Prioritization of potential pharmacological targets for the development of anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway: the reconstruction and analysis... by P. S. Demenkov, E. A. Antropova, A. V. Adamovskaya, E. I. Mishchenko, T. M. Khlebodarova, T. V. Ivanisenko, N. V. Ivanisenko, A. S. Venzel, I. N. Lavrik, V. A. Ivanisenko

“…Hepatocellular carcinoma (HCC) is a common severe type of liver cancer characterized by an extremely aggressive course and low survival rates. …”
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The association of lifestyle with cardiovascular and all-cause mortality based on machine learning: a prospective study from the NHANES by Xinghong Guo, Mingze Ma, Lipei Zhao, Jian Wu, Yan Lin, Fengyi Fei, Clifford Silver Tarimo, Saiyi Wang, Jingyi Zhang, Xinya Cheng, Beizhu Ye

“…The participants underwent a comprehensive in-person interview and medical laboratory examinations, and subsequently, their records were linked with the National Death Index for further analysis. Extreme gradient enhancement, random forest, support vector machine and other machine learning methods are used to build the prediction model. …”
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MOLECULAR SCREENING OF POTATO VARIETIES BRED IN THE NORTHWESTERN ZONE OF THE RUSSIAN FEDERАTION by Т. A. Gavrilenko, N. S. Klimenko, O. Yu. Antonova, V. A. Lebedeva, Z. Z. Evdokimova, N. M. Gadjiyev, O. V. Apalikova, N. V. Alpatyeva, L. I. Kostina, N. M. Zoteyeva, F. T. Mamadbokirova, K. V. Egorova

“…Potato varieties and hybrids created in different periods of time in this institute and in the Ltd Breeding company “LiGa” were included in marker-assisted selection with 22 markers of 14 R genes conferring extreme resistance to viruses PVY and PVX, resistance to cyst nematodes Globodera pallida (patotypes Pa2, Pa3) and G. rostochiensis (pathotype Ro1) and resistance to late blight. …”
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Emergency Laparotomy in the Critically Ill: Futility at the Bedside by Niels D. Martin, Sagar P. Patel, Kristen Chreiman, Jose L. Pascual, Benjamin Braslow, Patrick M. Reilly, Lewis J. Kaplan

“…The need for BSL portends an extremely high mortality rate and is likely useful in preintervention counselling. …”
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Positive impacts of typical desert photovoltaic scenarios in China on the growth and physiology of sand-adapted plants by Ruibing Meng, Ruibing Meng, Ruibing Meng, Zhongju Meng, Zhongju Meng, Zhongju Meng, Xiaomeng Ren, Jiale Cai, Jiale Cai, Jiale Cai, Xufang Tong, Xufang Tong, Xufang Tong

“…Desert regions are characterized by complex terrain, frequent wind–sand activities, and extreme environmental conditions making vegetation recovery after disturbances difficult. …”
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Bayesian reinforcement learning models reveal how great-tailed grackles improve their behavioral flexibility in serial reversal learning experiments by Lukas, Dieter, McCune, Kelsey, Blaisdell, Aaron, Johnson-Ulrich, Zoe, MacPherson, Maggie, Seitz, Benjamin, Sevchik, August, Logan, Corina

“…The changes in behavioral flexibility that grackles showed in their experience of the serial reversals also influenced their behavior in a subsequent experiment, where individuals with more extreme rates or sensitivities solved more options on a multi-option puzzle box. …”
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Model for End-Stage Liver Disease and Sodium Velocity Predicts Overall Survival in Nonmetastatic Hepatocellular Carcinoma Patients by Justin Y. Tang, Nitin Ohri, Rafi Kabarriti, Santiago Aparo, Jennifer Chuy, Sanjay Goel, Jonathan M. Schwartz, Milan Kinkhabwala, Andreas Kaubisch, Chandan Guha

“…We identified a subset of HCC patients who have extremely poor prognosis by incorporating the rate of short-term change in MELD-Na to baseline MELD-Na score.…”
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Pharmacist-led DE-eSCALation of opioids post-surgical dischargE (DESCALE) – A multi-centre, non-randomised, feasibility study protocol [version 2; peer review: 1 approved, 2 approv... by Ellie Santer, Julie H Hedayioglu, Vanessa J Short, Sabina Hulbert, Emma L Veale, Melanie Rees-Roberts, Johanna Theron

