Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice by Sorim Choung, Kyong Hye Joung, Bo Ram You, Sang Ki Park, Hyun Jin Kim, Bon Jeong Ku

“…Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance. …”
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The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes by Gabriele Forlani, Carlo Giorda, Roberta Manti, Natalia Mazzella, Salvatore De Cosmo, Maria Chiara Rossi, Antonio Nicolucci, Paolo Di Bartolo, Antonio Ceriello, Pietro Guida, AMD-Annals Study Group

“…We studied the prevalence of nonalcoholic fatty liver disease (NAFLD) and its clinical correlates in a population of patients with type 2 diabetes mellitus (T2DM). …”
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Association between NAFLD and liver fibrosis with nutritional risk index based on the NHANES 2017–2018 by Jieming Jian, Rui Zhang, Yuan Dong, Hongting Zheng, Xiaoyu Liao

“…Abstract Background Nutrition and its associated inflammation have been acknowledged as vital factors in the etiopathogenesis of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis. The nutritional risk index (NRI) has been widely recognized as a valid indicator of nutritional status in several diseases, including osteoporosis and cardiovascular disease. …”
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Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD by Charles I. V. Drummer, Fatma Saaoud, Yu Sun, Diana Atar, Keman Xu, Yifan Lu, Ying Shao, Candice Johnson, Lu Liu, Huimin Shen, Nirag C. Jhala, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We performed a panoramic analysis on both human nonalcoholic steatohepatitis (NASH) microarray data and microarray/RNA-seq data from various mouse models of nonalcoholic fatty liver disease NASH/NAFLD with total 4249 genes examined and made the following findings: (i) human NASH and NAFLD mouse models upregulate both cytokines and chemokines; (ii) pathway analysis indicated that human NASH can be classified into metabolic and immune NASH; methionine- and choline-deficient (MCD)+high-fat diet (HFD), glycine N-methyltransferase deficient (GNMT-KO), methionine adenosyltransferase 1A deficient (MAT1A-KO), and HFCD (high-fat-cholesterol diet) can be classified into inflammatory, SAM accumulation, cholesterol/mevalonate, and LXR/RXR-fatty acid β-oxidation NAFLD, respectively; (iii) canonical and noncanonical inflammasomes play differential roles in the pathogenesis of NASH/NAFLD; (iv) trained immunity (TI) enzymes are significantly upregulated in NASH/NAFLD; HFCD upregulates TI enzymes more than cytokines, chemokines, and inflammasome regulators; (v) the MCD+HFD is a model with the upregulation of proinflammatory cytokines and canonical and noncanonical inflammasomes; however, the HFCD is a model with upregulation of TI enzymes and lipid peroxidation enzymes; and (vi) caspase-11 and caspase-1 act as upstream master regulators, which partially upregulate the expressions of cytokines, chemokines, canonical and noncanonical inflammasome pathway regulators, TI enzymes, and lipid peroxidation enzymes. …”
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Prevalence of Nonalcoholic Steatohepatitis and Associated Fibrosis Stages Among US Adults Using Imaging-Based vs Biomarker-Based Noninvasive Tests by Jesse Fishman, Tom O'Connell, Christina M. Parrinello, Jonathan J. Woolley, Eric Bercaw, Michael R. Charlton

“…**Introduction:** Nonalcoholic fatty liver disease (NAFLD) is believed to be the most common chronic liver disease worldwide. …”
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Comparison of Resistive Index, Pulsatility Index, and Arterial Waveform at the Comparison of Resistive Index, Pulsatility Index, and Arterial Waveform at the Site of Hepatic Artery... by Hussein Soleimantabar, Saeed Nasiri, Farshad Gharebakhshi, Samaneh Ahmadi

“…Background: Nonalcoholic fatty liver disease (NAFLD) is common. Noninvasive methods to assess fibrosis stage are limited, and biopsy remains the gold standard. …”
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Metabolic and Hepatic Effects of Energy-Reduced Anti-Inflammatory Diet in Younger Adults with Obesity by Gordana Kenđel Jovanović, Ines Mrakovcic-Sutic, Sandra Pavičić Žeželj, Indira Benjak Horvat, Lucia Šuša, Dario Rahelić, Sanja Klobučar Majanović

“…Associated with epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disease worldwide. …”
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Characteristics of NAFLD Based on Hypopituitarism by Kazuhisa Kodama, Atsuhiro Ichihara, Yasufumi Seki, Yuichi Ikarashi, Takaomi Sagawa, Tomomi Kogiso, Maiko Taniai, Katsutoshi Tokushige

“…Hypopituitarism and hypothalamic disorders, which induce central obesity and appetite disorder, are associated with nonalcoholic fatty liver disease (NAFLD). We retrospectively analyzed the clinical features of NAFLD patients with hypopituitarism. …”
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Prevalence and risk factors of hyperuricaemia in non-obese Chinese: a single-centre cross-sectional study by Chengfu Xu, Jinghua Wang, Xinyu Wang, Yishu Chen, Shenghui Chen, Haoliang Zhai

“…Participants with hyperuricaemia showed a higher prevalence of metabolic syndrome and fatty liver disease than participants with normouraemia. …”
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Evaluation of the Effect of Cichorium intybus L. on the Liver Enzymes in Burn Patients: A Randomized Double-Blind Clinical Trial by Abdolkhalegh Keshavarzi, Rahimeh Akrami, Mohammad M. Zarshenas, Saeid Zareie, Tayyeb Ghadimi, Ali Najafi, Mahsa Rostami Chijan, Azizallah Dehghan, Elham Zarenezhad

