Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index by María Pardo, Ana B. Crujeiras, María Amil, Zaida Aguera, Susana Jiménez-Murcia, Rosa Baños, Cristina Botella, Rafael de la Torre, Xavier Estivill, Ana B. Fagundo, Jose M. Fernández-Real, José C. Fernández-García, Gema Fruhbeck, Javier Gómez-Ambrosi, Roser Rodríguez, Francisco J. Tinahones, Fernando Fernández-Aranda, Felipe F. Casanueva

“…The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). …”
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Chromosome-level genome assembly and annotation of the gynogenetic large-scale loach (Paramisgurnus dabryanus) by Lei Zhang, Wanting Zhang, Yingyin Cheng, Yutong Fang, Xin Guan, Ao Gong, Yanxin Jiang, You Duan, Lei Huang, Waqar Younas, Yaping Wang, Mijuan Shi, Xiao-Qin Xia

“…In this study, we performed PacBio HiFi and Hi-C sequencing on a female (ZW) specimen and assembled the first high-quality chromosome-level genome of the large-scale loach. …”
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Research involvement among undergraduate medical students in Bangladesh: a multicenter cross-sectional study by Mohammad Jahid Hasan, Salwa Islam, Hasnat Sujon, Fahmida Islam Chowdhury, Muna Islam, Mostak Ahmed, Mahbuba Shabnam, Mahbub Mayukh Rishad, Mohammad Nurunnabi, Md Marufur Rahman, Jannatul Fardous, Mir Susmita Zaman, Mir Paramita Zaman, Mir Ahsan Ali, Md Rabiual Awal, Taha Choudhury, Ahmed Ullah Shuvo, Sabrina Sultana, Tanjina Tabassum, Monjur Rahman, Anindita Das Barshan, Tamanna Tabassum, Md. Abdur Rafi, Sharmeen Yasmeen

“…Results The mean age of the students was 21.8 ± 1.8 (SD) years, with the majority being female (61.8%). Overall, 21.5% (n = 617) were actively participating in research beyond academic activities. …”
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Artificial intelligence conversational agents in mental health: Patients see potential, but prefer humans in the loop by Hyein S. Lee, Hyein S. Lee, Colton Wright, Julia Ferranto, Jessica Buttimer, Clare E. Palmer, Andrew Welchman, Kathleen M. Mazor, Kimberly A. Fisher, David Smelson, Laurel O’Connor, Laurel O’Connor, Nisha Fahey, Nisha Fahey, Apurv Soni, Apurv Soni, Apurv Soni

“…Data were collected from December 2022 to February 2023, and three researchers conducted rapid qualitative analysis to identify and synthesize themes.ResultsThe sample included 29 adults (ages 19-66), predominantly under age 35, non-Hispanic, White, and female. Participants reported a range of positive and negative experiences with AI conversational agents. …”
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Sex Differences in the Prognostic Value of Circulating Biomarkers in Patients Presenting With Acute Chest Pain by Gard Mikael Sæle Myrmel, MD, Nasir Saeed, Ole Thomas Steiro, MD, Hilde Lunde Tjora, MD, PhD, Jørund Langørgen, MD, PhD, Rune Oskar Bjørneklett, MD, PhD, Øyvind Skadberg, MD, Vernon Vijay Singha Bonarjee, MD, PhD, Øistein Rønneberg Mjelva, MD, Eva Ringdal Pedersen, MD, PhD, Kjell Vikenes, MD, PhD, Torbjørn Omland, MD, PhD, Kristin Moberg Aakre, MD, PhD

“…Conclusions: In contrast to CRP and GDF-15, increasing concentrations of hs-cTn, hs-cTnI, and NT-proBNP are associated with higher risk of death and CV events in female than in male patients presenting with suspected NSTE-ACS. …”
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Immunization with OPN5 increased seasonal degradation of reproductive activity in Magang ganders by Jianqiu Pan, Xu Shen, Hongjia Ouyang, Junfeng Sun, Sui Liufu, Danli Jiang, Wenjun Chen, Siyue Peng, Danning Xu, Yunbo Tian, Yunmao Huang, Jianhua He