“…Used appropriately, opioids deliver extremely favourable pain relief. Used longer than 90-days, however, can result in health complications, including unintentional overdose and addiction. …”
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Diurnal and Daily Variations of PM2.5 and its Multiple-Wavelet Coherence with Meteorological Variables in Indonesia by Nani Cholianawati, Tiin Sinatra, Ginaldi Ari Nugroho, Didin Agustian Permadi, Asri Indrawati, Halimurrahman, Meta Kallista, Moch Syarif Romadhon, Ilma Fauziah Ma’ruf, Dipo Yudhatama, Tesalonika Angela Putri Madethen, Asif Awaludin

“…Meanwhile, the investigation on the extreme rise of PM2.5 in Pontianak due to peatland forest fires using HYSPLIT shows that emission from the surrounding area significantly raises the maximum half-hourly in Pontianak to 700 μg m−3.…”
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Identification and susceptibility assessment of landslide disasters in the red bed formation along the Nanjian-Jingdong Expressway by Yifan Cao, Zhifang Zhao, Mingchun Wen, Xin Zhao, Dingyi Zhou, Jingyi Qin, Liu Ouyang, Jingyao Cao

“…By analyzing nine evaluation indicators, this study assesses the susceptibility of landslide disasters in the research area by applying Random Forest (RF), Extreme Gradient Boosting (XGBoost), Categorical Boosting (CatBoost), and Stacking Ensemble Strategies (Stacking). …”
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Consensus evidence-based clinical practice guide for the diagnosis and management of osteoporosis in childhood and adolescence by Yasser El Miedany, Hala Lotfy, Maha El Gaafary, Naglaa Gadallah, Annie Nasr Mehanna, Safaa Mahran, Waleed Hassan, Mohammed Hassan Abu-Zaid, Samar Abdelhamed Tabra, Mohamed Mortada, Ahmed R. Radwan, Dalia El Mikkawy, S. Esam Maher, Ghada Eldrainy, Hala Abdulhady, Marwa Mahgoub, Youmna Amer, Walaa Elwakil

“…Conclusion For the management of children with osteoporosis, consulting a pediatric bone specialist is strongly advised, either by referral or by advice. This is extremely relevant because children are uniquely capable of recovering spontaneously or with the assistance of medication. …”
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Severe pneumonia caused by Nocardia otitidiscaviarum in a patient with bronchiectasis and IgA nephropathy: a case report by Yi Lin, Zhao-Zhao Jiang, Xiao-Qian Chi, Jian-Sheng Chen, Chao Wen, Chao Zhang, Ying-Ying Wang, Guang-Liang Xie

“…The patient presented with tongue and lip ulcers, chest distress, cough, expectoration, and fever as the initial symptoms, which were extremely similar to common bacterial pulmonary infections. …”
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Comparison of Maternal, Perinatal, and Neonatal Outcomes of Asymptomatic and Symptomatic Pregnant Women with Coronavirus Disease-2019 by Tayfun VURAL, Burak BAYRAKTAR, Suna YILDIRIM KARACA, Ozan ODABAS, Nisel YILMAZ, Pınar SAMLIOGLU, Mehmet OZEREN

“…Additionally, the total cesarean section rate was extremely high in both groups. We expected more adverse outcomes in symptomatic patients; however, we found similar maternal, perinatal, and neonatal outcomes between both groups.…”
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Thermal radiation effects of ternary hybrid nanofluid flow in the activation energy: Numerical computational approach by Hakeem Ullah, Syed Arshad Abas, Mehreen Fiza, Aasim Ullah Jan, Ali Akgul, Magda Abd El-Rahman, Seham M. Al-Mekhlafi

“…Significance: The remarkable thermal conductivity and heat transfer characteristics of nanofluids make them extremely valuable in thermal engineering and other areas. …”
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Classification of Wheezing Children in Rural Bangladesh by Intensity of Ascaris Infection, Total and Specific IgE Levels, History of Pneumonia, and Other Risk Factors by Haruko Takeuchi, Md Alfazal Khan, Khalequz Zaman, Sayaka Takanashi, S. M. Tafsir Hasan, Mohammad Yunus, Tsutomu Iwata

