Sarco(endo)plasmic Reticulum Ca2+-ATPase-2 Gene: Structure and Transcriptional Regulation of the Human Gene by Angel Zarain-Herzberg, Georgina Alvarez-Fernandez

“…In addition, the human gene has several repeated sequences mainly of the Alu and L2 type located upstream from position -1.7 kb, spanning in a continuous fashion for more than 40 kb. In this study, we report the cloning of 2.4 kb of 5’-regulatory region and demonstrate that the proximal promoter region is sufficient for expression in cardiac myocytes, and the region from -225 to -1232 bp contains regulatory DNA elements which down-regulate the expression of the SERCA2 gene in neonatal cardiomyocytes.…”
Get full text

Responses of Multipotent Retinal Stem Cells to IL-1β, IL-18, or IL-17 by Shida Chen, Defen Shen, Nicholas A. Popp, Alexander J. Ogilvy, Jingsheng Tuo, Mones Abu-Asab, Ting Xie, Chi-Chao Chan

“…Treatment with IL-1β, IL-18, or IL-17A decreased RSC viability in a dose-dependent fashion and led to damage in cellular ultrastructure including pyroptotic and/or necroptotic cells. …”
Get full text

The McGill University Health Centre Cancer Pain Clinic: A Retrospective Analysis of an Interdisciplinary Approach to Cancer Pain Management by Jordi Perez, Sara Olivier, Emmanouil Rampakakis, Manuel Borod, Yoram Shir

“…This tailored approach includes pharmacological and nonpharmacological therapies offered concurrently in an interdisciplinary fashion. Objectives. Description of the interdisciplinary MUHC cancer pain approach and analysis of treatments and outcomes. …”
Get full text

Exploring a high-level programming model for the NWP domain using ECMWF microphysics schemes by S. Ubbiali, C. Kühnlein, C. Schär, L. Schlemmer, T. C. Schulthess, T. C. Schulthess, M. Staneker, H. Wernli

“…GT4Py encodes stencil operators in an abstract and hardware-agnostic fashion, thus enabling more concise, readable, and maintainable scientific applications. …”
Get full text

La villégiature anglaise et l’invention de la Côte d’Azur by Alain Bottaro

“…Thus, neighborhoods of English holiday homes start to grow early on and fashion the landscape through the introduction of new building methods and new town planning. …”
Get full text

Cervical heterotopic heart transplantation in mice using a novel suture technique by Hao Dun, MD MSc, Maura Sticco-Ivins, Yuriko Terada, MD PhD, Amber Berning, MD, Kory J. Lavine, MD PhD, Daniel Kreisel, MD PhD, Benjamin J. Kopecky, MD PhD

“…Recently, cervical heterotopic heart transplantation in mice has emerged as an alternative due to several advantages but is conventionally performed by suture or cuff techniques in an end-to-end fashion. Therefore, we introduce an end-to-side anastomosis technique. …”
Get full text

Effect of Nebivolol and Olmesartan on 24-Hour Brachial and Aortic Blood Pressure in the Acute Stage of Ischemic Stroke by Eleni Georgianou, Panagiotis I. Georgianos, Konstantinos Petidis, Konstantinos Markakis, Ioanna Zografou, Asterios Karagiannis

“…Methods. In a single-blind fashion, 60 patients with acute ischemic stroke and clinic systolic BP (SBP) 160–220 mmHg were randomized to nebivolol (5 mg/day), olmesartan (20 mg/day), or no-treatment between Day 4 and Day 7 of stroke onset. …”
Get full text

A Tensioned Human Skin Explant Model Used for Preliminary Assessment of Chemexfoliant-Stimulated Bioeffects by Michael J. Conneely, Jin Namkoong, Francis Allison, S. Kyoko Hirata Tsutsumi, Dominic Grussu, Ryan Willis, Kyle Henderson, Paul A. Campbell, Melissa Moy, Ewelina Lesniak, Joanna Wu, Robyn P. Hickerson

“…The performance of an innovative trichloroacetic acid–free chemexfoliation agent was then measured and, upon comparison with the previous benchmarking data, indicated that dermal remodeling factors could be upregulated in fashion comparable with that of the trichloroacetic acid–containing agents but with significant suppression of inflammatory response. …”
Get full text

Impedance mapping with high-density microelectrode array chips reveals dynamic heterogeneity of in vitro epithelial barriers by Alessandra Venz, Bastien Duckert, Liesbet Lagae, Saeedeh Ebrahimi Takalloo, Dries Braeken