“…Some research confirmed that the preparations of the extract are very suitable for the treatment of nonalcoholic fatty liver disease. This is a double-blind randomized controlled clinical trial. …”
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Evaluating body roundness index and systemic immune inflammation index for mortality prediction in MAFLD patients by Di Zeng, Qingyue Zeng, Shuangqing Li, Jiong Lu, Nansheng Cheng

“…Abstract Metabolic dysfunction-associated fatty liver disease (MAFLD) is a major cause of liver-related morbidity and mortality, contributing to both cardiovascular and non-cardiovascular deaths. …”
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Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional study by Chunqi Jiang, Bo Wang, Jun Wang, Yinuo Qu, Xin Zhang, Xin Zhang

“…IntroductionFatty liver disease is potentially linked to chronic kidney disease (CKD), yet the association between the Framingham Steatosis Index (FSI) and CKD remains uncharted. …”
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Risk factors for hepatocellular carcinoma: an umbrella review of systematic review and meta-analysis by Jie Wang, Kaijie Qiu, Songsheng Zhou, Yichao Gan, Keting Jiang, Donghuan Wang, Haibiao Wang

“…Smoking, obesity, non-alcoholic fatty liver disease, diabetes, low platelet, elevated liver enzymes and liver fluke infection increase HCC risk, while coffee consumption, a healthy diet, and bariatric surgery lower it. …”
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Interface Hepatitis over Grade 2 May Differentiate Chronic Inflammation Associated with CHB from NAFLD in the Early Stage by Yong-fen Zhu, Jin Wang, Jia-zhui Fang, Qiao Yang, Fang-fang Lv

“…Patients with chronic hepatitis B (CHB) concomitant with nonalcoholic fatty liver disease (NAFLD) are increasing. Objectives. …”
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The AMPK–mTOR Pathway Is Inhibited by Chaihu Shugan Powder, Which Relieves Nonalcoholic Steatohepatitis by Suppressing Autophagic Ferroptosis by Zheng Liang, Dajin Pi, Jianwei Zhen, Haizhen Yan, Chuiyang Zheng, July Liang Chen, Wen Fan, Qingliang Song, Jinyue Pan, Dongdong Liu, Maoxing Pan, Qinhe Yang, Yupei Zhang

“…Nonalcoholic steatohepatitis (NASH) is the advanced stage of nonalcoholic fatty liver disease (NAFLD), which is distinguished by the accumulation of fat in the liver, damage to liver cells, and inflammation. …”
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Smad4 deficiency in hepatocytes attenuates NAFLD progression via inhibition of lipogenesis and macrophage polarization by Wei Yang, Xuanxuan Yan, Rui Chen, Xin Xin, Shuang Ge, Yongxiang Zhao, Xinlong Yan, Jinhua Zhang

“…Abstract Nonalcoholic fatty liver disease (NAFLD), a major cause of chronic liver disorders, has become a serious public health issue. …”
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The Effect of Mesenchymal Stem Cell-Derived Exosomes and miR17-5p Inhibitor on Multicellular Liver Fibrosis Microtissues by Farnaz Sani, Mina Soufi Zomorrod, Negar Azarpira, Masoud Soleimani

“…Although several studies have been conducted on modeling human liver disease, it is still challenging to mimic nonalcoholic fatty liver disease in vitro. Here, we aimed to develop a fibrotic liver microtissue composed of hepatocytes, hepatic stellate, and endothelial cells. …”
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Mouse Models of Nonalcoholic Steatohepatitis: Head-to-Head Comparison of Dietary Models and Impact on Inflammation and Animal Welfare by Andreas Kroh, Vanina Ivanova, Hannah Drescher, Julia Andruszkow, Thomas Longerich, Jochen Nolting, Roman Eickhoff, D. Heise, Karl P. Rheinwalt, Ulf P. Neumann, Florian T. Ulmer

“…The WD represents a model of advanced-stage NASH, and the HFD60 is a strong model of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome. However, the CAFD should not be considered a NASH model.…”
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Foxp3 Expression in Liver Correlates with the Degree but Not the Cause of Inflammation by Matthaios Speletas, Nikoletta Argentou, Georgios Germanidis, Themistoclis Vasiliadis, Konstantinos Mantzoukis, Kalliopi Patsiaoura, Pavlos Nikolaidis, Vaios Karanikas, Konstantinos Ritis, Anastasios E. Germenis

“…Liver biopsies obtained from 69 individuals (26 chronic HBV hepatitis, 14 chronic HCV hepatitis, 11 nonalcoholic fatty liver disease, 8 autoimmune diseases, 2 methotrexate-related toxicity, and 8 controls) were examined, by qRT-PCR, for the mRNA expression of Foxp3, IL-10, TGF-β1, Fas, FasL, TRAIL, caspase-3, TNF-α, IFN-γ, and IL-1β. …”
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Association between metabolic dysfunction associated steatotic liver disease and gallstones in the US population using propensity score matching by Yingying Zhang, Jingjing Zhang, Dan Yu, Fan Tu, Jun Liu, Bing Han, Binghua Li, Yihang Yuan, Chaobo Chen, Mingli Zhou

“…While the relationship between gallstones and Non-Alcoholic Fatty Liver Disease (NAFLD) has been debated, the association between MASLD and gallstones remains unclear. …”
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