Development of an easy non‐destructive particle isolation protocol for quality control of red blood cell concentrates by Marine Ghodsi, Anne‐Sophie Cloos, Anaïs Lotens, Marine De Bueger, Patrick Van Der Smissen, Patrick Henriet, Nicolas Cellier, Christophe E. Pierreux, Tomé Najdovski, Donatienne Tyteca

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Editorial: Viral infection pathogenesis and pathology in nervous system by A. Alwin Prem Anand

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Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems by Yuxuan Liu, Yaohui Ou, Linlin Hou

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Editorial: The expanding Frontiers of stem cells therapy in oral maxillo-facial engineering and regenerative medicine by Christiane L. Salgado, Christiane L. Salgado, Andrea Cochis, Elena M. Varoni, Rui Amaral Mendes, Rui Amaral Mendes, Rui Amaral Mendes, Rui Amaral Mendes

Subjects: “…dental MSC and extracellular vesicles applications…”
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In vivo trafficking of cancer-derived exosomes and their role in metastasis by Shih-Yen Wei, Sarah E. Shelton, Ying-Chieh Chen, Ke Huang

“…Extracellular Vesicle…”
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Potential and development of cellular vesicle vaccines in cancer immunotherapy by Wenxi Zhao, Xianjun Li, Jialu Guan, Shuai Yan, Lizhi Teng, Xitong Sun, Yuhan Dong, Hongyue Wang, Weiyang Tao

“…This paper presents the advantages of these three bacteria/extracellular vesicles as cancer vaccines and discusses the potential applications of functionally modified extracellular vesicles as cancer vaccines after cellular engineering or genetic engineering, as well as current clinical trials of extracellular vesicle vaccines. …”
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IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING by Xue Zeng, Xiaosong Li, Yundong Zhang, Chaoxia Cao, Qin Zhou

“…Here, we found that IL6 increased reactive oxygen species (ROS) generation by enhancing the NADPH oxidase (NOX) level and induced mtDNA leakage in EC cells, which further caused the activation of the downstream cGAS-STING signaling and increased production of extracellular vesicle (EV) production from EC cells. Besides, the activation of cGAS-STING signaling enhanced the expression of type I IFN and its downstream molecule PD-L1 through the TBK1-IRF3 pathway. …”
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Increasing the concentration of plasma molecules improves the biological activity of platelet-rich plasma for tissue regeneration by Mikel Sánchez, Jon Mercader Ruiz, Daniel Marijuán Pinel, Pello Sánchez, Nicolás Fiz, Jorge Guadilla, Juan Azofra, Maider Beitia, Diego Delgado

“…Different growth factor (GF) levels were measured using Enzyme Linked Immunosorbent Assay (ELISA), and in addition to the increase in intra-platelet GFs found in standard PRP (sPRP), BPCP also showed a higher concentration of plasmatic protein. Furthermore, extracellular vesicle (EV) concentration was significantly higher in BPCP. …”
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Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade by Xiaolin Liu, Xiao Liu, Xiaonan Luo, Maorong Zhu, Nannan Liu, Juan Li, Qi Zhang, Cheng Zou, Yuxin Wu, Zhengcong Cao, Shuangxin Ma, Weizhong Wang, Guangzhao Yang, Jintao Gu, Wei Liu, Meng Li, Anan Yin, Yalong He, Wei Lin

“…Thus, we have developed an engineered multifunctional extracellular vesicle (EV) delivery system that offers an "all-in-one" strategy for GBM therapy. …”
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tiRNA-Gln-CTG is Involved in the Regulation of Trophoblast Cell Function in Pre-eclampsia and Serves as a Potent Biomarker by Yixiao Wang, Xiaohong Ji, Hengmei Shi, Sicong Liu, Hong Yu

“…In vitro experiments revealed that tiRNA-Gln-CTG influences the proliferation, cycling, migration, and invasion of HTR-8/SVneo cells, possibly by targeting the 3′UTR region of thrombospondin-2 messenger ribonucleic acid (mRNA) for degradation. Extracellular vesicle (EV) carriers may mediate the level of tiRNA-Gln-CTG in the circulation. …”
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An aggregation-induced emission-active lysosome hijacker: Sabotaging lysosomes to boost photodynamic therapy efficacy and conquer tumor therapeutic resistance by Hang Zou, Pingping Wang, Zhihao Bai, Liping Liu, Jingtong Wang, Yanfang Cheng, Bairong He, Zujin Zhao, Lei Zheng

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Menopause mysteries: the exosome-inflammation connection by Aarushi Sultania, Subhashini Brahadeeswaran, Aparna Eledath Kolasseri, Sivaraman Jayanthi, Ramasamy Tamizhselvi

“…Abstract Extracellular vesicles, or exosomes, are produced by every type of cell and contain metabolites, proteins, lipids, and nucleic acids. …”
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Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity by Kenji Tsuji, Shinji Kitamura, Jun Wada

“…The regenerations induced by MSCs are primarily mediated by the paracrine release of soluble factors and extracellular vesicles, including exosomes and microvesicles. …”
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Effect of Lidocaine and Epinephrine on Human Erythrocyte Shape and Vesiculability of Blood Cells by Tanja Slokar, Carlos Lopez-Mariscal, Judita Lea Krek, Roman Štukelj, Oskar Zupanc, Veronika Kralj-Iglič

“…Whole blood and plasma were incubated with lidocaine/epinephrine. Extracellular vesicles were isolated by centrifugation and washing and counted by flow cytometry. …”
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Effect of mesenchymal stem cells on animal semen during storage by E. Yu. Zakirova, A. G. Malanyeva, A. M. Aimaletdinov

“…The stem cells, like any other cells, exert their effect on surrounding cells and tissues by secreting extracellular vesicles. The extracellular vesicles of the stem cells possess biological activity of parent cells. …”
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MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis by Ruonan Li, Haotian Wang, Xiaolong Wang, Yanbin Yang, Kai Zhong, Xuemei Zhang, Heping Li

“…This study investigated the effect of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) isolated from umbilical cord blood and human umbilical cord plasma-derived extracellular vesicles (UCB-EVs) on wound healing and scar formation reduction. …”
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Promising Therapeutic Functions of Bone Marrow Mesenchymal Stem Cells Derived-Exosome in Asthma by Jia-Ying Yuan, Xiang-Yun Wang, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yi Zhang, Yan Shang

“…Studies have revealed that bone marrow mesenchymal stem cells (BMMSCs) hold various curative effects in asthma and may benefit in the long term with high safety. Extracellular vesicles (EVs) enriched in body fluid were characterized as subcomponents of extracellular vesicles and delivered carriers combined with genetic messages in vivo. …”
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A Bibliometric Analysis of Macrophage Research Associated with Periodontitis Over the Past Two Decades by Yu Qiu, Zhenzhen Ding, Deqin Yang

“…The utilization of extracellular vesicles derived from diverse sources to regulate M1/M2 macrophage polarization presents a promising strategy for the treatment of periodontitis.…”
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Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value by Yuanyuan Shao, Xiaofeng Pan, Rong Fu

“…Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most eukaryotic cells. …”
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Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke by Yongdan Cun, Yaju Jin, Danli Wu, Li Zhou, Chengcai Zhang, Simei Zhang, Xicheng Yang, null Zuhong Wang, Pengyue Zhang

“…Exosomes are the heterogeneous population of extracellular vesicles which play critical roles in intercellular communication through transmitting various proteins and nucleic acids to nearby and distant recipient cells by body fluids and circulation. …”
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