“…On days 0, 15 and 30, ganders in the immunized group were immunized with OPN5-KLH protein vaccine, and ganders in the control were immunized with the same amount of blank emulsified vaccine. Additionally, 120 female geese were provided to stimulate the reproductive activities of male geese. …”
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Utilisation of alcohol-related treatment after a first alcohol use disorder diagnosis in Hamburg, Germany by Jakob Manthey, Kilian Huß, Sven Buth, Ludwig Kraus, Anna Schranz, Carolin Kilian, Jürgen Gallinat, Ingo Schäfer, Bernd Schulte

“…Treatment utilisation was associated with younger age, female sex, unemployment, German nationality, and lower physical comorbidity. …”
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Impact of Sex on Infection Risk in Patients with Systemic Lupus Erythematosus by R. Borrelli, S. Nicola, F. Corradi, I. Badiu, L. Lo Sardo, N. Rashidy, A. Quinternetto, M. Mazzola, F. Meli, E. Saracco, I. Vitali, S. Negrini, L. Brussino

“…<b>Results:</b> A total of 119 patients (107 females and 12 males) were included in the analysis. …”
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Cross-cultural adaptation of the simple Chinese version of the medication adherence reasons scale in patients undergoing adjuvant endocrine therapy for breast cancer by Lei Xu, Ping Li, Yan Hu, Weijie Xing, Jiajia Qiu, Xiaoju Zhang, Lingying Jia, Feng Jing, Ye Liu, Lili Li, Chunyang Lu

“…Inclusion criteria were: (a) female, (b) aged 18 years or older, (c) diagnosed with Stage I to III BrCa, (d) completed primary treatment for hormone receptor-positive BrCa and had been on AET for more than six months but less than five years, (e) proficient in Mandarin, and (f) provided informed consent. …”
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Idiopathic multicentric Castleman disease in children: a single-center retrospective analysis by Junye Du, Jiafeng Yao, Honghao Ma, Li Li, Ang Wei, Liping Zhang, Dong Wang, Zhigang Li, Rui Zhang, Tianyou Wang

“…Results A total of 9 children were enrolled, with a median age of onset of median 11 (2–15) years, 6 males and 3 female. 3 cases were pathologically typed as plasma cell type, 1 case was mixed type, and the remaining 5 cases were hyaline vascular type. 9 children received different regimens of chemotherapy. …”
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CBCT Analysis of Mandibular Ramus as a Donor Site for Cortical Bone Graft: A Retrospective Analytical Study by Pallabi Das, Samiran Ghosh, Kaushik Dutta, Richi Burman, Amit Ray, Debolina Pramanick, Siddhartha Chatterjee, Somak Saha

“…Results: Among 55 sites, 25 (45.5%) were from female candidates and 30 (54.5%) were from males. …”
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Botulinum Toxin Injection with Conjunctival Microincision for the Treatment of Acute Acquired Comitant Esotropia and Its Effectiveness by Hongjia Xu, Weifeng Sun, Shuying Dai, Yanyan Cheng, Jing Zhao, Yuan Liu, Juan Wang, Ya’nan Wang, Yu Gao, Huifang Han, Aijun Han

“…Twenty-nine patients were included, of whom 22 were male and 7 were female. The mean age at onset was 14.2 ± 7.4 (range, 4–34) years. …”
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Platelet-rich plasma combined with gypenosides for the treatment of psoriasis-like inflammation in mice by LI Dandan, WANG Bing, GE Yu, CHENG Hong, LI Mengxue, WANG Zhicheng, XIA Rong

“…[Methods] The 6-8 week-old female SPF BALB/c mice were randomly divided into five groups: control, model, PRP, GPs and PRP+GPs group, with 5 mice in each group. …”
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Experience in laparoscopic transcystic common bile duct exploration for super-elderly patients with choledocholithiasis—A 96-year-old case report by Zongming Zhang, Limin Liu, Chong Zhang, Zhuo Liu, Yue Zhao, Hui Qi, Haiyan Yang, Baijiang Wan, Mingwen Zhu, Hai Deng, Jinqiu Feng, Fucheng Liu, Zhentian Guo, Peijie Yao

“…Case summary: This case study presents the case of a 96-year-old female patient with acute calculous cholecystitis and choledocholithiasis. …”
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Psychosocial risks and mental health of health and social care workers in the context of the COVID-19 pandemic by Nadia Vilahur Chiaraviglio

