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Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1
Published 2025-02-01Subjects: Get full text
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CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells
Published 2025-02-01Subjects: Get full text
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Identification of hub genes and pathogenesis in Kawasaki disease based on bioinformatics analysis
Published 2024-04-01“…Results: In this study, 32 Co-DEGs were identified, and these genes mainly participated in neutrophil degranulation, neutrophil activation involved in immune response, and negative regulation of cytokine production involved in immune response; meanwhile, they were primarily enriched in starch and sucrose metabolism, fatty acid metabolism, autophagy and apoptosis, ferroptosis, and other pathways. …”
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Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease
Published 2020-05-01“…The regulation of fatty acid metabolism involves enzymes desaturase (FADS1, FADS2) and elongase (ELOVL2 and ELOVL5) fatty acids. …”
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Cannabidiol attenuates lipid metabolism and induces CB1 receptor-mediated ER stress associated apoptosis in ovarian cancer cells
Published 2025-02-01“…Fatty acid metabolic profiling and flow cytometry analysis revealed that CBD has the ability to decrease fatty acid levels and significantly suppress the transcription of genes involved in fatty acid uptake and synthesis in ES-2 cells. …”
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Target miRNA identification for the LPL gene in large yellow croaker (Larimichthys crocea)
Published 2025-02-01“…Quantitative PCR assays suggested that miR-84a and miR-1231-5p might influence LPL expression during the starvation phase, intimating the regulatory role of miRNA in fatty acid metabolism within hepatic and muscular tissue under starvation. …”
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Metabolomics-based study on the effect of low-voltage electrostatic field treatment on the storage quality of postharvest square bamboo shoots
Published 2025-01-01“…These changes were closely related to fatty acid metabolism, TCA cycle, and phenylalanine metabolism pathways. …”
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Salinity affects the lipid metabolism and intestinal microbial composition of swimming crab Portunus trituberculatus
Published 2025-03-01“…In conclusion, hepatopancreatic fatty acid metabolism was more active in the 19 ‰ group, whereas the 28 ‰ group not only promoted triglyceride synthesis in the hepatopancreas, but also facilitated ovarian development of P. trituberculatus by influencing the gut microbial composition.…”
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Valproic acid targets IDH1 mutants through alteration of lipid metabolism
Published 2024-08-01“…We conclude that targeting fatty acid metabolism through HDAC inhibition and/or FASN inhibition may be a novel therapeutic opportunity in IDH1 mutant gliomas.…”
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ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism
Published 2025-02-01“…Additionally, ANO7 downregulated genes involved in fatty acid metabolism and induced changes in lipid composition of the cells, characterized by longer acyl chain lengths and increased unsaturation, suggesting a role for ANO7 in regulating lipid metabolism in the prostate. …”
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Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease
Published 2025-01-01“…We further validated PTPRD as a STAT3 phosphatase in the liver, acting as a regulator of peroxisomal fatty acid metabolism. During MASH, low PTPRD led to increased liver steatosis in Ptprd+/− mice and a pronounced unfolded protein response, which impacts insulin signalling. …”
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