Feasibility and potential diagnostic value of [18F]PI-2620 PET in patients with down syndrome and Alzheimer’s disease: a case series by Olivia Wagemann, Olivia Wagemann, Matthias Brendel, Nicolai Franzmeier, Nicolai Franzmeier, Nicolai Franzmeier, Georg Nübling, Georg Nübling, Johannes Gnörich, Mirlind Zaganjori, Catharina Prix, Anna Stockbauer, Anna Stockbauer, Elisabeth Wlasich, Sandra V. Loosli, Sandra V. Loosli, Katja Sandkühler, Lukas Frontzkowski, Günter Höglinger, Günter Höglinger, Günter Höglinger, Johannes Levin, Johannes Levin, Johannes Levin

“…We aim at illustrating feasibility and potential diagnostic value of tau PET imaging with [18F]PI-2620 for the diagnosis of DS-AD.Materials and methodsFive adults with DS (40% female, aged 43–62) and cognitive decline underwent clinical assessments, neuropsychological testing, lumbar puncture and multimodal neuroimaging. …”
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Inappropriate medication prescribing, polypharmacy, potential drug-drug interactions and medication regimen complexity in older adults attending three referral hospitals in Asmara,... by Nuru Abdu, Saleh Idrisnur, Hanae Said, Lude Kifle, Natnael Habte, Semira Ghirmai, Tomas Tewelde, Senai Mihreteab Siele, Eyasu H. Tesfamariam

“…Results A total of 430 respondents, with a similar male to female ratio, were included. The prevalence of polypharmacy was 5.3% (95%CI: 3.2, 7.5). …”
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The role of the TAPSE/sPAP ratio as a predictor of mortality in Pulmonary Arterial Hypertension: Its value for patient risk stratification by Paul Palacios-Moguel, MD, Guillermo Cueto-Robledo, MD, Héctor González-Pacheco, MD, Jorge Ortega-Hernández, MD, María Berenice Torres-Rojas, MD, Dulce Iliana Navarro-Vergara, MD, Marisol García-Cesar, MD, Cinthia Alejandra González-Nájera, MD, Carlos Alfredo Narváez-Oríani, MD, Julio Sandoval, MD

“…Results: Most patients were female (86.5%), with a median age of 45.5 (IQR: 29–58) years. …”
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Symptoms of anxiety, depression, and post-traumatic stress disorder 6 weeks and 6 months after ICU: Six out of 10 survivors affected by E van der Merwe, L Stroud, G Sharp, N van Vuuren, M Mosola, T Fodo, F Paruk

“…Associations for significant psychological symptoms comprised female sex, younger age, a diagnosis of trauma and frightening memories of the ICU admission. …”
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Have the COVID-19 pandemic and lockdown affected children’s mental health in the long term? A repeated cross-sectional study by Alan Johnson, Sayan Mukherjee, Sushant Mane, Manas Pustake, Ajit Bhagwat, Mohammad Arfat Ganiyani, Misba Sayed, Varada Mithbavkar, Zaid Memon, Abdus Samad Momin, Krishna Deshmukh, Ayush Chordia, Sabyasachi Parida, Sanket Warghade, Deepankar Varma

“…Regression analysis showed that many factors, including the duration of smartphone use, female gender and only child status, were associated with increased anxiety or depression levels.Conclusion A large proportion of children had elevated anxiety and depressive symptoms during the pandemic relative to before the pandemic, suggesting a need for measures to engage children in healthy habits to protect children’s mental health and continuous monitoring of children during such scenarios.…”
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Hiatal Hernia Repair with Gore Bio-A Tissue Reinforcement: Our Experience by Agrusa Antonino, Romano Giorgio, Frazzetta Giuseppe, De Vita Giovanni, Di Giovanni Silvia, Chianetta Daniela, Di Buono Giuseppe, Sorce Vincenzo, Gulotta Gaspare

“…We present a case of a 65-year-old female patient with a 6-year classic history of GERD. …”
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Psychosocial factors are associated with community mobility and participation in persons with dizziness by Pamela M. Dunlap, Jeffrey P. Staab, Patrick J. Sparto, Patrick J. Sparto, Joseph M. Furman, Susan L. Whitney, Susan L. Whitney

