Association and Interaction Analysis of Lipid Accumulation Product with Impaired Fasting Glucose Risk: A Cross-Sectional Survey by Jian Song, Xue Chen, Yuhong Jiang, Jing Mi, Yuyuan Zhang, Yingying Zhao, Xuesen Wu, Huaiquan Gao

“…The present study is aimed at (i) analyzing the predictive performances of LAP in the identification of impaired fasting glucose (IFG) in Chinese population and (ii) exploring the potentially interactive effect between LAP and other factors on IFG risk. …”
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Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

“…These results provide a theoretical basis for a deeper understanding of the mechanisms of stem cell therapy and for exploring suitable delivery pathways of stem cell treatment.…”
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Serum ALT activity and its isoenzymes as potential biomarkers for diagnosis of Sarcopenia in older adults: a retrospective, cross-sectional study by Jiangping Zeng, Nannan Li, Jiaying Ge, Huihui Ma, Siqi Sun, Yujie Jing, Chunhua Qian, Ran Cui, Shen Qu, Hui Sheng

“…Despite this, its association with sarcopenia remains inadequately explored. This study aims to investigate the correlation between serum levels of ALT-related indicators (ALT activity, ALT1, ALT2, and ALT1/ALT2 ratio) and sarcopenia measures, as well as to develop a diagnostic model for sarcopenia in older individuals. …”
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Identification of Lauric Acid as a Potent Sodium Channel NaV1.5 Blocker from Compound Chinese Medicine Wenxin Keli by Xie W, Gao J, Liang Y, Huang C, Zhang B, Chen X, Yao X, Nan G, Wu H, Wang Y, Wu L, Wang T, Zhu Y

“…This study focused on identifying the active inhibitor of INa in WXKL and exploring their mode of action in electrophysiological conduction.Methods: A chemical fraction library was constructed from an aqueous extract of WXKL and screened using an automated patch-clamping system in cells stably expressing the NaV 1.5 gene SCN5A. …”
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Thiol-Disulfide Homeostasis in Noise-Induced Hearing Loss in Rats by Enes Aydın, Serpil Mungan Durankaya, Osman Yilmaz, Günay Kirkim, Safiye Aktaş, Salim Neşelioğlu, Özcan Erel, Yüksel Olgun, Abdullah Dalgıç

“…After sacrificing the rats, the right and left temporal bones of each rat were removed and stained with hematoxylin eosin for histological studies to explore any pyknotic changes in spiral ganglion cells. …”
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Evaluating the Impact of Pharmacotherapy in Augmenting Quit Rates Among Hispanic Adults in an App-Delivered Smoking Cessation Intervention: Secondary Analysis of a Randomized Contr... by Margarita Santiago-Torres, Kristin E Mull, Brianna M Sullivan, Ana Paula Cupertino, Ramzi G Salloum, Matthew Triplette, Michael J Zvolensky, Jonathan B Bricker

“…ObjectiveThis secondary analysis used data from a randomized controlled trial that compared the efficacy of 2 smoking cessation apps, iCanQuit (based on acceptance and commitment therapy) and QuitGuide (following US clinical practice guidelines), to explore the association between pharmacotherapy use and smoking cessation outcomes among the subsample of 173 Hispanic participants who reported on pharmacotherapy use. …”
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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…Additional in vivo and in vitro experiments, including CCK-8 assays, colony formation and mouse xenograft models, were conducted to explore the biological role of NAT10-mediated ac4C modifications. …”
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Elliptic and Quadrangular Flow of Protons in the High-Baryon-Density Region by Shaowei Lan, Zuowen Liu, Like Liu, Shusu Shi

“…In addition to comparing the transverse momentum (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>p</mi><mi>T</mi></msub></semantics></math></inline-formula>), rapidity, and centrality dependence of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>v</mi><mn>4</mn></msub><mo>/</mo><msubsup><mi>v</mi><mrow><mn>2</mn></mrow><mn>2</mn></msubsup></mrow></semantics></math></inline-formula> between HADES data and model calculations, we also explore its time evolution and energy dependence across <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msqrt><msub><mi>s</mi><mrow><mi>N</mi><mi>N</mi></mrow></msub></msqrt><mo>=</mo></mrow></semantics></math></inline-formula> 2.4 to 4.5 GeV. …”
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Prediction of slaughter weight with body components and liner body measurement of Hararge cattle at Haramaya University abattoir, Ethiopia by Takele Wolkaro, Yosef Tadesse, Mengistu Urge, Merga Bayisa

“…Simple (linear, quadratic) and multiple (linear, quadratic) regression models were used to explore the relationships between SW, and four linear body measurements. …”
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Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in People Living With HIV Attending Centre of Excellence in HIV Care at a Tertiary Level Teaching Hospital in North... by Ragini Ram, Anuradha Subramanian MD, MSc, FRCP, Rajeshwari K. MD, PhD, FRCPCH

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) in adults with HIV infection in India has not been explored to date. In this study, we attempted to assess the existence of MASLD in thirty adults registered at the Centre of Excellence in ART Care at a tertiary teaching hospital in New Delhi. …”
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Association of dietary quality and mortality in the non-alcoholic fatty liver disease and advanced fibrosis populations: NHANES 2005–2018 by Xingyong Huang, Xiaoyue Zhang, Xuanyu Hao, Tingting Wang, Peng Wu, Lufan Shen, Yuanyuan Yang, Wenyu Wan, Wenyu Wan, Wenyu Wan, Kai Zhang