“…The |Z| 1kHz maps of proliferating Caco-2 cells and the differentiating epithelial tissue developing 3D domes aligned with the corresponding optical images at cellular resolution, which demonstrates the capability of the chip in tracking the dynamic heterogeneity of Caco-2 tissues in a label free and real-time fashion. Importantly, |Z| 1kHz maps acquired during chemically induced barrier disruption showed electrodes covered with 3D cell domes experienced a stronger decrease in impedance than those covered with adherent cells (-41% ± sd 10% against -16% ± sd 10%, respectively). …”
Get full text

Ex vivo delivery of recombinant IL-10 to human donor lungs by Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee

“…Conclusions: Gene therapy remains superior as it allows for continued production of IL-10 within the alveoli where it has the potential to continuously act on alveolar macrophages and epithelial cells in a paracrine fashion.…”
Get full text

Virological and Immunological Aspects of AIDS Pathogenesis by Brian Conway, Francisco J Diaz-Mitoma

“…More recent work evaluated the combined use of proviral load (expressed as a dichotomous variable based on values above or below one copy/a03 CD4 cells) and resistance in a prospective fashion. In five patients with high proviral loads and isolates resistant to their current therapy. a mean decrease of 72 CD4 cells/µL was observed over 12 months of observation. …”
Get full text

Environmental effect of the Coronavirus-19 determinants and lockdown on carbon emissions by R. Parvin, F.T. Johora, M.A. Alim

Get full text

Does Context Matter? Governance Models in Local Administration by Stefanie Vedder, Benjamin Friedländer, Simon Bogumil-Uçan, Tanja Klenk

“…The article delves into the question of whether and to what extent different branches of public administration within the same administrative system adopt global public administration ideas in a similar fashion. Design/Methodology/Approach: The article employs a comparative design to analyse the adoption of global public administration concepts across different administrative branches. …”
Get full text

Changing Attitudes Towards Research Through a Course-based Undergraduate Research Experience by Keith Brazendale, Michael Rovito, Jeanette Garcia

“…Course-based undergraduate experiences (CUREs) can provide research-related experiences to a large number of students in a convenient fashion, thus, are well-positioned to shift student perceptions of research. …”
Get full text

Circular economy: A sustainable model for waste reduction and wealth creation in the textile supply chain by Anik Kumar Das, Md. Farhad Hossain, Borhan Uddin Khan, Md. Mahfuzur Rahman, M. A. Z. Asad, Mahmuda Akter

“…Abstract The textile industry has long been a cornerstone of the global economy, but its environmental impact has come under scrutiny, particularly with the rise of fast fashion driven by rapid population growth and short‐term trends. …”
Get full text

Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascend... by Annette Janus, Daniël Dumas, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, Philip Kremer, Yann Godfrin

“…Participants received 5 or 10 mg/kg NX210c or placebo (10-min infusion) thrice weekly for 4 weeks in an ascending dose fashion. Follow-up was conducted 2 weeks after last dosing. …”
Get full text

IŠ KO KYLA ŽMOGAUS TEISĖS? by Evaldas Nekrašas

“…Evaldas Nekrašas Summary The traditional understanding of human rights as divine or inborn is out of fashion today. Positivism succeeded in undermining it. …”
Get full text

The Role of Clinician-Developed Applications in Promoting Adherence to Evidence-Based Guidelines: Pilot Study by Madhu Prita Prakash, Aravinda Thiagalingam

“…The app utilizes a sequential design, requiring participants to input patient data in a step-wise fashion to reach the final patient risk stratification. …”
Get full text

Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells by Carl D. Richards, Laura Izakelian, Anisha Dubey, Grace Zhang, Steven Wong, Karen Kwofie, Aatif Qureshi, Fernando Botelho

“…Oncostatin M stimulated IL-33 mRNA and IL-33 full length protein in C10 mouse type 2 alveolar epithelial cells in culture in time-dependent and dose-dependent fashion, whereas IL-6, LIF, IL-31, IL-4, or IL-13 did not, and TGFβ repressed IL-33. …”
Get full text

Microstructural and Mechanical Behaviors of Friction Stir Welded Dissimilar AA6082-AA7075 Joints by M. Vetrivel Sezhian, K. Giridharan, D. Peter Pushpanathan, G. Chakravarthi, B. Stalin, Alagar Karthick, P. Manoj Kumar, Murugesan Bharani

Get full text