“…We used exploratory factor analysis to identify constructs measured using patient-reported outcomes of psychosocial factors.ResultsThere were 100 participants who completed the baseline assessment [mean age (SD) = 49.2 (15.7) years; 73% female] and 68 participants completed the questionnaire at the 3-month follow-up. …”
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Diminished ovarian reserve is associated to euploidy rate: a single center study by Edoardo Carnesi, Stefano Castellano, Stefano Castellano, Elena Albani, Andrea Busnelli, Andrea Busnelli, Antonella Smeraldi, Ozgur Bulbul, Emanuela Morenghi, Valentina Immediata, Paolo Emanuele Levi-Setti, Paolo Emanuele Levi-Setti

“…The relationship between these biomarkers and embryo chromosomal status remains complex and poorly understood.MethodsWe conducted a retrospective analysis of in vitro fertilization (IVF) cycles performed between 2015 and 2022, involving 773 female patients who underwent IVF and pre-implantation genetic screening for aneuploidy (PGT-A). …”
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The spatially informed mFISHseq assay resolves biomarker discordance and predicts treatment response in breast cancer by Evan D. Paul, Barbora Huraiová, Natália Valková, Natalia Matyasovska, Daniela Gábrišová, Soňa Gubová, Helena Ignačáková, Tomáš Ondris, Michal Gala, Liliane Barroso, Silvia Bendíková, Jarmila Bíla, Katarína Buranovská, Diana Drobná, Zuzana Krchňáková, Maryna Kryvokhyzha, Daniel Lovíšek, Viktoriia Mamoilyk, Veronika Mancikova, Nina Vojtaššáková, Michaela Ristová, Iñaki Comino-Méndez, Igor Andrašina, Pavel Morozov, Thomas Tuschl, Fresia Pareja, Jakob N. Kather, Pavol Čekan

“…On a retrospective cohort of 1082 female breast tissues, we develop and validate mFISHseq, which integrates multiplexed RNA fluorescent in situ hybridization with RNA-sequencing, guided by laser capture microdissection. …”
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Food choice motivations and perceptions of healthy eating: a cross-sectional study among consumers in the UAE by Leila Cheikh Ismail, Tareq M. Osaili, Reyad Shaker Obaid, Mona Hashim, Marya Ahmed, Fatma Al-Fayadh, Aisha Farah, Hanin Sad, Humood Alghanem, Maysm N. Mohamad, Sheima T. Saleh, Rameez Al Daour, Emad Masuadi, Lily Stojanovska, Habiba I. Ali, Ayesha S. Al Dhaheri

“…Cluster 1 encompasses more female participants than males, while Cluster 2 comprises a more significant proportion of males and individuals falling within higher income brackets (p < 0.001). …”
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Implementation of a genotyped African population cohort, with virtual follow-up: A feasibility study in the Western Cape Province, South Africa [version 2; peer review: 2 approved,... by Robert J Wilkinson, Francisco Lakay, Nicki Tiffin, Joel A Dave, Catherine Riou, Peter Raubenheimer, Anna K Coussens, Tsaone Tamuhla, Melissa J Blumenthal, Maleeka Abrahams

“…Results 2267346 variants were analysed in 459 participant samples, of which 229 (66.8%) are female. 78.6% of SNPs and 74% of samples passed quality control (QC). …”
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Sporadic Burkitt Lymphoma First Presenting as Painful Gingival Swellings and Tooth Hypermobility: A Life-Saving Referral by Erofili Papadopoulou, Maria Kouri, Dimitrios Velonis, Anastasia Andreou, Maria Georgaki, Spyridon Damaskos, Evangelia Piperi, Konstantina Delli, Ioannis K. Karoussis, Antonia Vlachou, Georgia Avgerinou, Antonis Kattamis, Nikolaos G. Nikitakis

“…<b>Case report:</b> An 11-year-old Caucasian female was referred for the evaluation of hypermobility of posterior lower teeth, associated with painful gingival swellings of 20 days duration. …”
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Oral Administration of 17α-Methyltestosterone Increased Male Percentage of Freshwater Crayfish Cherax quadricarinatus by O. Carman, M.Y. Jamal, . Alimuddin

“…Sex was determined by visual observation; the male sex organ is located at the fifth walking leg while the female is at the third.  Data was analyzed by F and BNT tests.  …”
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Sequential use of low-load-blood-flow-restricted vs. high-load resistance training on neuromuscular activation, hypertrophy and neuromuscular performance by Romina Ledergerber, Paul Ritsche, Eric Lichtenstein, Martin Keller