“…Results shows very high prevalences for many mental health problems and conditions across the sector, also in their more severe clinical forms, and identifies sub-groups at potentially higher risk of suffering mental health problems in a female-dominated sector. Furthermore, it systematically maps and assesses the range of interventions conducted since 2020 to increase psychosocial wellbeing and prevent and manage mental health problems in the sector, to offer practical guidance and a range of scalable examples to workplaces.  …”
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Automatic etiological classification of stroke thrombus digital photographs using a deep learning model by Álvaro Lucero-Garófano, Álvaro Lucero-Garófano, Alicia Aliena-Valero, Isabel Vielba-Gómez, Isabel Vielba-Gómez, Irene Escudero-Martínez, Irene Escudero-Martínez, Lluís Morales-Caba, Lluís Morales-Caba, Fernando Aparici-Robles, Fernando Aparici-Robles, Diana L. Tarruella Hernández, Diana L. Tarruella Hernández, Gerardo Fortea, Gerardo Fortea, José I. Tembl, José I. Tembl, Juan B. Salom, Juan B. Salom, José V. Manjón

“…The metrics used were DICE coefficient for the segmentation network, and accuracy, precision, sensitivity, specificity and area under the curve (AUC) for the predictions of the classification network.ResultsA total of 166 patients (mean age 69 [SD, 13], 67 female) were included. TOAST classification was: 31 atherothrombotic, 87 cardioembolic, and 48 cryptogenic. …”
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Fluoride in drinking water and associated non-carcinogenic health risk in Inner Mongolia Autonomous Region, 2022: a monitoring data analysis by Wenqian ZHANG, Jiake ZHU, Wenyu ZHANG, Xinrui JIA, Xuanzhi YUE, Huan LI, Duoduo WU, Yuhan QIN, Yaochun FAN

“…The non-cancer health risk of oral fluoride exposure was similar for male and female adults (HQ = 0.31), and the non-cancer health risk was higher (HQ = 0.33 – 0.45) for children aged 9 months – < 3 years than for adults. …”
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A single residue switch mediates the broad neutralization of Rotaviruses by Yang Huang, Feibo Song, Yuanjun Zeng, Hui Sun, Roufang Sheng, Xuechun Wang, Liqin Liu, Guoxing Luo, Yanan Jiang, Yaling Chen, Mengxuan Zhang, Shiyin Zhang, Ying Gu, Hai Yu, Shaowei Li, Tingdong Li, Qingbing Zheng, Shengxiang Ge, Jun Zhang, Ningshao Xia

“…Here, focusing on the pivotal viral protein VP4 of rotavirus (RV), we identify a potent bNAb, 7H13, exhibiting broad-spectrum neutralization across diverse RV genotypes and demonstrating strong prevention of virus infection in female mice. A combination of time-resolved cryo-electron microscopy (cryo-EM) and in situ cryo-electron tomography (cryo-ET) analysis reveals a counterintuitive dynamic process of virus inactivation, in which 7H13 asymmetrically binds to a conserved epitope in the capsid-proximal aspect of VP4, triggers a conformational switch in a critical residue—F418—thereby disrupts the meta-stable conformation of VP4 essential for normal viral infection. …”
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Case report: Atypical young case of MV1 Creutzfeldt-Jakob disease with unusually long survival by Lucie Yeongran Ahn, Mark L. Cohen, Mark L. Cohen, Ignazio Cali, Ignazio Cali, Tia Russell, Jessica Ludwig, Xun Jia, Alberto Bizzi, Lawrence B. Schonberger, Ryan A. Maddox, Rohini Paul, Tania C. Ghazarian, Jaspreet Garcha, Mostafa Hammoudi, Brian Stephen Appleby, Brian Stephen Appleby, Brian Stephen Appleby, Brian Stephen Appleby

“…Here, we present a 21-year-old female who died with a sporadic prion disease. She presented with psychiatric symptoms followed by a rapidly progressive neurocognitive and motor decline. …”
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Effectiveness of late and very late antivenom administration on recovery from snakebite-induced coagulopathy in French Guiana: a population-based studyResearch in context by Jean Marc Pujo, Stephanie Houcke, Guy Roger Lontsi Ngoulla, Vivian Laurent, Boubacar Signaté, Rémi Mutricy, Alexis Frémery, Flaubert Nkontcho, Ibtissem Ben Amara, José María Gutiérrez, Dabor Resiere, Hatem Kallel

“…The median age of patients was 42 years (IQR: 29–53), 65.4% were male and 34.6% were female (104 and 55 out of 159 patients) without difference regarding the demographic parameters between groups. …”
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