“…Despite the abundance of dietary guidelines for managing NAFLD, the precise impact of diet quality on mortality among individuals with advanced fibrosis remains elusive. This study aims to explore the influence of five dietary quality indexes on mortality among NAFLD patients and advanced fibrosis patients.MethodsThis study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2005 to 2018 to assess dietary quality based on the Alternate Mediterranean Diet (aMED), Healthy Eating Index-2020 (HEI-2020), Dietary Approach to Stop Hypertension (DASH), Alternate Healthy Eating Index (AHEI), and Dietary Inflammatory Index (DII). …”
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Cohort retention in a pandemic response study: lessons from the SARS-CoV2 Immunity & Reinfection Evaluation (SIREN) study by Anna Howells, Katie Munro, Sarah Foulkes, Atiya Kamal, Jack Haywood, Sophie Russell, Dominic Sparkes, Erika Aquino, Jennie Evans, Dale Weston, Susan Hopkins, Jasmin Islam, Victoria Hall

“…We conducted two focus groups with research teams in February 2023 and conducted thematic analysis exploring cohort retention challenges and facilitators. …”
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Mechanism of Electroacupuncture Mediated Macrophages Infiltration on Dorsal Root Ganglion to Alleviate Paclitaxel-Induced Neuropathic Pain by XIANG Hongchun, ZHANG Hong, LI Jing, LONG Man, LI Man, CAI Guowei

“…ObjectiveTo observe the effects of electroacupuncture (EA) at bilateral Zusanli acupoint (ST 36) on the expressions of macrophage marker CD68, monocyte chemotactic protein-1 (MCP-1), interleukin-1β (IL-1β) and inducible nitric oxide synthase (iNOS) in dorsal root ganglion (DRG) of mouse model with paclitaxel-induced neuropathic pain, and to explore the mechanism of EA in regulating paclitaxel-induced neuropathic pain.MethodsA total of 30 adult C57 mice were randomly divided into control group, model group and EA group, with 10 mice in each group. …”
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The triglyceride-glucose index trajectories are associated with cardiovascular diseases in people living with HIV: evidence from a prospective cohort study in China, 2005–2022 by Yinsong Luo, Liqin Sun, Yun He, Fang Zhao, Duo Shan, Fan Bu, Lingyun Ge, Xiaorui Li, Yiyao Hu, Xi Xiao, Hongzhou Lu, Jiaye Liu

“…Further studies are needed to validate these findings in other cohorts and to explore their applicability in women.…”
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A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity by Wen Wang, Wen Wang, Meiting Wang, Huanbai Wang, Weifeng Xu, Conggang Wang, Jie Pei, Xiaodan Li, Dongting Zhangsun, Dongting Zhangsun

“…This study aims to examine the activities of [D1G, ΔQ14] LvIC and explore its potential mechanisms in vivo.MethodsThe study involved the injection of [D1G, ΔQ14] LvIC into the lateral cerebral ventricle (LV) of mice. …”
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The role of FTO in m6A RNA methylation and immune regulation in Staphylococcus aureus infection-related osteomyelitis by Sijing Liu, Sijing Liu, Sijing Liu, Kai Li, Changhai Long, Mingwu Lao, Biao Ma, Changquan Liu, Haoyuan He, Chunjiang Wang, Wangzhu Chen, Bin Yu

“…BackgroundRegulators of n6-methyladenosine (m6A) RNA modification play important roles in many diseases; however, their involvement in Staphylococcus aureus (S. aureus)-related osteomyelitis remains inadequately explored. Therefore, this study aims to investigate the role of m6A in S. aureus infection-related osteomyelitis and elucidate its underlying mechanisms.MethodsWe downloaded the S. aureus infection-related osteomyelitis infection dataset GSE30119 from the Gene Expression Omnibus database. …”
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Chain-mediated effect of physical activity between Chinese language-based L2 motivational self-system and intended effort by Zixia Bu, Yu Liu, Yi Ba, Shan Jiang, Huijuan Liu, Jiyuan Li, Fuqiang Dong, Haohan Yu, Xindi Zhao

“…Therefore, the present study examined PA as a mediator and explored its ameliorative effects in L2MSS. A total of 981 international students from different countries were selected from 8 universities in Beijing as research subjects and were surveyed by International Physical Activity Questionnaire (IPAQ), L2MSS, Learning Experience Scale, and Intended Effort Scale. …”
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A c-type lectin HcLec1 with dual function of immunology and mineralization from the freshwater oyster (Hyriopsis cumingii Lea) by Xiaofeng Chen, Xiaoya Shen, Shijun Liu, Wenjuan Li, Wenjuan Li, He Wang, Jiale Li, Jiale Li, Zhiyi Bai, Zhiyi Bai

“…In vitro calcium carbonate crystallization assays were conducted to explore the direct role of HcLec1 in calcium carbonate crystal formation.ResultsThe HcLec1 gene sequence is a full-length cDNA of 1552 bp, encoding 240 amino acids. …”
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Spatial Changes in Soil Nutrients in Tea Gardens from the Perspective of South-to-North Tea Migration: A Case Study of Shangluo City by Ziqi Shang, Jichang Han, Yonghua Zhao, Ziru Niu, Tingyu Zhang

“…[Objective] This study focused on the primary tea-producing regions of Shangluo City (ranging from 108°34′20″ E to 111°1′25″ E and 33°2′30″ N to 34°24′40″ N), which include Shangnan County, Zhen’an County, Zhashui County, Danfeng County, and Shanyang County. The aim was to explore the characteristics and influencing factors of soil nutrient content variation across different tea gardens in the area. …”
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Attitudes Toward Psychotherapeutic Treatment and Health Literacy in a Large Sample of the General Population in Germany: Cross-Sectional Study by Rebekka Schröder, Tim Hamer, Ralf Suhr, Lars König

“…Additionally, associations between sociodemographic factors, experience with psychotherapy, and attitudes toward psychotherapy were explored. MethodsA random sample was drawn from a panel representative of the German-speaking population with internet access in Germany and invited to participate in the study via email. …”
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