The evolutionary history of Plasmodium falciparum from mitochondrial and apicoplast genomes of China-Myanmar border isolates by Yini Tian, Run Ye, Dongmei Zhang, Yilong Zhang

“…Additionally, by mapping global patterns of mt/apico genome polymorphism, we will gain valuable insights into the evolutionary history of P. falciparum and optimised strategies for controlling P. falciparum malaria at international borders. Graphical Abstract…”
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Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum by Tabish Qidwai, Farrukh Jamal, Mohd Y. Khan, Bechan Sharma

“…To overcome the problem of falciparum malaria, the metabolic pathways in parasite apicoplast have been used as antimalarial drug targets. …”
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Artemether/Lumefantrine for the Treatment of P. malariae in a Patient on Hemodialysis by Rita Patrocínio-Jesus, João Cunha, Diva Trigo, Bárbara Flor-de-Lima, Patrícia Pacheco

“…The combination of artemether/lumefantrine is indicated for the treatment of acute uncomplicated Plasmodium falciparum malaria. There have been no clinical trials to assess the efficacy of this medication in patients with renal impairment. …”
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Thrombocytopenia in Plasmodium vivax Malaria: How Significant? by Arti Muley, Jitendra Lakhani, Saurabh Bhirud, Abhinam Patel

“…Thrombocytopenia is frequently noticed with P. falciparum malaria but is less reported and studied with P. vivax. …”
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Congenital Malaria in a 2-Day-Old Neonate: A Case Report and Literature Review by Dickson Kajoba, Walufu Ivan Egesa, Habonimana Jean Petit, Muhiadin Omar Matan, Goretty Laker, William Mugowa Waibi, Daniel Asiimwe

“…Laboratory tests indicated that the neonate had a positive Giemsa-stained peripheral smear for Plasmodium falciparum, with a positive malaria rapid diagnostic test (MRDT) for P. falciparum malaria. The mother had a negative peripheral film for malaria and a negative MRDT. …”
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Improving Accuracy of Malaria Diagnosis in Underserved Rural and Remote Endemic Areas of Sub-Saharan Africa: A Call to Develop Multiplexing Rapid Diagnostic Tests by Rasheed O. Makanjuola, Andrew W. Taylor-Robinson

“…Hence, a diagnosis of non-P. falciparum malaria is missed. In turn, in resource-constrained settings where optimal microscopy is not available, a misdiagnosis of bacterial infection based on signs and symptoms alone often results in an inappropriate prescription of antibiotics. …”
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Variation in Malaria Transmission Dynamics in Three Different Sites in Western Kenya by S. S. Imbahale, W. R. Mukabana, B. Orindi, A. K. Githeko, W. Takken

“…Rainfall was found to be significantly associated with the occurrence of P. falciparum malaria parasites, but not relative humidity and air temperature. …”
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Acquisition of Fc-afucosylation of PfEMP1-specific IgG is age-dependent and associated with clinical protection against malaria by Mary Lopez-Perez, Zakaria Seidu, Mads Delbo Larsen, Wenjun Wang, Jan Nouta, Manfred Wuhrer, Gestur Vidarsson, Michael F. Ofori, Lars Hviid

“…Our findings provide new insights regarding protective immunity to P. falciparum malaria and highlight the importance of cell-mediated destruction of IgG-opsonized IEs.…”
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Molecular Assessment of Domain I of Apical Membrane Antigen I Gene in Plasmodium falciparum: Implications in Plasmodium Invasion, Taxonomy, Vaccine Development, and Drug Discovery by Che Roland Achungu, Damian Nota Anong, Robert Adamu Shey, Cevie Jesenta Tabe

“…Thirty individuals with Plasmodium falciparum malaria had blood samples taken using Whatman’s filter papers. …”
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Genetic Polymorphism of msp1 and msp2 in Plasmodium falciparum Isolates from Côte d’Ivoire versus Gabon by William Yavo, Abibatou Konaté, Denise Patricia Mawili-Mboumba, Fulgence Kondo Kassi, Marie L. Tshibola Mbuyi, Etienne Kpongbo Angora, Eby I. Hervé Menan, Marielle K. Bouyou-Akotet