“…Cluster 3 (n=32) consisted of participants with the most episodes of pneumonia and lower titers of the total and specific IgEs. The extremely high prevalence of Ascaris infection found in Clusters 1-3 was 78%, 77%, and 72%, respectively. …”
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October 7th Mass Casualty Attack in Israel: Injury Profiles of Hospitalized Casualties by Sharon Goldman, MPH, Ari M. Lipsky, MD, Irina Radimislensky, BSc, Adi Givon, BSc, Ofer Almog, MD, Avi Benov, MD, Israel Trauma Group, Eldad Katorza, MD, MSC, MBA, H. Bahouth, A. Bar, A. Braslavsky, D. Czeiger, D. Fadeev, A. L. Goldstein, I. Grevtsev, G. Hirschhorn, I. Jeroukhimov, A. Kedar, Y. Klein, A. Korin, B. Levit, I. Schrier, A. D. Schwarz, W. Shomar, D. Soffer, M. Weiss, O. Yaslowitz, I. Zoarets

“…The most frequently injured body regions were lower (49%) and upper (42%) extremities, abdominal (28%), and thoracic (23%) injuries. …”
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Comparative assessment of empirical and hybrid machine learning models for estimating daily reference evapotranspiration in sub-humid and semi-arid climates by Siham Acharki, Ali Raza, Dinesh Kumar Vishwakarma, Mina Amharref, Abdes Samed Bernoussi, Sudhir Kumar Singh, Nadhir Al-Ansari, Ahmed Z. Dewidar, Ahmed A. Al-Othman, Mohamed A. Mattar

“…The ML models examined include Random Forest (RF), M5 Pruned (M5P), eXtreme Gradient Boosting (XGBoost), and Light Gradient Boosting Machine (LightGBM), with hybrid combinations of RF-M5P, RF-XGBoost, RF-LightGBM, and XGBoost-LightGBM. …”
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The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors by Mingchuan Huang, Shenghui Wu, Pengfei Gao, Li Zhou, Qian Fu, Chenglin Wu, Huanxi Zhang, Yitao Zheng, Xiaojun Su, Wenrui Wu, Jinghong Tan, Qiang Zhang, Pei Xia, Zhe Xu, Longshan Liu, Jun Li, Changxi Wang

“…However, significant donor-recipient weight mismatch, particularly when the ratio is less than 1:10, may contribute to increased surgical complications and poorer graft survival. Efforts to minimize extreme weight mismatch are recommended to optimize outcomes.…”
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Prognosis conferred by molecular features of appendix-derived Pseudomyxoma Peritonei by Ruiqing Ma, Guojun Li, Yingjiang Ye, Lei Liang, Chong Wang, Haipeng Zhou, Pu Zhang, Lubiao An, Guanjun Shi, Qian Chen, Hongbin Xu, Zhidong Gao

“…Introduction: Pseudomyxoma Peritonei (PMP) is an extremely rare disease characterized by progressive accumulation of mucinous ascites and implants in the peritoneum. …”
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Evaluation of the planting performance for planting substrate using the SQI-CRITIC combination model based on the least squares method by Ning Wang, Dong Xia, Dong Xia, Dong Xia, Xiaoming Duan, Bingqin Zhao, Bingqin Zhao, Wennian Xu, Wennian Xu

“…BackgroundTo improve the scientificity of the evaluation results of the planting performance of the Yellow River sediment based on planting substrate.MethodsThis study replaced the natural soil with Yellow River sediment, used cement as the cementing material, added different proportions of organic matter and amendment of habitat material to prepare planting substrate based on the Yellow River sediment, and carried out experiments by using oats and proposed a combined SQI-CRITIC combined weighting calculation method based on the least square method for its evaluation.ResultsThe results showed that (1) different proportions of cement and amendment of habitat material led to significant variations in the planting performance of the planting substrate based on Yellow River sediment: among the 5# mix ratio, the plant height (12.5 cm) and biomass (3.06 g) of oats reached extreme values. Photosynthetic rate (1.97 μmol∙m−2∙s−1) and transpiration rate (0.25 mmol∙m−2∙s−1) were significantly higher than the other fitness ratio components (P < 0.05), while the stomatal width (87.03 μm) was the largest and stomatal density (19.6%) was the lowest (P < 0.05). (2) The results calculated by the SQI-CRITIC combination model based on the least square method are scientific and effective, more accurate and in line with the actual situation. (3) The comprehensive analysis recommended the use of a quality mix ratio (mixture of sediment, amendment of habitat material, organic matter, cement = 100:3:12:4) in ecological restoration to achieve the best plant growth and ecological restoration effect.ConclusionThe experimental results can be extended to more areas that need to use sandy soil for ecological restoration, with a view to providing a theoretical basis for soil quality evaluation, soil and water conservation control, and ecological construction in the Yellow River Basin.…”
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