Prevalence and influencing factors of occupational burnout among healthcare workers in the Chinese mainland during the late 2022 Omicron COVID-19 outbreak: a multicenter cross-sect... by Shu Jing, Zhenwei Dai, Yijin Wu, Xin Liu, Ling Zhang, Xiaoyang Liu, Tianrui Ren, Jiaqi Fu, Xu Chen, Wenjun Wang, Xiaofen Gu, Li Ma, Shaokai Zhang, Yanqin Yu, Li Li, Zhili Han, Xiaoyou Su, Youlin Qiao

“…The results showed that the prevalence of occupational burnout and associated mental disorders, such as depressive symptoms, anxiety, and PTSD in HCWs were 44.56%, and 70.75%, 47.87%, and 37.49%, respectively. Older age, female gender, higher income, more doses of COVID-19 vaccine, a higher level of mindfulness, resilience, and perceived social support were protective factors of occupational burnout. …”
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Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model by Tala Curry-Koski, Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Mitra Esfandiarei, Mitra Esfandiarei, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas

“…Despite these significant clinical observations, investigation into cerebrovascular dysfunction and neuropathology in MFS remains limited.MethodsUsing 6M-control (C57BL/6) and 6M-MFS (Fbn1C1041G/+) and healthy 12M-control male and female mice, we test the hypothesis that abnormal Fbn1 protein expression is associated with altered cerebral microvascular density, BBB permeability, and neuroinflammation in the PCA-perfused hippocampus, all indicative of a pre-mature aging brain phenotype. …”
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Evaluation of clinical, laboratory, radiographical and histopathological characteristics in patients with spinal tuberculosis in the context of HIV infection: An analysis of 52 pat... by J Scherer, M Locketz, S Castelein, R Dunn, M Held, F Thienemann

“…We assessed 52 patients with STB (mean (standard deviation (SD) age 38 (15.2) years, range 17 - 80 years), of whom 55.8% were female, and 59.6% HIV infected. Five (9.6%) patients were identified with multidrug-resistant TB of the spine, with four (19.0%) in the HIV-infected cohort and one in the HIV-uninfected cohort (p=0.058). …”
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Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study by Jie Yuan, Hai Long, Min Liu, Juan He, Jue Liu, Yu Wu, Wenzhan Jing, Min Du, Manna Zhang, Yaping Wang, Su Song, Siqi Liu, Guiying Cao, Yuedong Liang, Xiaoxin Xie, Yanhua Fu

“…Results from multivariate logistic regression showed that females had increased odds of anaemia (adjusted OR (aOR)=1.60, 95% CI: 1.42 to 1.81) compared with males. …”
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Establishment and Evaluation of a Rat Model of Non-Puerperal Mastitis by YIN Yulian, MA Lina, TU Siyuan, CHEN Ling, YE Meina, CHEN Hongfeng

“…Methods Twelve SPF-grade Wistar female rats were evenly divided into a control group and a model group. …”
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Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity by Claire E. Otero, Sophia Petkova, Martin Ebermann, Husam Taher, Nessy John, Katja Hoffmann, Angel Davalos, Matilda J. Moström, Roxanne M. Gilbride, Courtney R. Papen, Aaron Barber-Axthelm, Elizabeth A. Scheef, Richard Barfield, Lesli M. Sprehe, Savannah Kendall, Tabitha D. Manuel, Teresa Beechwood, Linh Khanh Nguyen, Nathan H. Vande Burgt, Cliburn Chan, Michael Denton, Zachary J. Streblow, Daniel N. Streblow, Alice F. Tarantal, Scott G. Hansen, Amitinder Kaur, Sallie Permar, Klaus Früh, Hartmut Hengel, Daniel Malouli, Philipp Kolb

“…When RhCMV-naïve male rhesus macaques were infected with vFcγR-deleted RhCMV, peak plasma DNAemia levels and anti-RhCMV antibody responses were comparable to wildtype infections of both male and female animals. However, the duration of plasma DNAemia was significantly shortened in immunocompetent, but not in CD4 + T cell-depleted animals. …”
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Application of a 3D Fusion Model to Evaluate the Efficacy of Clear Aligner Therapy in Malocclusion Patients: Prospective Observational Study by Chaofeng Liu, Yan Liu, Chunyan Yi, Tao Xie, Jingjun Tian, Peishen Deng, Changyu Liu, Yan Shan, Hangyu Dong, Yanhua Xu