“…Isolates collected from 100 and 73 falciparum malaria infections in sites of Côte d’Ivoire (West Africa) and Gabon (Central Africa), respectively, were analyzed by a nested PCR amplification of msp1 and msp2 genes. …”
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Very low prevalence of Plasmodium falciparum histidine-rich protein 2 (pfhrp2) gene deletion in the Brazil, Venezuela, and Guyana tri-border by Maria Eduarda Pereira Mascarenhas, Jaime Louzada, Renato Amorim Rosa, Gabriela Maíra Pereira de Assis, Flora Satiko Kano, Joseli Oliveira-Ferreira, Tais Nobrega de Sousa

“…Abstract Rapid Diagnostic Tests (RDTs) have been an important diagnostic tool for detecting P. falciparum malaria in resource-limited settings. Most tests are designed to detect the Histidine-rich Protein 2 (HRP2). …”
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Plasmodium falciparum Merozoite Surface Proteins Polymorphisms and Treatment Outcomes among Patients with Uncomplicated Malaria in Mwanza, Tanzania by Karol J. Marwa, Eric Lyimo, Eveline T. Konje, Anthony Kapesa, Erasmus Kamugisha, Göte Swedberg

“…Therefore, this study is aimed at examining msp genetic diversity and multiplicity of infection (MOI) among P. falciparum malaria patients. The influence of MOI on peripheral parasite clearance and adequate clinical and parasitological response (ACPR) was also assessed. …”
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IMRAS-Immunization with radiation-attenuated Plasmodium falciparum sporozoites by mosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS. by Martha Sedegah, Michael R Hollingdale, Harini Ganeshan, Maria Belmonte, Jun Huang, Arnel Belmonte, Sandra Inoue, Rachel Velasco, Bradley Hickey, Nimfa Teneza-Mora, Joanne Lumsden, Sharina Reyes, Jo Glenna Banania, Anatalio Reyes, Ivelese Guzman, Thomas L Richie, Judith E Epstein, Eileen Villasante

“…<h4>Background</h4>Immunization with radiation-attenuated sporozoites (RAS) by mosquito bites provides >90% sterile protection against Plasmodium falciparum malaria in humans. We conducted a clinical trial based on data from previous RAS clinical trials that suggested that 800-1200 infected bites should induce ~50% protective vaccine efficacy (VE) against controlled human malaria infection (CHMI) administered three weeks after the final immunization. …”
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Comparative Study of Chikungunya Only and Chikungunya-Scrub Typhus Coinfection in Children: Findings from a Hospital-Based Observational Study from Central Nepal by Santosh Pathak, Nagendra Chaudhary, Prativa Dhakal, Sanjay Ray Yadav, Binod Kumar Gupta, Om Prakash Kurmi

“…Among the 42 chikungunya cases, 17 (40.5%) tested positive for scrub typhus and one positive for falciparum malaria. Out of a total of 42 chikungunya cases, myalgia, nausea/vomiting, headache, abdominal pain, lymphadenopathy, hepatomegaly, splenomegaly, and edema were 81%, 73.8%, 66.7%, 64.3%, 59.5%, 52.4%, 40.5%, and 38.1%, respectively. …”
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Genetic Diversity, Repeat Motifs, and Natural Selection at the C-Terminal Knob-Associated Histidine Rich Protein (KAHRP) of Plasmodium falciparum Clinical Samples from Saudi Arabia by Saad M. Bin Dajem, Md Atique Ahmed, Marie Fe F Bohol, Syeda Wasfeea Wazid, Mohammed I. Shafeai, Fuad H. Rudiny, Ali M. Motaen, Kareem Morsy, Hani Alothaid, Ahmed A. Al-Qahtani

“…Since this is the first study to report on genetic diversity of C-terminal PfKAHRP interaction domain and the repeat motifs from clinical samples in Saudi Arabia, it will contribute towards the rational design of antiadhesion drug therapies for P. falciparum malaria.…”
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Cost of introducing and delivering malaria vaccine (RTS,S/AS01E) in areas of seasonal malaria transmission, Mali and Burkina Faso by Jean Bosco Ouédraogo, Alassane Dicko, Ranju Baral, Clint Pecenka, Halimatou Diawara, Fadima Yaya Bocoum, Ann Levin, Cynthia Lee, Fatoumata Koita, Rosemonde Guissou, Seydou Yabré, Seydou Traoré, Winthrop Morgan

“…Background The WHO recommends use of the RTS,S/AS01E (RTS,S) malaria vaccine for young children living in areas of moderate to high Plasmodium falciparum malaria transmission and suggests countries consider seasonal vaccination in areas with highly seasonal malaria. …”
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