“…Methods In this 10-week randomized controlled trial, 37 healthy male and female adults (35-60 years) completed progressive resistance training for knee extensors either 8 weeks with low-load BFRT followed by 2 weeks of HLT, or exclusively HLT. …”
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Mitochondrial oxygen metabolism as a potential predictor of weight loss after laparoscopic sleeve gastrectomy for class III obesity by Markus Engelmann, Markus Engelmann, Juliane Götze, Juliane Götze, Philipp Baumbach, Philipp Baumbach, Charles Neu, Charles Neu, Utz Settmacher, Michael Ardelt, Hermann Kissler, Sina M. Coldewey, Sina M. Coldewey

“…We compared the values obtained in patients with obesity with those of age- and sex-matched healthy controls and investigated changes up to one year after LSG. 48 patients (46.5 years [35.5-55.3]; 38/48 female (79.2%); BMI 46.7 [42.5-51.0]) completed the study. …”
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Incidence of self-reported tuberculosis treatment with community-wide universal testing and treatment for HIV and tuberculosis screening in Zambia and South Africa: A planned analy... by L Telisinghe, S Floyd, D MacLeod, A Schaap, R Dunbar, J Bwalya, N Bell-Mandla, E Piwowar-Manning, D Donnell, K Shaunaube, P Bock, S Fidler, R J Hayes, H M Ayles, HPTN 071 (PopART) study team

“…In a cohort of randomly selected adults (18 to 44 years) enrolled between 2013 and 2015 from all 21 communities (total size 38,474; 27,139 [71%] female; 8,004 [21%] HIV positive) and followed-up annually for 36 months to measure the population-level impact of the interventions, data on self-reported TB treatment in the previous 12 months (self-reported TB) were collected by trained research assistants and recorded using a structured questionnaire at each study visit. …”
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Effect of retirement on the body mass index in China: a nationwide study based on the regression discontinuity design by Jiarun Mi, Xueyan Han, Hanchao Cheng, Zhaoyang Pan, Jian Guo, Hailu Zhu, Qi Wang, Yicong Wang, Yuanli Liu, Congyi Zheng, Xin Wang, Xue Cao, Zhen Hu, Yixin Tian, Zengwu Wang, Tianjia Guan

“…Notably, retirement significantly impacted the male participants, resulting in an increase in their BMI of 2.18 (95% CI 0.23–4.13), but did not affect the BMI of the female participants. Furthermore, individuals with lower educational backgrounds experienced more pronounced BMI changes upon retirement. …”
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Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat by Mingxuan Han, Xinbo Wang, Haidong Du, Yanlong Cao, Zhanqiang Zhao, Shuran Niu, Xuxu Bao, Youjun Rong, Xiaofang Ao, Furong Guo, Qincheng Xia, Fangzheng Shang, Ruijun Wang, Yanjun Zhang

“…In this study, we used the MGISEQ-T7 platform to re-sequence 240 Zhongwei goats (133 male; 107 female) belonging to 5 metrics of growth traits at different growth stages (40 days and 6 months, here in after referred to as 40d and 6 m), namely, Body Weight (BW), Body Height (BH), Body Length (BL), Chest Circumference (CC), Tube Circumference (TC) were examined. …”
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Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study by Yanning Qu, Rui Tang, Zhuyan Duan, Mengyi Sheng, Hui Wang, Shuang Liu, Jiao Li, Linlin Guo, Linying Guo, Si Zheng, Si Zheng

“…Univariate and multivariate logistic regression analyses were conducted to identify risk factors associated with hospitalization.ResultsOverall, a total of 718 patients with acute non-pharmaceutical toxic exposures was included in this study, infants and toddlers accounting for 57.9%. The male-to-female ratio was 1.16:1. The majority exposure events occurred at home (89.3%) and in urban settings (78.4%). …”
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Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study by Lin Cai, Wen Wang, Ping Yuan, Lan Lin, Kuicheng Zheng, Sihan Wu, Liangxiang Huang, Bingshan Wu, Tiehui Chen, Xiaoqing Li

“…Objective To explore the relationships between gastric cancer and serum pepsinogen I (PG I), PG II, PG I/II ratio, gastrin 17 (G-17) and Helicobacter pylori infection, and to investigate dietary and lifestyle risk factors for gastric cancer in Fujian Province, China.Design A hospital-based, 1:1 matched case–control study.Setting Patients with newly diagnosed gastric cancer were recruited from the Fujian Provincial Hospital and the No. 900 Hospital of the Joint Support Force of the Chinese People’s Liberation Army between July 2014 and December 2016.Participants A total of 180 pairs of patients with gastric cancer and control subjects were recruited in the study, including 134 (74.4%) male pairs and 46 (25.6%) female pairs.Investigation and analysis measures Serological indicators were tested with ELISA kits. …”
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