“…Among the 136 participants, 90 (66%) were female, 46 (34%) were male, 64 (47%) were adolescents, 72 (53%) were adults, 38 (28%) underwent extraction, and 98 (72%) did not. …”
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Retrospective comparative survival analysis of ablation plus systemic therapy versus systemic therapy alone for breast cancer liver metastases, stratified by extrahepatic metastase... by Xuxiazi Zou, Hong-Liang Zou, Xuan Luo, Xu-Wei Chen, Wei-Ling Huang, Chao Zhang, Ge Ren, Jin-Hua Huang, Xue Han, Yi-Quan Jiang

“…Results: The study included 1021 female patients, with a median follow-up of 39.6 months. …”
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Clinical and analytical monitoring of patients with multiple sclerosis on anti-CD20 therapeutics: a real-world safety profile study by André Aires Fernandes, André Aires Fernandes, Ana Lídia Neves, Ana Lídia Neves, Daniela Ferro, Daniela Ferro, Mafalda Seabra, Mafalda Seabra, Teresa Mendonça, Ricardo Soares dos Reis, Ricardo Soares dos Reis, Maria José Sá, Joana Guimarães, Joana Guimarães, Pedro Abreu, Pedro Abreu

“…Clinical and paraclinical parameters were evaluated, including complete blood count and immunoglobulins measurements.ResultsA total of 160 with multiple sclerosis (pwMS) were included in our study, of whom 110 (68.8%) were female and 147 are currently receiving anti-CD20 therapies. …”
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Efficacy of the Bushen Jianpi Huoxue Formula on Beclin-1/Bcl-2-mediated autophagy and apoptosis in osteoblasts by Yanping Lin, Yanping Lin, Rui Zhao, Rui Zhao, Jiachun Huang, Tongying Chen, Tongying Chen, Haolin Yang, Haolin Yang, Haiwei Guo, Lei Wan, Zhihai Zhang, Ying Li, Genfu Zhu, Hongxing Huang, Hongxing Huang

“…Additionally, it initially explores the functional mechanism of Beclin-1/Bcl-2-related apoptosis.MethodsOsteoblasts were isolated from the calvaria of three-day-old Sprague-Dawley female rats. The lyophilized power of the Bushen Jianpi Huoxue Formula was prepared from the following ingredients: Fructus Psoraleae, Epimedii Folium, Desertliving Cistanche, Prepared Rehmannia Radix, Radix paeoniae alba, Astragali Radix, Semen Cuscuta, Radix Salviae miltiorrhizae, Angelica sinensis, and Jujube. …”
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Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry by Jae Myeong Kang, Manchumad Manjavong, Chengshi Jin, Adam Diaz, Miriam T. Ashford, Joseph Eichenbaum, Emily Thorp, Elizabeth Wragg, Kenton H. Zavitz, Francesca Cormack, Anna Aaronson, R. Scott Mackin, Rachana Tank, Bernard Landavazo, Erika Cavallone, Diana Truran, Sarah Tomaszewski Farias, Michael W. Weiner, Rachel L. Nosheny

“…Results Participants (n = 16,683) had an average age of 69.07 ± 7.34, 72.04% were female, and had an average of 16.66 ± 2.26 years of education. …”
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A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction by Gwyneth Kong, Jaycie Koh, Jobelle Chia, Bryan Neo, Yiming Chen, Grace Cao, Bryan Chong, Mark Muthiah, Hui Wen Sim, Gavin Ng, Chieh Yang Koo, Chin Meng Khoo, Mark Yan-Yee Chan, Poay-Huan Loh, Nicholas W. S. Chew

“…The lean T2DM phenotype was an independent predictor of long-term mortality following AMI, although this association was stronger in males than in females.…”
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plaTform fOr Urinary tract infection diagnostiC evAluatioN (TOUCAN): a protocol for a prospective diagnostic accuracy study of point-of-care testing in patients suspected of acute... by Thomas R Fanshawe, Philip J Turner, Gail N Hayward, Margaret Glogowska, Alastair D Hay, Michael Moore, Mark Lown, Christopher C Butler, Mandy Wootton, Mark H Wilcox, Jane Freeman, Nicola Kenealy, Valerie Tate, Owain Llion, Rebecca Lowe

