ciolfi, Simone Pizzi, Maura Massimino, Veronica Biassoni, Elisabetta Schiavello, Marco Gessi, Sofia Asioli, Angela Mastronuzzi, Antonio d’Amati, Giuseppina Catanzaro, Elisabetta Viscardi, David Capper, Felice Giangaspero, Manila Antonelli

“…Background/Objectives: Astroblastoma is a rare glial neoplasm more frequent in young female patients, with unclear clinical behaviors and outcomes. …”
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Genome sequences of four Ixodes species expands understanding of tick evolution by Alexandra Cerqueira de Araujo, Benjamin Noel, Anthony Bretaudeau, Karine Labadie, Matéo Boudet, Nachida Tadrent, Benjamin Istace, Salima Kritli, Corinne Cruaud, Robert Olaso, Jean-François Deleuze, Maarten J. Voordouw, Caroline Hervet, Olivier Plantard, Aya Zamoto-Niikura, Thomas Chertemps, Martine Maïbèche, Frédérique Hilliou, Gaëlle Le Goff, Jindřich Chmelař, Vilém Mazák, Mohamed Amine Jmel, Michalis Kotsyfakis, José María Medina, Michael Hackenberg, Ladislav Šimo, Fotini A. Koutroumpa, Patrick Wincker, Petr Kopáček, Jan Perner, Jean-Marc Aury, Claude Rispe

“…Results Here, we present the genome sequences of four tick species, derived from a single female individual, with a particular focus on the European species Ixodes ricinus, achieving a chromosome-level assembly. …”
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Association of thoracic aortic calcium with incident cardiovascular disease and all-cause mortality across the spectrum of coronary artery calcium burden by Alexander C. Razavi, Omar Dzaye, Miguel Cainzos-Achirica, Zeina Dardari, Marly Van Assen, Arshed A. Quyyumi, Khurram Nasir, J. Jeffrey Carr, Matthew J. Budoff, Roger S. Blumenthal, Paolo Raggi, Carlo N. De Cecco, Laurence S. Sperling, Michael J. Blaha, Seamus P. Whelton

“…Results: The mean age was 62.1 years old, 53% were female, and 28% had TAC. Over a median follow-up of 17.7 years, 48% of participants with TAC ≥500 experienced CVD and 72% died. …”
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IOP-lowering effect of glaucoma surgery: retrospective analysis by I.B. Alekseev, M.M. Soshina, K.I. Bel'skaja, А.К. Aylarova, Yu.G. Kopchenova, I.A. Koroleva, A.R. Isaev

“…</i> </p> <p> <i><b>Conclusions</b>: female sex, older and senile age, and advanced disease stage reduce the duration of IOP-lowering effect of glaucoma surgery. …”
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Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study by Robert Landewé, Désirée van der Heijde, Filip van den Bosch, Maxime Dougados, Anna Molto, Stefan Siebert, Juergen Braun, Yuko Kaneko, Adeline Ruyssen-Witrand, Martin Soubrier, Atsuo Taniguchi, Masato Okada, Alain Cantagrel, Shigeto Kobayashi, Jon Packham, Philippe Goupille, Rene-Marc Flipo, Alain Saraux, Philippe Gaudin, Roberto Caporali, Raj Sengupta, James Cheng-Chung Wei, Tetsuya Tomita, Fernando Pimentel-Santos, Alberto Ortiz, Gaëlle Varkas, Alejandro Martínez, Shigeyoshi Tsuji, Alejandro Alvarellos, José Maldonado-Cocco, Yoshinori Taniguchi, Fadoua Allali, Raquel Almodovar González, Elena Alonso Blanco-Morales, Maria Aparicio Espinar, Pamir Atagunduz, Pauline Bakker, Leila Benbrahim, Bahia Benchekroun, Alberto Berman, Pedro Carvalho, Gustavo Casado, Francisco Colombres, Eugenio del Miguel Mendieta, Vanesa Duarte, Cristina Fernandez Carballido, Manuel Fernandez-Prada, Pilar Font Ugalde, Dolors Grados Cánovas, Jordi Gratacós Masmitjá, Vittorio Grosso, Naomi Ichikawa, Hisashi Inoue, Taku Kawasaki, Manjari Lahiri, Hernán Maldonado-Ficco, Kazuo Matsui, Ramón Mazzuchelli Esteban, Corinne Micelli, Chisun Min, Mitsuhiro Morita, Juan Mulero Mendoza, Gisela Pendón, Dora Pereira, Hanan Rkain, Oscar Rillo, Carlos Rodriguez Lozano, Adrián Salas, Carlos Salinas-Ramos, Amelia Santosa, Caroline Spiegel, Carmen Stolwijk, Kurisu Tada, Naoho Takizawa, Chung Tei Chou, Lay-Keng Teoh, Wen-Chan Tsai, Olga Tsyplenkova, Kiana Vakil-Gilani, Rafael Valle-Oñate, Virginia Villaverde, Ai Yap, Pedro Zarco Montejo, Juan C Barreira, Juan D Diaz-Garcia, Michel De Bandt, Astrid van Tubergen, Rodolfo Pérez-Alamino, T Marhadour, Christian Waimann, Mari CruzFernandez Espartero, Jose Raul NogueraPons, José A PereiradaSilva

“…Age at disease onset (OR 1.02), axial symptom (OR 16.25), peripheral arthritis (OR 6.81), decade at disease onset (OR 3.80) and extra-musculoskeletal manifestation (OR 2.89) were associated with an early diagnosis, while female gender (OR 0.66) was inversely associated.Conclusions The proportion of patients with early SpA diagnosis improve from 15% before 1980 to 88% when first symptoms occurred after 2010. …”
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Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study by Jiayu Qiu, Yueming Yu, Dingwei Liu, Sihai Chen, Youhua Wang, Jianxiang Peng, Jinliang Xie, Chengyun Wu, Feng Zhou, Hui Fang, Qirui Lai, Yong Xie

“…In subgroup analysis, the adjusted association between three IR surrogate markers and H. pylori infection were more likely to be observed in female and Non-Hispanic White. Additionally, the RCS curve revealed a positive linear correlation between TyG index and H. pylori infection across all three models, and between METS-IR and H. pylori infection in Model 3. …”
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Definitional differences in “outpatient” surgery can influence study outcomes related to total shoulder arthroplasty by Junho Song, MD, Jennifer Yu, BS, Avanish Yendluri, BS, William A. Ranson, MD, Nikan K. Namiri, MD, John J. Corvi, MD, David E. Kantrowitz, MD, Thomas Boucher, MD, Leesa M. Galatz, MD, Paul J. Cagle, MD, Bradford O. Parsons, MD, Robert L. Parisien, MD

“…Compared to SDD, HDO was associated with female sex, higher body mass index, functional dependence, diabetes, chronic obstructive pulmonary disease, congestive heart failure, hypertension, American Society of Anesthesiologists ≥3, longer operation time, and nonhome discharge. …”
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Risk of angioedema and thrombolytic therapy among stroke patients: An analysis of data from the FDA Adverse Event Reporting System database by Hunong Xiang, Yu Ma, Xiaochao Luo, Jian Guo, Minghong Yao, Yanmei Liu, Ke Deng, Xin Sun, Ling Li

“…Multivariate analysis revealed that ACE-inhibitors use (aROR 9.73 [95 ​% CI, 7.29–12.98]), female sex (aROR 1.38 [95 ​% CI, 1.13–1.67]) and hypertension (aROR 2.11 [95 ​% CI, 1.52–2.92]) were significant risk factors for angioedema among alteplase-treated stroke patients. …”
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