“…To progress novel tests towards implementation, a diagnostic field study is required, to allow for parallel and sequential evaluation of multiple tests in a primary care population.Methods and analysis We will recruit participants assigned female at birth from primary care clinics in England who contact their clinic with symptoms of acute uncomplicated UTI. …”
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Prevalence and genetic characterization of viral gastroenteritis in hospitalized children aged <5 years in Yunnan Province, China, 2020–2022 by Nan Li, Enfa Qiao, Zhaojun Duan, Lili Li, Lili Jiang, Jianping Cun, Xiaofang Zhou, Zhi Chao Wang, Yongming Zhou, Yihui Cao

“…Male children had a higher incidence of AGE than female children upon infection with RV, NoV, and HAdV. …”
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Deregulated methylation and expression of PCDHGB7 in patients with non-small cell lung cancer: a novel prognostic and immunological biomarker by Yue Yuan, Yue Yuan, Xin Nie, Jiayi Gao, Jiayi Gao, Yumeng Tian, Yumeng Tian, Liuer He, Liuer He, Xue Wang, Ping Zhang, Junling Ma, Lin Li, Lin Li

“…BackgroundsProtocadherin gamma subfamily B, 7 (PCDHGB7), a member of the protocadherin family, plays critical roles in neuronal connections and has been implicated in female reproductive system cancers. Its function in lung cancer has not been elucidated.MethodsWe comprehensively investigated PCDHGB7 expression, prognosis, biological function, methylation patterns, and it’s relationship with immune infiltration and immunotherapy response through public datasets (HPA, TCGA, GEO, OncoDB and MEXPRESS). …”
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Association between body size and atrial myopathy: Investigation using the prevalence of left atrial low-voltage areas by Yasuhiro Matsuda, Masaharu Masuda, Hiroyuki Uematsu, Ayako Sugino, Hirotaka Ooka, Satoshi Kudo, Subaru Fujii, Mitsutoshi Asai, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takuya Tsujimura, Yosuke Hata, Naoko Higashino, Sho Nakao, Masaya Kusuda, Toshiaki Mano

“…Methods: In total, 1,479 (age, 68 ± 10 years; female, 500 [34 %]) consecutive patients who underwent initial AF ablation were enrolled. …”
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The impact of oxidative balance on all-cause and cause-specific mortality in US adults and cancer survivors: evidence from NHANES 2001–2018 by Juan Wu, Yingdong Han, Menghui Yao, He Zhao, Zhikai Li, Tiange Xie, Yun Zhang, Xuejun Zeng

“…Methods This study included 37,317 adults (52% female) from the National Health and Nutrition Examination Survey (2001–2018). …”
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Efficacy of a Mobile Health–Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial by Ana Maria Ruiz-Leon, Rosa Casas, Sara Castro-Barquero, Sofia Alfaro-González, Petia Radeva, Emilio Sacanella, Francesc Casanovas-Garriga, Ainhoa Pérez-Gesalí, Ramon Estruch

“…MethodsA 12-week, parallel, single-blind randomized controlled trial was conducted with 123 participants (62/123, 50%, female; mean age 58.25 years, SD 9.46 years) recently diagnosed with T2D. …”
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Predictive value of CT-based and AI-reconstructed 3D-TAPSE in patients undergoing transcatheter tricuspid valve repair by Johannes Kirchner, Muhammed Gerçek, Hazem Omran, Kai Peter Friedrichs, Felix Rudolph, Tobias Rossnagel, Misagh Piran, Arseniy Goncharov, Maria Ivannikova, Volker Rudolph, Tanja Katharina Rudolph

“…Thus, this study aimed to analyze whether CT-captured TAPSE provides additional value in predicting outcomes after TTVI.Methods and resultsFor TTVI procedure planning, 75 patients (mean age, 77 ± 8 years; 61% female) with severe TR underwent full cardiac cycle CT. …”
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Predicting Time in Range Without Hypoglycaemia Using a Risk Calculator for Intermittently Scanned CGM in Type 1 Diabetes by Fernando Sebastian‐Valles, Jose Alfonso Arranz Martin, Julia Martínez‐Alfonso, Jessica Jiménez‐Díaz, Iñigo Hernando Alday, Victor Navas‐Moreno, Teresa Armenta Joya, Maria del Mar delFandiño García, Gisela Liz Román Gómez, Jon Garai Hierro, Luis Eduardo Lander Lobariñas, Carmen González‐Ávila, Purificación deMartinez de Icaya, Vicente Martínez‐Vizcaíno, Miguel Antonio Sampedro‐Nuñez, Mónica Marazuela

“…Methods This retrospective study included 1072 type 1 diabetes patients (49.0% female) from three centres using isCGM systems. Clinical data and net income from the census tract were collected for each individual. …”
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